Bulletin of Tokyo Dental College最新文献

{"title":"Interdisciplinary Treatment of Non-syndromic 5-Tooth Agenesis Involving Miniscrews.","authors":"Chiaki Endo, Kazuaki Nishimura, Mika Unno, Nobuhiro Yoda, Kaoru Igarashi","doi":"10.2209/tdcpublication.2025-0030","DOIUrl":"10.2209/tdcpublication.2025-0030","url":null,"abstract":"<p><p>Agenesis of 5 or more permanent teeth is infrequent, and orthodontic treatment for asymmetric or multiple consecutive missing teeth is challenging. Collaboration among dental specialists to develop individualized treatment plans is critical to achieving optimal outcomes and ensuring patient satisfaction. A 15-year-old non-syndromic girl presented with skeletal Class I malocclusion. She had agenesis of 5 asymmetric permanent teeth, comprising 3 consecutive teeth (the maxillary left canine and first and second premolars), the maxillary right second premolar, and the mandibular right first premolar, and 5 persistent deciduous teeth. Miniscrews were placed distal to the mandibular right first deciduous molar and first molar. The mandibular right molars were uprighted and the space left by first premolar agenesis closed by miniscrew-assisted mesial movement of the molars. The bilateral maxillary deciduous second premolars were preserved. After extracting the maxillary left deciduous canine and the first deciduous molar, 2 miniscrew-supported pontics were placed perpendicular to the alveolus to control the adjacent teeth and maintain space. Active treatment lasted 36 months. Prosthetic treatment for the maxillary left canine and first premolar was completed 3 years after dental implant placement. Occlusion remained stable, even after 5 years of retention. This report highlights the finding that excellent occlusion and esthetics can be achieved by collaborative management involving orthodontists, oral surgeons, and prosthodontists in cases of hypodontia.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"77-88"},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Undergraduate Dental Student Comprehension of Occlusal Balance in Complete Dentures through Small-Group Discussions Combined with Digital Model.","authors":"Tomofumi Takano, Masahiro Ryu, Midori Ohta, Takeshi Saito, Kazuma Nakazawa, Takafumi Kobayashi, Yoshinori Yamamoto, Takayuki Ueda","doi":"10.2209/tdcpublication.2025-0038","DOIUrl":"10.2209/tdcpublication.2025-0038","url":null,"abstract":"<p><p>Understanding occlusal balance in complete dentures requires conceptualizing mandibular movement and denture dynamics, which many dental students find difficult. This study introduced and evaluated an instructional digital model designed to facilitate accurate 3-dimensional and dynamic representation of these phenomena. This model allowed 360° visualization of mandibular movement and denture dynamics. Its effectiveness was evaluated when used in conjunction with small-group discussions (SGDs) for teaching occlusal balance to undergraduate dental students. Fifth-year students (n=128) at Tokyo Dental College completed both an SGD session and a digital-model learning session, with the order randomized at the small-group level (SGD-first group, n=67; digital model-first group, n=61). Comprehension was assessed using a pre-test and two posttests administered after each session (post-test 1 and post-test 2), each scored on a 10-point scale. Inter- and intra-group comparisons were performed using the Mann-Whitney U and Wilcoxon signed-rank tests, respectively. There were no significant differences between the SGD-first and digital model-first groups in pre-test (4.01±1.90 vs. 4.20±2.00) or post-test 1 scores (5.12±1.91 vs. 4.54±2.20). After completing both sessions, post-test 2 scores were higher in students who completed SGD followed by digital model learning (6.12±2.09) than in those who completed digital model learning followed by SGD (5.59±2.10), with a statistically significant difference between instructional sequences (p=0.046). Intra-group analyses also showed a statistically significant difference between post-test 1 and post-test 2 in both groups, with higher scores at post-test 2 (p<0.05). These results suggest that combining SGDs with the digital model enhances student comprehension of occlusal schemes and balance as it allows these phenomena to be confirmed visually.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"69-76"},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational Challenges Associated with Edentulous Models for Teaching Structure of Edentulous Mucosa and Submucosa of Older Adults.","authors":"Masahiro Ryu, Tomofumi Takano, Midori Ohta, Takeshi Saito, Kazuma Nakazawa, Takafumi Kobayashi, Yoshinori Yamamoto, Shinichi Abe, Takayuki Ueda","doi":"10.2209/tdcpublication.2025-0036","DOIUrl":"10.2209/tdcpublication.2025-0036","url":null,"abstract":"<p><p>As a population ages, the need for complete dentures and other large, removable prostheses remains high in edentulous adults. Appropriate denture fabrication requires comprehension of the anatomical structures of the edentulous mucosa and submucosa. This study aimed to clarify the educational challenges of teaching these structures. Dental student level of comprehension and instructor perception of teaching difficulty when using edentulous models were evaluated. Participants comprised 137 third-year dental students at Tokyo Dental College. Before a lecture on anatomical landmarks and the structure of the edentulous mucosa and submucosa, they were required to complete a pre-test to assess identification of 10 mucosal and 10 submucosal structures in the maxillary and mandibular edentulous ridges. Following the lecture, they participated in a practical session using a commercially available soft-tissue edentulous model under guidance from 19 instructors. A post-test followed this practical session. Correct answer rates were determined and total mucosal and submucosal scores compared. Instructors also completed a questionnaire regarding the difficulty of teaching each structure. The mean mucosal score increased from 60.7% (pre) to 83.8% (post), and the submucosal score increased from 39.3% to 72.3%. Both changes were statistically significant (p<0.0001). However, pre-test scores for submucosal structures were markedly lower than those for mucosal structures. Seven of the 10 mucosal structures were reported by 10% or fewer of the instructors as difficult to teach, whereas 9 of the 10 submucosal structures were reported by over 50% of the instructors as difficult to teach. Despite lectures and currently available models, comprehension of submucosal structures remains challenging for students. Moreover, these structures are perceived to be difficult to teach. Improved educational tools that reproduce the 3-dimensional relationships between mucosa and underlying bone are needed to enhance education regarding complete denture fabrication.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"59-67"},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Rehabilitation of Mandibular Defect Using CAD/CAM System.","authors":"Fusa Maeta, Koichiro Ogami, Taiga Edono, Shuya Yoshida, Takayuki Ueda","doi":"10.2209/tdcpublication.2025-0023","DOIUrl":"10.2209/tdcpublication.2025-0023","url":null,"abstract":"<p><p>This report describes a case in which a removable partial mandibular denture made of polycarbonate resin was fabricated using a computer-aided design and manufacturing (CAD/CAM) system for a patient with microstomia and trismus caused by scar contracture in the maxillofacial region after multiple tumor resections and reconstructive surgeries. The patient was an 82-year-old woman with a history of multiple oral cancer surgeries and radiotherapy. She presented with a markedly narrow oral aperture circumference (145 mm) and had no prior experience with dentures. Given the difficulty of applying conventional impression techniques in this case, impressions were obtained using unilateral stock trays and split custom trays. The denture base and artificial teeth were milled from a polycarbonate disk into a single-piece structure to create a denture with no microgaps. One month after insertion, the patient's Oral Health Impact Profile-54 score improved from 36 to 6, masticatory efficiency increased from 84 mg/dL to 131 mg/dL, and the facial scale score improved from 13/20 to 7/20. Furthermore, the smooth denture surface minimized denture plaque adhesion, aiding oral hygiene maintenance. In addition to the low water absorption and high smoothness of polycarbonate resin, integrated design achieved using CAD/CAM contributes to the prevention of denture stomatitis and oral candidiasis.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"41-49"},"PeriodicalIF":0.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Perceived Brushing Sensation.","authors":"Seitaro Suzuki, Mami Endoh, Chisachi Ogura, Midori Yokokura, Emi Kuramochi, Hiroe Nakamura, Yukiyo Ando, Moeka Araki, Azusa Ito, Atsushi Yamagishi, Atsushi Takayanagi","doi":"10.2209/tdcpublication.2025-0037","DOIUrl":"10.2209/tdcpublication.2025-0037","url":null,"abstract":"<p><p>The aim of this study was to identify which factors influenced the perceived brushing sensation of different manual toothbrushes. A total of 23 dental hygiene students from a vocational school in the Kanto region of Japan evaluated five commercially available toothbrushes through paired comparisons across 16 sensory and functional attributes. An exploratory factor analysis was conducted to determine the underlying structure of the 16 items measuring perceived brushing sensation. Two distinct factors were identified: one reflecting tactile and functional characteristics, such as firmness and plaque removal, and another associated with usability and post-brushing sensation, including head size and feelings of freshness. The findings of this study suggest that the perceived brushing sensation of manual toothbrushes is influenced primarily by bristle hardness and brush head dimensions.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"51-56"},"PeriodicalIF":0.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Incidence of Lateral Incisive Canals in a Japanese Population Using Dental Cone-Beam Computed Tomography.","authors":"Atsushi Ogawa, Yunosuke Ikeda, Tadashi Kawai, Akira Fujimura, Hiroyuki Yamada","doi":"10.2209/tdcpublication.2025-0028","DOIUrl":"10.2209/tdcpublication.2025-0028","url":null,"abstract":"<p><p>This observational study employed dental cone-beam computed tomography (CBCT) to evaluate the incidence and anatomical features of neurovascular structures within the lateral incisive canal (LIC). Images obtained from 221 patients were evaluated to determine the presence, diameter, and length of the LIC. Lateral incisive canals were identified in 24.4% of the CBCT images examined (bilaterally in 61.1% and unilaterally in 38.9%). One LIC was observed in 57.4% of cases, 2 in 16.7%, and 3 in 14.8%, with only a minority of cases displaying 4 to 6 LICs. The mean diameter of the LIC was 0.7±0.3 mm (0.3-1.8 mm) while that of the foramen was 0.8±0.4 mm (0.3-2.3 mm). Moreover, the mean length of the LIC was 8.9±4.1 mm (2.1-32.3 mm). The incidence of LICs (24.4%) was lower than that reported in previous CBCT studies of Asian populations. However, there may be regional differences in the incidence of anatomical structures, even among individuals of the same ethnic group. These results show that using CBCT to identify LICs can provide valuable information in the planning of surgical procedures involving the anterior maxilla.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"35-40"},"PeriodicalIF":0.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remimazolam Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.","authors":"Nobuyuki Matsuura, Yuka Sendai, Minami Hasegawa, Mio Fukada, Natsuko Aida, Shoko Onodera, Kyotaro Koshika, Tatsukuni Ohno","doi":"10.2209/tdcpublication.2025-0003","DOIUrl":"10.2209/tdcpublication.2025-0003","url":null,"abstract":"<p><p>Remimazolam (Re) is an ultra-short-acting benzodiazepine used for intravenous sedation, general anesthesia, and intensive care unit sedation. Although benzodiazepines, including midazolam, possess anti-inflammatory properties and suppress macrophage activity, the impact of Re on macrophage-mediated immune responses remains uncertain. The purpose of this study was to investigate the effects of Re on lipopolysaccharide (LPS)-stimulated macrophage activation using thioglycolate-induced mouse peritoneal macrophages (TGC-macrophages). The findings demonstrated that Re significantly attenuated the production of proinflammatory cytokines, tumor necrosis factor α, and interleukin-6 by LPS-stimulated TGC-macrophages. Notably, this inhibitory effect on cytokine production remained unaffected by flumazenil, a specific antagonist of the γ-aminobutyric acid type A (GABAA), indicating that Re exerts its anti-inflammatory effects on macrophages through a mechanism independent of GABAA receptor signaling. In Re-treated macrophages, the expression levels of antigen presentation-related molecules, including CD86, a costimulatory molecule, and major histocompatibility complex class II, were significantly reduced following LPS stimulation. Conversely, Re did not affect the phagocytic capacity of TGC-macrophages, as evaluated by fluorescein isothiocyanate-labeled dextran, even at concentrations that inhibited inflammatory cytokine production and costimulatory molecule expression in LPS-activated TGC-macrophages. These findings suggest that Re exerts anti-inflammatory effects without suppressing essential innate immune functions, such as phagocytosis by macrophages.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"1-10"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Impaired Fasting or Diabetes Compared with That of Smoking Habit on Tooth Loss.","authors":"Hideyuki Kamijo, Atsushi Oyama, Seitaro Suzuki, Yuki Onose, Takako Eguchi, Koichi Yoshino, Atsushi Takayanagi, Yoshikazu Takahashi, Naoki Sugihara","doi":"10.2209/tdcpublication.2024-0058","DOIUrl":"10.2209/tdcpublication.2024-0058","url":null,"abstract":"<p><p>The purpose of this study was to investigate the impacts of diabetes and smoking on the risk of tooth loss in adults and the elderly. Dental receipts and specific health checkup data were used to assess increase in tooth extraction among people with a high blood glucose level or a smoking habit. The data were obtained from a database maintained by DeSC Healthcare Corporation, which supports the integrity of data held by health insurers. Dental receipts and specific health checkup data from 2018 to 2021 were used to obtain information on fasting blood glucose levels, smoking habits, and tooth extraction in 12,219 individuals aged 45-69 years. The results showed that the proportion of tooth extractions between 2018 and 2021 (32.3%) was higher in those with hyperglycemia. The proportion of tooth extractions in smokers (34.0%) was also significantly higher than that in non-smokers (21.6%). These results suggest that measures must be taken to promote dental and oral health care in those with hyperglycemia and in those with a smoking habit.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"27-32"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-syndromic Bilateral Posterior Maxillary Supernumerary Teeth: Rare Combination of Paramolar and Distomolar.","authors":"Yunosuke Ikeda, Atsushi Ogawa, Noriaki Takahashi, Hiroyuki Yamada","doi":"10.2209/tdcpublication.2025-0016","DOIUrl":"10.2209/tdcpublication.2025-0016","url":null,"abstract":"<p><p>When teeth or odontogenic structures are present in excess of the normal number in the dental arch they are referred to as supernumerary. This paper describes a rare case of a maxillary right distomolar and left paramolar in an otherwise non-syndromic individual. The patient was a 23-year-old Japanese man who presented at our clinic seeking periodontal treatment. Intraoral examination revealed supernumerary teeth in the maxilla, and an extraction plan including the wisdom teeth was developed.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"11-15"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Oral Management for 2q37 Deletion Syndrome Patient.","authors":"Hiromi Homma, Atsuo Sakurai, Dai Ariizumi, Yasushi Nishii, Seikou Shintani","doi":"10.2209/tdcpublication.2025-0022","DOIUrl":"10.2209/tdcpublication.2025-0022","url":null,"abstract":"<p><p>2q37 deletion syndrome is an extremely rare chromosomal disorder, with approximately 150 cases reported worldwide. Affected individuals are known to have multisystem involvement, though dental findings associated with this syndrome remain poorly documented. This report describes the long-term dental management and oral characteristics of a pediatric patient with 2q37 deletion syndrome. The patient was an 11-year 2-monthold boy who presented with the chief complaints of dental caries and maxillary anterior crowding. Similarly to in previous reports regarding this syndrome, a clinical examination revealed short stature (120 cm, approximately 3 standard deviations below the mean), intellectual disability, tetralogy of Fallot, and habitual vomiting. Intraoral findings included 6 carious teeth, a high-arched palate, a constricted maxillary arch, and severe anterior crowding. Mild dental erosion associated with habitual vomiting was also noted. The initial dental treatment addressed the caries in the maxillary first molars and anterior teeth. Due to limited cooperation from the patient, orthodontic treatment was deferred, though regular follow-up examinations were conducted over a period of 7 years. Caregiver motivation remained high and patient cooperation improved, and sectional orthodontic treatment was initiated when he reached the age of 18 years 2 months. Throughout the approximately 10-year period of dental care, the mother of the patient, serving as caregiver, has remained consistently engaged, allowing for routine dental management to be maintained. No new carious lesions have developed during this period and notable improvement in anterior alignment has been achieved. Long-term follow-up will be continued.</p>","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":"17-25"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}