Turkish Journal of Pathology最新文献_第2页

Pre-Mortem Histopathologic Evidence of Endothelial Injury and Thrombotic Microangiopathy in an Infant With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome (MIS-C). 新生儿sars - cov -2相关多系统炎症综合征（MIS-C）的内皮损伤和血栓性微血管病变的死前组织病理学证据

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-06-22 DOI: 10.5146/tjpath.2026.15124

Meral Uner, Fariba Amini, Sefika Karabulut, Diclehan Orhan

{"title":"Pre-Mortem Histopathologic Evidence of Endothelial Injury and Thrombotic Microangiopathy in an Infant With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome (MIS-C).","authors":"Meral Uner, Fariba Amini, Sefika Karabulut, Diclehan Orhan","doi":"10.5146/tjpath.2026.15124","DOIUrl":"https://doi.org/10.5146/tjpath.2026.15124","url":null,"abstract":"Multisystem inflammatory syndrome in children (MIS-C) represents a severe postinfectious hyperinflammatory condition following SARS-CoV-2 infection. Despite extensive clinical characterization, histopathologic data-especially from pre-mortem pediatric biopsies-remain scarce. We report a 9-month-old male infant with confirmed SARS-CoV-2 infection and rapid multiorgan failure. Pre-mortem incisional biopsies from the myocardium, lung, and pleura revealed degenerative myocyte changes, endothelial swelling, and fibrin-platelet microthrombi consistent with thrombotic microangiopathy. Immunohistochemistry demonstrated mild CD3+ T-cell-predominant infiltrates and focal SARS-CoV-2 antigen positivity confined to alveolar and bronchiolar epithelium, while myocardial and pleural tissues were negative. These findings highlight early morphologic correlates of immune-mediated vascular injury in MIS-C, characterized by endothelial dysfunction, microvascular inflammation, and T-cell-driven immunopathology in the absence of direct viral cytopathy. This case provides rare pre-mortem evidence of immune-thrombotic endotheliopathy in an infant, bridging clinical and histologic manifestations of pediatric SARS-CoV-2-associated hyperinflammatory disease.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series: Malignant Flower Cells in Peripheral Blood. 病例系列：外周血恶性花细胞。

IF 2.1

Turkish Journal of Pathology Pub Date : 2026-05-12 DOI: 10.5146/tjpath.2026.15185

Ursula Matos, Wan Ying Tan, Kapil Meleveedu, Yara Hamadah, Ritika Vankina, Victoria Forbes, Dong Chen

引用次数: 0

NTRK3-Rearranged Sarcoma of the Cervix: An Emerging Tumor Entity - Case Report and Review of the Literature. 子宫颈ntrk3重排肉瘤：一种新出现的肿瘤实体-病例报告及文献复习。

IF 2.1

Turkish Journal of Pathology Pub Date : 2026-03-04 DOI: 10.5146/tjpath.2026.14692

Ruchi Rathore, Sarita Kumari, Babita Kataria, Bhatla Neerja, Sandeep R Mathur

{"title":"NTRK3-Rearranged Sarcoma of the Cervix: An Emerging Tumor Entity - Case Report and Review of the Literature.","authors":"Ruchi Rathore, Sarita Kumari, Babita Kataria, Bhatla Neerja, Sandeep R Mathur","doi":"10.5146/tjpath.2026.14692","DOIUrl":"https://doi.org/10.5146/tjpath.2026.14692","url":null,"abstract":"NTRK-rearranged sarcoma of the cervix was recognized by the World Health Organization in 2020 as an emerging tumor entity under mesenchymal tumors of the lower female genital tract. Defined by characteristic NTRK gene fusions, this rare tumor is therapeutically targetable due to same. We report a case of a 23-year-old woman who presented with abnormal vaginal bleeding and a polypoid cervical mass. Histopathological examination of preliminary biopsy revealed spindle cell sarcoma demonstrating immunopositivity for Pan-TRK, CD34, and S100. Break-apart fluorescence in situ hybridization (FISH) confirmed the presence of an NTRK3 gene rearrangement. This patient represents one of the few reported cases of NTRK3-rearranged cervical sarcoma with lymph node metastasis in a young female. We also extensively review the existing literature and summarize the clinicopathological features, molecular profiles, and treatment implications of this report. Given the availability of effective TRK inhibitors, it is imperative to consider NTRK-rearranged sarcoma in the differential diagnosis of spindle cell sarcomas of the lower genital tract.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Testicular Aspergillus fumigatus Abscess in a Renal Transplant Recipient Diagnosed on Fine Needle Aspiration Cytology`. 一例罕见的肾移植受者睾丸烟曲霉脓肿经细针穿刺细胞学诊断。

IF 2.1

Turkish Journal of Pathology Pub Date : 2026-01-26 DOI: 10.5146/tjpath.2026.14714

Kanchan Kothari, Mona Agnihotri, Aditi Raj, Pallavi Surase

引用次数: 0

Artificial Intelligence-Assisted Invasion Risk Scoring in Tru-Cut Biopsies of Ductal Carcinoma in Situ; Predictive Role of Estrogen Receptor and HER2 Expression. 人工智能辅助导管原位癌真切活检浸润风险评分雌激素受体和HER2表达的预测作用。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2026.14901

Evren Uzun, Kubra Bulut

{"title":"Artificial Intelligence-Assisted Invasion Risk Scoring in Tru-Cut Biopsies of Ductal Carcinoma in Situ; Predictive Role of Estrogen Receptor and HER2 Expression.","authors":"Evren Uzun, Kubra Bulut","doi":"10.5146/tjpath.2026.14901","DOIUrl":"10.5146/tjpath.2026.14901","url":null,"abstract":"Objective: Invasion can be detected in up to 50% of excision specimens in cases diagnosed with ductal carcinoma in-situ (DCIS) in tru-cut biopsies. The predicting of invasion is critical for managing the treatment. The objective of this study was to ascertain the predictive role of histological characteristics and estrogen receptor (ER) and HER2 expression of DCIS with respect to invasion and to create an artificial intelligence (AI)-assisted invasion risk scoring.Material and methods: A total of 140 tru-cut biopsies with DCIS were included. We evaluated the predominant structural pattern, nuclear grade, presence of comedonecrosis, and ER/HER2 expressions and their relationship with invasion upstage. Based on the results, an invasion risk scoring system was created using OpenAI-ChatGPT 5.2.Results: Of the 140 cases, 70 (50%) were high-grade (DCIS-3), 49 (35%) were intermediate-grade (DCIS-2), and 21 (15%) were low-grade (DCIS-1). DCIS-1 and DCIS-2 showed significant association with a cribriform pattern, and DCIS-3 showed with a solid pattern. When the results were compared with those of the final specimens, invasion upstaging occurred in 9.5% of DCIS-1, 38.7% of DCIS-2, and 52.8% of DCIS-3 cases. A solid pattern, high nuclear grade, comedonecrosis, and ER-/HER2- profile showed high correlation with invasion. In AI-assisted risk scoring, DCIS cases were divided into three groups: low, medium, and high risk. The invasion upstaging rates in these groups were 11.44%, 28.97%, and 64.19%, respectively.Conclusion: DCIS with high nuclear grade, comedonecrosis, a solid pattern, and the ER-/HER2+ or ER-/HER2- immunoprofile should be considered high risk for invasion. They should be approached as invasive tumors and evaluated in terms of lymph node staging and neoadjuvant treatment.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"174-182"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encountering A Rare Entity: A Case Report of Prostatic Sarcomatoid Adenocarcinoma. 前列腺肉瘤样腺癌1例报告。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2025.14116

Harshinee S, Renuka Patil, Altaf Khan

{"title":"Encountering A Rare Entity: A Case Report of Prostatic Sarcomatoid Adenocarcinoma.","authors":"Harshinee S, Renuka Patil, Altaf Khan","doi":"10.5146/tjpath.2025.14116","DOIUrl":"10.5146/tjpath.2025.14116","url":null,"abstract":"Sarcomatoid carcinoma of the prostate is a rare and aggressive malignancy characterized by biphasic differentiation with epithelial and mesenchymal components. Diagnosing this entity is challenging due to its overlapping histological features with other prostatic neoplasms. We report a case of an elderly patient who presented with acute urinary retention and a history of lower urinary tract symptoms, including difficulty in micturition and poor urinary stream. A transrectal ultrasound-guided biopsy was performed for an ill-defined lesion in the right lobe of the prostate with an elevated PSA level of 30 ng/mL. A bone scan revealed metastatic lesions. Histopathological examination confirmed sarcomatoid carcinoma with a Gleason score of 8 (Grade Group 4). The tumor exhibited a biphasic morphology, with malignant spindle cells interspersed with a high-grade carcinoma component. Immunohistochemistry demonstrated vimentin, smooth muscle actin (SMA), and SATB2 positivity in the sarcomatoid component, while the carcinomatous component showed positivity for pan-cytokeratin (pan-CK), CK7, and CK20. PSA was negative in both components. This case highlights the aggressive nature of sarcomatoid carcinoma and highlights the essential role of histopathology and immunohistochemistry in its accurate diagnosis and differentiation from other spindle cell tumors.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"42 3","pages":"183-187"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Utility of NKX3.1 in Mesenchymal Chondrosarcoma on Needle Biopsy: A Case Report of a Supraclavicular Soft Tissue Mass with Literature Review. NKX3.1在针活检间充质软骨肉瘤中的诊断价值：锁骨上软组织肿块1例报告并文献复习。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2025.13752

Sunil Pasricha, Divya Bansal, Himanshu Rohela, Anila Sharma, Rakesh Oberoi, Vikas Reddy, Ullas Batra, Anurag Mehta

引用次数: 0

Evaluation of Morphological and Immunohistochemical Prognostic Parameters in Giant Cell Tumor of Bone. 骨巨细胞瘤形态学及免疫组化预后指标的评价。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2026.14827

Cem Berk Turk, Huseyin Kemal Turkoz, Omer Sofulu, Bulent Erol

{"title":"Evaluation of Morphological and Immunohistochemical Prognostic Parameters in Giant Cell Tumor of Bone.","authors":"Cem Berk Turk, Huseyin Kemal Turkoz, Omer Sofulu, Bulent Erol","doi":"10.5146/tjpath.2026.14827","DOIUrl":"10.5146/tjpath.2026.14827","url":null,"abstract":"Objective: Giant cell tumor of bone (GCTB) is a rarely metastasizing, locally aggressive tumor. Recurrence and metastasis in GCTB are thought to be driven by the biological behavior of the neoplastic stromal mononuclear cells. Several pathophysiological mechanisms, including expressions of p63, RANK, RANKL, and VEGF, have been proposed to influence this aggressive potential. This study aimed to identify histomorphological and immunohistochemical parameters that may predict recurrence and metastasis in patients with GCTB.Material and methods: This retrospective study included 32 GCTB patients. Clinical, radiological, and pathological data were reviewed. Histomorphological features, including surgical margins, bone cortex invasion, soft tissue invasion, mitotic count, vascular invasion, percentage of spindle cell areas, and presence of tumor-associated lymphocytes (TALs), along with tumor size and demographic features, were evaluated. Tissue sections were stained with p63, RANK, RANKL, and VEGF. The relationship between these parameters and post-surgical recurrence or metastasis was analyzed.Results: A higher percentage of spindled pattern was significantly associated with a lower frequency of recurrence. A larger tumor diameter at diagnosis was associated with the development of metastasis. Other histomorphological parameters and the expression of p63, RANK, RANKL, and VEGF were not significantly associated with recurrence or metastasis.Conclusion: Percentage of spindled pattern and primary tumor diameter are potential prognostic factors for recurrence and metastasis, respectively, in GCTB.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"85-92"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Cysts Strike: A Unique Case of Isolated Renal Hydatid Disease in a Child. 当囊肿发作：一个儿童孤立肾包虫病的独特病例。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2025.13871

Nikhil Kumar, Sandip Kumar Rahul, Harish Kumar Bohra, Vimal Singh Munda, Varsha Vijayan, Nidhi Priya Allie-Barla

引用次数: 0

A Rare Case of Primary Ovarian Mucinous Carcinoma with Signet-Ring Cells and Literature Review. 一例罕见的原发性卵巢黏液性癌（Signet-Ring 细胞）及文献综述。

IF 1.5

Turkish Journal of Pathology Pub Date : 2026-01-01 DOI: 10.5146/tjpath.2024.13669

Fatma Gundogdu, Alp Usubutun

{"title":"A Rare Case of Primary Ovarian Mucinous Carcinoma with Signet-Ring Cells and Literature Review.","authors":"Fatma Gundogdu, Alp Usubutun","doi":"10.5146/tjpath.2024.13669","DOIUrl":"10.5146/tjpath.2024.13669","url":null,"abstract":"The presence of signet-ring cells in the ovary is almost always associated with metastatic mucinous carcinomas known as Krukenberg tumors. Here we report a primary ovarian mucinous carcinoma with signet-ring cells, which is scarcely encountered, and a review of the literature to summarize the clinical and morphological features of these tumors. The patient was a 26-year-old female who had a large multicystic lesion in the right ovary. Macroscopic examination of the cyst revealed a 30 cm-sized multicystic lesion filled with mucinous material. The capsule was intact, and there was no surface involvement. Microscopically, a multicystic mucinous tumor with a predominantly borderline background and three well-demarcated nodules composed of signet ring cells without desmoplastic stroma were noted in the cyst wall. There was only one invasive focus seen. Immunohistochemically, conventional mucinous areas were diffusely positive for Keratin 7 and Keratin 20, and focally positive for PAX8, while negative for CDX2. Signet ring cells were positive for Keratin 20, CDX2, and Keratin 7, while negative for PAX8. In the systemic examinations, no potential primary site was found. The patient has not received any adjuvant treatment and has been followed for six years without disease, which is the longest follow-up time among previously reported cases. Signet ring cells can be present in primary ovarian mucinous carcinomas. The distinction from the more frequently seen metastatic carcinomas needs a complete evaluation of clinicopathological findings. Early-stage primary mucinous carcinomas having localized signet-ring cell nodules seem to have favorable prognosis without adjuvant treatment.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"53-58"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12925391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0