Muscle Mass Adjusted for Body Weight Is Associated with Significant Liver Fibrosis in Young Adults with Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study from a Korean Military Hospital.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Obesity & Metabolic Syndrome Pub Date : 2023-09-30 Epub Date: 2023-09-04 DOI:10.7570/jomes23035

Jaejun Lee, Seongjoo Na, Taeyun Kim, Seong-Woo Lee, Myoung Jung Kim, Chang In Han, Si Hyun Bae

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引用次数: 0

Abstract

Background: Sarcopenia has been associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the correlation between liver fibrosis and muscle mass in young adults with NAFLD.

Methods: We conducted a retrospective review of 88 Korean soldiers <35 years of age who underwent bioelectrical impedance analysis and liver stiffness measurements. A FibroScan-aspartate aminotransferase score >0.35 was used to determine the presence of liver fibrosis.

Results: Among the 88 patients, 38 were classified as having significant fibrosis. In the univariate analysis, muscle mass percentage (MMP), muscle-to-fat ratio (MFR), waist-to-hip ratio (WHR), body mass index, impaired fasting glucose or diabetes mellitus, and alanine transaminase (ALT) level were all significantly associated with fibrosis (P<0.001). After adjusting for ALT level, height, and age, MMP and WHR were associated with fibrosis.

Conclusion: In young adults, MMP and MFR were significantly associated with hepatic fibrosis.

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根据体重调整后的肌肉质量与患有非酒精性脂肪肝的年轻人的严重肝纤维化有关：一项来自韩国军事医院的横断面研究。

背景：Sarcopenia与非酒精性脂肪肝（NAFLD）有关。本研究旨在调查年轻NAFLD患者的肝纤维化与肌肉质量之间的相关性。方法：我们对88名韩国士兵进行了回顾性审查。0.35用于确定肝纤维化的存在。结果：在88例患者中，38例被归类为具有显著纤维化。在单变量分析中，肌肉质量百分比（MMP）、肌脂比（MFR）、腰臀比（WHR）、体重指数、空腹血糖或糖尿病受损以及丙氨酸转氨酶（ALT）水平均与肝纤维化显著相关（P结论：在年轻人中，MMP和MFR与肝纤维化明显相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

8.30

自引率

9.60%

发文量

审稿时长

19 weeks

期刊介绍： The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).