Journal of Obesity & Metabolic Syndrome最新文献_第10页

Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry. 肥胖与COVID-19住院时间之间的关系:来自美国心脏协会国家COVID-19登记处的意外见解。

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-09-30 DOI: 10.7570/jomes22042

William J Collins, Andrew Y Chang, Yingjie Weng, Alex Dahlen, Connor G O'Brien, Jason Hom, Neera Ahuja, Fatima Rodriguez, Nidhi Rohatgi

{"title":"Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry.","authors":"William J Collins, Andrew Y Chang, Yingjie Weng, Alex Dahlen, Connor G O'Brien, Jason Hom, Neera Ahuja, Fatima Rodriguez, Nidhi Rohatgi","doi":"10.7570/jomes22042","DOIUrl":"https://doi.org/10.7570/jomes22042","url":null,"abstract":"Background: The mechanism for possible association between obesity and poor clinical outcomes from Coronavirus Disease 2019 (COVID-19) remains unclear.Methods: We analyzed 22,915 adult COVID-19 patients hospitalized from March 2020 to April 2021 to non-intensive care using the American Heart Association National COVID Registry. A multivariable Poisson model adjusted for age, sex, medical history, admission respiratory status, hospitalization characteristics, and laboratory findings was used to calculate length of stay (LOS) as a function of body mass index (BMI). We similarly analyzed 5,327 patients admitted to intensive care for comparison.Results: Relative to normal BMI subjects, overweight, class I obese, and class II obese patients had approximately half-day reductions in LOS (-0.469 days, P<0.01; -0.480 days, P<0.01; -0.578 days, P<0.01, respectively).Conclusion: The model identified a dose-dependent, inverse relationship between BMI category and LOS for COVID-19, which was not seen when the model was applied to critically ill patients.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 3","pages":"277-281"},"PeriodicalIF":5.2,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/34/jomes-31-3-277.PMC9579478.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms 长链脂肪酸对脂肪组织生物学的调控:代谢效应和分子机制

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-06-13 DOI: 10.7570/jomes22014

Sunhye Shin

{"title":"Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms","authors":"Sunhye Shin","doi":"10.7570/jomes22014","DOIUrl":"https://doi.org/10.7570/jomes22014","url":null,"abstract":"Long-chain fatty acids (LCFA) modulate metabolic, oxidative, and inflammatory responses, and the physiological effects of LCFA are determined by chain length and the degree of saturation. Adipose tissues comprise multiple cell types, and play a significant role in energy storage and expenditure. Fatty acid uptake and oxidation are the pathways through which fatty acids participate in the regulation of energy homeostasis, and their dysregulation can lead to the development of obesity and chronic obesity-related disorders, including type 2 diabetes, cardiovascular diseases, and certain types of cancer. Numerous studies have reported that many aspects of adipose tissue biology are influenced by the number and position of double bonds in LCFA, and these effects are mediated by various signaling pathways, including those regulating adipocyte differentiation (adipogenesis), thermogenesis, and inflammation in adipose tissue. This review aims to describe the underlying molecular mechanisms by which different types of LCFA influence adipose tissue metabolism, and to further clarify their relevance to metabolic dysregulation associated with obesity. A better understanding of the effects of LCFA on adipose tissue metabolism may lead to improved nutraceutical strategies to address obesity and obesity-associated diseases.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 1","pages":"147 - 160"},"PeriodicalIF":5.2,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44494491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Triglyceride–Glucose Index Predicts Cardiovascular Outcome in Metabolically Unhealthy Obese Population: A Nationwide Population-Based Cohort Study 甘油三酯-葡萄糖指数预测代谢不健康肥胖人群心血管结局:一项全国性人群队列研究

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-06-13 DOI: 10.7570/jomes21086

Y. Cho, Hwi Seung Kim, J. Park, W. Lee, Ye-Jee Kim, C. Jung

{"title":"Triglyceride–Glucose Index Predicts Cardiovascular Outcome in Metabolically Unhealthy Obese Population: A Nationwide Population-Based Cohort Study","authors":"Y. Cho, Hwi Seung Kim, J. Park, W. Lee, Ye-Jee Kim, C. Jung","doi":"10.7570/jomes21086","DOIUrl":"https://doi.org/10.7570/jomes21086","url":null,"abstract":"Background This study assesses the prognostic value of the triglyceride–glucose (TyG) index for cardiovascular (CV) risk in subgroups based on metabolic health and obesity status. Methods Originally, 514,866 participants were enrolled from the Korean National Health Insurance Service-National Health Screening Cohort. The study participants were categorized into four groups: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). The TyG index was calculated using the following formula: ln (fasting triglyceride [mg/dL]×fasting plasma glucose [mg/dL]/2). Participants were followed from 2009 to 2015 for CV events and CV mortality according to the TyG index. Results After exclusions, the final study cohort contained 292,206 people. During the follow-up, 9,138 CV events and 1,163 CV deaths were documented. When the high and low TyG groups were compared, the high TyG group had a substantially increased risk of CV events among the MUNO and MUO participants (multivariable-adjusted hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.07–1.30 and 1.27 [1.14–1.42], respectively). In participants with MUO status, CV mortality was also significantly increased in the high TyG group compared with the corresponding low TyG group (multivariable-adjusted HR, 1.48; 95% CI, 1.13–1.93). In contrast, a high TyG index was not related to CV mortality in the MHNO, MHO, and MUNO groups. Conclusion The predictive value of the TyG index can vary across populations. Among MUO participants, the TyG index was significantly and positively correlated with unfavorable CV outcomes.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 1","pages":"178 - 186"},"PeriodicalIF":5.2,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42137521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Retraction: Birth Weight Predicts Anthropometric and Body Composition Assessment Results in Adults: A Population-Based Cross-Sectional Study (J Obes Metab Syndr 2021;30:279-88) 退缩：出生体重预测成年人的人体测量和身体成分评估结果：一项基于人群的横断面研究（肥胖代谢综合杂志2021；30:279-88）

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-06-09 DOI: 10.7570/jomes22039

I. Salmi, S. Hannawi

引用次数: 0

Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans 牛磺酸对动物和人类代谢参数的有益影响

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-06-07 DOI: 10.7570/jomes21088

Minkyung Bae, Kainat Ahmed, J. Yim

引用次数: 8

Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hypertension 碳水化合物限制饮食和间歇性禁食对肥胖、2型糖尿病和高血压管理的影响:韩国肥胖研究学会、韩国糖尿病协会和韩国高血压学会的共识声明

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-06-07 DOI: 10.7570/jomes22009

Jong Han Choi, Y. Cho, Hyun-Jin Kim, S. Ko, S. Chon, J. Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, K. Song, G. Nam, K. Kim

{"title":"Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hypertension","authors":"Jong Han Choi, Y. Cho, Hyun-Jin Kim, S. Ko, S. Chon, J. Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, K. Song, G. Nam, K. Kim","doi":"10.7570/jomes22009","DOIUrl":"https://doi.org/10.7570/jomes22009","url":null,"abstract":"Carbohydrate-restricted diets and intermittent fasting (IF) have been rapidly gaining interest among the general population and patients with cardiometabolic disease, such as overweight or obesity, diabetes, and hypertension. However, there are limited expert recommendations for these dietary regimens. This study aimed to evaluate the level of scientific evidence on the benefits and harms of carbohydrate-restricted diets and IF to make responsible recommendations. A meta-analysis and systematic literature review of 66 articles on 50 randomized controlled trials (RCTs) of carbohydrate-restricted diets and 10 articles on eight RCTs of IF was performed. Based on the analysis, the following recommendations are suggested. In adults with overweight or obesity, a moderately-low carbohydrate or low carbohydrate diet (mLCD) can be considered as a dietary regimen for weight reduction. In adults with type 2 diabetes mellitus, mLCD can be considered as a dietary regimen for improving glycemic control and reducing body weight. In contrast, a very-low carbohydrate diet (VLCD) and IF are recommended against in patients with diabetes. Furthermore, no recommendations are suggested for VLCD and IF in adults with overweight or obesity, and carbohydrate-restricted diets and IF in patients with hypertension. Here, we describe the results of our analysis and the evidence for these recommendations.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 1","pages":"100 - 122"},"PeriodicalIF":5.2,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42841720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Type 2 Diabetes Remission with Significant Weight Loss: Definition and Evidence-Based Interventions 2型糖尿病缓解并显著减轻体重：定义和循证干预

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-05-27 DOI: 10.7570/jomes22001

J. Ko, Tae Nyun Kim

{"title":"Type 2 Diabetes Remission with Significant Weight Loss: Definition and Evidence-Based Interventions","authors":"J. Ko, Tae Nyun Kim","doi":"10.7570/jomes22001","DOIUrl":"https://doi.org/10.7570/jomes22001","url":null,"abstract":"Type 2 diabetes (T2D) has long been regarded as an incurable and chronic disease according to conventional management methods. Clinical and pathophysiological studies on the natural course of T2D have shown that blood glucose control worsens with an increase in the number of required anti-hyperglycemic agents, as β-cell function progressively declines over time. However, recent studies have shown remission of T2D after metabolic surgery, intensive lifestyle modification, or medications, raising the possibility that β-cell function may be preserved or the decline in β-cell function may even be reversible. The World Health Organization as well as the American Diabetes Association and the European Association for the Study of Diabetes recognize remission as an appropriate management aim. In the light of the state of evidence for T2D reversal, physicians need to be educated on treatment options to achieve T2D remission so that they can actively play a part in counseling patients who may wish to explore these approaches to their disease. This review will introduce each of these approaches, summarizing their beneficial effects, supporting evidence, degree of sustainability, and challenges to be addressed in the future.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 1","pages":"123 - 133"},"PeriodicalIF":5.2,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41393661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Maintaining Physical Activity Is Associated with Reduced Major Adverse Cardiovascular Events in People Newly Diagnosed with Diabetes 在新诊断的糖尿病患者中，保持体育活动与减少主要心血管不良事件有关

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-05-27 DOI: 10.7570/jomes22007

D. Kim, Jaehun Seo, K. Ha, D. Kim

{"title":"Maintaining Physical Activity Is Associated with Reduced Major Adverse Cardiovascular Events in People Newly Diagnosed with Diabetes","authors":"D. Kim, Jaehun Seo, K. Ha, D. Kim","doi":"10.7570/jomes22007","DOIUrl":"https://doi.org/10.7570/jomes22007","url":null,"abstract":"Background We investigated the association between changes in physical activity and the risk of a major adverse cardiovascular event (MACE) in people with newly diagnosed diabetes. Methods Using a nationwide database, we identified 8,596 people with newly diagnosed diabetes who underwent national health examinations within a year before and after a diabetes diagnosis. Cox proportional hazards models, hazard ratios (HRs) and 95% confidence intervals (CIs) for MACE risks were calculated according to changes in physical activity before and after a diagnosis of diabetes. Results During a median follow-up of 2.3 years, study participants who engaged in sustained physical activity after a diagnosis of diabetes had a 34% lower MACE risk compared to those with sustained inactivity (HR, 0.66; 95% CI, 0.44–0.98). An advantage was observed in those with a history of cardiovascular disease, although this was of borderline statistical significance (HR, 0.63; 95% CI, 0.40–1.01; P=0.054). In people considered obese, physical activity was significantly associated with a decreased risk of a MACE, regardless of the period preceding and following the diabetes diagnosis. Those who became inactive to active had the lowest risk of a MACE (HR, 0.38; 95% CI, 0.18–0.79). Conclusion Maintaining active physical activity before and after a diagnosis of diabetes is essential to preventing cardiovascular disease. Early intervention strategies are necessary to promote physical activity and exercise routines after a diagnosis of diabetes in people with obesity and those with pre-existing cardiovascular disease.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 1","pages":"187 - 195"},"PeriodicalIF":5.2,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46025041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Report of Journal of Obesity and Metabolic Syndrome in the Last 3 Years of Upheaval. 《肥胖与代谢综合征杂志》在剧变的最近3年的报道

IF 4.7

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-03-30 DOI: 10.7570/jomes22020

Eun-Jung Rhee

引用次数: 0

Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood 发育迟缓和成年糖代谢紊乱的小孕龄子代小鼠模型

IF 5.2

Journal of Obesity & Metabolic Syndrome Pub Date : 2022-03-17 DOI: 10.7570/jomes22013

H. Moon, Han-Kyeom Kim, Bohye Kim, Min-Seon Kim, Jae Hyun Kim, Obin Kwon

引用次数: 0