Turkish Journal of Pathology最新文献_第5页

Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance. 子宫腺肉瘤微卫星不稳定状态、p16和Cyclin D1蛋白表达及其临床病理意义。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01580

Alev Ok Atilgan, Eda Yilmaz Akcay, Ozlem Ozen, A Reyhan, Ali Ayhan

{"title":"Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance.","authors":"Alev Ok Atilgan, Eda Yilmaz Akcay, Ozlem Ozen, A Reyhan, Ali Ayhan","doi":"10.5146/tjpath.2022.01580","DOIUrl":"10.5146/tjpath.2022.01580","url":null,"abstract":"Objective: Uterine adenosarcoma has low malignant potential, except in cases with sarcomatous overgrowth (SOG) and a high-grade morphology. We here point out the prognostic clinicopathological and immunohistochemical features as well as the microsatellite instability (MSI) status of high- and low-grade adenosarcomas.Material and method: In this study, DNA mismatch repair proteins, p16, cyclin D1, ER, PR, and CD10 were examined in uterine adenosarcoma cases using immunohistochemistry. The association between these proteins and clinicopathological parameters was also evaluated.Results: ER, PR and CD10 expressions were lower and weaker in high-grade adenosarcomas with SOG compared to low-grade adenosarcomas without SOG (p < 0.05). p16 positivity was more frequent in high-grade adenosarcomas than low-grade adenosarcomas (p < 0.05). There was no statistically significant difference between cyclin D1 positivity, MSI, and other clinicopathological parameters (p ≥ 0.05). Cyclin D1 positivity and loss of CD10 expression were associated with shorter disease-free survival (DFS). Loss of ER and CD10 expression was associated with shorter overall survival (OS) (p < 0.05). MSI was not associated with DFS or OS (p ≥ 0.05).Conclusion: These results suggested that p16 positivity, and loss of ER, PR, and CD10 expression were predictors of high-grade morphology. Additionally, the current study showed that cyclin D1-positive tumors had high recurrence rates; however, no significant relationships were found between MSI and DFS or OS in patients with uterine adenosarcoma. Further investigations are required to determine the importance of p16, cyclin D1, and MSI in uterine adenosarcomas.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"31-41"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeds or Parasites? Clinical and Histopathological Features of Seeds and Parasites in the Appendix. 种子还是寄生虫？附录中种子和寄生虫的临床和组织病理学特征。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01586

Gizem Issin, Fatih Demir, Hasan Aktug Simsek, Diren Vuslat Cagatay, Mahir Tayfur, Ali Kandemir, Mecdi Gürhan Balci

{"title":"Seeds or Parasites? Clinical and Histopathological Features of Seeds and Parasites in the Appendix.","authors":"Gizem Issin, Fatih Demir, Hasan Aktug Simsek, Diren Vuslat Cagatay, Mahir Tayfur, Ali Kandemir, Mecdi Gürhan Balci","doi":"10.5146/tjpath.2022.01586","DOIUrl":"10.5146/tjpath.2022.01586","url":null,"abstract":"Objective: Parasites and plant seeds may both be found in appendectomy specimens. Each plant seed has a different appearance and can thus exhibit wide variations under the microscope. Fragmented seeds may histologically mimic parasites. The differential diagnosis between seeds and parasites can be challenging in such cases. This study aimed to determine the incidence of parasites, seeds, and foreign bodies in appendectomy materials and highlight the most characteristic histopathological features associated with these structures.Material and method: In this study, pathology slides of 9,480 patients, who underwent appendectomy between 2010 and 2021, were reviewed, and cases that contained parasites, seeds, or foreign bodies were identified. We reviewed the literature on seeds and parasites in appendectomy specimens.Results: Parasites were observed in 56 (0.6%) cases. Of these cases, 45 had Enterobius vermicularis (80%), and 11 had Taenia subspecies (20%). Plant seeds were observed in 47 cases (0.5%), and were macroscopically recognizable in 5 of them as olive, lemon, and cherry seeds. Parasites and seeds were usually observed in the lumen of appendix vermiformis, filled with abundant fecal materials.Conclusion: Seeds are seen in approximately 0.5% of the appendectomy specimens. Though rarely seen, the fragmented seed appearance may cause diagnostic difficulties. In this context, the key morphological features of parasites and plant seeds outlined in this study may be helpful in their differential diagnosis.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"42-54"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10545933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Relative Frequency of Pulmonary Hypoplasia and Various Anomalies Associated with Pulmonary Hypoplasia in Fetal Autopsy Study. 胎儿尸检研究中肺发育不良和与肺发育不良相关的各种异常的相对频率评估。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01594

Aparna Sajjan, Surekha U Arakeri, Subhashchandra Mudanur

{"title":"Evaluation of Relative Frequency of Pulmonary Hypoplasia and Various Anomalies Associated with Pulmonary Hypoplasia in Fetal Autopsy Study.","authors":"Aparna Sajjan, Surekha U Arakeri, Subhashchandra Mudanur","doi":"10.5146/tjpath.2022.01594","DOIUrl":"10.5146/tjpath.2022.01594","url":null,"abstract":"Objective: Pulmonary hypoplasia (PH) is one of the commonest causes of neonatal morbidity and mortality. The suggested diagnostic criteria for PH are the Lung Weight:Body Weight (LW:BW) ratio ≤ 0.012 and/or Radial Alveolar Count (RAC) ≤ 4.1. The present study was done to determine the relative frequency of PH in fetal autopsy study by the LW:BW ratio and RAC along with evaluation of the defects/anomalies associated with PH.Material and method: A prospective observational study was done on fetal autopsy specimens in the Department of Pathology. Examination and grossing were done as per the standard format of fetal autopsy study. Evaluation of PH was done using the LW:BW ratio and RAC. Diagnostic criteria for PH were taken as LW:BW ratio < 0.012 and/ or RAC < 4.1. Chi-square test, Student T test and Kruskal Wallis test were used in statistical analysis.Results: A diagnosis of PH was made in 45 cases. Concordance between the LW:BW ratio and RAC was observed in 33 cases amounting to 73.33%. The mean LW:BW ratio was the lowest in oligohydramnios. The mean RAC was the lowest in congenital cystic adenomatoid malformation.Conclusion: A diagnosis of PH was rendered in a greater number of cases when evaluation was done by considering both the LW:BW ratio and RAC. Hence, evaluation by both the LW:BW ratio and RAC provides a reliable index of lung growth and should be an essential part of fetal autopsy study.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"199-205"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35254769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Impact of Tumor Border Configuration, Tumor Budding and Tumor Stroma Ratio in Colorectal Carcinoma. 结直肠癌中肿瘤边界形态、肿瘤出芽和肿瘤间充质比率对预后的影响。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01579

Lamia Sabry Aboelnasr, Hala Said El-Rebey, Asmaa Mohamed, Asmaa Gaber Abdou

{"title":"The Prognostic Impact of Tumor Border Configuration, Tumor Budding and Tumor Stroma Ratio in Colorectal Carcinoma.","authors":"Lamia Sabry Aboelnasr, Hala Said El-Rebey, Asmaa Mohamed, Asmaa Gaber Abdou","doi":"10.5146/tjpath.2022.01579","DOIUrl":"10.5146/tjpath.2022.01579","url":null,"abstract":"Objective: Tumor border configuration, tumor budding and tumor stroma ratio are reliable histopathological parameters that play a central role in the invasion-metastasis cascade. This study aimed to investigate the prognostic impact of these parameters and a new combined score in colorectal cancer. Material and Method: A cohort of 103 colorectal cancer surgical specimens was retrospectively evaluated for tumor border configuration, tumor budding and tumor stroma ratio using H&E sections. A combined risk score was then constructed to divide cases into low risk-tumors and high risk-tumors. Results: Infiltrating tumor border, high tumor budding, low tumor stroma ratio and high combined risk score were associated with positive lymph node involvement, presence of metastasis, high tumor grade, lymphovascular invasion, poor overall survival and short recurrence-free survival. Infiltrating tumor border, high tumor budding and high combined risk score were associated with advanced T stage. High tumor budding, and low tumor stroma ratio were associated with perineural invasion. Infiltrating tumor border was associated with increased tumor size and conventional adenocarcinoma, high tumor budding and low tumor stroma ratio. Low tumor stroma ratio was associated with high tumor budding. On multivariate survival analysis, tumor stroma ratio was found to be an independent predictor for overall survival and recurrence-free survival. Conclusion: Tumor border configuration, tumor budding, tumor stroma ratio and the newly constructed combined risk score are potential predictors of outcome in colorectal cancer patients, suggesting that their incorporation in the routine histopathological evaluation could be useful in determining the prognosis of colorectal cancer cases.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"83-93"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10591672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides. TOX在早期蕈样肉芽肿的组织病理学诊断中优于FOXP3、CD4和GATA3。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01578

Mona Mostafa Ahmed, Abdelmonem Awad Hegazy, Ahmed Embaby, Esraa Mohammad Nawwar, Salwan Abdelmonem Hegazy, Hanaa M Ibrahim, Mai Ahmed Gobran

{"title":"TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides.","authors":"Mona Mostafa Ahmed, Abdelmonem Awad Hegazy, Ahmed Embaby, Esraa Mohammad Nawwar, Salwan Abdelmonem Hegazy, Hanaa M Ibrahim, Mai Ahmed Gobran","doi":"10.5146/tjpath.2022.01578","DOIUrl":"10.5146/tjpath.2022.01578","url":null,"abstract":"Objective: Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The early stage of MF is a difficult diagnostic case, as it is often confused with many benign inflammatory dermatoses (BID). The study aimed to evaluate the diagnostic utility of TOX, FOXP3, CDD4 and GATA3 in differentiating early stages of MF from histologically overlapping BID lesions.Material and method: A retrospective cross-sectional study was performed, in which immunohistochemistry (IHC) was used to evaluate the expression of TOX, FOXP3, CD4 and GATA3 in formalin-fixed paraffin-embedded (FFPE) sections of skin lesions from 30 cases with BID and 30 patients with early-stage MF.Results: The association between TOX expression and early-stage MF was statistically significant (P < 0.001). TOX had the highest sensitivity of 96.77% and accuracy of 85.71% in diagnosis of MF; followed by CD4 with sensitivity of 85.71% and accuracy of 78.95%; and then, GATA3 with sensitivity of 76.7% and finally FOXP3 with sensitivity of 70.0%.Conclusion: TOX is suggested to be of higher diagnostic value in the early stages of MF than the conventionally used CD4 and other markers examined.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 1","pages":"15-22"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10537569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

25-Year Storage of Human Choroid Plexus in Methyl Salicylate Preserves Its Antigen Immunoreactivity. 人绒毛丛在水杨酸甲酯中储存25年可保持其抗原免疫反应性。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01581

Dina A Sufieva, Elena A Fedorova, Vladislav S Yakovlev, Olga V Kirik, Daria L Tsyba, Igor P Grigorev, Dmitrii E Korzhevskii

{"title":"25-Year Storage of Human Choroid Plexus in Methyl Salicylate Preserves Its Antigen Immunoreactivity.","authors":"Dina A Sufieva, Elena A Fedorova, Vladislav S Yakovlev, Olga V Kirik, Daria L Tsyba, Igor P Grigorev, Dmitrii E Korzhevskii","doi":"10.5146/tjpath.2022.01581","DOIUrl":"10.5146/tjpath.2022.01581","url":null,"abstract":"Objective: Immunohistochemical investigation of archival histological material is a serious problem, since long-term storage of biological tissues, most often in formalin, leads to a loss of antigenic properties. However, the biological material can also be stored in the clearing agent methyl salicylate. The aim of this study was to assess the antigenicity of the human choroid plexus after extra long-term storage in methyl salicylate.Material and method: The study was performed on samples of fixed human choroid plexus (occasionally with attached neighboring pineal gland) stored in either methyl salicylate or paraffin blocks for 25 years. Chromogenic and fluorescence immunohistochemistry of vimentin, GFAP, type IV collagen, β-catenin, α-smooth muscle actin, von Willebrand factor, CD68, mast cell tryptase, TMEM119, and synaptophysin was carried out.Results: The storage of human choroid plexus in methyl salicylate for 25 years does not impair its histomorphology and preserves the properties of all the antigens assessed, which makes their immunohistochemical visualization possible using both light and fluorescence microscopy. Additionally, we found that long-term storage of human choroid plexus in methyl salicylate does not cause an increase in autofluorescence.Conclusion: Methyl salicylate can be recommended as a medium for long-term storage of biological tissue, as it provides excellent brain tissue preservation and retains its antigenic properties for up to 25 years.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 2","pages":"109-116"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lobomycosis in a Post-Covid 19 Patient: A Case Report and Review of Literature. 一例19岁后患者的脑脊髓炎：病例报告和文献回顾。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2023.01604

Sateesh S Chavan, Thotadamane Nagaraja Chandrashekhar

{"title":"Lobomycosis in a Post-Covid 19 Patient: A Case Report and Review of Literature.","authors":"Sateesh S Chavan, Thotadamane Nagaraja Chandrashekhar","doi":"10.5146/tjpath.2023.01604","DOIUrl":"10.5146/tjpath.2023.01604","url":null,"abstract":"Aim: To document a case of lobomycosis and to discuss its epidemiology & diagnosis.Case report: A 53-year-old male presented with a history of nasal congestion, nasal discharge, and epistaxis following Covid 19 infection. On physical examination, there was necrotic slough in the nasal vestibule near the inferior turbinate. Scrapings and punch biopsy were taken from the lesion. Hematoxylin-eosin-stained sections showed necrotic and mucoid areas with mixed inflammatory cell infiltration and numerous budding yeasts 3- 7μm diameter in singles, and small clusters with single narrow based budding as well as multiple budding including sequential budding forming \"chains of yeasts\". A diagnosis of Lobomycosis was made. Yeasts of lobomycosis are often confused with other yeasts such as P. brasiliensis, Candida spp., B. dermatitidis, and Cryptococci, but characteristic 'sequential budding' with a 'chain of yeasts\" aid in the final diagnosis. Demonstration of yeasts with characteristic chains either in tissue sections or in potassium hydroxide (KOH) preparation of scraped material, exudate, or exfoliative cytology is the mainstay in the diagnosis as the organisms are uncultivable in vitro in culture medium.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"206-211"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9505783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic Features for Overall Survival in Merkel Cell Carcinoma: A Case Series with Intact Mismatch Repair Protein Expression. Merkel细胞癌总体生存的组织病理学特征：一个完整错配修复蛋白表达的病例系列。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2023.01603

Selin Kestel, Betul Ogut, Mehmet Arda Inan, Ozlem Erdem

{"title":"Histopathologic Features for Overall Survival in Merkel Cell Carcinoma: A Case Series with Intact Mismatch Repair Protein Expression.","authors":"Selin Kestel, Betul Ogut, Mehmet Arda Inan, Ozlem Erdem","doi":"10.5146/tjpath.2023.01603","DOIUrl":"10.5146/tjpath.2023.01603","url":null,"abstract":"Objective: In a study of Merkel cell carcinoma (MCC), a fusion transcript between MLH1 and SPATA4 was identified. This fusion has the potential to generate the inactive or dominant-negative form of the protein. Therefore, we aimed to investigate whether mismatch repair protein deficiency occurr in MCC cases or not, in addition to the overall survival association with histopathologic features.Material and method: A retrospective review of 15 patients diagnosed with a biopsy-proven Merkel Cell Carcinoma between 2012 and 2019 was performed. Mismatch repair (MMR) protein expressions were evaluated by immunohistochemistry.Results: The median follow-up time was 36 months (mean 41, range 2-103 months). Six (40%) patients died during follow-up. The overall survival (OS) at 1 year, 2 years, 3 years, and 5 years were 87%, 80%, 62%, and 53%, respectively. The patients diagnosed at < 60 years had an improved OS compared to those ≥60 years of age (p=0.016). Patients in clinical stage I had better OS than patients in clinical stage IV (p=0.011). Cases with pathological tumor stage (pT) 1 had better OS than pT3 and pT4 (p=0.045). Adjuvant radiotherapy or adjuvant radiotherapy+chemotherapy treatment improved OS compared to adjuvant chemotherapy (p=0.003). MMR protein nuclear expression was intact in 12 cases available for immunohistochemical study.Conclusion: To the best of our knowledge, this is the second study that preferentially investigated the mismatch repair protein status of Merkel Cell Carcinoma. No mismatch repair protein deficiency of MCC cases was identified in the current study.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"169-178"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Lesions in Children: Evaluation of Clinicopathological Findings. 儿童皮肤病变：临床病理结果的评估。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2023.01599

Begum Calim-Gurbuz, Burcin Pehlivanoglu, Tuce Soylemez-Akkurt, Ozan Erdem, Anvar Ahmedov

{"title":"Skin Lesions in Children: Evaluation of Clinicopathological Findings.","authors":"Begum Calim-Gurbuz, Burcin Pehlivanoglu, Tuce Soylemez-Akkurt, Ozan Erdem, Anvar Ahmedov","doi":"10.5146/tjpath.2023.01599","DOIUrl":"10.5146/tjpath.2023.01599","url":null,"abstract":"Objective: Pediatric skin diseases may show various manifestations, occasionally affecting the patients' quality of life. Histopathological examination may be required for the diagnosis. The aim of this study was to evaluate the spectrum of clinicopathological features in pediatric skin lesions.Material and method: A total of 368 biopsies of 359 consecutive patients were included. The clinicopathological findings were retrospectively evaluated. Non-neoplastic (inflammatory) lesions (ILs) (n=186) were grouped per their origin, while neoplastic/proliferative lesions (NPLs) (n=182) were grouped based on their pattern. The clinical and histopathological characteristics were statistically analyzed.Results: 51% were male and the median age was 10.4±4.9 years (range 0-17). ILs mainly involved the head and neck, and NPLs were mostly located in the lower extremity (p < 0.001). The most common NPLs were benign nevus (18%, n=33) and pilomatrixoma (15%, n=27), while the most frequent IL was spongiotic/psoriasiform dermatitis (38%). Skin appendage/connective tissue tumors were the largest among NPLs (p=0.02). NPLs were more frequently seen in children > 12 years old compared to ILs (p=0.03). The discordance rate between clinical and histopathological diagnoses was higher for NPLs (27% vs. 15%).Conclusion: Although the spectrum of skin lesions is broad in pediatric patients, most are benign in nature. The higher frequency of melanocytic and/or cystic lesions among children > 12 years old may be attributed to increased self-care during puberty. Neoplastic/proliferative lesions of childhood seem to be less commonly recognized by clinicians, and a multidisciplinary approach remains the optimal method, considering the relatively high rate of discordance between the clinical and histopathological diagnoses.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"192-198"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10694938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of SMARCA4 and SMARCA2 Loss in Lung Sarcomatoid Carcinomas. 肺肉瘤样癌SMARCA4和SMARCA2缺失分析。

IF 1

Turkish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5146/tjpath.2022.01590

Halide Nur Urer, Nurcan Unver, Neslihan Fener

{"title":"Analysis of SMARCA4 and SMARCA2 Loss in Lung Sarcomatoid Carcinomas.","authors":"Halide Nur Urer, Nurcan Unver, Neslihan Fener","doi":"10.5146/tjpath.2022.01590","DOIUrl":"10.5146/tjpath.2022.01590","url":null,"abstract":"Objective: Sarcomatoid carcinomas of the lung are a group of aggressive tumors. It has been reported that losses of SMARCA4 and SMARCA2, which play a role in the repair and remodeling of chromatin, contribute to the initiation, progression, and differentiation of neoplasms. The aim of our study was to examine SMARCA4 and SMARCA2 profiles in sarcomatoid carcinomas of the lung.Material and method: We screened pleomorphic carcinomas (PCs), carcinosarcomas (CSs), and pulmonary blastomas (PBs). The loss of SMARCA4 and SMARCA2 expression in the tumors was evaluated using immunohistochemical methods. The tumors were also examined to determine immunophenotype, histological tumor diagnosis, surgical resection, tumor histological component, largest tumor diameter, and lymph node metastasis status.Results: Sixty-nine cases were screened, of which 84% were PCs, 13% were CSs, and 2.8% were PBs. In PCs components, 84.4% were biphasic and 15.5% were monophasic. The PCs showed the most frequent loss of SMARCA4 (25.8%) and SMARCA2 (44.8%). A loss of SMARCA4 and SMARCA2, respectively, was detected in 14.2% and 24.4% in both components of biphasic PCs; 12.2% and 14.2% in the sarcoma component of biphasic PCs; 0% and 8.1% in the carcinoma component of biphasic PCs; 22.2% and 33.3% in monophasic PCs; 0% and 22.2% in both components of CSs; and 0% and 22.2% in the sarcoma component of CSs.Conclusion: These findings demonstrate a loss of expression of SMARCA4 and SMARCA2 in pulmonary sarcomatoid carcinomas. Loss of the SMARCA complex may be caused by the heterogeneous morphological profile of sarcomatoid carcinomas, independent of tumor histopathological parameters.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"39 2","pages":"147-153"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1