Journal of Obesity & Metabolic Syndrome最新文献

Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk. 代谢调节中的神经免疫相互作用：脑和脂肪组织的串扰。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-25 DOI: 10.7570/jomes25050

Chan Hee Lee

{"title":"Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk.","authors":"Chan Hee Lee","doi":"10.7570/jomes25050","DOIUrl":"https://doi.org/10.7570/jomes25050","url":null,"abstract":"The global obesity epidemic underscores the urgent need to elucidate the mechanisms underlying metabolic disorders. Although excessive caloric intake and sedentary lifestyles have traditionally been viewed as primary contributors, recent evidence highlights significant roles for genetic, environmental, and immunological factors. Notably, dysfunction within the central nervous system (CNS), particularly the hypothalamus, has emerged as a crucial regulator of metabolic homeostasis through CNS-peripheral interactions. Hypothalamic inflammation is primarily mediated by microgliosis, which disrupts systemic homeostasis. This review discusses the detrimental effects of hypothalamic microgliosis on energy metabolism and highlights emerging evidence suggesting paradoxically beneficial roles of hypothalamic microgliosis in metabolic regulation. Within adipose tissue, immune cells, including adipose tissue macrophages (ATMs), T cells, and B cells, exert significant influence over systemic metabolism. Short-term activation of the sympathetic nervous system (SNS) promotes the anti-inflammatory polarization of ATMs and enhances the induction of regulatory T cells; thereby, improving insulin sensitivity. In contrast, chronic SNS activation may exacerbate inflammation due to β-adrenergic receptor desensitization and catecholamine resistance. Parasympathetic acetylcholine signaling is also known to suppress inflammation through activation of α7 nicotinic receptors on macrophages; however, parasympathetic innervation within white adipose tissue is considerably limited. Despite the critical role of the nervous system in systemic metabolism, comprehensive insight into neuro-immune interactions remains lacking. In-depth studies using advanced technologies are needed to deepen knowledge in this field and to cover novel therapeutic targets for obesity and related metabolic disorders.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus. 弓形核产氧神经元对摄食行为和体重的调节。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-25 DOI: 10.7570/jomes25059

Yu Fu

引用次数: 0

Hijacked Brain in Modern Obesity: Cue, Habit, Addiction, Emotion, and Restraint as Targets for Personalized Digital Therapy and Electroceuticals. 现代肥胖中被劫持的大脑：暗示、习惯、成瘾、情感和克制作为个性化数字治疗和电子药物的目标。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-24 DOI: 10.7570/jomes25053

Taesung Lee, Seeun Park, Seokhyun Lee, Areum Hwangbo, HanGyeol Bae, Yumin Lee, Hyung Jin Choi

{"title":"Hijacked Brain in Modern Obesity: Cue, Habit, Addiction, Emotion, and Restraint as Targets for Personalized Digital Therapy and Electroceuticals.","authors":"Taesung Lee, Seeun Park, Seokhyun Lee, Areum Hwangbo, HanGyeol Bae, Yumin Lee, Hyung Jin Choi","doi":"10.7570/jomes25053","DOIUrl":"https://doi.org/10.7570/jomes25053","url":null,"abstract":"The global obesity epidemic can no longer be explained by personal choice or caloric excess alone. Mounting evidence points to underlying neurobehavioral dysfunction, exacerbated by environments engineered to promote overconsumption. Modern obesity is driven by five interrelated neurobehavioral factors: cue-evoked eating, habitual-context eating, food addiction, emotional eating, and restrained eating. These maladaptive eating patterns arise from a decoupling of homeostatic and hedonic brain circuits in an obesogenic environment. This review synthesizes evidence from neuroimaging, behavioral experiments, and animal studies to illustrate how each factor contributes to obesity risk and relapse after weight loss. We further discuss emerging interventions-including digital therapeutics (DTx) and electroceuticals-that target these drivers with increasing precision. DTx platforms deliver scalable, phenotype-informed interventions through cognitive-behavioral modules, real-time monitoring, and artificial intelligence-driven coaching. Electroceutical strategies, including non-invasive brain stimulation and vagus nerve modulation, show promise in reshaping dysfunctional circuits. Finally, we propose a neurobehavioral subtyping model to guide personalized obesity treatment, integrating brain-based phenotyping with multimodal interventions. This framework may offer a path toward sustained and mechanism-driven obesity care.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-fermented Soy Consumption and Obesity-Contextual Evidence to Inform Culturally Tailored Dietary Advice in Korean Adults. 非发酵大豆消费和肥胖——韩国成年人文化定制饮食建议的背景证据。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-17 DOI: 10.7570/jomes25063

YoonJu Song

引用次数: 0

Response: Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index for Classification of Patients with Steatotic Liver Disease (J Obes Metab Syndr 2024;33:222-8). 酒精性肝病/非酒精性脂肪性肝病分级指标对脂肪变性肝病患者的影响[J]； journal of nurses training; 2009；

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-15 DOI: 10.7570/jomes25055

Akash Roy, Mahesh K Goenka

引用次数: 0

Effects of Exercise Intervention in Subjects with Metabolic Dysfunction-Associated Steatotic Liver Disease. 运动干预对代谢功能障碍相关脂肪变性肝病患者的影响

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-11 DOI: 10.7570/jomes25028

Chieh Liu, Chun-Jen Liu

{"title":"Effects of Exercise Intervention in Subjects with Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Chieh Liu, Chun-Jen Liu","doi":"10.7570/jomes25028","DOIUrl":"https://doi.org/10.7570/jomes25028","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder globally, including in Asia-Pacific countries. In addition to contributing to severe liver disorders, MASLD increases the risk of various complications. Currently, resmetirom is the only U.S. Food and Drug Administration-approved treatment for MASLD-related fibrosis in the United States. Therefore, lifestyle modifications, particularly regular exercise, remain a crucial approach in managing MASLD. Exercise is generally classified into two types: aerobic and resistance. The two forms offer benefits for individuals with MASLD, despite the difference between their effects and underlying mechanisms. Aerobic exercise is accessible, low cost, and promotes high energy expenditure, improving several MASLD-related clinical parameters. However, associated fatigue and discomfort can reduce long-term adherence. Resistance exercise, referring to muscle contractions performed to This is a PDF file of an article accepted, but it is not yet the definitive version of record. 3 counteract external resistance, enhances muscle strength, muscle mass, and bone mineral density while also helping to correct metabolic derangement. It is especially suitable for subjects with MASLD who cannot conduct aerobic exercise or have poor cardiorespiratory function. Mechanistically, aerobic exercise enhances insulin sensitivity, while resistance exercise improves metabolic flexibility through adenosine monophosphate-activated protein kinase activation, muscle fiber adaptation, and muscle-liver cross-talk. In terms of aerobic training, traditional moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) have shown comparable benefits. This review is designed to offer refreshed perspectives on the advantages of exercise, compare the effects and mechanisms of aerobic and resistance exercise, and evaluate the advantages and disadvantages of MICT and HIIT, with emphasis on their impact on hepatic steatosis in subjects with MASLD.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Consumption of Non-fermented and Fermented Soy Foods with Obesity in Korean Adults: Analysis of Data from the KoGES-HEXA Study. 韩国成年人食用非发酵和发酵大豆食品与肥胖的关系：KoGES-HEXA研究数据分析

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-07-07 DOI: 10.7570/jomes25018

Bo Hwi Kim, Hye Ran Shin, SuJin Song

{"title":"Association of Consumption of Non-fermented and Fermented Soy Foods with Obesity in Korean Adults: Analysis of Data from the KoGES-HEXA Study.","authors":"Bo Hwi Kim, Hye Ran Shin, SuJin Song","doi":"10.7570/jomes25018","DOIUrl":"https://doi.org/10.7570/jomes25018","url":null,"abstract":"Background: This study examined the association of soy foods consumption with obesity in Korean adults.Methods: Data on 131,477 adults (47,828 men and 83,649 women) were selected from the Korean Genome and Epidemiology Study-Health Examinees study. Consumption of soy foods was estimated using a food frequency questionnaire based on classes of non-fermented soy foods or fermented soy paste. General obesity was defined as a body mass index ≥25 kg/m2 and abdominal obesity as a waist circumference ≥90 cm in men and ≥85 cm in women. The association of soy foods consumption with obesity was examined using multiple logistic regression.Results: Greater consumption of non-fermented soy foods was inversely associated with abdominal obesity in both men and women (≥7 servings/week vs. non-consumers: odds ratio [OR], 0.71; 95% confidence interval [CI], 0.57 to 0.87; P for trend=0.001 in men; OR, 0.82; 95% CI, 0.70 to 0.94; P for trend <0.001 in women). Among non-fermented soy foods, higher consumption of legumes was inversely associated with general and abdominal obesity in women. Consumption of tofu or soymilk was inversely associated with obesity in both men and women. Higher consumption of fermented soy paste was associated with a reduced OR for general obesity in men and increased OR for abdominal obesity in women. The inverse association between non-fermented soy foods consumption and obesity was more prominent in postmenopausal women.Conclusion: Greater consumption of non-fermented soy foods is inversely associated with obesity in Korean adults. Further cohort studies are needed to confirm the relationship between soy foods consumption and obesity.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle Type-Specific Modulation of Autophagy Signaling in Obesity: Effects of Caloric Restriction and Exercise. 肥胖中自噬信号的肌肉类型特异性调节：热量限制和运动的影响。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-06-26 DOI: 10.7570/jomes24048

Fujue Ji, Jong-Hee Kim

{"title":"Muscle Type-Specific Modulation of Autophagy Signaling in Obesity: Effects of Caloric Restriction and Exercise.","authors":"Fujue Ji, Jong-Hee Kim","doi":"10.7570/jomes24048","DOIUrl":"https://doi.org/10.7570/jomes24048","url":null,"abstract":"Background: Obesity causes metabolic dysregulation and contributes to diseases, and autophagy plays a pivotal role in that process. In mice, autophagy, a cellular recycling mechanism, is influenced by factors beyond obesity, including caloric restriction (CR) and CR combined with voluntary wheel running (CR+Ex). However, the regulation of autophagy in skeletal muscle during obesity, CR, and CR+Ex remains poorly understood.Methods: Mice (n=42) were randomly divided into six groups: normal diet, normal diet CR, normal diet CR+Ex, high-fat diet, high-fat diet CR, and high-fat diet CR+Ex. All mice were fed ad libitum with either a normal or high-fat diet for the first 4 months, followed by the respective interventions for the subsequent 4 months. Body composition, motor function, and autophagy signaling were assessed.Results: Obesity resulted in increased total mass, lean mass, fat mass, and fat percentage in tissue and decreased grip strength and endurance capacity. Notably, CR+Ex reduced total mass, lean mass, and fat mass in obese mice. In both the normal and obese conditions, the expression of the autophagy markers p62, light chain 3B (LC3B)-I, and LC3B-II was significantly higher in red muscle than white muscle. Obesity led to a reduction in cathepsin L expression, and CR further increased LC3B-I expression in red muscle.Conclusion: CR+Ex was an effective strategy for counteracting the adverse changes in body composition associated with obesity. Compared with red muscle, white muscle exhibits lower autophagy-related protein levels and might require elevated cathepsin L expression to mitigate the negative effects of obesity.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could a Short Incremental Test Be a Valid Cardiorespiratory Efficiency Assessment Tool in Obese Adults? A Comparison between Two Exercise Testing Protocols. 短期增量试验能否成为肥胖成人有效的心肺功能评估工具？两种运动测试方案的比较。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-06-25 DOI: 10.7570/jomes24049

Dafne Ferrari, Valerio Bonavolontà, Matteo Campanella, Ludovica Cardinali, Lavinia Falcioni, Gian Pietro Emerenziani, Silvia Migliaccio, Edoardo Mocini, Marco Meucci, Carlo Baldari, Andrea De Giorgio, Laura Guidetti

{"title":"Could a Short Incremental Test Be a Valid Cardiorespiratory Efficiency Assessment Tool in Obese Adults? A Comparison between Two Exercise Testing Protocols.","authors":"Dafne Ferrari, Valerio Bonavolontà, Matteo Campanella, Ludovica Cardinali, Lavinia Falcioni, Gian Pietro Emerenziani, Silvia Migliaccio, Edoardo Mocini, Marco Meucci, Carlo Baldari, Andrea De Giorgio, Laura Guidetti","doi":"10.7570/jomes24049","DOIUrl":"https://doi.org/10.7570/jomes24049","url":null,"abstract":"Background: To assess cardiorespiratory efficiency in obese adults, two exercise test treadmill protocols with 2- or 3-min stages were compared.Methods: Thirty-six obese adult subjects were involved in this study. Sixteen men (age 51.5±10.5 years; BMI 36.7±4.8 kg/m2) and 20 women (age 42.4±12.4 years; BMI 36.5±4.7 kg/m2) performed submaximal incremental graded tests on treadmills with 2- or 3-minute stages on different days. During each testing session, heart rate (HR), oxygen uptake (VO2 mL/min/kg), rate of perceived exertion (RPE), fat oxidation (FO) at maximal fat oxidation (MFO) and maximal fat oxidation zone (Fatmax zone) were measured.Results: No differences were found for HR, VO2, and RPE at MFO between the two protocols. Significant differences (2-minute vs. 3-minute) were found for FO (576.3±162.9 mg/min vs. 506.0±148.1 mg/min respectively; P<0.05) at MFO between the two protocols. No differences were found for VO2 and HR in high and low Fatmax zone borders. Moreover, a difference was found for FO at the low and high borders.Conclusion: Exercise intensity at which the MFO and Fatmax zone occur is not influenced by the duration of stage-to-stage increments. The two exercise testing protocols could be considered interchangeable to assess HR, VO2, and RPE at MFO.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MASLD Complicated By Diabetes: Pathophysiology and Emerging Therapies. MASLD合并糖尿病：病理生理学和新兴疗法。

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2025-06-20 DOI: 10.7570/jomes25017

Hisanori Goto, Toshinari Takamura

{"title":"MASLD Complicated By Diabetes: Pathophysiology and Emerging Therapies.","authors":"Hisanori Goto, Toshinari Takamura","doi":"10.7570/jomes25017","DOIUrl":"10.7570/jomes25017","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver manifestation of diabetes that is often associated with obesity and insulin resistance, with hyperglycemia worsening its progression. Recent studies have shown a bidirectional relationship between MASLD and diabetes: MASLD contributes to insulin resistance, and hyperglycemia accelerates the progression of MASLD to metabolic dysfunction-associated steatohepatitis (MASH). Hepatokines upregulated by overnutrition and hyperglycemia are implicated in the link between liver steatosis and insulin resistance in skeletal muscle, highlighting inter-organ crosstalk in the progression of both MASLD and diabetes. In individuals with diabetes, hyperglycemia and free fatty acid influx promote de novo lipogenesis and enhance lipid oxidation and oxidative phosphorylation in the liver, potentially leading to increased oxidative stress, inflammation, and fibrosis. Transcriptome analyses of human MASH and diabetic MASH model animals have revealed liver endothelial cell damage in diabetic conditions. Most drugs proven effective for MASH in randomized controlled trials are antidiabetic agents. Recently, pioglitazone, glucagon-like peptide-1 (GLP-1) receptor agonists, and dual agonists of glucose-dependent insulinotropic polypeptide and GLP-1 have been recommended as preferred options for glycemic control in MASH patients with type 2 diabetes mellitus. Meanwhile, the efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors for MASH has also been reported, primarily in East Asia. Given the diversity in MASLD/MASH pathology among populations, ranging from lean to obese individuals with and without diabetes, population-specific approaches might help elucidate the pathogenesis of MASLD/MASH and develop treatment strategies.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0