African Journal of Laboratory Medicine最新文献

{"title":"Performance comparison of three commercial multiplex molecular panels for respiratory viruses at a South African academic hospital.","authors":"Clinton van der Westhuizen, Mae Newton-Foot, Pieter Nel","doi":"10.4102/ajlm.v13i1.2415","DOIUrl":"10.4102/ajlm.v13i1.2415","url":null,"abstract":"<p><strong>Background: </strong>Respiratory infections are a major contributor to hospital admissions. Identification of respiratory pathogens by means of conventional culture and serology methods remains challenging. Multiplex molecular assays are an appealing alternative that endeavours to be rapid, more accurate and less arduous.</p><p><strong>Objective: </strong>The study aimed to compare the clinical performance of three commercial multiplex molecular assays for respiratory viruses.</p><p><strong>Methods: </strong>Forty-eight respiratory specimens obtained from patients at Tygerberg Hospital in the Western Cape province of South Africa were studied. These specimens were collected between May 2020 and August 2020. The results of the Seegene Anyplex™ II RV16, FilmArray^® Respiratory 2.1 <i>plus</i> Panel (FARP), and QIAstat-Dx^® Respiratory SARS-CoV-2 Panel (QRP) were analysed based on the overlapping targets. A composite reference standard was applied to provide a standard reference for comparison.</p><p><strong>Results: </strong>The overall sensitivity of the Seegene Anyplex™ II RV16 was 96.6% (57/59), the FARP 98.2% (56/57) and the QRP 80.7% (46/57). The overall specificities were 99.8% (660/661), 99.0% (704/711) and 99.7% (709/711), respectively. The QRP failed to detect coronaviruses and parainfluenza viruses in 41.7% (5/12) and 28.6% (4/14) of positive specimens, respectively, while the FARP produced the lowest target specificity of 88.4% (38/43) for rhinovirus/enterovirus.</p><p><strong>Conclusion: </strong>The overall specificity of all three platforms was comparable; however, the sensitivity of the QRP was inferior to that of the ARV and FARP.</p><p><strong>What this study adds: </strong>This study adds to the body of performance characteristics described for respiratory multiplex panels, especially in the African context where molecular diagnostics for infectious diseases are gaining momentum.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2415"},"PeriodicalIF":1.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of antimicrobial resistance surveillance in Ghana using the Integrated Disease Surveillance and Response strategy.","authors":"Beverly Egyir, Alfred Bortey, Kwabena O Duedu, Gifty Boateng, Franklin A Bekoe, George Hedidor, Michael Adjabeng, Nicholas T K D Dayie, Noah Obeng-Nkrumah, Japheth A Opintan","doi":"10.4102/ajlm.v13i1.2404","DOIUrl":"10.4102/ajlm.v13i1.2404","url":null,"abstract":"","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2404"},"PeriodicalIF":1.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invisible and undervalued: A qualitative study of laboratory workers' experiences and perceptions of laboratory strengthening in Sierra Leone.","authors":"Mohamed B Jalloh, Eva Vernooij, Alice Street","doi":"10.4102/ajlm.v13i1.2292","DOIUrl":"10.4102/ajlm.v13i1.2292","url":null,"abstract":"<p><strong>Background: </strong>The 2013-2016 West Africa Ebola outbreak highlighted the importance of laboratory capacity to outbreak response while also revealing its long-standing neglect. The outbreak prompted massive international investment into strengthening laboratory services across multiple healthcare settings.</p><p><strong>Objective: </strong>In this article, we explore hospital-based clinical laboratory workers' experiences and perceptions of their everyday working environment in Sierra Leone, and how recent investments in laboratory strengthening have shaped these.</p><p><strong>Methods: </strong>This qualitative study draws on in-depth interviews with eight laboratory workers and participant observation of laboratory practices at a tertiary referral hospital in Freetown between April 2019 and December 2019. Interview and observational data were coded and analysed using a reflexive thematic approach.</p><p><strong>Results: </strong>The Ebola outbreak prompted international investments in automated devices, biosafety training, and a new dedicated infectious diseases laboratory. However, little investment was made in the infrastructure and supply systems needed to sustain routine laboratory work or keep machines functioning. Laboratory workers perceived their work to be under-recognised and undervalued by the government, hospital managers and clinical staff, a perception compounded by under-use of the hospital's laboratory services by clinicians.</p><p><strong>Conclusion: </strong>Understanding laboratory technicians' views, experiences, and priorities is essential to any sustainable laboratory-strengthening effort. Investments in personnel should match investments in technologies and infrastructure for outbreak response.</p><p><strong>What this study adds: </strong>This study contributes to an understanding of how clinical laboratory personnel in Sierra Leone view and experience their work, and introduces the concept of social invisibility to explain these experiences.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2292"},"PeriodicalIF":1.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternally inherited diabetes and deafness with a variable presentation across three generations within a pedigree, South Africa.","authors":"Herbert Makgopa, Tanja Kemp, Surita Meldau, Engela M Honey, Bettina Chale-Matsau","doi":"10.4102/ajlm.v13i1.2384","DOIUrl":"10.4102/ajlm.v13i1.2384","url":null,"abstract":"<p><strong>Introduction: </strong>Maternally inherited diabetes and deafness (MIDD) is caused by the m.3243A>G pathogenic variant in maternally inherited mitochondrial DNA. Diabetes is prevalent in our setting; however, MIDD is rarely diagnosed. This study, undertaken in Pretoria, South Africa, highlights the variable presentation of MIDD in different patients within the same family.</p><p><strong>Case presentation: </strong>A 45-year-old man (proband) with hearing impairment was referred to the endocrine unit in July 2015 due to poor glycaemic control (HbA1c = 13%). His clinical and biochemical features were in keeping with MIDD. A genetic study of accessible maternal relatives was pursued. His mother had difficulty hearing and reportedly died from an unspecified cardiovascular cause. Two sisters with diabetes and deafness died of cardiac-related conditions. One nephew had diabetes (HbA1c = 7.7%), hearing loss and tested positive for m.3243A>G. A third sister tested positive for m3243A>G, but aside from bilateral mild hearing loss in higher frequencies, showed no other signs of target organ damage. Her daughter developed end-stage kidney failure necessitating a transplant, while her son had no biochemical abnormalities and was negative for m.3243A>G.</p><p><strong>Management and outcome: </strong>A multidisciplinary team managed and screened for complications of the patient and his maternal relatives. Proband died prior to genetic testing.</p><p><strong>Conclusion: </strong>Most MIDD patients initially present with symptoms of diabetes only, and it is probable that many cases remain undiagnosed. A high index of suspicion is necessary when encountering a family history of both diabetes and impaired hearing, and screening should be offered to the patient's maternal relatives.</p><p><strong>What the study adds: </strong>This study demonstrates the importance of proper assessment when evaluating a patient with diabetes and a family history of hearing loss.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2384"},"PeriodicalIF":1.1,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Field study to determine the reliability of HIV viral load results shows minimal impact of delayed testing in South Africa.","authors":"Diana R Hardie, Howard Newman, Joanna Reid, Nei-Yuan Hsiao, Gert van Zyl, Lucia Hans, Jasantha Odayar, Stephen Korsman","doi":"10.4102/ajlm.v13i1.2364","DOIUrl":"10.4102/ajlm.v13i1.2364","url":null,"abstract":"<p><strong>Background: </strong>Understanding factors that impact HIV viral load (VL) accuracy in resource-limited settings is key to quality improvement.</p><p><strong>Objective: </strong>We evaluated whether testing delay and specimen storage between 25 °C and 30 °C before testing affected results.</p><p><strong>Methods: </strong>Between November 2019 and June 2023, 249 individuals on antiretroviral therapy, or with newly diagnosed HIV, were recruited from clinics in Cape Town and Gqeberha, South Africa, and three plasma preparation tubes were collected. One tube was tested within 24 h, while the others were stored uncentrifuged at ambient temperatures before testing. Centrifugation and testing of matched samples were performed on Day 4 and Day 7 after collection.</p><p><strong>Results: </strong>Time delay and ambient storage had minimal impact in specimens with a Day 1 VL of > 100 copies/mL. When grouped by Day 1 VL range, 96% - 100% of specimens at Day 4 and 93% - 100% at Day 7 had VLs within 0.5 log copies/mL of the first result. The greatest variability at Days 4 and 7 was observed when the Day 1 VL was < 100 copies/mL. However, there was no trend of increasing difference over time. Of Day 1 specimens with undetectable VL, or VL < 50 copies/mL, 80% had concordant results at Day 4 and 78% at Day 7.</p><p><strong>Conclusion: </strong>These results show that VL is stable in plasma preparation tubes for 7 days when stored at room temperature. There is significant variability in specimens with low VL, but variability is not affected by testing delay.</p><p><strong>What this study adds: </strong>Ideal HIV VL testing conditions are frequently unachievable in resource-limited settings. Data are needed on whether this impacts on the validity of test results. Our results provide reassurance that storage at ambient temperature for up to 7 days before testing does not substantially affect the VL result.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2364"},"PeriodicalIF":1.1,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel laboratory compliance with best practices in Burkina Faso's antimicrobial resistance surveillance network.","authors":"Dame Yenyetou, Emmanuel Zongo, Emilie Dama, Merci Muhigwa, Issouf Sanou, Charles Sawadogo, Soumaya Ouangraoua, Ibrahim Sangare, Abdoulaye Nikiema, Anicet G Dahourou, Abdoul S Ouedraogo","doi":"10.4102/ajlm.v13i1.2259","DOIUrl":"10.4102/ajlm.v13i1.2259","url":null,"abstract":"<p><strong>Background: </strong>Standardising procedures is the best way to harmonise and strengthen the quality of laboratory-based antimicrobial resistance surveillance. Since 2018, Burkina Faso has developed and disseminated the national manual of procedures for performing antibiotic susceptibility tests in sentinel laboratories within its national antimicrobial resistance surveillance network.</p><p><strong>Objective: </strong>Our study aimed to assess these sentinel laboratories' compliance with good practices for antibiotics susceptibility tests.</p><p><strong>Methods: </strong>Four teams evaluated the antimicrobial resistance sentinel sites laboratories throughout Burkina Faso from 19 to 28 September 2022. Eighteen out of 19 sentinel laboratories were evaluated. A four-member technical committee designed and validated the evaluation tool composed of three Microsoft Excel sheets. The evaluation emphasised quality controls for culture media, antibiotic discs and compliance with antimicrobial susceptibility testing procedures by the laboratories. Excel software was used for data recording and graphs and table design. The free R software version 4.2.0 was used for descriptive statistics. An overall score below 80% was considered noncompliance.</p><p><strong>Results: </strong>Most (83.33%) of the sentinel laboratories conducted at least one quality control activity for culture media, and 66.67% conducted at least one quality control activity for antibiotic discs. Over three-quarters (76.47%) of the laboratories were more than 80% compliant with the modified Kirby Bauer antimicrobial susceptibility testing method.</p><p><strong>Conclusion: </strong>The evaluation revealed the noncompliance of sentinel laboratories with the national procedure manual, particularly in the quality control component.</p><p><strong>What this study adds: </strong>This study has provided baseline data on the sentinel laboratories' compliance with the national antimicrobial susceptibility testing procedures manual, particularly in areas performing quality control checks or meeting quality indicators for culture media and antibiotic discs.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2259"},"PeriodicalIF":1.1,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fighting cervical cancer in Africa: Taking a closer look at human papillomavirus 35.","authors":"Sophia U Okeke","doi":"10.4102/ajlm.v13i1.2243","DOIUrl":"10.4102/ajlm.v13i1.2243","url":null,"abstract":"","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2243"},"PeriodicalIF":1.1,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of potassium test sample rejections on routine laboratory service, South Africa","authors":"Sarah McAlpine, B. Chale-Matsau","doi":"10.4102/ajlm.v12i1.2239","DOIUrl":"https://doi.org/10.4102/ajlm.v12i1.2239","url":null,"abstract":"Background: Accurate potassium measurements are necessary for effective clinical management of hyperkalaemia. Pre-analytical factors may affect laboratory measurements, leading to erroneous results and inappropriate patient management and negatively impact the efficiency and finances of laboratories and hospitals.Objective: This study evaluated the impact of rejected potassium test requests on laboratory service.Methods: We conducted a retrospective descriptive study to assess potassium test data at a public laboratory in Pretoria, Gauteng, South Africa, using samples collected from an academic hospital, peripheral hospitals, and outpatient clinics between January 2018 to December 2018. We assessed the relationship between reasons for rejection and health facility type, as well as financial implications for the laboratory.Results: The potassium result rejection rate was 15.1% (29 806 samples), out of the 197 405 requests received. The most common reasons for rejection were old sample ( 1 day old) (41.4%; 12 348 rejections) and haemolysis (38.2%; 11 398 rejections). The most frequent reason for rejections at the central, academic hospital was haemolysis (42.0%), while old sample was the most common reason for rejection at peripheral hospitals (43.4%; 4119/9493 requests) and outpatient health facilities (57.2%; 7208/12 605 requests) (p = 0.022). The total cost of potassium sample rejection over the study period was substantial, given the resource constraints in this setting.Conclusion: Peripheral hospitals and outpatient departments accounted for the majority of rejected potassium testing results, possibly resulting from delays in transportation; causing substantial financial impact on the laboratory. Improved sample collection, handling, and expedited transportation are recommended.What this study adds: This study highlights the importance of appropriate sample collection and handling and the undesirable consequences of non-adherence to these pre-analytical considerations.","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"8 2","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138947787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical values notification: A nationwide survey of practices among clinical laboratories across Nigeria.","authors":"Lucius C Imoh, Idris Y Mohammed, Ifeyinwa D Nnakenyi, Ephraim U Egbuagha, Tomisin M Adaja, Chinelo P Onyenekwu","doi":"10.4102/ajlm.v12i1.2249","DOIUrl":"10.4102/ajlm.v12i1.2249","url":null,"abstract":"<p><strong>Background: </strong>Critical value notification (CVN) entails notifying doctors or other laboratory users of aberrant laboratory results that threaten the patient's life and of any values for which reporting delays could negatively impact the patient's health. Critical value notification practices in clinical laboratories in Nigeria and sub-Saharan Africa are largely unknown.</p><p><strong>Objective: </strong>We conducted a nationwide survey to obtain baseline information on CVN practice by Nigeria's laboratories.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among purposively selected secondary- and tertiary-tier, public and private clinical laboratories across northern and southern Nigeria between October 2015 and December 2015. Consenting senior laboratory staff completed and returned a structured questionnaire, that gathered data on respondents' demographics, designations, and institutional characteristics and practices regarding CVN.</p><p><strong>Results: </strong>One hundred and thirty-four laboratories responded to the questionnaires. Only 69 (51.5 %) laboratories practised CVN; only 23 (33.3%) had existing written policies guiding the practice. Most (43; 62.3%) laboratories use similar critical values (CVs) for adult and paediatric populations. Most laboratories (27; 39.1%) obtained their CVs by combining published literature and local opinions from stakeholders. Physical dispatch (42; 60.9%) followed by telephone calls (38; 55.1%) were the most common means of notification. Private laboratories, compared with public hospital laboratories, were likelier to have separate paediatric CV lists (<i>p</i> = 0.019) and practise telephone notifications (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Critical value notification practices vary and are often suboptimal in many clinical laboratories in Nigeria, which is exacerbated by the absence of guiding policies and national recommendations for post-analytical procedures.</p><p><strong>What this study adds: </strong>This study provides baseline information on CVN practice by Nigeria's laboratories. The study explores the causes of practice variations that can serve as a foundation for enhancing critical reporting and post-analytical services, particularly in clinical laboratories in sub-Saharan Africa.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"12 1","pages":"2249"},"PeriodicalIF":1.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gaps in newborn screening programmes: Challenges and opportunities to detect haemoglobinopathies in Africa.","authors":"Seth Twum, Kwadwo Fosu, Robin A Felder, Kwabena A N Sarpong","doi":"10.4102/ajlm.v12i1.2225","DOIUrl":"10.4102/ajlm.v12i1.2225","url":null,"abstract":"<p><strong>Background: </strong>Haemoglobinopathies, including sickle cell disease and β-thalassaemia, are monogenic disorders with a relatively higher prevalence among malaria-endemic areas in Africa. Despite this prevalence, most African countries lack the necessary resources for diagnosing and managing these debilitating conditions.</p><p><strong>Aim: </strong>This study provides a critical review of newborn screening for detecting haemoglobinopathies in Africa, highlighting challenges and proposing strategies for improved diagnosis and management.</p><p><strong>Methods: </strong>A literature search on haemoglobinopathies in Africa was conducted in PubMed, Google Scholar and ScienceDirect, using specific keywords and Boolean operators, including articles published from January 1981 to December 2022.</p><p><strong>Results: </strong>The data show that sickle cell disease is prevalent among populations in Central and West Africa; however, β-thalassaemia is prevalent among people in the northern parts of Africa. Newborn screening pilot initiatives for haemoglobinopathies were being implemented in Angola, Nigeria, Ghana, the Democratic Republic of Congo and the Republic of Benin. The cost of testing, lack of sufficient and accessible medical records, and inadequacy in healthcare infrastructure pose significant challenges in bridging the gaps in newborn screening. Furthermore, the stigmatisation and lack of awareness of haemoglobinopathies and access to newborn screening programmes pose additional challenges.</p><p><strong>Conclusion: </strong>This review highlights the challenges associated with haemoglobinopathy testing, effective strategies for mitigating these challenges, and future perspectives for expanding efforts toward detecting and managing these disorders across Africa. Providing affordable diagnostic tools, mobile clinics, government subsidies, education campaigns, and the implementation of electronic medical records systems could help bridge the gaps in newborn screening in Africa.</p><p><strong>What this study adds: </strong>The study presents a comprehensive view of newborn screening of haemoglobinopathies in Africa, provides a detailed outline of the challenges faced by newborn screening for haemoglobinopathies in Africa, and offers strategies for better diagnosis and care.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"12 1","pages":"2225"},"PeriodicalIF":1.1,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}