Journal of Obesity & Metabolic Syndrome最新文献

{"title":"Amylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity.","authors":"Chae Won Chung, Jaetaek Kim","doi":"10.7570/jomes25085","DOIUrl":"10.7570/jomes25085","url":null,"abstract":"<p><p>Amylin is a pancreatic peptide hormone that regulates blood glucose levels and appetite. This review outlines the physiological role of amylin and highlights recent clinical studies exploring its therapeutic potential in diabetes and obesity. Amylin lowers postprandial glucose levels by delaying gastric emptying and suppressing glucagon secretion, while promoting satiety via central nervous system pathways. Preclinical research has driven the development of long-acting amylin analogs with enhanced pharmacokinetics and reduced aggregation, resulting in significant weight loss and metabolic benefits in animal models. Clinically, the synthetic analog pramlintide has been shown to modestly improve glycemic control and induce weight loss in patients with diabetes. More recently, cagrilintide, a long-acting analog, has produced substantial weight reduction in individuals with obesity. Combination therapy with glucagon like peptide-1 receptor agonists has achieved synergistic effects, with weight loss exceeding 15%, positioning amylin analogs as a promising approach for treatment of diabesity-the co-existence of diabetes and obesity. This review summarizes recent advancements and discusses their implications for future therapeutic applications in diabesity management.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"38-48"},"PeriodicalIF":12.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Guidelines for Enhancing Mobility and Stability in Individuals with Severe Obesity.","authors":"Hae Sung Lee, Min-Hwa Suk, Hee Seung Jang, Jong-Hee Kim","doi":"10.7570/jomes24047","DOIUrl":"10.7570/jomes24047","url":null,"abstract":"<p><p>Severe obesity is frequently accompanied by restricted joint mobility and chronic pain, both of which compromise quality of life and functional independence. Despite well-documented benefits of exercise in managing severe obesity, adherence remains low due to perceived physical limitations and discomfort. This study identified primary physical limitations faced by individuals with severe obesity and proposed evidence-based, accessible exercise modalities tailored to their needs. A systematic literature search was conducted using Scopus, PubMed, Web of Science, and Google Scholar. Search terms included combinations of 'obese,' 'severe obesity,' 'exercise,' 'training,' 'stability,' 'mobility,' and 'pain.' Ten studies examining effects of exercise interventions on mobility, stability, and pain in severely obese individuals were selected based on predefined inclusion criteria. Findings consistently indicated that low-impact exercise modalities such as yoga-based stretching, core training, and stabilization exercises using balance pads, chairs, and gym balls significantly improve mobility, enhance postural stability, and reduce musculoskeletal pain over intervention periods as short as 4 weeks. Interventions incorporating core muscle stretching and instability-based training were particularly effective in improving functional outcomes and balance control. This review highlights prevalent musculoskeletal and neuromuscular impairments associated with severe obesity and underscores the functional role of core musculature in mitigating these limitations. Based on synthesized evidence, we propose a set of low-complexity, high-accessibility exercise strategies feasible in both clinical and home-based settings. These recommendations provide a practical framework for improving physical function and reducing pain among individuals with severe obesity, supporting more sustainable engagement in physical activity.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"1-13"},"PeriodicalIF":12.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Consequences of Adverse Social Transitions among Aging Adults: A Gender-Sensitive Prospective Study of the Canadian Longitudinal Study on Aging Cohort (2011-2021).","authors":"Rana Madani Civi, Gilciane Ceolin, Sanaz Mehranfar, Gerry Veenstra, Wei Zhang, Nadia A Khan, Annalijn I Conklin","doi":"10.7570/jomes25012","DOIUrl":"10.7570/jomes25012","url":null,"abstract":"<p><strong>Background: </strong>Social connections impact morbidity and mortality, yet their influence on waist circumference (WC) and potential gender differences remains unclear.</p><p><strong>Methods: </strong>Prospective study of the Canadian Longitudinal Study on Aging (CLSA, 2011-2021) on changes in marital status, living arrangements, and social participation (baseline to follow-up 1) in relation to changes in WC (follow-up 1 to follow-up 2) used stratified, multivariable random coefficient regression with post-estimated predicted means. Sample sizes varied: 13,941 participants for marital and living arrangement transitions and 13,921 for changes in social participation.</p><p><strong>Results: </strong>Mean WC declined over time in aging cisgender heterosexual women and men in Canada. We found genders-specific associations between changes in different social connections changes in mean WC. Among women, decreased social participation was significantly associated with changes in WC (0.47 cm; 95 confidence interval [CI], 0.11 to 0.83), compared to women with stable social participation. Among men, becoming divorced was significantly associated with changes in WC (1.45 cm; 95% CI, 0.14 to 2.75), compared to men remained partnered. Women who decreased their social participation had a predicted mean WC of 87.61 cm (95% CI, 87.14 to 88.09), and men who became divorced had a predicted mean WC of 100.54 cm (95% CI, 99.17 to 101.91). Results for living arrangement changes were not significant, though patterned appeared gendered. All social connection transitions were associated with clinically meaningful predicted mean WC, placing both women and men with altered connections in the 'high risk' category for poor health outcomes.</p><p><strong>Conclusion: </strong>Decreased social participation increased WC among cisgender heterosexual women, whereas becoming divorced increased WC among cisgender heterosexual men in Canada.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"49-60"},"PeriodicalIF":12.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Ferritin: A Non-inflammatory Iron Marker Linked to Insulin Resistance and Metabolic Syndrome Components.","authors":"Isa Galvão-Rodrigues, Laura Gallardo-Nuell, Basma El Emrani-Azariah, Rafael Ramos, Josep Garre-Olmo, Josep Puig, José María Moreno-Navarrete, Jordi Mayneris-Perxachs, José Manuel Fernández-Real","doi":"10.7570/jomes25033","DOIUrl":"10.7570/jomes25033","url":null,"abstract":"<p><strong>Background: </strong>Serum ferritin is well known to be associated with chronic inflammation and insulin resistance. This study investigates urinary ferritin as a potential non-invasive biomarker for metabolic alterations and insulin resistance.</p><p><strong>Methods: </strong>This study analyzed ferritin levels in urine samples from two independent cross-sectional cohorts: IRONMET-continuous glucose monitoring (CGM) (a middle-aged cohort, n=78) and Aging Imageomics (an aged cohort, n=47). Associations between urinary ferritin and clinical and biochemical parameters were assessed using correlation analyses. Untargeted plasma metabolomics was performed in the IRONMET-CGM cohort, and differentially abundant metabolites associated with urinary ferritin and ultrasensitive C-reactive protein were identified using linear models for microarray regression analysis.</p><p><strong>Results: </strong>In the IRONMET-CGM cohort, urinary ferritin correlated positively with serum glucose, serum ferritin, and transferrin saturation and negatively with transferrin and total iron-binding capacity. In the Aging Imageomics cohort, urinary ferritin showed positive associations with serum glucose, fasting plasma insulin, low-density lipoprotein cholesterol, serum ferritin, right ankle diastolic blood pressure, and the percentage of mean arterial pressure of the right brachial pulse wave and a negative association with high-density lipoprotein cholesterol. Plasma metabolomics profiling revealed that urinary ferritin was positively associated with succinic acid, adipic acid and cis-4-decenoic acid concentrations, suggesting disruptions in fatty acid metabolism. In contrast, metabolites linked to elevated ultrasensitive C-reactive protein, including 3-hydroxyanthranilic acid and formyl-5-hydroxykynurenamine, were associated with the kynurenine pathway and systemic inflammation.</p><p><strong>Conclusion: </strong>Urinary ferritin is a promising, non-invasive marker of iron metabolism disturbances and metabolic dysregulation. Its associations with glucose metabolism, lipid profiles, and distinct metabolomics signatures suggest potential utility for early detection of metabolic alterations.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"112-121"},"PeriodicalIF":12.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Toward Precision in Obesity Diagnosis: Progress, Pitfalls, and the Path Ahead (J Obes Metab Syndr 2025;34:85-7).","authors":"Jose Eric M Lacsa","doi":"10.7570/jomes25071","DOIUrl":"10.7570/jomes25071","url":null,"abstract":"","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"122-123"},"PeriodicalIF":12.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study (J Obes Metab Syndr 2025;34:65-74).","authors":"Young Hye Cho, Jung In Choi, Sang Yeoup Lee","doi":"10.7570/jomes25056","DOIUrl":"10.7570/jomes25056","url":null,"abstract":"","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"467-469"},"PeriodicalIF":7.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal Microbiota Transplantation by Rectal Enema Improves Short-Term Insulin Resistance in Metabolic Syndrome: A Pilot Randomized Controlled Trial.","authors":"Setthachai Piwchan, Natsuda Aumpan, Soonthorn Chonprasertsuk, Bubpha Pornthisarn, Sith Siramolpiwat, Patommatat Bhanthumkomol, Pongjarat Nunanan, Navapan Issariyakulkarn, Arti Wongcha-Um, Muhammad Miftahussurur, Varocha Mahachai, Yoshio Yamaoka, Ratha-Korn Vilaichone","doi":"10.7570/jomes25014","DOIUrl":"10.7570/jomes25014","url":null,"abstract":"<p><strong>Background: </strong>The gut microbiota plays a vital role in various physiological processes, including metabolism. Fecal microbiota transplantation (FMT) involves transferring fecal matter from a healthy donor to rebalance a patient's intestinal dysbiosis. The impact of FMT on metabolic syndrome (MetS) is subject to debate. This study assesses the effects of FMT on MetS when administered by rectal enema.</p><p><strong>Methods: </strong>In a double-blind, randomized controlled trial, subjects with MetS were assigned to receive either FMT (n=8) or a sham intervention (n=10) via rectal enema. Participants were followed at 6 and 12 weeks. The primary outcome was changes in the homeostatic model assessment of insulin resistance (HOMA-IR). Secondary outcomes included fasting blood glucose (FBG), body mass index (BMI), inflammatory markers, and hepatic steatosis. The mean adjusted difference (MAD) and 95% confidence interval (CI) between groups were reported as treatment effects using a linear marginal model for repeated measures.</p><p><strong>Results: </strong>The study included patients with a mean age of 50.4±10.7 years. Baseline BMI and HOMA-IR were similar between groups. Over 6 weeks, FMT significantly improved HOMA-IR (MAD, -1.63; 95% CI, -2.63 to -0.64; <i>P</i>=0.001). The FMT group also showed improvements in serum FBG and high-sensitivity C-reactive protein compared with levels in the sham group (<i>P</i>=0.044 and <i>P</i>=0.025, respectively). However, no significant changes in MetS-associated variables or liver steatosis were evident at 12 weeks. Stool microbiota analysis revealed a reduced relative abundance of <i>Desulfovibrio</i>, <i>Bacteroides</i>, and <i>Parabacteroides</i> after FMT.</p><p><strong>Conclusion: </strong>FMT by rectal enema produced favorable changes in IR in patients with MetS. FMT may be an effective treatment for patients with metabolism-related diseases. Further research into the long-term benefits of the procedure is warranted.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"434-445"},"PeriodicalIF":7.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Clinical Practice Guidelines for the Diagnosis and Pharmacologic Treatment of Overweight and Obesity by the Korean Society for the Study of Obesity.","authors":"Jae Hyun Bae, Ji-Hee Haam, Eonju Jeon, Seo Young Kang, SuJin Song, Cheol-Young Park, Hyuktae Kwon","doi":"10.7570/jomes25042","DOIUrl":"10.7570/jomes25042","url":null,"abstract":"<p><p>The Korean Society for the Study of Obesity has published the 9th edition of its Clinical Practice Guidelines to provide updated, evidence-based recommendations for the management of overweight and obesity. Developed through a structured process of systematic literature review and expert consensus, these guidelines incorporate recent clinical evidence for obesity management. Key clinical questions were formulated using the Population, Intervention, Comparison, and Outcome framework and addressed through comprehensive evaluations of randomized controlled trials, cohort studies, systematic reviews, and existing guidelines. Major updates include the inclusion of the concept of clinical obesity, defined as excessive adiposity with tissue and organ dysfunction. The revised guidelines expand recommendations for pharmacologic treatments and introduce a new section on health functional foods. Emphasis is placed on early assessment of treatment response and individualized therapeutic adjustments to improve long-term outcomes. The guidelines also highlight the importance of recognizing obesity-related health conditions and ensuring equitable access to care. They promote shared decision-making and ethical prescribing practices to support a person-centered approach. All recommendations are evaluated using the Grading of Recommendations Assessment, Development and Evaluation system, which reflects the strength of evidence and the balance of expected benefits and harms. These updates are intended to assist healthcare providers in delivering personalized, evidence-informed care and underscore the evolving role of pharmacotherapy within risk-based obesity management strategies.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"322-343"},"PeriodicalIF":7.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Score for Significant Diastolic Dysfunction in Patients with Morbid Obesity Undergoing Bariatric Surgery.","authors":"Aphichat Suphathamwit, Kamheang Vacharaksa, Chaowanan Khamtuikrua, Chanakan Jerdmathawut, Voraboot Taweerutchana, Chutharat Wetchakama, Nipaporn Sangarunakul","doi":"10.7570/jomes25019","DOIUrl":"10.7570/jomes25019","url":null,"abstract":"<p><strong>Background: </strong>Morbid obesity is a well-established risk factor for cardiovascular disease. Diastolic dysfunction, particularly in non-cardiac surgeries, has been associated with increased incidence of adverse cardiovascular events. This study aimed to evaluate the prevalence of diastolic dysfunction in morbidly obese patients undergoing bariatric surgery and to identify associated clinical risk factors using transesophageal echocardiography (TEE).</p><p><strong>Methods: </strong>In this prospective observational study, 113 morbidly obese patients scheduled for bariatric surgery between April 2019 and January 2023 were enrolled. Diastolic function was assessed after anesthesia induction using TEE and categorized as normal or grade I, II, or III dysfunction based on the E/e' ratio. The primary study outcome was the prevalence of diastolic dysfunction, while secondary outcomes included identification of risk factors, development of a predictive score and evaluation of perioperative complications.</p><p><strong>Results: </strong>Diastolic dysfunction was identified in 45.1% of patients (grade I: 21.2%; grade II: 19.5%; and grade III: 4.4%). Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01 to 1.08) and continuous positive airway pressure (CPAP) use for obstructive sleep apnea (OSA) (OR, 4.22; 95% CI, 1.02 to 17.55) were significantly associated with high-grade dysfunction (grades II-III). A predictive score demonstrated high diagnostic accuracy with a cutoff of >120 points. The score was calculated as (age×2)+(coronary artery disease×51)+(chronic kidney disease×102)+(OSA without CPAP×2)+(OSA with CPAP×63). Postoperative outcomes did not differ significantly between groups.</p><p><strong>Conclusion: </strong>Diastolic dysfunction is prevalent among morbidly obese patients undergoing bariatric surgery. A predictive score exceeding 120 points may aid in identifying individuals at elevated risk.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"446-455"},"PeriodicalIF":7.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Body Mass Index: Toward a Focus on Body Composition and Function.","authors":"Kyung Hee Park","doi":"10.7570/jomes25091","DOIUrl":"10.7570/jomes25091","url":null,"abstract":"","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"319-321"},"PeriodicalIF":7.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12583789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}