Turkish Journal of Pathology最新文献_第5页

Histoplasmosis of the Head and Neck Region Mimicking Malignancy: A Clinic-Pathological Predicament. 模拟恶性肿瘤的头颈部组织浆体病：临床病理困境。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01585

Neha Mittal, Asawari Patil, Priyamvada Singhal, Munita Meenu Bal, Swapnil Ulhas Rane, Shivakumar Thiagarajan

{"title":"Histoplasmosis of the Head and Neck Region Mimicking Malignancy: A Clinic-Pathological Predicament.","authors":"Neha Mittal, Asawari Patil, Priyamvada Singhal, Munita Meenu Bal, Swapnil Ulhas Rane, Shivakumar Thiagarajan","doi":"10.5146/tjpath.2022.01585","DOIUrl":"10.5146/tjpath.2022.01585","url":null,"abstract":"Objective: Histoplasmosis is a systemic, deep mycotic infection caused by Histoplasma capsulatum. Disseminated histoplasmosis (DH) is synonymous with HIV seropositive immunocompromised individuals; however, isolated histoplasmosis involving the head and neck mucosal sites mimicking malignancy is a clinical predicament. The result, in a superficial biopsy with marked pseudoepitheliomatous hyperplasia (PEH), in a tertiary care cancer center where the number of squamous carcinomas far outnumber the infectious diseases, could be catastrophic.Material and method: The archives of a tertiary care cancer hospital were searched (2010-2019) for cases of histoplasmosis involving the head and neck mucosal sites in HIV non-reactive patients.Results: Six cases of isolated head and neck histoplasmosis were seen in biopsies from 4 men and 2 women, with an age range of 46-72 years. Three of these patients suffered from chronic illnesses. The most common site involved was the larynx (vocal cords) in three cases, two cases were involving lips, and one involving the tongue. The biopsies were reviewed in-house with a clinical diagnoses of malignancy in all and an outside biopsy diagnosis of \"squamous cell carcinoma\" in 2 cases. The important histological findings in the biopsy were PEH (3 cases), granulomas (2 cases), lymphoplasmacytic inflammation (all cases). Eosinophils were conspicuous by their absence. Intracellular histoplasma was seen in all cases, albeit to varying density, which was confirmed with GMS stain.Conclusion: A high index of suspicion, meticulous history taking by oncologists, and appropriate distinction of PEH from neoplastic squamous proliferation by pathologists in superficial biopsies and an apropos deeper wedge biopsy are essential to clinch the correct diagnosis.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 2","pages":"133-139"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of COVID-19 Pandemic on Pathology Residency Program: An Experience from India. 新冠肺炎大流行对病理住院计划的影响：印度的经验。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01587

Arti Khatri, Somshankar Chowdhury, Dipti Sidam, Sonali Malik, Toshali Pandey, Sumanashree Mallappa

{"title":"Impact of COVID-19 Pandemic on Pathology Residency Program: An Experience from India.","authors":"Arti Khatri, Somshankar Chowdhury, Dipti Sidam, Sonali Malik, Toshali Pandey, Sumanashree Mallappa","doi":"10.5146/tjpath.2022.01587","DOIUrl":"10.5146/tjpath.2022.01587","url":null,"abstract":"Objective: To study the impact of the COVID-19 pandemic on pathology residents through a questionnaire-based survey.Material and method: We designed a Google survey questionnaire with 20-questions and distributed it to the pathology residents across India via e-mail and WhatsApp. All the responses collected were analysed using appropriate statistical methods.Results: We received a total of 81 responses. The majority (n=55, 68.8%) of the residents were aged 26-30 years with a male-female ratio of 1:2.2. Residents reported a significant decrease in classes as compared to pre-covid times. However, most institutions (90%) shifted to the virtual method for various teaching sessions. About 94.7% of the residents felt a fall in the quality of training due to Covid. A significant number of junior residents (76.92%) reported an inability to complete the target thesis enrolment. The residents saw a substantial decrease in the number of peripheral smears, bone marrow, cytology, and histopathology cases compared to pre-Covid times (p value < 0.001 for all). An overwhelming 83.8% of the pathology residents were posted for COVID-19 duties. About 48.8% turned Covid positive. About 77.5% (n=62) of residents felt that the necessary training period would be extended.Conclusion: The COVID-19 pandemic has immensely affected the training and teaching of pathology residents in India. Similarly, this pandemic must have affected pathology residents all across the globe. Therefore, institutions can consider offering an extended period of up to one year, depending upon residents' requests.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 2","pages":"140-146"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9481720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Tumor Infiltrating Lymphocytes Are Associated with Overall Survival and Good Prognostic Parameters in Endometrial Endometrioid Carcinoma Patients. 高肿瘤浸润淋巴细胞与子宫内膜样子宫内膜癌患者的总体生存率和良好的预后参数有关。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01596

Cigdem Ozturk, Gokce Askan, Seda Duman Ozturk, Oguzhan Okcu, Bayram Sen, Recep Bedir

{"title":"High Tumor Infiltrating Lymphocytes Are Associated with Overall Survival and Good Prognostic Parameters in Endometrial Endometrioid Carcinoma Patients.","authors":"Cigdem Ozturk, Gokce Askan, Seda Duman Ozturk, Oguzhan Okcu, Bayram Sen, Recep Bedir","doi":"10.5146/tjpath.2022.01596","DOIUrl":"10.5146/tjpath.2022.01596","url":null,"abstract":"Objective: The mortality incidence of endometrial carcinomas (ECs) has increased in recent years. Therefore, recent studies have focused on the cellular and microenvironmental properties of ECs. Tumor-infiltrating lymphocytes (TILs), a component of the microenvironment, have been found to be associated with the prognosis in many tumors. Although TILs were mostly evaluated by immunohistochemical studies in ECs, in our study, the evaluation was done with a light microscope as a practical approach, and we aimed to determine the prognostic importance of TILs in endometrioid ECs.Material and method: 104 patients were included in the study. TILs in the stromal area (sTILs) were evaluated on hematoxylin and eosin (HE) stained-sections at X200 objective. The presence of TILs was evaluated as follows; 0-10% as low, 20-40% as moderate, and 50-90% as intense. Then TILs were grouped as low and high.Results: Tumors with high TILs were more prone to have FIGO (International Federation of Gynecology and Obstetrics) grade 1 tumors, low nuclear grade, early pathological stage, smaller size, no lymphovascular invasion, myometrial invasion below 50%, and no cervical involvement. In the presence of high TILs, the overall survival showed significant increase but no significant correlation was found with disease-free survival.Conclusion: Interest in the molecular properties of ECs has increased in recent years. TIL, which can be easily evaluated in HE sections, is an important parameter in patient selection for molecular tests and determining the prognosis of patients.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"75-82"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10539787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma. cERBB-2/Her-2 Neu在子宫癌肉瘤中的过度表达及其预后意义。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01588

Huseyin Salih Semiz, Emel Ebru Pala, Behzat Can, Elif Atag, Hatice Gungor, Muzaffer Sanci

{"title":"cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma.","authors":"Huseyin Salih Semiz, Emel Ebru Pala, Behzat Can, Elif Atag, Hatice Gungor, Muzaffer Sanci","doi":"10.5146/tjpath.2022.01588","DOIUrl":"10.5146/tjpath.2022.01588","url":null,"abstract":"Objective: There is not enough data in the literature regarding Her-2 overexpression in uterine carcinosarcomas or its association with the prognosis. The aim of this study was to determine the Her-2 overexpression rate in uterine carcinosarcoma and to evaluate its relationship with the prognosis.Material and method: Her-2 protein and gene status were evaluated by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively, in hysterectomy specimens from 51 patients with uterine carcinosarcoma.Results: Her-2 protein expression in the epithelial component was negative in 42 patients (score 0 in 33 cases, score (+1) in 9 cases), score (+2) in 7 patients and score (+3) in 2 patients. None of the patients had Her-2 protein expression within the sarcomatous component of the tumors. Her-2 gene was not amplified in epithelial or mesenchymal tumor areas according to the FISH method. There was no difference between the Her-2 overexpression negative and positive groups in terms of disease-free survival (DFS) and overall survival (OS). Her-2 overexpression was significantly higher in tumors of patients diagnosed at 65 years or older (p=0.046).Conclusion: In our study, no relationship could be shown between Her-2 overexpression and prognosis in uterine carcinosarcoma. More comprehensive studies are needed to illustrate the relationship between Her-2 overexpression and carcinosarcoma prognosis.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"55-63"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10542952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors. 输卵管神经内分泌肿瘤和卵巢浆液性腺癌：多中心原发性肿瘤。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01589

Nataliia Hyriavenko, Mykola Lуndіn, Vladyslav Sikora, Ruslana Chyzhma, Yulia Lуndіna, Kateryna Sikora, Wireko Andrew Awuah, Anatolii Romaniuk

{"title":"Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors.","authors":"Nataliia Hyriavenko, Mykola Lуndіn, Vladyslav Sikora, Ruslana Chyzhma, Yulia Lуndіna, Kateryna Sikora, Wireko Andrew Awuah, Anatolii Romaniuk","doi":"10.5146/tjpath.2022.01589","DOIUrl":"10.5146/tjpath.2022.01589","url":null,"abstract":"Neuroendocrine tumors (NETs) comprise a large group of tumors that are most often localized in the gastrointestinal tract and lungs. They are rarely found in the organs of the female reproductive tract; such NETs are primarily localized in the ovaries. We present a case of multicentric primary low-grade NET of the fallopian tube and high-grade ovarian serous adenocarcinoma. In both tumor regions, the histotypes of neoplasms were determined by morphological and immunohistochemical investigations. The NET of the fallopian tube was diffusely positive for chromogranin A and CD56, but wild type for p53 and negative for CK7, CK20, and ER; Ki-67 expression was observed in 3% of the neoplastic cells. The ovarian serous adenocarcinoma was positive for CK7 and ER, mutant for p53, but negative for chromogranin A, CK20, and CD56; Ki-67 expression was observed in 45% of the tumor cells. These results support the possibility that NET can occur in the female reproductive tract and coexist with other malignant tumors.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 2","pages":"161-166"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9481718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance. 子宫腺肉瘤微卫星不稳定状态、p16和Cyclin D1蛋白表达及其临床病理意义。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01580

Alev Ok Atilgan, Eda Yilmaz Akcay, Ozlem Ozen, A Reyhan, Ali Ayhan

{"title":"Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance.","authors":"Alev Ok Atilgan, Eda Yilmaz Akcay, Ozlem Ozen, A Reyhan, Ali Ayhan","doi":"10.5146/tjpath.2022.01580","DOIUrl":"10.5146/tjpath.2022.01580","url":null,"abstract":"Objective: Uterine adenosarcoma has low malignant potential, except in cases with sarcomatous overgrowth (SOG) and a high-grade morphology. We here point out the prognostic clinicopathological and immunohistochemical features as well as the microsatellite instability (MSI) status of high- and low-grade adenosarcomas.Material and method: In this study, DNA mismatch repair proteins, p16, cyclin D1, ER, PR, and CD10 were examined in uterine adenosarcoma cases using immunohistochemistry. The association between these proteins and clinicopathological parameters was also evaluated.Results: ER, PR and CD10 expressions were lower and weaker in high-grade adenosarcomas with SOG compared to low-grade adenosarcomas without SOG (p < 0.05). p16 positivity was more frequent in high-grade adenosarcomas than low-grade adenosarcomas (p < 0.05). There was no statistically significant difference between cyclin D1 positivity, MSI, and other clinicopathological parameters (p ≥ 0.05). Cyclin D1 positivity and loss of CD10 expression were associated with shorter disease-free survival (DFS). Loss of ER and CD10 expression was associated with shorter overall survival (OS) (p < 0.05). MSI was not associated with DFS or OS (p ≥ 0.05).Conclusion: These results suggested that p16 positivity, and loss of ER, PR, and CD10 expression were predictors of high-grade morphology. Additionally, the current study showed that cyclin D1-positive tumors had high recurrence rates; however, no significant relationships were found between MSI and DFS or OS in patients with uterine adenosarcoma. Further investigations are required to determine the importance of p16, cyclin D1, and MSI in uterine adenosarcomas.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"31-41"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeds or Parasites? Clinical and Histopathological Features of Seeds and Parasites in the Appendix. 种子还是寄生虫？附录中种子和寄生虫的临床和组织病理学特征。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01586

Gizem Issin, Fatih Demir, Hasan Aktug Simsek, Diren Vuslat Cagatay, Mahir Tayfur, Ali Kandemir, Mecdi Gürhan Balci

{"title":"Seeds or Parasites? Clinical and Histopathological Features of Seeds and Parasites in the Appendix.","authors":"Gizem Issin, Fatih Demir, Hasan Aktug Simsek, Diren Vuslat Cagatay, Mahir Tayfur, Ali Kandemir, Mecdi Gürhan Balci","doi":"10.5146/tjpath.2022.01586","DOIUrl":"10.5146/tjpath.2022.01586","url":null,"abstract":"Objective: Parasites and plant seeds may both be found in appendectomy specimens. Each plant seed has a different appearance and can thus exhibit wide variations under the microscope. Fragmented seeds may histologically mimic parasites. The differential diagnosis between seeds and parasites can be challenging in such cases. This study aimed to determine the incidence of parasites, seeds, and foreign bodies in appendectomy materials and highlight the most characteristic histopathological features associated with these structures.Material and method: In this study, pathology slides of 9,480 patients, who underwent appendectomy between 2010 and 2021, were reviewed, and cases that contained parasites, seeds, or foreign bodies were identified. We reviewed the literature on seeds and parasites in appendectomy specimens.Results: Parasites were observed in 56 (0.6%) cases. Of these cases, 45 had Enterobius vermicularis (80%), and 11 had Taenia subspecies (20%). Plant seeds were observed in 47 cases (0.5%), and were macroscopically recognizable in 5 of them as olive, lemon, and cherry seeds. Parasites and seeds were usually observed in the lumen of appendix vermiformis, filled with abundant fecal materials.Conclusion: Seeds are seen in approximately 0.5% of the appendectomy specimens. Though rarely seen, the fragmented seed appearance may cause diagnostic difficulties. In this context, the key morphological features of parasites and plant seeds outlined in this study may be helpful in their differential diagnosis.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"42-54"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10545933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Relative Frequency of Pulmonary Hypoplasia and Various Anomalies Associated with Pulmonary Hypoplasia in Fetal Autopsy Study. 胎儿尸检研究中肺发育不良和与肺发育不良相关的各种异常的相对频率评估。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01594

Aparna Sajjan, Surekha U Arakeri, Subhashchandra Mudanur

{"title":"Evaluation of Relative Frequency of Pulmonary Hypoplasia and Various Anomalies Associated with Pulmonary Hypoplasia in Fetal Autopsy Study.","authors":"Aparna Sajjan, Surekha U Arakeri, Subhashchandra Mudanur","doi":"10.5146/tjpath.2022.01594","DOIUrl":"10.5146/tjpath.2022.01594","url":null,"abstract":"Objective: Pulmonary hypoplasia (PH) is one of the commonest causes of neonatal morbidity and mortality. The suggested diagnostic criteria for PH are the Lung Weight:Body Weight (LW:BW) ratio ≤ 0.012 and/or Radial Alveolar Count (RAC) ≤ 4.1. The present study was done to determine the relative frequency of PH in fetal autopsy study by the LW:BW ratio and RAC along with evaluation of the defects/anomalies associated with PH.Material and method: A prospective observational study was done on fetal autopsy specimens in the Department of Pathology. Examination and grossing were done as per the standard format of fetal autopsy study. Evaluation of PH was done using the LW:BW ratio and RAC. Diagnostic criteria for PH were taken as LW:BW ratio < 0.012 and/ or RAC < 4.1. Chi-square test, Student T test and Kruskal Wallis test were used in statistical analysis.Results: A diagnosis of PH was made in 45 cases. Concordance between the LW:BW ratio and RAC was observed in 33 cases amounting to 73.33%. The mean LW:BW ratio was the lowest in oligohydramnios. The mean RAC was the lowest in congenital cystic adenomatoid malformation.Conclusion: A diagnosis of PH was rendered in a greater number of cases when evaluation was done by considering both the LW:BW ratio and RAC. Hence, evaluation by both the LW:BW ratio and RAC provides a reliable index of lung growth and should be an essential part of fetal autopsy study.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"199-205"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35254769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Impact of Tumor Border Configuration, Tumor Budding and Tumor Stroma Ratio in Colorectal Carcinoma. 结直肠癌中肿瘤边界形态、肿瘤出芽和肿瘤间充质比率对预后的影响。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01579

Lamia Sabry Aboelnasr, Hala Said El-Rebey, Asmaa Mohamed, Asmaa Gaber Abdou

{"title":"The Prognostic Impact of Tumor Border Configuration, Tumor Budding and Tumor Stroma Ratio in Colorectal Carcinoma.","authors":"Lamia Sabry Aboelnasr, Hala Said El-Rebey, Asmaa Mohamed, Asmaa Gaber Abdou","doi":"10.5146/tjpath.2022.01579","DOIUrl":"10.5146/tjpath.2022.01579","url":null,"abstract":"Objective: Tumor border configuration, tumor budding and tumor stroma ratio are reliable histopathological parameters that play a central role in the invasion-metastasis cascade. This study aimed to investigate the prognostic impact of these parameters and a new combined score in colorectal cancer. Material and Method: A cohort of 103 colorectal cancer surgical specimens was retrospectively evaluated for tumor border configuration, tumor budding and tumor stroma ratio using H&E sections. A combined risk score was then constructed to divide cases into low risk-tumors and high risk-tumors. Results: Infiltrating tumor border, high tumor budding, low tumor stroma ratio and high combined risk score were associated with positive lymph node involvement, presence of metastasis, high tumor grade, lymphovascular invasion, poor overall survival and short recurrence-free survival. Infiltrating tumor border, high tumor budding and high combined risk score were associated with advanced T stage. High tumor budding, and low tumor stroma ratio were associated with perineural invasion. Infiltrating tumor border was associated with increased tumor size and conventional adenocarcinoma, high tumor budding and low tumor stroma ratio. Low tumor stroma ratio was associated with high tumor budding. On multivariate survival analysis, tumor stroma ratio was found to be an independent predictor for overall survival and recurrence-free survival. Conclusion: Tumor border configuration, tumor budding, tumor stroma ratio and the newly constructed combined risk score are potential predictors of outcome in colorectal cancer patients, suggesting that their incorporation in the routine histopathological evaluation could be useful in determining the prognosis of colorectal cancer cases.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"83-93"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10591672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides. TOX在早期蕈样肉芽肿的组织病理学诊断中优于FOXP3、CD4和GATA3。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01578

Mona Mostafa Ahmed, Abdelmonem Awad Hegazy, Ahmed Embaby, Esraa Mohammad Nawwar, Salwan Abdelmonem Hegazy, Hanaa M Ibrahim, Mai Ahmed Gobran

{"title":"TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides.","authors":"Mona Mostafa Ahmed, Abdelmonem Awad Hegazy, Ahmed Embaby, Esraa Mohammad Nawwar, Salwan Abdelmonem Hegazy, Hanaa M Ibrahim, Mai Ahmed Gobran","doi":"10.5146/tjpath.2022.01578","DOIUrl":"10.5146/tjpath.2022.01578","url":null,"abstract":"Objective: Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The early stage of MF is a difficult diagnostic case, as it is often confused with many benign inflammatory dermatoses (BID). The study aimed to evaluate the diagnostic utility of TOX, FOXP3, CDD4 and GATA3 in differentiating early stages of MF from histologically overlapping BID lesions.Material and method: A retrospective cross-sectional study was performed, in which immunohistochemistry (IHC) was used to evaluate the expression of TOX, FOXP3, CD4 and GATA3 in formalin-fixed paraffin-embedded (FFPE) sections of skin lesions from 30 cases with BID and 30 patients with early-stage MF.Results: The association between TOX expression and early-stage MF was statistically significant (P < 0.001). TOX had the highest sensitivity of 96.77% and accuracy of 85.71% in diagnosis of MF; followed by CD4 with sensitivity of 85.71% and accuracy of 78.95%; and then, GATA3 with sensitivity of 76.7% and finally FOXP3 with sensitivity of 70.0%.Conclusion: TOX is suggested to be of higher diagnostic value in the early stages of MF than the conventionally used CD4 and other markers examined.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"15-22"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10537569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0