Epstein-Barr Virus-Positive Leiomyosarcoma in Immunocompetent Patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.5146/tjpath.2023.01600

Hassan Al-Tarawneh, Alpaslan Alp, Gokhan Gedikoglu, Kemal Kosemehmetoglu

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引用次数: 0

Abstract

Objective: Epstein-Barr Virus-Associated Smooth Muscle Tumor (EBV-SMT) is a rare tumor with a higher rate of occurrence in unusual locations in the setting of immunodeficiency. In this study, we evaluated a cohort of ordinary leiomyosarcomas (LMS) for the presence of EBV and described the clinicopathological features deviating from routinely diagnosed cases of EBV-SMT.

Material and method: The sections of tissue microarrays including 93 classical LMS occurring in various locations were hybridized with EBER and stained for LMP1 antibody using the Leica Bond Autostainer. EBV real-time PCR assay was performed in 2 EBER-positive cases.

Results: Among the 93 LMS cases, 2 non-uterine cases (2.2%) were positive for EBER and negative for LMP1, and were referred to as `EBV-positive LMS`. Both were females in their 6th decade without immunosuppression. EBV real-time PCR assay revealed the presence of EBV in one of the cases. Tumors were located in the pancreas and chest wall. Morphologically, tumors were rather myxoid, multinodular, and composed of long fascicles of spindle cells with intermediate- to high-grade features. High mitotic activity and focal necrosis were present, whereas no accompanying lymphocytes were detected. One of the patients developed metastatic disease after 3 years.

Conclusion: EBV-positive LMS occurring in immunocompetent patients has features distinct from classical EBV-SMT seen in immunosuppressed patients.

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免疫功能正常患者中的 Epstein-Barr 病毒阳性 Leiomyosarcoma。

研究目的爱泼斯坦-巴氏病毒相关平滑肌瘤（EBV-SMT）是一种罕见的肿瘤，在免疫缺陷的情况下，其在特殊部位的发生率较高。在这项研究中，我们评估了一组普通的平滑肌瘤（LMS）是否存在 EBV，并描述了与常规诊断的 EBV-SMT 病例不同的临床病理特征：包括93例发生在不同部位的经典LMS的组织芯片切片与EBER杂交，并使用Leica Bond Autostainer进行LMP1抗体染色。对 2 例 EBER 阳性病例进行了 EBV 实时 PCR 检测：结果：在93例LMS病例中，2例（2.2%）非宫腔病例EBER阳性，LMP1阴性，被称为 "EBV阳性LMS"。两例病例均为女性，年龄均在60岁左右，无免疫抑制。EBV 实时 PCR 检测显示其中一例存在 EBV。肿瘤位于胰腺和胸壁。从形态上看，肿瘤呈肌样，多结节，由具有中高级特征的纺锤形细胞长束组成。有丝分裂活跃，有局灶性坏死，但未发现伴有淋巴细胞。其中一名患者在 3 年后出现转移性疾病：结论：发生在免疫功能正常患者身上的 EBV 阳性 LMS 具有不同于免疫抑制患者的典型 EBV-SMT 特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.