Journal of Obesity & Metabolic Syndrome最新文献

{"title":"Transcriptomic Profiling of Subcutaneous Adipose Tissue in Relation to Bariatric Surgery: A Retrospective, Pooled Re-analysis.","authors":"Youdinghuan Chen","doi":"10.7570/jomes22065","DOIUrl":"https://doi.org/10.7570/jomes22065","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery is the most effective intervention for weight loss possibly through modulating subcutaneous adipose tissue (SAT) molecular programs. The post-operative molecular and biological impacts, including gene expression, deserve in-depth investigation especially given the small sample sizes in the literature.</p><p><strong>Methods: </strong>Five existing datasets (n=237 SATs) were re-processed and corrected for batch-to-batch variation. Unsupervised approaches and robust linear mixed effect model were used to compare gene expression post- (n=126) to pre-operation (n=111).</p><p><strong>Results: </strong>Post-operative SATs showed distinct global gene expression. Forty-four and 395 genes were over- and under-expressed post-operation (all Bonferroni <i>P</i><0.05). The under-expressed genes significantly enriched for 21 biological processes/pathways (all Bonferroni <i>P</i><0.05), 17 (76.2%) and two (9.5%) directly involved in immunity and amino/proteo-glycan metabolism, respectively.</p><p><strong>Conclusion: </strong>Post-operative SATs might adopt distinct transcriptomic landscapes and undergo a reduction in immune-related processes and amino/proteo-glycan metabolism.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"32 1","pages":"98-102"},"PeriodicalIF":5.2,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/5f/jomes-32-1-98.PMC10088552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9293281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Function of Body Mass Index in the Older with Osteosarcopenia: A Systematic Review and Meta-analysis.","authors":"Yang Du,&nbsp;Shuting Tao,&nbsp;Chorong Oh,&nbsp;Jaekyung No","doi":"10.7570/jomes22057","DOIUrl":"https://doi.org/10.7570/jomes22057","url":null,"abstract":"<p><strong>Background: </strong>Due to the aging population worldwide, diseases that frequently attack elderly people, such as sarcopenia and osteoporosis, are major public health issues.</p><p><strong>Methods: </strong>This study used a systematic review and meta-analysis to examine the associations among body mass index (BMI), sarcopenia, and bone mineral density (BMD) in a group of adults older than 60 years. Eight studies with a total of 18,783 subjects were examined using a random effect model.</p><p><strong>Results: </strong>In sarcopenia patients, total hip BMD (d=0.560; 95% confidence interval [CI], 0.438 to 0.681; <i>P</i><0.01; I²=53.755%), femoral neck BMD (d=0.522; 95% CI, 0.423 to 0.621; <i>P</i><0.01; I²=77.736%) and lumbar spine BMD (d=0.295; 95% CI, 0.111 to 0.478; <i>P</i><0.01; I²=66.174%) were lower than in control subjects. Additionally, BMI (d=0.711; 95% CI, 0.456 to 0.996; <i>P</i><0.01; I²=97.609%) correlated with the BMD of the total hip, femoral neck, and lumbar spine. That is, sarcopenia patients with low BMD levels in the total hip, femoral neck, and lumbar spine also had low fat levels. Thus, sarcopenia patients with low BMD in the total hip, femoral neck and lumbar spine and low BMI could have a higher than average risk of osteosarcopenia. No sex effects were significant (<i>P</i>>0.05) for any variable.</p><p><strong>Conclusion: </strong>BMI could be a key point in osteosarcopenia, suggesting that a low body weight could be facilitate the transition from sarcopenia to osteosarcopenia.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"32 1","pages":"77-86"},"PeriodicalIF":5.2,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/42/jomes-32-1-77.PMC10088551.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9470299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.","authors":"Kyoung-Kon Kim, Ji-Hee Haam, Bom Taeck Kim, Eun Mi Kim, Jung Hwan Park, Sang Youl Rhee, Eonju Jeon, Eungu Kang, Ga Eun Nam, Hye Yeon Koo, Jeong-Hyun Lim, Jo-Eun Jeong, Jong-Hee Kim, Jong Won Kim, Jung Ha Park, Jun Hwa Hong, Sang Eok Lee, Se Hee Min, Seung Jun Kim, Sunyoung Kim, Yang-Hyun Kim, Yeon Ji Lee, Yoon Jeong Cho, Young-Jun Rhie, Youn-Hee Kim, Jee-Hyun Kang, Chang Beom Lee","doi":"10.7570/jomes23016","DOIUrl":"10.7570/jomes23016","url":null,"abstract":"<p><p>The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent multi-level review and cross-checking and received endorsement from relevant scientific societies. This edition of the guidelines includes criteria for diagnosing obesity, abdominal obesity, and metabolic syndrome; evaluation of obesity and its complications; weight loss goals; and treatment options such as diet, exercise, behavioral therapy, pharmacotherapy, and bariatric and metabolic surgery for Korean people with obesity. Compared to the previous edition of the guidelines, the current edition includes five new topics to keep up with the constantly evolving field of obesity: diagnosis of obesity, obesity in women, obesity in patients with mental illness, weight maintenance after weight loss, and the use of information and communication technology-based interventions for obesity treatment. This edition of the guidelines features has improved organization, more clearly linking key questions in PICO format to recommendations and key references. We are confident that these new Clinical Practice Guidelines for Obesity will be a valuable resource for all healthcare professionals as they describe the most current and evidence-based treatment options for obesity in a well-organized format.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"32 1","pages":"1-24"},"PeriodicalIF":4.7,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/af/jomes-32-1-1.PMC10088549.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9836238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the Association of Visceral Adipose Tissue Growth Differentiation Factor-15 and MicroRNA in Type 2 Diabetes Mellitus.","authors":"Dipayan Roy, Purvi Purohit, Manoj Khokhar, Anupama Modi, Ravindra Kumar Gayaprasad Shukla, Ramkaran Chaudhary, Shrimanjunath Sankanagoudar, Praveen Sharma","doi":"10.7570/jomes22010","DOIUrl":"10.7570/jomes22010","url":null,"abstract":"<p><strong>Background: </strong>Growth differentiation factor-15 (GDF-15) is involved in insulin resistance and diabetes. In this study, we determine the associations of GDF-15 with miR-181b-5p, miR-330-3p, mothers against decapentaplegic homolog 7 (SMAD7), and insulin resistance in visceral adipose tissue (VAT) and peripheral blood mononuclear cells (PBMCs) in type 2 diabetes mellitus (T2DM) patients.</p><p><strong>Methods: </strong>Sixty patients, equally divided into those with T2DM and non-diabetic controls, were recruited for gene expression analysis. Protein-protein interaction (STRING), target prediction (miRNet), and functional enrichment were conducted accordingly.</p><p><strong>Results: </strong>Our study showed that VAT and PBMCs had similar expression profiles, where GDF-15 and miR-181b-5p were upregulated, whereas SMAD7 and miR-330-3p were downregulated. Serum GDF-15 could differentiate between T2DM and non-diabetic patients (<i>P</i><0.001). Target prediction revealed a microRNA (miRNA)-messenger RNA regulatory network, transcription factors, and functional enrichment for the miRNA that suggested involvement in T2DM pathogenesis.</p><p><strong>Conclusion: </strong>VAT GDF-15 is associated with insulin resistance and is possibly regulated by miR-181b-5p, miR-330-3p, and SMAD7 in T2DM.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"32 1","pages":"64-76"},"PeriodicalIF":4.7,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/75/jomes-32-1-64.PMC10088550.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9643116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric Surgery in Kidney Transplant Candidates and Recipients: Experience at an Asian Center.","authors":"Sarah Ying Tse Tan,&nbsp;Phong Ching Lee,&nbsp;Sonali Ganguly,&nbsp;Peng Chin Kek,&nbsp;Terence Kee,&nbsp;Quan Yao Ho,&nbsp;Sobhana Thangaraju","doi":"10.7570/jomes21090","DOIUrl":"https://doi.org/10.7570/jomes21090","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant (KT) candidates and recipients with obesity experience more frequent complications such as infection, poorer allograft outcomes, diabetes, and mortality, limiting their eligibility for transplantation. Bariatric surgery (BS) is not commonly performed among KT patients given concerns about immunosuppression absorption, wound healing, infections, and graft outcomes. Its role has not been described before in an Asian KT patient setting.</p><p><strong>Methods: </strong>A retrospective review of patients who underwent BS at the largest KT center in Singapore from 2008 to 2020 was conducted. Metabolic outcomes, immunosuppression doses, graft outcomes, and mortality were studied.</p><p><strong>Results: </strong>Seven patients underwent BS and KT (4 underwent BS before KT, 3 underwent BS after KT; 4 underwent sleeve gastrectomy, 3 underwent gastric bypass). Mean total weight losses of 23.8% at 1 year and 18.6% at 5 years post-BS were achieved. Among the five patients with diabetes, glycemic control improved after BS. There were no deaths in the first 90 days or graft loss in the first year after KT and BS. Patients who underwent BS after KT had no significant changes in immunosuppression dose.</p><p><strong>Conclusion: </strong>BS can be safely performed in KT recipients and candidates and results in sustainable weight losses and improvements in metabolic comorbidities. Although no major complications were observed in our study, close monitoring of this complex group of patients is imperative.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"325-333"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/ab/jomes-31-4-325.PMC9828702.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9097786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Updates on Associations among Various Obesity Metrics and Cognitive Impairment: from Body Mass Index to Sarcopenic Obesity.","authors":"Chan-Hee Jung,&nbsp;Ji-Oh Mok","doi":"10.7570/jomes22058","DOIUrl":"https://doi.org/10.7570/jomes22058","url":null,"abstract":"<p><p>Obesity and obesity-associated morbidity continues to be a major public health issue worldwide. Dementia is also a major health concern in aging societies and its prevalence has increased rapidly. Many epidemiologic studies have shown an association between obesity and cognitive impairment, but this relationship is not as well established as other comorbidities. Conflicting results related to the age and sex of participants, and the methodology used to define obesity and dementia may account for the uncertainty in whether obesity is a modifiable risk factor for dementia. More recently, sarcopenia and sarcopenic obesity have been reported to be associated with cognitive impairment. In addition, new mediators such as the muscle-myokine-brain axis and gut-microbiota-brain axis have been suggested and are attracting interest. In this review, we summarize recent evidence on the link between obesity and cognitive impairment, especially dementia. In particular, we focus on various metrics of obesity, from body mass index to sarcopenia and sarcopenic obesity.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"287-295"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/ab/jomes-31-4-287.PMC9828704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Waist Circumference Measurement Site on Visceral Fat and Metabolic Risk in Youth.","authors":"SoJung Lee,&nbsp;Yejin Kim,&nbsp;Minsub Han","doi":"10.7570/jomes22046","DOIUrl":"https://doi.org/10.7570/jomes22046","url":null,"abstract":"<p><p>Although the rate of childhood obesity seems to have plateaued in recent years, the prevalence of obesity among children and adolescents remains high. Childhood obesity is a major public health concern as overweight and obese youth suffer from many co-morbid conditions once considered exclusive to adults. It is now well demonstrated that abdominal obesity as measured by waist circumference (WC) is an independent risk factor for cardiovascular disease and metabolic dysfunction in youth. Despite the strong associations between WC and cardiometabolic risk factors, there is no consensus regarding the optimal WC measurement sites to assess abdominal obesity and obesity-related health risk in children and adolescents. Currently, the WC measurement site that provides the best reflections of visceral fat and the best correlations with cardiometabolic risk factors is unclear. The purpose of this review is to explore whether WC measurement sites influence the relationships between WC, visceral fat, and cardiometabolic risk factors in children and adolescents.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"296-302"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/f5/jomes-31-4-296.PMC9828705.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Hepatic Fibrosis and Steatosis in Metabolic Syndrome (J Obes Metab Syndr 2022;31:61-9).","authors":"Young-Gyun Seo","doi":"10.7570/jomes22049","DOIUrl":"https://doi.org/10.7570/jomes22049","url":null,"abstract":"J Obes Metab Syndr 2022;31:350-351 Nonalcoholic fatty liver disease has a worldwide prevalence of 25%, which includes diseases ranging from steatosis to steatohepatitis, and has a bidirectional association with metabolic syndrome (MetS).1 Although a few studies have investigated the association between liver fibrosis and MetS, their findings have been controversial. A recent cohort study of a large patient-centered medical home found that a heavy burden of MetS components was associated with high or indeterminate risk for advanced fibrosis when noninvasive indices were used.2 The results of studies evaluating fibrosis confirmed by liver biopsy were different. MetS was not significantly related to advanced liver fibrosis in biopsy-proven metabolic dysfunction-associated fatty liver disease patients3 and MetS was not associated with hepatic fibrosis among individuals with hereditary hemochromatosis.4 Gangireddy et al.5 reported useful findings in an article entitled “Hepatic fibrosis and steatosis in metabolic syndrome.” In analysis using National Health and Nutrition Examination Survey (NHANES) data, 26% of the participants had steatosis; 7.5% had fibrosis; and 3.3% had fibrosis without steatosis. The adjusted odds ratios were 4.12 for steatosis, 3.34 for fibrosis, and 2.67 for fibrosis without steatosis in participants with MetS compared to those without. The strength of Gangireddy et al.’s study5 is that it was population-scale study conducted in the United States. It also has some strengths in that hepatic fibrosis and steatosis were evaluated through liver ultrasound. However, as mentioned in the paper, the fact that hepatic fibrosis and steatosis were not evaluated by liver biopsy is one limitation, and it is necessary to consider a method to address this weakness. Another limitation is that noninvasive indices were not used. By using hepatic fibrosis and steatosis indices such as fatty liver index6 and fibrosis-4 index7 instead of or in addition to liver ultrasound, which was employed only during specific years of the NHANES dataset, the study period could be significantly extended, and a large-scale evaluation of the general population would be possible. Nevertheless, as a study targeting the general population in the United States, Gangireddy et al.’s study5 is meaningful and proves a relationship between hepatic fibrosis and steatosis and MetS. Therefore, further detailed analysis using noninvasive or invasive methods is needed to determine the direct association between hepatic fibrosis and steatosis and MetS. In addition, multi-ethnic-group studies would give us more concrete data regarding the impact of MetS on hepatic fibrosis and steatosis and improve the generalizability of these findings across various populations.","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"350-351"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/1f/jomes-31-4-350.PMC9828699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gangwon Obesity and Metabolic Syndrome Study: Methods and Initial Baseline Data.","authors":"Yoon Jeong Cho,&nbsp;Sohyun Park,&nbsp;Sung Soo Kim,&nbsp;Hyo Jin Park,&nbsp;Jang Won Son,&nbsp;Tae Kyung Lee,&nbsp;Sangmo Hong,&nbsp;Jee-Hyun Kang,&nbsp;Seon Mee Kim,&nbsp;Yang-Hyun Kim,&nbsp;Won Jun Kim,&nbsp;Young Eun Seo,&nbsp;Yoosuk An,&nbsp;Sang Youl Rhee,&nbsp;Suk Chon,&nbsp;Sookyoung Jeon,&nbsp;Kyungho Park,&nbsp;Bong-Soo Kim,&nbsp;Chang Beom Lee,&nbsp;Kyoung-Kon Kim,&nbsp;Jung Eun Lee","doi":"10.7570/jomes22064","DOIUrl":"https://doi.org/10.7570/jomes22064","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of obesity has been continuously increasing, especially in rural areas of South Korea. Therefore, it is important to examine various genetic, behavioral, and environmental factors associated with obesity in these rural areas. The Korean Society for the Study of Obesity commenced a community-based prospective cohort study of the Gangwon area called the Gangwon Obesity and Metabolic Syndrome (GOMS) study to investigate longitudinal changes in the status of obesity and its related factors.</p><p><strong>Methods: </strong>A total of 317 adults 40-69 years of age were recruited from Hongcheon and Inje districts, Gangwon province, as part of the first wave of this cohort study. Information on participants' demographic, behavioral, psychological, dietary, and environmental factors and past medical histories were collected by self-administered questionnaires and interviewer-administered questionnaires. Anthropometric measurements, blood tests, and a hand grip strength test were performed, and skin keratin and stool samples were collected. Among the 317 enrolled subjects, two participants who did not have anthropometric data were excluded from the data analyses, resulting in an inclusion of a total of 315 participants.</p><p><strong>Results: </strong>The mean age of the 315 participants in the GOMS initial baseline survey was 58.5 years old, 87 of them were men, and the mean body mass index was 24.7±3.7 kg/m². Among all participants, 48.9% had hypertension, 21.4% had diabetes mellitus (DM), 55.6% had dyslipidemia, and 46.0% had metabolic syndrome (MS). Both the prevalence rates of DM and MS were significantly higher in men.</p><p><strong>Conclusion: </strong>The first baseline survey of the GOMS study was initiated, and a more detailed analysis of respondents' data is expected to be continued. Further follow-up and additional recruitment will allow the investigation of risk factors and the etiology of obesity and its comorbidities in rural areas of Gangwon province.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"303-312"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/a5/jomes-31-4-303.PMC9828700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip Strength Is Associated with Metabolic Syndrome and Insulin Resistance in Children and Adolescents: Analysis of Korea National Health and Nutrition Examination Survey 2014-2018.","authors":"Hae Woon Jung,&nbsp;Jieun Lee,&nbsp;Jaehyun Kim","doi":"10.7570/jomes22053","DOIUrl":"https://doi.org/10.7570/jomes22053","url":null,"abstract":"<p><strong>Background: </strong>Reduced handgrip strength (HGS) is associated with adverse cardiometabolic health outcomes. We examined HGS, metabolic syndrome (MetS), and insulin resistance (IR) in children and adolescents.</p><p><strong>Methods: </strong>The following population-based data from 2,797 participants (aged 10-18 years) of the Korea National Health and Nutrition Examination Survey 2014-2018 were analyzed: complete anthropometric measures, HGS, MetS, and IR (subgroup with fasting insulin, n=555). HGS was analyzed as the combined HGS (CHGS) and the normalized CHGS (nCHGS=CHGS divided by body weight).</p><p><strong>Results: </strong>At a mean age of 14.4 years, 276 participants (9.9%) had abdominal obesity, 56 (2.0%) had MetS, and 118 (20.9%) had IR. Individual components of MetS and IR were inversely associated with the nCHGS. The odds ratios (ORs) for MetS and IR decreased significantly with higher nCHGS after adjustment for sex, age, physical activity, and sedentary times. The optimal cut-off values that predicted MetS were 0.80 kg/kg (males) and 0.71 kg/kg (females), with significant associations with MetS (OR: 7.4 in males; 5.7 in females) and IR (OR: 3.3 in males; 3.2 in females) observed when nCHGS values were lower than those cut-offs.</p><p><strong>Conclusion: </strong>HGS is associated with MetS and IR and might be a useful indicator of cardiometabolic risk factors in children and adolescents.</p>","PeriodicalId":45386,"journal":{"name":"Journal of Obesity & Metabolic Syndrome","volume":"31 4","pages":"334-344"},"PeriodicalIF":5.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/4f/jomes-31-4-334.PMC9828701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}