{"title":"Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.","authors":"Yu Fu","doi":"10.7570/jomes25059","DOIUrl":null,"url":null,"abstract":"<p><p>The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptide and pro-opiomelanocortin neurons have been discovered to play critical roles in feeding and body weight regulation. Recent studies have started to reveal the functional significance of other neuronal populations, especially those that promote feeding (orexigenic neurons). In this review, we discuss the history and key findings of the arcuate nucleus, with a focus on orexigenic neurons. We also highlight current challenges and knowledge gaps that remain to be addressed in future studies.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obesity & Metabolic Syndrome","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7570/jomes25059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptide and pro-opiomelanocortin neurons have been discovered to play critical roles in feeding and body weight regulation. Recent studies have started to reveal the functional significance of other neuronal populations, especially those that promote feeding (orexigenic neurons). In this review, we discuss the history and key findings of the arcuate nucleus, with a focus on orexigenic neurons. We also highlight current challenges and knowledge gaps that remain to be addressed in future studies.
期刊介绍：
The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).
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