Association between Body Fat Distribution and Nonalcoholic Fatty Liver Disease/Fibrosis Based on Race/Ethnicity.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM
Donghee Kim, George Cholankeril, Aijaz Ahmed
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引用次数: 0

Abstract

Background: Body fat distribution may impact nonalcoholic fatty liver disease (NAFLD) and significant fibrosis differently according to race/ethnicity. We determined the relationship between body fat distribution and NAFLD/significant fibrosis according to race/ethnicity.

Methods: A cross-sectional study of 2,395 participants used the National Health and Nutrition Examination Survey 2017 to 2018. NAFLD and significant fibrosis (≥F2) were defined by controlled attenuation parameter scores and liver stiffness measurements on transient elastography, respectively. Visceral and subcutaneous fat volumes were defined by dual-energy X-ray absorptiometry.

Results: The odds ratio (OR) for NAFLD per 1-standard deviation in visceral fat volume and subcutaneous fat volume was 2.31 (95% confidence interval [CI], 1.50 to 3.39) and 1.93 (95% CI, 1.43 to 2.61) in total population, respectively. Visceral fat in non-Hispanic Blacks had the highest odds for NAFLD (OR, 2.86; 95% CI, 1.45 to 5.62), and non-Hispanic Whites (OR, 2.29; 95% CI, 1.19 to 4.40) and non-Hispanic Asians (OR, 1.61; 95% CI, 1.13 to 2.29) were in order. Significant associations between subcutaneous fat volume (OR, 2.10; 95% CI, 1.34 to 3.29; P=0.003) or visceral fat volume (OR, 1.35; 95% CI, 1.05 to 1.73; P=0.023) and significant fibrosis were noted among individuals with NAFLD. Hispanics had the highest odds for NAFLD-associated significant fibrosis (OR, 2.74; 95% CI, 1.32 to 5.70), and non-Hispanic Whites (OR, 2.35; 95% CI, 1.11 to 4.98) and non-Hispanic Asians (OR, 2.01; 95% CI, 1.01 to 4.01) were in order.

Conclusion: Visceral adiposity was associated with NAFLD and significant fibrosis despite the association of subcutaneous adiposity in NAFLD and significant fibrosis. Racial/ethnic differences in the association between body fat distribution on NAFLD and significant fibrosis were noted.

基于种族/族裔的体脂分布与非酒精性脂肪肝/纤维化之间的关系。
背景:不同种族/族裔的体脂分布可能会对非酒精性脂肪肝(NAFLD)和明显纤维化产生不同的影响。我们根据种族/族裔确定了体脂分布与非酒精性脂肪肝/明显纤维化之间的关系:一项针对 2395 名参与者的横断面研究使用了 2017 年至 2018 年全国健康与营养调查。非酒精性脂肪肝和明显纤维化(≥F2)分别通过受控衰减参数评分和瞬态弹性成像的肝脏硬度测量来定义。内脏和皮下脂肪量由双能 X 射线吸收测定法确定:在总人口中,内脏脂肪量和皮下脂肪量每增加 1 个标准差,非酒精性脂肪肝的几率比(OR)分别为 2.31(95% 置信区间 [CI],1.50 至 3.39)和 1.93(95% CI,1.43 至 2.61)。非西班牙裔黑人的内脏脂肪导致非酒精性脂肪肝的几率最高(OR,2.86;95% CI,1.45 至 5.62),非西班牙裔白人(OR,2.29;95% CI,1.19 至 4.40)和非西班牙裔亚洲人(OR,1.61;95% CI,1.13 至 2.29)的几率依次递减。在非酒精性脂肪肝患者中,皮下脂肪量(OR,2.10;95% CI,1.34 至 3.29;P=0.003)或内脏脂肪量(OR,1.35;95% CI,1.05 至 1.73;P=0.023)与明显纤维化之间存在显著关联。西班牙裔人患非酒精性脂肪肝相关性显著纤维化的几率最高(OR,2.74;95% CI,1.32 至 5.70),非西班牙裔白人(OR,2.35;95% CI,1.11 至 4.98)和非西班牙裔亚洲人(OR,2.01;95% CI,1.01 至 4.01)依次排序:结论:尽管皮下脂肪与非酒精性脂肪肝和明显纤维化有关,但内脏脂肪与非酒精性脂肪肝和明显纤维化有关。结论:尽管皮下脂肪量与非酒精性脂肪肝和明显纤维化有关,但内脏脂肪量与非酒精性脂肪肝和明显纤维化有关,体脂分布与非酒精性脂肪肝和明显纤维化之间存在种族/人种差异。
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来源期刊
Journal of Obesity & Metabolic Syndrome
Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
8.30
自引率
9.60%
发文量
39
审稿时长
19 weeks
期刊介绍: The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).
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