Turkish Journal of Pathology最新文献

Gabapentin-Induced Sub-Chronic Neurotoxicity in Rats and the Protective Role of Alpha-Tocopherol. 加巴喷丁诱导的大鼠亚慢性神经毒性及α -生育酚的保护作用。

IF 2.1

Turkish Journal of Pathology Pub Date : 2025-07-28 DOI: 10.5146/tjpath.2025.14236

Mohammad Abd-El-Same'e El-Kattan, Eman Saeed, Mahmoud Ahmed Khattab, Fatma Maksoud, Maha Emad Eldein, Nada Elsayed Abdel-Roaf, Walaa Awad, Ahmed Elshatory

{"title":"Gabapentin-Induced Sub-Chronic Neurotoxicity in Rats and the Protective Role of Alpha-Tocopherol.","authors":"Mohammad Abd-El-Same'e El-Kattan, Eman Saeed, Mahmoud Ahmed Khattab, Fatma Maksoud, Maha Emad Eldein, Nada Elsayed Abdel-Roaf, Walaa Awad, Ahmed Elshatory","doi":"10.5146/tjpath.2025.14236","DOIUrl":"https://doi.org/10.5146/tjpath.2025.14236","url":null,"abstract":"Objective: The past ten years have seen an increase in gabapentin (GBP) overuse and abuse in Egypt after pregabalin scheduling. Numerous studies have demonstrated the detrimental effects of pregabalin; nonetheless, GBP`s effects are minimal. The objective of this investigation is to study GBP-induced neurotoxicity in rats and the protective benefits of alpha-tocopherol (vitamin E `Vit E`).Material and methods: Forty (40) adult male albino rats were randomly split into four groups: (10 rats each): Group I, which was subdivided into group Ia (5 rats), received a regular diet as a negative control; group Ib (5 rats) received corn oil as a positive control; group II received alpha-tocopherol; group III (GBP misuse); and group IV received GBP + alpha-tocopherol. The corresponding medicines were administered to every rat for fifty days. Neurobehavioral tests were performed on the day of scarification. Hippocampal tissues were collected for immunohistochemical and histological analysis.Results: Weight gain rose considerably by the end of the research in the drug-treated groups. In neurobehavioral tests, controls performed better and had higher locomotor indices. The group that misused GBP showed more deteriorated cells and more negative effects on hippocampal tissues. These histological alterations dramatically decreased with alpha-tocopherol therapy.Conclusion: GBP in high doses had neurotoxic effects, disrupted hippocampal tissues, and increased the number of degenerated cells. Alpha-tocopherol treatment significantly attenuated the deleterious effects induced by GBP.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Challenge of a Rare Cause of Anemia After Kidney Transplant: Seronegative Parvovirus B19 Detected by PCR and Bone Marrow Findings. 肾移植后罕见贫血病因的诊断挑战：PCR和骨髓结果检测血清阴性细小病毒B19

IF 2.1

Turkish Journal of Pathology Pub Date : 2025-07-28 DOI: 10.5146/tjpath.2025.14331

Derya Demir, Volkan Karakus, Ayca Inci, Muammer Avci, Nazan Ozsan, Mine Hekimgil

{"title":"Diagnostic Challenge of a Rare Cause of Anemia After Kidney Transplant: Seronegative Parvovirus B19 Detected by PCR and Bone Marrow Findings.","authors":"Derya Demir, Volkan Karakus, Ayca Inci, Muammer Avci, Nazan Ozsan, Mine Hekimgil","doi":"10.5146/tjpath.2025.14331","DOIUrl":"https://doi.org/10.5146/tjpath.2025.14331","url":null,"abstract":"Objective: Anemia is a common complication in kidney transplant patients, often attributed to viral infections. Our objective was to describe a rare case of severe anemia secondary to Parvovirus B19 infection in a kidney transplant recipient, highlighting diagnostic and therapeutic challenges in the immunosuppressed setting.Case report: We present a 43-year-old woman with end-stage renal disease secondary to polycystic kidney disease who received a living-kidney transplant from her husband. Seven months after transplantation, she presented with severe anemia, fatigue, and palpitations. Laboratory findings demonstrated severe normocytic, normochromic anemia (Hb: 5.8 g/dL). Parvovirus B19 serology tests were negative twice, while PCR testing revealed a significant viral load (25×10⁶ copies/mL). Bone marrow biopsy findings included giant proerythroblasts with characteristic viral nuclear inclusions. The patient received intravenous immunoglobulin (IVIG, 100 mg/kg/day for 4 days), and mycophenolate mofetil was discontinued. After therapy, hemoglobin levels and viral load improved significantly, leading to successful resolution of anemia.Conclusion: This case emphasizes the importance of considering Parvovirus B19 in the differential diagnosis of anemia in transplant patients. In immunosuppressed individuals, PCR and bone marrow analysis can be essential for diagnosis, especially when serologic tests are inconclusive. Timely intervention can lead to favorable outcomes.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Cysts Strike: A Unique Case of Isolated Renal Hydatid Disease in a Child. 当囊肿发作：一个儿童孤立肾包虫病的独特病例。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-03-17 DOI: 10.5146/tjpath.2025.13871

Nikhil Kumar, Sandip Kumar Rahul, Harish Kumar Bohra, Vimal Singh Munda, Varsha Vijayan, Nidhi Priya Allie-Barla

引用次数: 0

Bone Marrow Necrosis After Curative Allogeneic Hematopoietic Stem Cell Transplant Associated with Deep Diving. 与深潜相关的同种异体造血干细胞移植治疗后骨髓坏死。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-03-17 DOI: 10.5146/tjpath.2024.13488

Hajdhica Thanasi, Daniele Avenoso, Liron Barnea Slonim

引用次数: 0

Investigation of the Effectiveness of an Algorithm as an Auxiliary Method in Intraoperative Consultations of Central Nervous System Tumors. 将算法作为中枢神经系统肿瘤术中会诊辅助方法的有效性研究

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2024.13494

Emel Cakir, Ismail Saygin, Ayten Livaoglu, Gizem Teoman, Zeynep Sagnak Yilmaz, Arife Cicek Malat, Muserref Muge Ustaoglu

{"title":"Investigation of the Effectiveness of an Algorithm as an Auxiliary Method in Intraoperative Consultations of Central Nervous System Tumors.","authors":"Emel Cakir, Ismail Saygin, Ayten Livaoglu, Gizem Teoman, Zeynep Sagnak Yilmaz, Arife Cicek Malat, Muserref Muge Ustaoglu","doi":"10.5146/tjpath.2024.13494","DOIUrl":"10.5146/tjpath.2024.13494","url":null,"abstract":"Objective: One of the most difficult areas in a surgical pathology practice is intraoperative consultation. In a previous study, we proposed an algorithm that provides a systematic approach to intraoperative consultation for central nervous system tumors. Our aim was to demonstrate the effectiveness of this algorithm.Material and methods: 102 cases were selected from intraoperative consultation procedures performed at our institution between 2012 and 2020. The algorithm was tested by five observers. The observers examined the smears and frozen sections without the algorithm, and then with the algorithm.Results: The percentage change in the rate of correct diagnoses made by the four observers (O) increased after using the algorithm (O2: 8%, O3: 5%, O4: 8% and O5: 13%), but decreased for only one observer (O1) (5%). The most common error made by the four observers was `grading of glial tumors` (O1: 40%; O2: 23%; O4: 40% and O5: 27.5%), and this group of errors was mostly corrected by using the algorithm (O1: 33%; O2: 3.8%; O4: 23% and O5: 10%). For two observers (O2 and O5), a statistically significant change in diagnostic levels was observed after using the algorithm (p=0.024 and p=0.040; respectively). In addition, thanks to the use of the algorithm, a high degree of agreement was found between the observers` diagnoses (77.7%, p < 0.001).Conclusion: In the intraoperative consultation of central nervous system lesions, algorithms can help to increase the accuracy of the diagnosis and reduce interobserver variability. This study demonstrates that an algorithmic approach is an effective method for pathologists in intraoperative consultation procedures.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"9-15"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Rectal Ulcer Syndrome - A Rare Entity in the Pediatric Population. 孤立性直肠溃疡综合征-一种罕见的儿童疾病。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2025.13667

Megha Sawhney, Jyotsna Madan, Devajit Nath, Akanksha Bhatia, Neema Tiwari, Umesh Shukla

{"title":"Solitary Rectal Ulcer Syndrome - A Rare Entity in the Pediatric Population.","authors":"Megha Sawhney, Jyotsna Madan, Devajit Nath, Akanksha Bhatia, Neema Tiwari, Umesh Shukla","doi":"10.5146/tjpath.2025.13667","DOIUrl":"10.5146/tjpath.2025.13667","url":null,"abstract":"Objective: To study and correlate the clinicopathological findings of Solitary Rectal Ulcer Syndrome (SRUS) in 10 pediatric patients.Material and methods: This study is a retrospective study of patients from January 2017 to June 2024. The clinical records were reviewed for details of the clinical presentation, colonoscopic findings, associated local and systemic diseases, and other investigations.Results: The mean age of presentation was 10±1 years, and the youngest child was 6 years old. The most common clinical presentation was rectal bleeding and a single ulcer on endoscopy. Histological findings included crypt distortion, crypt branching, and fibromuscular obliteration of the lamina propria. Immunohistochemistry (IHC) for Smooth Muscle Actin (SMA) and special staining with Masson Trichrome (MT) were used to highlight fibromuscular areas whenever in doubt.Conclusion: The pathogenesis of SRUS is not well understood. It may be associated with chronic mucosal and hypoperfusion-induced ischemic injury to the rectal mucosa due to trauma or increased rectal pressure during straining. Solitary rectal ulcer is a misnomer, as the patient may present with multiple or no ulcers. Endoscopy and histopathology help to diagnose SRUS. Timely and correct diagnosis reduces the morbidity associated with this entity.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"16-20"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Language Models as Tool for Pathology Report Data Extraction: Comment. 大型语言模型作为病理报告数据提取的工具：评论。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2024.13439

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Diagnostic Utility of NKX3.1 in Mesenchymal Chondrosarcoma on Needle Biopsy: A Case Report of a Supraclavicular Soft Tissue Mass with Literature Review. NKX3.1在针活检间充质软骨肉瘤中的诊断价值：锁骨上软组织肿块1例报告并文献复习。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2025.13752

Sunil Pasricha, Divya Bansal, Himanshu Rohela, Anila Sharma, Rakesh Oberoi, Vikas Reddy, Ullas Batra, Anurag Mehta

引用次数: 0

Mixed Neuroendocrine Non-Neuroendocrine Tumor (MINEN) of the Liver: Report of Two Cases and Review of the Literature. 肝脏非神经内分泌混合瘤（MINEN）：两例病例报告及文献综述。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2024.13492

Basharat Mubeen, Malini Eapen, S Sudhindran, Nikhil Krishna Haridas

{"title":"Mixed Neuroendocrine Non-Neuroendocrine Tumor (MINEN) of the Liver: Report of Two Cases and Review of the Literature.","authors":"Basharat Mubeen, Malini Eapen, S Sudhindran, Nikhil Krishna Haridas","doi":"10.5146/tjpath.2024.13492","DOIUrl":"10.5146/tjpath.2024.13492","url":null,"abstract":"Objective: To highlight two cases mixed neuroendocrine non-neuroendocrine tumors (MINEN) of the liver and to review the literature till date. To present two cases of MINEN of the liver diagnosed in our centre with clinical & diagnostic workup, the treatment modalities, and follow up. Extensive review of the literature and compilation of the presentation and treatment modalities used in those cases.Case reports: Thirty-three cases of MINEN of the liver have been reported till date including ours. Our cases presented as incidental masses in liver during workup for other symptoms. AFP levels were normal in both cases but PIVKA (Protein induced by vitamin K absence) levels were increased. Resection was done in one of the cases while the other patient had to undergo transplantation. A diagnosis of MINEN was made on H&E, and confirmed on IHC. One patient was unfit for systemic chemotherapy whereas the other patient received cisplastin and etoposide based chemotherapy. Both patients developed metastasis on follow up but are still alive after 12-15 months.Conclusion: MINEN is an uncommon tumor of the liver with a poor prognosis as shown by the few studies available. Recurrence and distant metastases are often described even after complete resection and the course is fatal. The role of adjuvant chemotherapy following surgical resection is not fully elucidated. Mean survival in the cases reported ranged from 1 month to 33 months. However, no significant differences were seen in the clinicopathologic profile of the cases described so far. Further multiinstitutional studies and follow up will help to further characterize this subtype for appropriate treatment.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"21-29"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Significance of Regulatory CD25+ T Cells in Bladder Cancer: An Immunohistochemical Analysis. 调节性CD25+ T细胞在膀胱癌中的预后意义：免疫组织化学分析。

IF 1.1

Turkish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5146/tjpath.2025.13848

Sarra Ben Rejeb, Nadia Kouki, Hassen Khouni, Rami Boulma, Khadija Bellil

{"title":"Prognostic Significance of Regulatory CD25+ T Cells in Bladder Cancer: An Immunohistochemical Analysis.","authors":"Sarra Ben Rejeb, Nadia Kouki, Hassen Khouni, Rami Boulma, Khadija Bellil","doi":"10.5146/tjpath.2025.13848","DOIUrl":"10.5146/tjpath.2025.13848","url":null,"abstract":"Objective: Tumor-infiltrating lymphocytes (TILs) have been shown to predict outcomes in several cancers. This study aimed to evaluate the density and location of regulatory T cells (Tregs) using immunohistochemistry (IHC) in urothelial carcinomas (UC) of the bladder and to assess their prognostic value.Material and methods: We have retrospectively collected all cases of UC of the bladder infiltrating at least the lamina propria, diagnosed in our pathology department between 2011-2021. Specimens were stained for CD3 and CD25. TILs were assessed separately in the tumor core and the stroma. The median TIL count was used as a cut-off to classify cases into low- or high-density groups.Results: A total of 30 cases were included in the study. The median age of the patients was 65 years, with a male-to-female ratio of 9:1. The distribution of TILs was heterogeneous across locations among patients. CD3+ (p=0.035) and CD25+ (p=0.051) TILs were predominantly observed in the stroma. The density of CD25+ and CD3+ TILs were not associated with clinicopathological features. Multivariate analysis revealed that advanced histological stage and a high density of regulatory CD25+ T lymphocytes were predictive factors of poorer event-free survival (respectively p=0.041 and p=0.052).Conclusion: Regulatory T cells appear to predict worse survival outcomes. Further studies are needed to confirm their prognostic value.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0