Turkish Journal of Pathology最新文献_第3页

Are We Where We Want to Be in Undergraduate Pathology Education? 我们在本科病理学教育方面达到预期目标了吗？

IF 1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2023.13048

Sibel Sensu, Nusret Erdogan

{"title":"Are We Where We Want to Be in Undergraduate Pathology Education?","authors":"Sibel Sensu, Nusret Erdogan","doi":"10.5146/tjpath.2023.13048","DOIUrl":"10.5146/tjpath.2023.13048","url":null,"abstract":"Objective: This review which aims to examine the recent and current status of pathology education in medical schools, and covers the publications related to undergraduate pathology education published between 2010 January and June 2023.Material and method: A search was performed through PubMed, Google Scholar, Semantic Scholar, and Ulakbim search engines for the Science Citation Index, Science Citation Index Expanded, Emerging Sources Citation Index, Directory of Open Access Journals, Scopus, PubMed as well as TR Dizin indexed articles. The findings are categorized into two periods as 2010 January - 2020 April (pre-COVID-19 pandemic) and May 2020 - 2023 June. A total of 24 reviews/editorials/letters to the editor and 63 research articles in the pre-pandemic period and 11 reviews/ editorials/ letters to the editor and 35 research articles between 2020 May and 2023 June are included in the analysis.Results: Currently, medical education generally depends on core education programs with defined learning objectives and outcomes. Moreover, problem-based, case-based, and team-based interactive learning are being used along with traditional didactic courses. Additionally, digital/ web-based/remote education methods have gained prominence after the COVID-19 pandemic. The virtual or augmented reality and 3D drawing applications are offered as a solution for the autopsy and macroscopy courses. A scarce number of publications are found on measuring and evaluating the effectiveness of learning.Conclusion: Artificial intelligence in pathology education is a topic that looks likely to become important in the near future. National and international comprehensive standardization is a necessity. A joint effort and collective intelligence are needed to achieve the desired goals in undergraduate pathology education.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"78-88"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot Trends in Pheochromocytoma and Paraganglioma: Are We Getting Closer to Personalized Dynamic Prognostication? 嗜铬细胞瘤和副神经节瘤的热点趋势：我们是否离个性化动态诊断越来越近了？

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2024.13681

C Christofer Juhlin, Ozgur Mete

引用次数: 0

Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients. 用免疫组化方法对恶性黑色素瘤患者的 CD80、CD86 和 PD-L1 表达进行临床病理学评估

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2023.01608

Esra Cobankent Aytekin, Betul Unal, Cumhur Ibrahim Bassorgun, Ozlenen Ozkan

{"title":"Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients.","authors":"Esra Cobankent Aytekin, Betul Unal, Cumhur Ibrahim Bassorgun, Ozlenen Ozkan","doi":"10.5146/tjpath.2023.01608","DOIUrl":"10.5146/tjpath.2023.01608","url":null,"abstract":"Objective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are directly related to escape from immune destruction. Therefore, we aimed to determine the expression levels of CD80, CD86, and PD -L1 in malignant melanoma tissue samples by immunohistochemistry and to investigate the possible relationship between these proteins and the clinicopathological features in this study.Material and methods: Hematoxylin and eosin staining and immunohistochemical staining for CD80, CD86, and PD-L1 were evaluated for clinical data, survival, prognosis, tumor location, malignant melanoma subtypes, tumor size, and prognostic findings.Results: Higher survival rates were observed in patients with lower PD-L1 staining scores in the tumor. The 5-year survival was higher in patients with CD80-positive and CD86-positive biopsies. Mortality was lower in superficial spreading melanoma and Lentigo maligna melanoma types, whereas staining positivity of CD80 and CD86 was higher. Furthermore, a relationship between clinical stage and Breslow thickness ( < 2mm/≥2mm), tumor ulceration, lymph node metastasis, and CD80 and CD86 expression was also identified.Conclusion: Our findings suggest that PD-L1, CD80, and CD86 expression are essential in malignant melanoma and could be used as prognostic markers.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"16-26"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Productivity Improvement in Pathology Laboratories Using Motion and Time Study Techniques. 利用运动和时间研究技术提高病理学实验室的生产力。

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2023.01610

Canan Cinar, Afsun Ezel Esatoglu

{"title":"Productivity Improvement in Pathology Laboratories Using Motion and Time Study Techniques.","authors":"Canan Cinar, Afsun Ezel Esatoglu","doi":"10.5146/tjpath.2023.01610","DOIUrl":"10.5146/tjpath.2023.01610","url":null,"abstract":"Objective: This study aimed to determine the standard time required for the performed job and to examine the standard job critically for productivity improvement in the pathology laboratory.Material and methods: In this study that was conducted at a tertiary teaching hospital, observation, fishbone diagram, and flow charts were used to collect the information about the job process. All employees were observed from September 2017 to June 2018. The observations were recorded by video camera in order to overcome the Hawthorne effect. Nine basic procedure steps were followed for productivity improvement.Results: Within the scope of the study, the jobs of `trimming tissue blocks` and `sectioning of tissue blocks` was selected. The standard time required was 0.19 minutes for `trimming tissue blocks` and 0.34 minutes for `sectioning of tissue blocks`. The procedure steps, named `Removal of tissue block` and `Fixing the block to the device`, were removed from the flow chart to define the improved method. The implementation of the improved method brought in a gain of 11.28 work days per year.Conclusion: It is obvious that the pathology laboratory needs to take certain measures to improve working conditions and increase efficiency. Our results demonstrate applying the study techniques could reduce the workload and processing time. This study also shows that the study techniques can be applied in the hospital laboratory. Incorporation of all pathology technicians in the change or innovation process will be important in maintaining the achievements.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"27-36"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Nasal Glial Heterotopia That Can Be Misdiagnosed as Storiform Patterned Sclerotic Fibroma/Collagenoma. 一例鼻腔胶质异位症，可误诊为星状花纹硬化性纤维瘤/胶原瘤。

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2023.13053

Fatma Gundogdu, Deniz Ates Ozdemir, Ibrahim Vargel

引用次数: 0

Large Language Models as a Rapid and Objective Tool for Pathology Report Data Extraction. 大语言模型作为病理报告数据提取的快速客观工具。

IF 1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2024.13256

Beyza Bolat, Ozgur Can Eren, A Humeyra Dur-Karasayar, Cisel Aydin Mericoz, Cigdem Gunduz-Demir, Ibrahim Kulac

{"title":"Large Language Models as a Rapid and Objective Tool for Pathology Report Data Extraction.","authors":"Beyza Bolat, Ozgur Can Eren, A Humeyra Dur-Karasayar, Cisel Aydin Mericoz, Cigdem Gunduz-Demir, Ibrahim Kulac","doi":"10.5146/tjpath.2024.13256","DOIUrl":"10.5146/tjpath.2024.13256","url":null,"abstract":"Medical institutions continuously create a substantial amount of data that is used for scientific research. One of the departments with a great amount of archived data is the pathology department. Pathology archives hold the potential to create a case series of valuable rare entities or large cohorts of common entities. The major problem in creation of these databases is data extraction which is still commonly done manually and is highly laborious and error prone. For these reasons, we offer using large language models to overcome these challenges. Ten pathology reports of selected resection specimens were retrieved from electronic archives of Koç University Hospital for the initial set. These reports were de-identified and uploaded to ChatGPT and Google Bard. Both algorithms were asked to turn the reports in a synoptic report format that is easy to export to a data editor such as Microsoft Excel or Google Sheets. Both programs created tables with Google Bard facilitating the creation of a spreadsheet from the data automatically. In conclusion, we propose the use of AI-assisted data extraction for academic research purposes, as it may enhance efficiency and precision compared to manual data entry.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"138-141"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinico-Pathological Spectrum of Alveolar Soft Part Sarcoma: Case Series from a Tertiary Care Cancer Referral Centre in India with a Focus on Unusual Clinical and Histological Features. 肺泡软组织肉瘤的临床病理学特征：来自印度一家三级癌症转诊中心的病例系列，聚焦异常临床和组织学特征。

IF 1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2023.01605

Kanwalpreet Kaur, Amisha Gami, Ashini Shah, Jahnvi Gandhi, Priti Trivedi

{"title":"Clinico-Pathological Spectrum of Alveolar Soft Part Sarcoma: Case Series from a Tertiary Care Cancer Referral Centre in India with a Focus on Unusual Clinical and Histological Features.","authors":"Kanwalpreet Kaur, Amisha Gami, Ashini Shah, Jahnvi Gandhi, Priti Trivedi","doi":"10.5146/tjpath.2023.01605","DOIUrl":"10.5146/tjpath.2023.01605","url":null,"abstract":"Objective: Alveolar soft part sarcoma (ASPS) is characterized by distinctive histomorphology of variably discohesive epithelioid cells arranged in nests and translocation of t(x;17) (p11.2;q25) resulting in ASPSCR1-TFE3 fusion. The aim of the present study is to review the clinical, histopathological, and immunohistochemical profile of ASPS with a focus on unusual histological features.Material and method: The present study is retrospective and descriptive. All cases with a diagnosis of ASPS were retrieved with clinical and radiology details.Results: 22 patients of ASPS were identified. The most common site was the lower extremity and the size range was 3-22 cm. 54.5% of the patients had metastasis, with the lung as the most common site. Metastasis preceded detection of primary tumour in two cases. All cases showed similar histopathology of monomorphic epithelioid cells arranged in nests encircled by sinusoidal vasculature. Architecturally, the organoid pattern (81.8%) was followed by the alveolar pattern. 68.2% of the cases showed apple bite nuclei as the predominant nuclear feature. Rare nuclear features included binucleation (n=13), multinucleation (n=8), pleomorphism (n=4), nuclear grooves in three cases and intranuclear inclusion in one case, mitosis (n=5), and focal necrosis (n=6). All cases were positive for TFE3 and negative for AE1/AE3, EMA, HMB45, PAX8, MyoD1, SMA, synaptophysin, and chromogranin. Only two cases showed focal S100 positivity while one showed focal desmin positivity.Conclusion: Diffuse strong nuclear TFE3 positivity is sensitive for ASPS in an appropriate clinicoradiological context. Due to the high propensity for early metastasis, complete metastatic work-up and long term follow up is recommended.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"89-100"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9505782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma. 胰腺导管腺癌基质和基质 SMA 表达的重要性

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2024.13521

Gamze Akbas, Pelin Bagci

{"title":"The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma.","authors":"Gamze Akbas, Pelin Bagci","doi":"10.5146/tjpath.2024.13521","DOIUrl":"10.5146/tjpath.2024.13521","url":null,"abstract":"Objective: Pancreatic stellate cells (PSC) have been defined to be the key players in pancreatic fibrogenesis and carcinogenesis. They undergo myofibroblast-like differentiation, express α-smooth muscle actin (α-SMA), and play a crucial role in injury and inflammation sites. This study aims to evaluate the relationship between α-SMA expression and histopathological parameters of pancreatic ductal adenocarcinoma (PDAC), and investigate their association with prognosis.Material and methods: Eighty-one consecutive pancreatectomies diagnosed as usual pancreatic ductal adenocarcinoma were included. The stromal density was scored as loose, moderate, or dense, and α-SMA expression was evaluated immunohistochemically.Results and conclusion: Mean survival was 19.6 months. Male gender, larger tumor diameter ( > 3.7 cm), and older age ( > 64 years) were identified as independent poor prognostic factors. Perineural invasion significantly effected survival. A statistically significant correlation was found between high α-SMA expression and the presence of angioinvasion (p=0.01). Stromal α-SMA expression in PDAC may help determine the risk of angioinvasion.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"181-189"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchiectatic Actinomycosis with Osseous Metaplasia Masquerading as Lung Cancer. 支气管扩张性放线菌病伴骨质增生伪装成肺癌

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2024.13407err

Archana Bhat, Manjunath J, Don Mascarenhas

引用次数: 0

Expression of Aberrant MicroRNAs and p16INK4a Associated with HPV (6, 11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 52, 53, and 56) in Oral Dysplasia and Squamous Cell Carcinoma: A Retrospective Study. 口腔发育不良和鳞状细胞癌中与 HPV（6、11、16、18、31、33、35、42、43、44、45、52、53 和 56）相关的异常 MicroRNA 和 p16INK4a 的表达：一项回顾性研究。

IF 1.1

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5146/tjpath.2024.12909

Layla Hafed, Olfat Shaker, Ghada Ayeldeen, Hatem Amer, Gamilah Al-Qadhi

{"title":"Expression of Aberrant MicroRNAs and p16INK4a Associated with HPV (6, 11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 52, 53, and 56) in Oral Dysplasia and Squamous Cell Carcinoma: A Retrospective Study.","authors":"Layla Hafed, Olfat Shaker, Ghada Ayeldeen, Hatem Amer, Gamilah Al-Qadhi","doi":"10.5146/tjpath.2024.12909","DOIUrl":"10.5146/tjpath.2024.12909","url":null,"abstract":"Objective: A few studies indicate that human papillomavirus (HPV) induces aberrant expression of microRNAs (miRNAs) and correlate this with p16INK4a in oral dysplasia (OD) and oral squamous cell carcinoma (OSCC). Therefore, this study aimed to evaluate the expression of miRNA-21, miRNA-22, and miRNA-224 by q-PCR and the p16 INK4a by immunohistochemical (IHC) as markers for HPV-positive OSCC and OD in comparison to controls as miRNA expression can be altered by the HPV oncogenes and hence can be used as a biomarker for HPV positive cases.Material and methods: Fifty-two specimens were collected from archived paraffin blocks for patients aged between 19 and 88 (31 males and 21 females) from various oral sites. They were examined by IHC using p16 INK4a , by RT-PCR for the detection of HPV (6, 11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 52, 53, 56), and by q-PCR for the expression of miRNA-21, miRNA-22, and miRNA-224 in positive specimens.Results: Out of the 15 OD, three were positive by both techniques. Meanwhile, 17 out of all OSCC specimens showed intense nuclear and cytoplasmic staining by p16 INK4a , and only 16 were also positive by RT-PCR. However, all control specimens were negative. MiRNA-21, miRNA-22, and miRNA-224 were overexpressed in 3 specimens of OD and 16 of OSCC.Conclusion: MiRNA-21, miRNA-22, and miRNA-224, besides p16 INK4a , could be used as indicators for HPV-associated OD and OSCC as their expression is attributed to the HPV oncoprotein. Further studies using follow-up data should be done to correlate it with miRNA overexpression.","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"149-161"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0