Turkish Journal of Pathology最新文献

{"title":"Human Umbilical Vein Endothelial Cells Express the DUX4 Protein: A Basis for Further Vascular Research.","authors":"Ceren Hangul, Dilek Bahar, Özlem Ekinci, Öznur Tokta, Yusuf Ozkul, Sibel Berker Karauzum","doi":"10.5146/tjpath.2025.14362","DOIUrl":"10.5146/tjpath.2025.14362","url":null,"abstract":"<p><strong>Objective: </strong>A growing body of evidence suggests a correlation between endothelial cell dysfunction and cancer, as well as facioscapulohumeral dystrophy, both of which are DUX4-related diseases. However, the endogenous expression of DUX4 within endothelial cells (ECs) remains unexplored. This study aims to investigate DUX4 expression in ECs and examine the presence of DUX4-counteracting proteins named PAX3 and PAX7.</p><p><strong>Material and methods: </strong>This is a cell study in which human umbilical vein endothelial cells (HUVECs) were selected as an in vitro representative of the EC population. The presence of the DUX4, PAX3 and PAX7 proteins in the HUVECs was examined using immunofluorescence staining. The mRNA levels of these proteins were investigated using qPCR with specific primers for each transcript.</p><p><strong>Results: </strong>It was observed that 51% of HUVECs expressed the DUX4 protein whereas only a small number of cells were stained with PAX3/PAX7 antibody. At the mRNA level, HUVECs exhibited expression of DUX4, PAX3 and PAX7. The mRNA levels of PAX3 and DUX4 were lower compared to PAX7 mRNA.</p><p><strong>Conclusion: </strong>The high rate of DUX4 protein expression observed in HUVECs is the first positive data and suggests a potential role for DUX4 protein in endothelial cells. Further analyses including the functional analyses of DUX4, PAX3 and PAX7 in ECs could improve our understanding of a vascular pathogenesis in DUX4-related diseases, particularly in the contexts of cancer and facioscapulohumeral dystrophy.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"113-122"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Reflex CMV Immunohistochemistry in Patients with Inflammatory Bowel Disease.","authors":"Melek Buyuk, Neslihan Berker, Dogu Vuralli Bakkaloglu, Elif Eroglu, Sevim Mese, Bilger Cavus, Aslı Cifcibasi Ormeci, Mustafa Onel, Ali Agacfidan, Mine Gulluoglu","doi":"10.5146/tjpath.2025.14375","DOIUrl":"10.5146/tjpath.2025.14375","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the association between CMV immunohistochemistry positivity and clinical, endoscopic, histologic, and tissue CMV PCR findings in ileocolonoscopic biopsies of inflammatory bowel disease patients, and to assess the diagnostic value of CMV immunohistochemistry as a reflex test during routine histopathologic evaluation.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of 191 patients (136 ulcerative colitis, 55 Crohn`s disease) between 2018 and 2021. We analyzed clinical data, endoscopic Mayo scores, histologic activity (Simplified Geboes Score), cytopathic changes, CMV immunohistochemistry and tissue CMV PCR results.</p><p><strong>Results: </strong>CMV immunohistochemistry was positive in 32.4% of cases, significantly associated with ulcerative colitis (p=0.003), symptomatic presentation (p=0.001), extensive colonic involvement (p < 0.001), high histologic activity scores (p < 0.001), and ulceration (p < 0.001). Notably, 74.2% of CMV immunohistochemistry-positive cases had no preliminary clinical suspicion of CMV infection. Viral cytopathic changes were identified in only 30.6% of immunopositive cases on hematoxylin-eosin staining. CMV immunohistochemistry showed a significant correlation with tissue PCR (p < 0.001), although some discordant cases occurred. The PCR-positive group had significantly higher immunopositive cell counts compared to the PCR-negative group (p < 0.001). The number of biopsy fragments did not affect CMV detection by immunohistochemistry.</p><p><strong>Conclusion: </strong>While evaluating endoscopic biopsies of patients with inflammatory bowel disease, CMV immunohistochemistry assessment as a reflex test may be considered by the pathologist-even in the absence of identifiable viral cytopathic effects with hematoxylin-eosin- particularly when severe histologic inflammation is present. Although the clinical significance of CMV immunohistochemistry could not be fully determined in this study, this approach may increase the likelihood of detecting CMV infection and, in the appropriate clinical context, could contribute to timely diagnosis and management.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"123-135"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma Cuniculatum Masquerading as Eumycetoma: An Unacquainted Entity Posing a Diagnostic Dilemma.","authors":"Pooja Sharma, Pragya Jain, Ankur Garg, Sonal Sharma","doi":"10.5146/tjpath.2024.13373","DOIUrl":"10.5146/tjpath.2024.13373","url":null,"abstract":"<p><p>Carcinoma cuniculatum (CC) is a rare and distinct clinicopathological variant of well-differentiated squamous cell carcinoma. It is a rare and slow-growing tumor with a peculiar infiltrative growth pattern resembling rabbit burrows (cuniculi). It usually occurs over the plantar aspect of the foot but can also occur at other sites like the oral cavity and genitals. The pathogenesis is unknown, with various hypotheses of trauma as proposed by different authors. It is essential to be aware of this entity as it commonly mimics benign and other low-grade squamous cell carcinoma (SCC). Diagnosis of CC can be challenging and requires repeated histological evaluation and clinical correlation. Herein, we present a case report of CC of the plantar and dorsal aspect of the foot in a 60-year-old male with a history of multiple chronic non-healing ulcers, which was clinically suspected as eumycetoma and remained inconclusive on numerous biopsies.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"65-69"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of HEG1 and Claudin-4 Immunohistochemistry in the Differential Diagnosis of Lung Adenocarcinoma from Malignant Mesothelioma in Pleural Effusion Cytology.","authors":"Aziza E Abdelrahman, Fatma A Elbadry, Taiseer R Ibrahim, Mohamed Ali Alabiad, Mohamed Awad","doi":"10.5146/tjpath.2025.13801","DOIUrl":"10.5146/tjpath.2025.13801","url":null,"abstract":"<p><strong>Objective: </strong>Cytological examination of pleural effusion is minimally invasive and low risk but faces challenges due to the lack of architectural features, low cell counts, and overlapping characteristics among reactive mesothelial cells (RMCs), carcinoma cells, and malignant epithelioid mesothelioma (MPM) cells. The aim of this was study to detect the diagnostic accuracy of the expression of HEG1 and Claudin-4 in distinguishing malignant mesothelioma from lung adenocarcinoma in pleural effusion.</p><p><strong>Material and methods: </strong>The present study was carried out on 84 cases of pleural effusion. Sixty-four representative cell blocks of the studied malignant cases and twenty control cases were stained with HEG1 and Claudin-4 immunostaining, and the results were recorded.</p><p><strong>Results: </strong>Positive membranous HEG1 immunoexpression was found in 95% of RMCs in benign effusions. Also, positive membranous HEG1 immunoexpression was found in 96% of cases of MPM, and only 2.6% of lung adenocarcinoma cases. There was a statistically significant difference between benign effusion with RMCs and lung adenocarcinoma immunoreactivity. There was a highly statistically significant difference between HEG1 immunoexpression in MPM and lung adenocarcinoma. On the other hand, all cases of benign effusions and all MPM cases had negative Claudin-4 immunoexpression while positive membranous Claudin-4 immunoexpression was found in 94.9% of lung adenocarcinoma cases. There was a statistically significant difference in immunoexpression of Claudin-4 between benign effusion and lung adenocarcinoma. There was a statistically significant difference in the immunoexpression of Claudin-4 between MPM and lung adenocarcinoma.</p><p><strong>Conclusion: </strong>HEG1 and Claudin-4 IHC staining is extremely valuable in the differential diagnosis between reactive or malignant mesothelial cells and adenocarcinoma in pleural effusion.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"42-50"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-Associated Long Non-Coding RNAs (lncRNAs) in Chronic Viral Hepatitis- Associated Hepatocellular Carcinoma.","authors":"Burcin Pehlivanoglu, Anil Aysal, Cihan Agalar, Tufan Egeli, Mucahit Ozbilgin, Tarkan Unek, Ilkay Tugba Unek, Ilhan Oztop, Safiye Aktas, Ozgul Sagol","doi":"10.5146/tjpath.2024.13593","DOIUrl":"10.5146/tjpath.2024.13593","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify the expression profile and prognostic significance of inflammation-associated lncRNAs in chronic viral hepatitis (CVH) and CVH-associated hepatocellular carcinoma (CVH-HCC).</p><p><strong>Material and methods: </strong>In the first step, lncRNA expression analysis was performed by real-time polymerase chain reaction (RT-PCR) using an array panel of 84 inflammation-associated lncRNAs in 48 formalin-fixed paraffin-embedded (FFPE) tissue samples (12 CVH-HCC, 12 peritumoral cirrhotic parenchyma, 12 nontumoral cirrhotic CVH parenchyma, 12 normal liver samples). In the second step, 7 lncRNAs (DLEU2, HOTAIR, LINC00635, LINC00662, RP11-549J18.1, SNHG16 and XIST) were chosen for RT-PCR assay testing in 72 samples (24 CVH-HCC, 24 peritumoral cirrhotic parenchyma, 24 nontumoral cirrhotic CVH parenchyma samples).</p><p><strong>Results: </strong>Fifty-six inflammation-associated lncRNAs were significantly up-regulated in the peritumoral cirrhotic parenchyma compared to the normal liver. Expression of 71 lncRNAs was significantly higher in peritumoral cirrhotic parenchyma compared to cirrhotic CVH parenchyma. DLEU2 and SNHG16 were up-regulated both in the tumor and peritumoral cirrhotic parenchyma compared to cirrhotic CVH parenchyma. Expression of LINC00662 was significantly higher in CVH-HCC than in cirrhotic CVH parenchyma. Expression of XIST was also increased in both tumor and peritumoral parenchyma samples, albeit without statistical significance. No significant association was found between lncRNA expressions and survival.</p><p><strong>Conclusion: </strong>Inflammation-associated lncRNAs DLEU2, SNHG16, LINC00662, and XIST are candidate diagnostic biomarkers in CVH-HCC. More evidence is needed to prove their utility as prognostic markers.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"1 1","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytohistological Correlation of Thyroid Cases with Emphasis on Papillary Thyroid Carcinoma and Analysis of the Causes of Diagnostic Errors on Cytology.","authors":"Soundarya Soundarya, S Mary Theresa-Sylvia, Banushree Chandrasekhar Srinivasamurthy","doi":"10.5146/tjpath.2025.13787","DOIUrl":"10.5146/tjpath.2025.13787","url":null,"abstract":"<p><strong>Objective: </strong>Fine needle aspiration cytology is the first line of investigation for thyroid lesions. Despite standard reporting formats, the diagnostic accuracy varies across institutions. In this study, we have reviewed our discordant cases on cytology and histopathology and analyzed the diagnostic errors.</p><p><strong>Material and methods: </strong>The thyroid cases with discrepant cytology and histopathology reports for a period of five years were analyzed for diagnostic errors. The papillary thyroid carcinoma (PTC) cases were studied in detail for all diagnostic parameters. Nuclear scoring was used to improve the detection of PTC.</p><p><strong>Results: </strong>Of the 166 cases, 18 (10%) had discrepant diagnoses. The sensitivity was 65.62% (CI 46.81-81.43%), specificity 94.78%, positive predictive value 75%, negative predictive value 92.03%, positive likelihood ratio 12.56, negative likelihood ratio 0.36, false positive rate 5.2%, false negative rate 34.3% and accuracy 89.16%. False negative (malignant cases diagnosed as benign) was due to inadequate/wrong site sampling, benign clusters/ cyst macrophages, marginal flares, thin colloid, larger fragments of calcification, and subtle nuclear features. An interesting flower head-like structure was observed in PTC cases. Nuclear scoring on false negative cases improved our diagnostic accuracy. False positivity was due to vigorous aspiration and over-interpretation of nuclear features.</p><p><strong>Conclusion: </strong>Analysis of our discrepant cases highlighted the importance of multiple passes, sampling all nodules, and ultrasound-guided aspiration to reduce sampling error. Application of nuclear scoring reduced overdiagnosis and missing out on PTC. Tissue fragments and hypercellularity were the major misleading factors in false positive cases.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":"1 1","pages":"51-58"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Tumor Microenvironment in Breast Cancer: Parameters that can be Assessed with Light Microscopy.","authors":"Seetu Palo","doi":"10.5146/tjpath.2024.13748","DOIUrl":"10.5146/tjpath.2024.13748","url":null,"abstract":"","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":"145-146"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Primary Ovarian Mucinous Carcinoma with Signet-Ring Cells and Literature Review.","authors":"Fatma Gundogdu, Alp Usubutun","doi":"10.5146/tjpath.2024.13669","DOIUrl":"https://doi.org/10.5146/tjpath.2024.13669","url":null,"abstract":"<p><p>The presence of signet-ring cells in the ovary is almost always associated with metastatic mucinous carcinomas known as Krukenberg tumors. Here we report a primary ovarian mucinous carcinoma with signet-ring cells, which is scarcely encountered, and a review of the literature to summarize the clinical and morphological features of these tumors. The patient was a 26-year-old female who had a large multicystic lesion in the right ovary. Macroscopic examination of the cyst revealed a 30 cm-sized multicystic lesion filled with mucinous material. The capsule was intact, and there was no surface involvement. Microscopically, a multicystic mucinous tumor with a predominantly borderline background and three well-demarcated nodules composed of signet ring cells without desmoplastic stroma were noted in the cyst wall. There was only one invasive focus seen. Immunohistochemically, conventional mucinous areas were diffusely positive for Keratin 7 and Keratin 20, and focally positive for PAX8, while negative for CDX2. Signet ring cells were positive for Keratin 20, CDX2, and Keratin 7, while negative for PAX8. In the systemic examinations, no potential primary site was found. The patient has not received any adjuvant treatment and has been followed for six years without disease, which is the longest follow-up time among previously reported cases. Signet ring cells can be present in primary ovarian mucinous carcinomas. The distinction from the more frequently seen metastatic carcinomas needs a complete evaluation of clinicopathological findings. Early-stage primary mucinous carcinomas having localized signet-ring cell nodules seem to have favorable prognosis without adjuvant treatment.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult Diagnosis of Interdigitating Dendritic Cell Sarcoma of the Retroperitoneum: A Case Report and A Brief Review of the Literature.","authors":"Galina Boyko, Igor Makarov","doi":"10.5146/tjpath.2024.13546","DOIUrl":"https://doi.org/10.5146/tjpath.2024.13546","url":null,"abstract":"<p><p>Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm classified within the M-group of malignant histiocytoses. Its diagnosis poses a significant challenge. This article aims to describe a rare clinical case of IDCS and to illustrate the differential diagnostic process undertaken by the authors in establishing this diagnosis. A 60-year-old woman was admitted for the resection of a retroperitoneal mass discovered via CT scan. Morphological examination revealed a 7.5×5.5×5.0 cm tumor, encapsulated by a thin fibrous capsule. The tumor was composed of 90-95% inflammatory infiltrate with lymphocyte-like cells showing mature nuclear morphology (CD3+ and CD20+ cells) mixed with histiocytes and plasma cells, and 5-10% large polymorphic spindle-shaped cells expressing expression of CD45, CD68, CD1a, CD21, CD35, CD31, and CD34. An extensive immunohistochemical panel was performed to exclude various other tumors. Based on the morphology and immunophenotype, a diagnosis of IDCS was established. Further literature analysis indicated the nonspecificity of symptoms in patients with this tumor localization and variability in CD45 and CD68 staining in tumor cells, with consistent lack of expression of CD21, CD23, CD35, CD1a, and specific T- and B-cell antigens. IDCS is a rare and poorly understood tumor with a poor prognosis. The nonspecificity of clinical symptoms and the need for extensive morphological differential diagnosis render this entity a diagnosis of exclusion, requiring significant diligence from the pathologist.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Cutaneous Adiaspiromycosis: A Case Report and Review of the Literature.","authors":"Sateesh Chavan S, Chandrashekar T N, Arathi S, Sunitha Vernekar","doi":"10.5146/tjpath.2025.13977","DOIUrl":"https://doi.org/10.5146/tjpath.2025.13977","url":null,"abstract":"<p><strong>Aim: </strong>To document a case of primary cutaneous Adiaspiromycosis.</p><p><strong>Introduction: </strong>Adiaspiromycosis is a rare emerging fungal infection caused by Chrysosporium Parvum var Crescens now called as `Emmonsia Crescens` belonging to the genus Emmonsia, order Onygenales, family Ajellomycetes.</p><p><strong>Case report: </strong>A 38-year-old male presented with an ulcerated nodule over the infra-axillary region with itching for 3 months. The lesion began as small nodule slowly growing to attain the present size. His routine investigations were within normal limits. Serological tests such as HBsAg and HIV were nonreactive. Fine needle aspiration cytology showed `suppurative granulomatous` inflammation. The nodule was excised and sent for histopathological examination. Histopathology showed numerous noncaseating granulomas and suppuration. Amidst suppuration, as well as inside the giant cells and within granulomas, numerous varying sized, thick-walled, round to oval `adiaspores` were seen. There was no evidence of budding or septation or endosporulation. They were PAS and GMS positive. He was treated with topical luliconazole and oral fluconazole. There was no recurrence on follow up of one years.</p><p><strong>Conclusion: </strong>Adiaspiromycosis is a rare fungal infection and primary cutaneous involvement is a rare distinct entity. Detailed morphological assessment in histopathology is essential for its identification as the organisms are difficult to isolate in fungal culture from human clinical material.</p>","PeriodicalId":45415,"journal":{"name":"Turkish Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}