Journal of Obesity & Metabolic Syndrome最新文献

{"title":"Pharmacological Therapy for Metabolic Dysfunction-Associated Steatotic Liver Disease in a New Era for Obesity and Metabolic Medicine: A State-of-the-Art Review.","authors":"Wah-Kheong Chan, Hak-Keith Leung, Guo-Jeng Tan, Quan-Hziung Lim, Lee-Ling Lim, Jeyakantha Ratnasingam, Shireene Ratna Vethakkan","doi":"10.7570/jomes26005","DOIUrl":"10.7570/jomes26005","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and a major cause of cirrhosis, hepatocellular carcinoma, and liver-related mortality. Weight loss via positive health behavioral changes is the cornerstone of management of MASLD. However, this is a huge challenge for many patients, highlighting the need for effective pharmacological therapies. Two pharmacological agents have received accelerated approval for the treatment of metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, namely resmetirom, an oral, liver-directed, selective thyroid hormone receptor-β agonist, and semaglutide, a glucagon-like peptide-1 receptor agonist. Despite recent advances, effective pharmacological therapy for MASH-related cirrhosis remains an unmet need, underscoring the importance of early identification and intervention. This narrative review summarizes the current pharmacological therapy landscape of MASLD, including emerging incretin-based therapies and fibroblast growth factor-21 analogues, as well as current guidance on the use of non-invasive tests for treatment selection and monitoring for treatment response. It also provides a background on recent advances in obesity and metabolic medicine, highlighting the evolving paradigm of complication-centric obesity management and the potential role of incretin-based therapies as the backbone of the management of obesity and obesity-related conditions, including MASLD.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"298-312"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Home-Based Exercise Training on Anthropometric Indices and Health-Related Quality of Life in Children and Adolescents with Overweight/Obesity: A Randomized Clinical Trial.","authors":"Alireza Ahmadi, Zohreh Sadat Navabi, Mohammad Reza Maracy, Fahimeh Moheb-Mohammadi, Mehdi Dehghani","doi":"10.7570/jomes25021","DOIUrl":"10.7570/jomes25021","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity are health challenges in children and adolescents and have increased in prevalence in years. This study evaluated the effects of home-based high-intensity interval training (HIIT), resistance training (RT), or combined HIIT+RT on anthropometric indices and health-related quality of life (HRQoL) in children and adolescents with overweight or obesity.</p><p><strong>Methods: </strong>A randomized, single-blinded clinical trial was conducted in Isfahan, Iran. A total of 120 patients (aged 10-18 years) with overweight or obesity participated. Eligible participants were recruited using a simple sampling method and randomly assigned to one of four groups: three intervention groups (HIIT, RT, and combined HIIT+RT) or one non-exercising control group with dietary advice. The intervention groups received 24 home-based training sessions over 2 months. Anthropometric indices and the KIDSCREEN-27 questionnaire were assessed both pre- and post-intervention.</p><p><strong>Results: </strong>After 2 months, body weight decreased significantly in the RT group compared with baseline measurements (<i>P</i>=0.010). Waist circumference (WC) also decreased significantly in the RT group (<i>P</i>=0.001), and hip circumference (HC) decreased significantly across the three intervention groups. Adjusted analyses revealed significant reductions in body weight (<i>P</i>=0.028), WC (<i>P</i>=0.024), and HC (<i>P</i>=0.006) across interventions. No significant changes were observed in waist-to-hip ratio or body mass index (BMI). In addition, an analysis of covariance showed no significant differences in the mean changes in HRQoL among the three intervention and control groups pre- and post-intervention.</p><p><strong>Conclusion: </strong>Home exercise was associated with improvements in anthropometric indices excluding BMI, whereas HRQoL remained unchanged in children and adolescents with overweight or obesity.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"360-369"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus on Behavioral Strategies for Adults with Obesity from the Korean Society for the Study of Obesity.","authors":"Euihyeon Na, Sangho Shin, Mirihae Kim, Jae-Won Yang, Jeong Kyung Ko, Min-Kyu Song, Jo-Eun Jeong, Jung-Joon Moon, Youl-Ri Kim","doi":"10.7570/jomes25098","DOIUrl":"10.7570/jomes25098","url":null,"abstract":"<p><p>Behavioral modification is a core component of obesity treatment. Many established behavioral programs have been developed within Western cultural and healthcare contexts; however, they may not directly translate to Korean lifestyles, eating patterns, and clinical settings. Thus, we used a consensus-based process to develop culturally adapted behavioral strategies for obesity management in Korean adults to address this gap. A modified nominal group technique was used to generate and refine behavioral strategies. A panel of experts independently proposed candidate strategies, which were subsequently discussed, merged, and ranked across iterative rounds. Strategies with high clinical feasibility and cultural appropriateness were finalized based on a consensus threshold of ≥75% agreement. The expert panel generated behavioral strategy statements, which were consolidated and refined to 10 core behavioral strategies. These strategies span five domains essential to obesity self-management: diet, physical activity, behavioral modification, environmental and clinical support, and psychosocial and physiological factors. This consensus statement provides a culturally grounded, clinically practical behavioral framework for obesity management in Korea. The strategies can be adapted for community health programs and primary care, as well as multidisciplinary obesity clinics. Future research is needed to evaluate implementation effectiveness and scalability in real-world Korean populations.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"269-281"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Dairy and Sugar-Sweetened Beverage Consumption among Korean Young Adults Aged 19-29 Years: Analysis of Korea National Health and Nutrition Examination Survey 2010-2021.","authors":"Jiwon Bang, Mi-Jung Choi, Eun-Hee Cho","doi":"10.7570/jomes25070","DOIUrl":"10.7570/jomes25070","url":null,"abstract":"<p><strong>Background: </strong>Beverage consumption patterns in Korea have shifted in response to rapid lifestyle changes, including the growth of cafe culture and increased access to convenience foods. This study examined trends in major beverage consumption among Korean young adults.</p><p><strong>Methods: </strong>Beverage consumption trends were analyzed using data from 7,681 participants aged 19-29 years from the Korea National Health and Nutrition Examination Survey (2010-2021). Dietary assessment methods differed by survey cycle: a simple food frequency questionnaire (FFQ) in 2010-2011, a semi-quantitative FFQ in 2012-2016, and beverage-specific questions in 2019-2021. Beverages included milk, yogurt, soda, coffee, and fruit juice. Weekly consumption frequency, consumption volume, and estimated sugar intake were analyzed by sex.</p><p><strong>Results: </strong>Beverage consumption patterns showed distinct temporal changes. The frequency of dairy product intake declined significantly (5.2 to 3.2 times/week; <i>P</i><0.0001), mainly because of reduced milk consumption. Yogurt intake initially increased and then declined, particularly among females. In contrast, the overall frequency of sugar-sweetened beverage (SSB) intake remained stable, although coffee intake frequency decreased and soda and fruit juice intake increased slightly. Total SSB volume increased from 1.9 to 2.8 L per week (<i>P</i><0.0001). The absolute increase was slightly greater in males (899.5 mL/week vs. 761.6 mL/week), whereas the relative increase in soda intake was greater in females (93% vs. 61%). Correspondingly, weekly sugar intake from SSBs rose sharply (122.7 to 177.6 g/week, <i>P</i><0.0001), whereas sugar intake from dairy products did not change significantly.</p><p><strong>Conclusion: </strong>Among Korean young adults, dairy consumption has declined, whereas SSB intake and related sugar exposure have increased markedly, with notable sex differences in beverage consumption patterns.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"313-323"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Group Averages: Rethinking Body Composition Assessment in the Era of Metabolic Bariatric Surgery: A Perspective from Korea.","authors":"Sung Il Choi","doi":"10.7570/jomes26024","DOIUrl":"10.7570/jomes26024","url":null,"abstract":"","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"35 3","pages":"265-268"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease and Low Handgrip Strength Are Associated with a Higher Risk of Cardiovascular Disease.","authors":"Eugene Han, Yong-Ho Lee, Sang Hoon Ahn, Hye Won Lee, Mi Na Kim, Jae Seung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung Up Kim","doi":"10.7570/jomes25061","DOIUrl":"10.7570/jomes25061","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the influence of metabolic dysfunction-associated steatotic liver disease (MASLD) and handgrip strength (HGS) on the risk of atherosclerotic cardiovascular disease (ASCVD) in the general population.</p><p><strong>Methods: </strong>We used data from 20,611 individuals from the 2014-2019 Korea National Health and Nutrition Examination Survey. MASLD was defined as a Framingham steatosis index of ≥23. Low HGS was defined as <28 kg in men and <18 kg in women. The 10-year ASCVD risk score was assessed, and high-probability ASCVD was defined as >10%.</p><p><strong>Results: </strong>Individuals with both MASLD and low HGS had a greater risk of high-probability ASCVD (odds ratio [OR], 6.88; 95% confidence interval [CI], 6.81 to 6.97; <i>P</i><0.001) than those without MASLD and with intact HGS. The association between low HGS and high-probability ASCVD was stronger when MASLD was accompanied by advanced liver fibrosis (OR, 20.94; 95% CI, 20.04 to 21.88; <i>P</i><0.001). In the population with MASLD, ASCVD risk was lower in individuals with low HGS who engaged in regular exercise than in those without low HGS who did not exercise regularly (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>Individuals with MASLD and low HGS had a significantly higher risk of ASCVD than those without MASLD. Concurrent advanced liver fibrosis was further associated with increased ASCVD risk among individuals with MASLD.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"324-334"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Could a Short Incremental Test Be a Valid Cardiorespiratory Efficiency Assessment Tool in Obese Adults? A Comparison between Two Exercise Testing Protocols (J Obes Metab Syndr 2025;34:282-90).","authors":"Abhijit Pratap, Pradnya Phalak, Anjali Garg","doi":"10.7570/jomes25074","DOIUrl":"10.7570/jomes25074","url":null,"abstract":"","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"376-377"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic Liver Disease Predicts Lower Likelihood of LDLR Gene Mutations in Young Korean Patients with Suspected Familial Hypercholesterolemia.","authors":"Chang In Han, Sung Hyun Cho, Keungmo Yang, Hyun Yang, Si Hyun Bae, Jaejun Lee","doi":"10.7570/jomes25090","DOIUrl":"10.7570/jomes25090","url":null,"abstract":"<p><strong>Background: </strong>Familial hypercholesterolemia (FH) is underdiagnosed in young adults, and universal genetic testing is costly. We evaluated whether steatotic liver disease (SLD) could predict low-density lipoprotein receptor (LDLR) mutations in suspected FH.</p><p><strong>Methods: </strong>We retrospectively analyzed 111 Korean military personnel aged 19-30 years who underwent LDLR sequencing and SLD assessment using controlled attenuation parameter (CAP) and hepatic steatosis index.</p><p><strong>Results: </strong>Pathogenic LDLR variants were identified in 23.4% of participants. Compared with non-carriers, carriers had lower CAP values (245.2 dB/m vs. 273.9 dB/m, <i>P</i>=0.085) and a significantly lower prevalence of SLD (52.9% vs. 82.0%, <i>P</i>=0.025). Multivariable logistic regression confirmed SLD was independently associated with lower odds of variant carriage (adjusted odds ratio, 0.11; 95% confidence interval, 0.02 to 0.56; <i>P</i>=0.009). Clustering analysis showed the highest variant prevalence in lean, non-SLD individuals.</p><p><strong>Conclusion: </strong>SLD was inversely associated with genetically confirmed FH. Incorporating SLD assessment may help prioritize genetic testing in populations with a high prevalence of SLD or limited access to sequencing resources.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"370-375"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip Strength in Korean Youth and Young Adults: Reference Values and Their Associations with Metabolic Syndrome.","authors":"Jieun Lee, Sung-Chan Kang, Mi Yang, Hwa Young Kim, Hakyung Lee, Seung-Sik Hwang, Jaehyun Kim","doi":"10.7570/jomes25082","DOIUrl":"10.7570/jomes25082","url":null,"abstract":"<p><strong>Background: </strong>Reduced handgrip strength (HGS) is associated with adverse cardiometabolic outcomes. This study aimed to determine reference values for HGS among Korean youth and young adults and to evaluate their relationships with metabolic syndrome (MS).</p><p><strong>Methods: </strong>We analyzed data from 9,024 individuals aged 10 to 29 years in the Korea National Health and Nutrition Examination Survey (2014-2019). The adjusted combined handgrip strength (aCHGS; the average of maximum values from both hands divided by body weight) was used as the primary outcome variable. Percentile curves for aCHGS were generated using the lambda-mu-sigma (LMS) method and locally estimated scatterplot smoothing regression analysis, excluding outliers. Associations between aCHGS z-scores and MS were assessed.</p><p><strong>Results: </strong>Percentile curves for aCHGS plateaued after 20 years of age in both sexes. At age 10, aCHGS was comparable between males and females. Males showed a marked rise in aCHGS after early adolescence, maintaining higher levels thereafter. The adjusted odds ratio for MS was 0.313 (95% confidence interval [CI], 0.276 to 0.354) using International Diabetes Federation (IDF) criteria and 0.348 (95% CI, 0.310 to 0.390) using modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. aCHGS z-scores demonstrated strong predictive power for MS (area under the curve, 0.802 for IDF and 0.776 for modified NCEP-ATP III criteria). The optimal aCHGS z-score cutoff values for predicting MS were -0.508 (IDF) and -0.519 (modified NCEP-ATP III).</p><p><strong>Conclusion: </strong>We established age- and sex-specific aCHGS reference values among Korean youth and young adults, demonstrating effectiveness in predicting MS risk. These standards may serve as a practical clinical tool to identify individuals at increased risk of MS early in development.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"349-359"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity in Adults with Type 1 Diabetes Mellitus.","authors":"Adnan Batman, Cem Sulu, Dilek Yazıcı, Luke Boyle, Barbara McGowan, Volkan Yumuk","doi":"10.7570/jomes26001","DOIUrl":"10.7570/jomes26001","url":null,"abstract":"<p><p>The prevalence of overweight and obesity in individuals with type 1 diabetes mellitus (T1DM) has increased significantly due to multifactorial causes, paralleling global trends. Beyond known causes of obesity, pathophysiological and biopsychosocial causes specific to T1DM also have a role in the development of obesity. Obesity in T1DM may arise from treatment-related factors (intensive insulin therapy and defensive carbohydrate intake), behavioral aspects (reduced physical activity due to fear of hypoglycemia), and pathophysiological mechanisms such as adipose tissue dysfunction. Clinically, obesity in T1DM is associated with increased risk of cardiovascular disease, nephropathy, retinopathy, and psychosocial burden. Weight gain and increased insulin dependence have created a vicious cycle in the management of obesity in T1DM. Recent clinical studies have shown that incretin-based therapies, particularly glucagon-like peptide-1 (GLP-1) receptor agonists and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 agonists, can reduce body weight and insulin requirements without significant safety concerns. Similarly, sodium-glucose cotransporter 2 inhibitors offer metabolic benefits but carry a risk of diabetic ketoacidosis. The lack of regulatory approval for obesity treatment agents in these patients highlights the importance of further research. In this review, we address the pathophysiology of obesity in T1DM, its clinical implications, and therapeutic approaches using an evidence-based approach.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":" ","pages":"282-297"},"PeriodicalIF":12.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13429850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}