Clinics and Practice最新文献

{"title":"Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease.","authors":"Luminita-Georgeta Confederat, Roxana Stefan, Mihaela-Iustina Condurache, Oana-Maria Dragostin","doi":"10.3390/clinpract15010007","DOIUrl":"10.3390/clinpract15010007","url":null,"abstract":"<p><p><b>Background</b>: Diabetes has become one of the most challenging public health problems due to the alarming increase in prevalence and the morbidity and mortality attributed to its acute and chronic complications. <b>Objective:</b> This study aimed to investigate the development of chronic microvascular complications in sulfonylureas-treated diabetic patients and their correlations with glycemic control, risk factors and duration of the disease. <b>Methods</b>: This study included 200 patients that presented to \"Providența\" Medical Center, Iași. The information was obtained in a retrospective manner based on the observation sheets of the patients. A database was created, analyzed and statistically processed using the <i>Microsoft Excel software</i> (Version 15) and the <i>chi-square test of independence</i>. <b>Results</b>: The prevalence of diabetic polyneuropathy was 33.5%, while diabetic retinopathy was found in 27% of cases. For diabetic polyneuropathy, the results of the statistical analysis demonstrated a statistically significant dependence of the risk factors hyperlipidemia (significance level = 0.01) and overweight/obesity (significance level = 0.05). For diabetic retinopathy, the results demonstrated a statistically significant dependence of the risk factors hypertension (significance level = 0.05) and hyperlipidemia (significance level = 0.01). <b>Conclusions</b>: The present study reveals a strong correlation between the presence of risk factors and the development of microvascular complications of diabetes.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrovascular Accidents After Orthotopic Liver Transplantation in Patients with Hepatopulmonary Syndrome: A Case Series.","authors":"Steffi K Chan, Manuel M Buitrago Blanco, Nicholas J Feduska, Vatche G Agopian, Samer S Ebaid, Tisha Wang, Ami Tamhaney, Igor Barjaktarevic","doi":"10.3390/clinpract15010005","DOIUrl":"10.3390/clinpract15010005","url":null,"abstract":"<p><p><b>Background:</b> Hepatopulmonary syndrome (HPS), defined by the presence of pulmonary vascular dilatations that cause right-to-left transpulmonary shunting of venous blood with a consequential increase in the alveolar-arterial oxygen gradient, is a relatively frequent complication of chronic liver disease. While orthotopic liver transplantation (OLT) is indicated and often curative in HPS patients with end-stage liver disease (ESLD), little is known about the peri- and post-operative-period risks of CVA in OLT recipients with HPS. <b>Case Presentation</b>: We report a case series of five non-consecutive OLT recipients with HPS who developed ischemic and/or hemorrhagic CVAs during or shortly after OLT, raising concern that the risks of neurological complications remain increased even after OLT. <b>Conclusions:</b> Our case series hopes to highlight the importance of close vigilance in this subset of patients, at a time when there may be multiple issues to be addressed in facilitating post-operative recovery.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Techniques for Post-Treatment Evaluation After External Beam Radiation Therapy of Prostate Cancer: Narrative Review.","authors":"Eleni Bekou, Admir Mulita, Ioannis Seimenis, Athanasia Kotini, Nikolaos Courcoutsakis, Michael I Koukourakis, Francesk Mulita, Efstratios Karavasilis","doi":"10.3390/clinpract15010004","DOIUrl":"10.3390/clinpract15010004","url":null,"abstract":"<p><p><b>Background/Objectives</b>: This study aimed to investigate the prognostic value of advanced techniques of magnetic resonance imaging (MRI) biochemical recurrence (BCR) after radiotherapy in patients with prostate cancer (PCa). <b>Methods</b>: A comprehensive literature review was conducted to evaluate the role of MRI in detecting BCR of PCa patients after external beam radiation therapy. <b>Results</b>: National guidelines do not recommend imaging techniques in clinical follow-up PCa. However, in 2021, the European Association of Urogenital Radiology (ESUR), the European Association of Urological Imaging (ESUI), and the PI-RADS Steering Committee introduced the Prostate Imaging for Recurrence Reporting (PI-RR) system. PI-RR incorporates the MRI biomarkers in the post-treatment process. In the last decade, a growing number of clinical researchers have investigated the role of various MRI techniques in BCR. <b>Conclusions</b>: The integration of advanced MRI technologies into clinical routine marks the beginning of a new era of BCR with accuracy.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Damage Assessment of Endodontic Instruments Based on Digital Image Stacking.","authors":"Raúl Argüello-Sánchez, Ivette Alejandra Calderón-Alday, Antonio Hernández-Morales, Benjamín Gonzalo Rodríguez-Méndez, Diego Medina-Castro, Régulo López-Callejas, Carlo Eduardo Medina-Solís","doi":"10.3390/clinpract15010003","DOIUrl":"10.3390/clinpract15010003","url":null,"abstract":"<p><strong>Background/objectives: </strong>The damage assessment of dental instruments, such as endodontic files, is crucial to ensure patient safety and treatment quality. Conventional scanning electron microscopy (SEM) has been the gold standard for this purpose; however, its limited accessibility and complex sample preparation protocols hinder its routine use in clinical settings. This study proposes a novel system that leverages digital photography and advanced image processing techniques as a viable alternative to SEM.</p><p><strong>Methods: </strong>Our system accurately detects early instrument damage by capitalizing on the high resolution of digital images. Its exceptionally user-friendly interface, portability, and key features make it highly suitable for daily clinical practice.</p><p><strong>Results: </strong>Our findings suggest that the proposed system provides image quality comparable to SEM.</p><p><strong>Conclusions: </strong>Image stacking provides a practical, efficient, and objective method for assessing endodontic instruments' morphology. By detecting early damage, this system significantly improves the safety and quality of endodontic procedures, especially for reusable NiTi files, instilling confidence and security in its use. It offers a cost-effective and user-friendly alternative to traditional methods such as visual inspection and SEM, making it a comfortable and confident choice for both research and clinical settings.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Critical Management of Spinal Cord Injury: A Narrative Review.","authors":"Emilio Moreno-González, Antonio Ibarra","doi":"10.3390/clinpract15010002","DOIUrl":"10.3390/clinpract15010002","url":null,"abstract":"<p><p>Spinal cord injury (SCI) is defined as physical damage that alters the function and structure of the spinal cord. Traumatic causes, such as vehicle accidents, falls, and violence, account for 90% of SCI cases. Recent evidence suggests that early intensive care unit (ICU) monitoring improves patient prognosis, highlighting the importance of prompt ICU admission and early decompression surgery. This review includes 50 publications selected based on specific criteria to gather evidence on the current management of SCI in acute settings. Pharmacological agents have been studied for their neuroprotective properties, offering hope for improved neurological outcomes. Several clinical trials are evaluating new pharmacological alternatives for SCI. In conclusion, the current management of acute SCI should focus on standardized treatments addressing ventilatory, cardiopulmonary, and hematologic complications, all of which directly impact long-term neurological and functional prognosis. New neuroprotective agents currently in clinical trials show promising results and should be further studied to determine their role in acute SCI management.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Ligament Reconstruction in an Adolescent Female Affected by Congenital Femoral Deficiency and Complete Anterior and Posterior Cruciate Ligament agenesis: A Case Report.","authors":"Simone Giusti, Maria Beatrice Bocchi, Edoardo De Fenu, Osvaldo Palmacci, Ezio Adriani","doi":"10.3390/clinpract15010001","DOIUrl":"10.3390/clinpract15010001","url":null,"abstract":"<p><p><b>Purpose:</b> Multi-ligament reconstruction in adolescent patients affected by congenital femoral deficiency is an extremely rare and delicate surgical procedure. There are very few reported cases of complete anterior and posterior cruciate ligament agenesis in these patients. <b>Methods:</b> We present a complex case of a 16-year-old girl affected by congenital femoral deficiency and ipsilateral tibial hypoplasia who was treated successfully for a complete agenesis of the anterior (ACL) and posterior (PCL) cruciate ligament with single-sitting ACL and PCL reconstruction. <b>Results:</b> The adolescent patient was successfully reconstructed with excellent clinical results. <b>Conclusions:</b> Knee MRI (Magnetic Resonance Imaging) should be requested in all patients affected by congenital femoral deficiency to exclude ligamentous agenesis. Where present, these should be reconstructed at an early stage as soon as limb-lengthening procedures are completed. If still skeletally immature, physeal-sparing surgical techniques should be implemented.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Significant Association Between Herpes Zoster and Breast Cancer: A German Outpatient Study with over 120,000 Participants.","authors":"Vedanth D Krishnan, Niklas Gremke, André Hajek, Karel Kostev, Matthias Kalder","doi":"10.3390/clinpract14060218","DOIUrl":"10.3390/clinpract14060218","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate a possible association between Herpes Zoster (HZ) and the subsequent diagnosis of breast cancer (BC).</p><p><strong>Methods: </strong>Utilizing the Disease Analyzer database, anonymized medical records from German office-based practices were accessed. Longitudinal data of female patients aged 18 years and above diagnosed with HZ between 2005 and 2021 were included. Individuals without HZ diagnoses were matched to HZ patients using a nearest neighbor propensity score matching (1:1) based on age, sex, index year, average yearly consultation frequency during the follow-up, and predefined co-diagnoses. The incidence of BC in the cohort with and without HZ was evaluated using Kaplan-Meier curves and compared using the log-rank test. Finally, a univariable Cox regression analysis was conducted to assess the association between HZ and BC.</p><p><strong>Results: </strong>This study included 64,255 women with HZ and an equal number without HZ, with comparable characteristics in terms of age, visit frequency, and comorbidities. Analysis revealed no significant association between HZ and subsequent BC incidence, with similar rates observed in both HZ and non-HZ cohorts across different age groups.</p><p><strong>Conclusions: </strong>In this retrospective cohort study consisting of well-matched patients, the results indicate no significant association between an HZ infection and the development of BC over a 10-year follow-up period. This is the largest study of its kind to date.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 6","pages":"2770-2777"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction of Patients with Multiple Sclerosis Towards the Provision of Healthcare Services at a Tertiary Care Setting in Saudi Arabia.","authors":"Dalal Salem Al-Dossari, Ibrahim Abdulaziz Al-Zaagi, Mashael Abdulrahman Bin Salamma, Faisal Abdulaziz Alghamdi, Ahmed Hasan Althobaiti, Abdullah Bin Dakhil Allah Bin Awad Al-Harbi, Abdullah Rashed Alshelali, Anham Nabil Hassan, Baleegh Mohammed Ali, Sheraz Ali","doi":"10.3390/clinpract14060217","DOIUrl":"10.3390/clinpract14060217","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is an autoimmune-mediated neurological disorder and the most frequent neurological disability in young adults. Assessing MS patient satisfaction with care is necessary to evaluate healthcare service quality and factors impacting it.</p><p><strong>Objectives: </strong>We aimed to determine the satisfaction of patients with MS towards the provision of healthcare services, and the factors affecting their satisfaction.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey from November 2022 to December 2022 at King Saud Medical City, Saudi Arabia. The study participants completed the CANHELP Lite27 questionnaire, which consists of 21 items.</p><p><strong>Results: </strong>A total of 300 patients with MS participated in this study. The majority were female (80%), with an average age of 31.6 years and a mean disease duration of 5.22 years. Overall, satisfaction was moderate (63.59 ± 14.54). Patients were most satisfied with general aspects of care (72.00 ± 16.46), doctor relationships (68.58 ± 14.88), and communication (67.72 ± 17.60), but less so with decision-making (64.98 ± 18.37) and illness management (59.60 ± 16.31). Correlation analysis revealed a negative association between disease duration and satisfaction across all domains (correlation coefficient ranged from -0.290 to -0.206, <i>p</i> < 0.01), while age showed no significant correlation (<i>p</i> > 0.05). Multiple linear regression identified age as positively influencing satisfaction, while longer disease duration had a negative impact. Higher education and marital status were associated with increased satisfaction, while employment status and having children showed mixed results.</p><p><strong>Conclusions: </strong>This research uncovered significant insights regarding MS patient satisfaction within healthcare services. Despite moderate satisfaction levels overall, specific interventions are necessary to address shortcomings in decision-making and illness management. The negative correlation between disease duration and satisfaction across all domains underscores the evolving needs of MS patients over time. Future research could examine the effectiveness of illness management programs in improving MS patient satisfaction.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 6","pages":"2759-2769"},"PeriodicalIF":1.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical Mechanisms and Rehabilitation Strategies in Osteoporosis-Related Pain: A Systematic Review.","authors":"Giorgia Natalia Iaconisi, Rachele Mancini, Vincenzo Ricci, Danilo Donati, Cristiano Sconza, Riccardo Marvulli, Maurizio Ranieri, Marisa Megna, Giustino Varrassi, Simone Della Tommasa, Andrea Bernetti, Loredana Capobianco, Giacomo Farì","doi":"10.3390/clinpract14060216","DOIUrl":"10.3390/clinpract14060216","url":null,"abstract":"<p><strong>Background/objectives: </strong>Osteoporosis causes a bone mass reduction and often determines acute and chronic pain. Understanding the biochemical and neurophysiological mechanisms behind this pain is crucial for developing new, effective rehabilitative and therapeutic approaches. This systematic review synthesizes recent advances in muscle-bone interactions and molecular pathways related to osteoporosis-associated pain.</p><p><strong>Methods: </strong>We carried out a systematic review including studies published from 2018 to 2024 using PubMed, Scopus, clinicaltrials.gov and Cochrane Library. The Cochrane Collaboration tool was used to assess bias risk. The review adhered to PRISMA guidelines and is registered with PROSPERO (CRD42024574456); Results: Thirteen studies were included. It emerged that osteoporosis causes progressive bone loss due to disruptions in biochemical processes and muscle-bone interactions. This condition is also closely associated with the development of pain, both acute and chronic. Key findings include the role of the miR-92a-3p/PTEN/AKT pathway and the impact of muscle-bone disconnection on bone health. Mechanotransduction is critical for bone maintenance. Effective pain management and rehabilitation strategies include physical therapy and physical exercise, yoga, Pilates, and cognitive behavioral therapy (CBT); they all improve pain relief and functional outcomes by enhancing muscle strength, flexibility, and balance. Pharmacological options such as NSAIDs, opioids, and new agents like SHR-1222, along with surgical interventions like percutaneous vertebroplasty, offer additional pain reduction, especially when included in individualized rehabilitation projects; Conclusions: This review highlights advancements in understanding osteoporotic pain mechanisms and identifies promising treatments. Integrating targeted therapies and rehabilitation strategies can enhance patients' pain relief.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 6","pages":"2737-2758"},"PeriodicalIF":1.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Spectrum, Intraoperative Findings, and Postoperative Outcomes in Native Knee Joint Infections: A Retrospective Analysis.","authors":"Jonas Roos, Britta Mangels, Max Jaenisch, Matthias Dominik Wimmer, Thomas Martin Randau, Christian Prangenberg, Kristian Welle, Martin Gathen","doi":"10.3390/clinpract14060215","DOIUrl":"10.3390/clinpract14060215","url":null,"abstract":"<p><p><b>Background:</b> Native knee joint infections, while uncommon, present a serious condition predominantly instigated by bacteria such as <i>Staphylococcus aureus</i>. Without timely intervention, they can result in joint destruction or sepsis, with risk factors encompassing preexisting medical conditions and iatrogenic procedures. The diagnostic process includes a comprehensive patient history, clinical evaluation, laboratory testing, imaging studies, and microbiological investigations. Treatment typically involves joint aspiration and arthroscopy. This study aims to examine and establish correlations between diagnostic criteria and treatment modalities, enhancing the speed and specificity of future therapeutic strategies. <b>Materials and methods:</b> The present study is a retrospective cohort study conducted at a 1200-bed university clinic between 2007 and 2017, with an in-depth examination of patient details, symptoms, treatments, and outcomes. A scoring system was developed to classify the severity of knee joint impairment, categorizing patients on the basis of hospital stay duration, surgeries, and postoperative factors such as recurring symptoms, pain, and range of motion. <b>Results:</b> This study of 116 patients with knee joint infections revealed that clinical symptoms such as pain, swelling, and effusion are common but not definitive for diagnosis. Laboratory analysis revealed no significant differences in CRP or leukocyte counts between cultures positive or negative for pathogens. Hospital stay and disease severity are influenced by factors such as age, sex, presence of polyarthritis, neutrophil count, and type of pathogen, with higher weight and cortisone treatment associated with poorer outcomes. <b>Conclusions:</b> This study highlights the diagnostic challenges in native knee joint infections, revealing the need for comprehensive approaches given the nonspecificity of clinical symptoms and laboratory findings. This underscores the importance of advancing research through standardized methodologies and prospective studies to increase the accuracy of diagnosis and the effectiveness of treatment in this field.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 6","pages":"2725-2736"},"PeriodicalIF":1.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}