Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Guías dietéticas para los estadounidenses (DGA) 2025-2030: coincidencias y contrastes con el documento de recomendaciones de la Sociedad Española de Arteriosclerosis (SEA) (actualización 2024)","authors":"Pablo Pérez-Martínez , José M. Ordovás","doi":"10.1016/j.arteri.2026.500896","DOIUrl":"10.1016/j.arteri.2026.500896","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 2","pages":"Article 500896"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aplicación de la secuenciación masiva al estudio de las principales poblaciones bacterianas en la estenosis carotídea","authors":"Alessandra Franze’ , Emma Plana , Nuria Jiménez-Hernández , Alejandro Artacho , Javier Pons , Andrés Moya , Alex Mira , F. Xavier López-Labrador , Manuel Miralles","doi":"10.1016/j.arteri.2025.500817","DOIUrl":"10.1016/j.arteri.2025.500817","url":null,"abstract":"<div><h3>Introduction</h3><div>The potential involvement of pathogens in the development of atherosclerosis has been studied for decades. Some previous studies have successfully identified the presence of pathogens in the atheromatous plaque. However, many of these determinations are aimed at detecting the presence of a particular species. The use of omics technologies allows for the analysis of the complete microbial profile of a given sample. In the specific case of atheromatous plaque, the study of the bacterial load composition would help to clarify the possible relationship between infection and atherosclerosis and identify whether there is a bacterial profile associated with unstable plaques and, therefore, with the consequent risk of ischemic events.</div></div><div><h3>Methodology</h3><div>We analyzed cross-sectional fragments of carotid atheromatous plaque (N<!--> <!-->=<!--> <!-->57) and serum (N<!--> <!-->=<!--> <!-->54) from patients with recent neurological symptoms and asymptomatic patients (control group). Nucleic acids were extracted from the samples by enzymatic digestion and homogenization, with additional treatment with type I collagenase in the case of plaques. Bacterial ribosomal RNA (16S-rRNA gene) was amplified and subjected to massive sequencing using the Illumina® Miseq platform. The bioinformatic analysis, to identify the taxonomic composition, and biostatistical analysis, to determine the significant taxa, of the 16S-rRNA was performed in the R environment. As contamination control, bacterial species ratios ≥10 with respect to negative controls were considered significant.</div></div><div><h3>Results</h3><div>The presence of bacterial 16S-rRNA was very low in both types of samples. The bacterial composition in terms of α diversity and β diversity differed between plaque and serum; however, we did not observe significant differences between samples from symptomatic and asymptomatic patients. The most abundant phylum and genus in plaque were <em>Firmicute</em>s and <em>Staphylococcus</em>, respectively. For <em>Staphylococcus</em>, we found 100% similarity homology of the 16S-rRNA with 3 species (<em>S. epidermidis</em>, <em>S. caprae</em>, and <em>S. capitis</em>). In serum, the most abundant phyla were <em>Firmicutes</em> and <em>Proteobacteria</em>, with <em>Streptococcus</em> being the dominant genus, for which we found 100% homology of the 16S-rRNA with 20 species of oral streptococci.</div></div><div><h3>Conclusions</h3><div>We have successfully applied massive sequencing techniques to determine the presence and relative abundance of bacterial species in atheromatous plaques and serum of patients undergoing carotid endarterectomy. We have not observed significant differences between symptomatic and asymptomatic patients regarding the main genera, so we cannot establish a direct connection between bacterial composition and atheromatous plaque vulnerability. However, a possible association between atherosclerosis and ","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500817"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between fibrates therapy and diabetes mellitus following primary acute pancreatitis with hypertriglyceridemia","authors":"Jiali Xu ,&nbsp;Nana Deng ,&nbsp;Zhouyue Zhang ,&nbsp;Mingming Deng ,&nbsp;Gang Luo","doi":"10.1016/j.arteri.2025.500800","DOIUrl":"10.1016/j.arteri.2025.500800","url":null,"abstract":"<div><h3>Objective</h3><div>Post-acute pancreatitis diabetes mellitus (PPDM-A) is a type of diabetes linked to pancreatic exocrine dysfunction, which increases the risk of pancreatic cancer and mortality. Hyperlipidemia, or high blood lipid levels, is the third leading cause of acute pancreatitis (AP) and is associated with a higher diabetes risk. However, the link between lipid-lowering treatments and PPDM-A is unclear. This study aims to explore this relationship.</div></div><div><h3>Methods</h3><div>A cohort of 223 patients diagnosed with AP and hyperlipidemia was categorized into PPDM-A and non-PPDM-A groups. Binary logistic regression was utilized to analyze the correlation between fibrate therapy and PPDM-A incidence. Mendelian randomization (MR) was used to determine whether there was a causal relationship between triglyceride levels and diabetes.</div></div><div><h3>Results</h3><div>Elevated blood glucose levels (GLU) (OR<!--> <!-->=<!--> <!-->1.360, <em>p</em> <!-->&lt;<!--> <!-->0.001), female (OR<!--> <!-->=<!--> <!-->0.091, <em>p</em> <!-->=<!--> <!-->0.030), severity of AP [moderately severe AP (MASP) (OR<!--> <!-->=<!--> <!-->5.585, <em>p</em> <!-->=<!--> <!-->0.019)], recurrent acute pancreatitis (RAP) (OR<!--> <!-->=<!--> <!-->6.399, <em>p</em> <!-->=<!--> <!-->0.007), and fibrate use (OR<!--> <!-->=<!--> <!-->0.109, <em>p</em> <!-->=<!--> <!-->0.001) emerged as independent influencing factors of PPDM-A. MR evidence suggests a causal relationship between triglyceride levels and diabetes risk (OR<!--> <!-->=<!--> <!-->1.088, <em>p</em> <!-->&lt;<!--> <!-->0.001), with a two-step MR showing that pancreatitis partially mediates this effect with a mediated proportion of 1.55% (<em>p</em> <!-->=<!--> <!-->0.048).</div></div><div><h3>Conclusion</h3><div>Fibrates demonstrate the potential to lower the risk of PPDM-A among individuals with AP and hypertriglyceridemia. Furthermore, the effect of triglyceride levels on diabetes risk was partly mediated by pancreatitis.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500800"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo aterogénico en 44.939 profesionales sanitarios españoles: variables asociadas","authors":"Pedro Javier Tárraga Marcos ,&nbsp;Ángel Arturo López-González ,&nbsp;Emilio Martínez-Almoyna Rifá ,&nbsp;Hernán Paublini Oliveira ,&nbsp;Cristina Martorell Sánchez ,&nbsp;Pedro Juan Tárraga López ,&nbsp;José Ignacio Ramírez-Manent","doi":"10.1016/j.arteri.2025.500821","DOIUrl":"10.1016/j.arteri.2025.500821","url":null,"abstract":"<div><div>The article evaluates the atherogenic risk in 44,939 Spanish healthcare professionals by identifying the variables associated with this risk. It explains atherogenesis as the key pathological process in the development of cardiovascular diseases, characterized by the formation of atherosclerotic plaques resulting from atherogenic dyslipidemia. To quantify this risk, lipid indices (total cholesterol/HDL-c, LDL-c/HDL-c, and triglycerides/HDL-c ratios) were analyzed and related to factors such as age, sex, professional category, smoking, physical activity, and adherence to the Mediterranean diet. The results indicate that increasing age, male sex, smoking, and the lack of physical activity or adherence to a healthy diet are associated with higher atherogenic risk values. Furthermore, the study discusses its strengths (such as the large sample size and rigorous methodological design) and limitations, emphasizing the importance of comprehensive interventions and public health policies for the prevention and management of cardiovascular disease.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500821"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efectos de la contaminación del aire dentro de la casa en la incidencia de enfermedades cardiovasculares","authors":"Patricio Lopez-Jaramillo ,&nbsp;Gladys Lizarazo ,&nbsp;Raúl Torres ,&nbsp;Fausto Posso ,&nbsp;Jose P. Lopez-Lopez ,&nbsp;Maya Caicedo ,&nbsp;Fernando Vargas-Mendoza","doi":"10.1016/j.arteri.2025.500770","DOIUrl":"10.1016/j.arteri.2025.500770","url":null,"abstract":"<div><div>Cardiovascular diseases (CVD) are the main cause of death globally, especially in low- and middle-income countries (LMICs), where the largest number of inhabitants on the planet are concentrated. Air pollution inside and outside the home by microparticles 2 5 (PM2·5) has become an important risk factor for the presence of CVD and other chronic non-communicable diseases, particularly in LMICs. The use of solid fuels as an energy source for cooking food and heating inside the home has negative effects not only on human health but also on the health of the planet, as it contributes to deforestation and the consequent effect on climate change. In this narrative review we update how air pollution inside the home from cooking food with firewood and charcoal impacts the risk of CVD, the factors that determine the use of these polluting fuels, and the actions necessary for the massive transition toward the use of non-polluting energy, highlighting the development of university research to offer a stove that uses green hydrogen as a non-polluting energy source.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500770"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalencia de dislipemias familiares, grado de control lipídico y relación con la enfermedad cardiovascular aterosclerótica en población general de Galicia. Estudio GALIPEMIAS","authors":"José Luis Díaz-Díaz ,&nbsp;M. Eugenia Ameneiros ,&nbsp;Rosa Argüeso Armesto ,&nbsp;José María Mostaza Prieto ,&nbsp;Xavier Pintó Sala ,&nbsp;Avelino Rodríguez González ,&nbsp;José Antonio Díaz-Peromingo ,&nbsp;Alberto del Alamo Alonso ,&nbsp;Pablo Fernández Catalina ,&nbsp;Manuel Suárez Tembra ,&nbsp;Carlos Alberto Názara Otero ,&nbsp;Marta Pena Seijo ,&nbsp;Javier Muñiz García ,&nbsp;Teresa Rosalía Pérez-Castro ,&nbsp;Antonio Pose Reino ,&nbsp;Juan Pedro-Botet Montoya","doi":"10.1016/j.arteri.2025.500804","DOIUrl":"10.1016/j.arteri.2025.500804","url":null,"abstract":"<div><h3>Objectives</h3><div>GALIPEMIAS is a study designed to determine the prevalence of familial dyslipidemias in the adult population of Galicia, evaluate the degree of lipid control according to the criteria of current clinical guidelines and analyze its association with atherosclerotic cardiovascular disease (ASCVD).</div></div><div><h3>Methods</h3><div>Cross-sectional study carried out in the general population over 18<!--> <!-->years of age residing in Galicia and with a health card from the Galician Health Service (n<!--> <!-->=<!--> <!-->1,000). The sample was selected by random cluster sampling. The prevalence of familial combined hyperlipidemia (FCH), hypercholesterolemia with dominant inheritance pattern (HC-DI) and familial hypertriglyceridemia (FHTG), as well as suspected familial dysbetalipoproteinemia (FDB) and the joint prevalence of familial dyslipidemias with dominant inheritance (FDL-DI) were analyzed. For the assessment of cardiovascular risk (CVR), the criteria of the 2021 European guidelines for cardiovascular prevention were followed. The LDL-C control target required according to the CVR level was defined according to the 2019 European ESC/EAS guidelines.</div></div><div><h3>Results</h3><div>The prevalence of FCH was 15.9% (95%<!--> <!-->CI: 13.6-18.4%), that of HC-DI 5.9% (95%<!--> <!-->CI: 4.5-7.6%), that of FHTG 1.7% (95%<!--> <!-->CI: 1.0-2.8%) and that of subjects with suspected FDB 0.9% (95%<!--> <!-->CI 0.4-1.6%). The joint prevalence of FDL-DI was 23.5% (95%<!--> <!-->CI: 20.8-26.3%), also present in 1 in 3 subjects with ASCVD. Overall, 60.5% of participants with FDL-DI had high or very high CV risk and 4.6% of them were on target for LDL-C control.</div></div><div><h3>Conclusions</h3><div>The presence of familial dyslipidemia with dominant inheritance is the majority among the adult population living in Galicia with dyslipidemia, with FCH being the most prevalent of them. These subjects are underdiagnosed, are generally at high or very high cardiovascular risk, hardly receive lipid-lowering treatment (1 in 3) and the degree of LDL-C control according to guidelines is very poor.</div><div>.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500804"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importancia del riesgo cardiovascular y aterogénico en profesionales sanitarios","authors":"Johanna Vicuña","doi":"10.1016/j.arteri.2025.500890","DOIUrl":"10.1016/j.arteri.2025.500890","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 1","pages":"Article 500890"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145876926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilidad de la grasa corporal y visceral determinada por bioimpedanciometría frente al índice de masa corporal y el perímetro de cintura en la identificación de valores elevados de diferentes escalas de riesgo de aterogénesis","authors":"María Gordito Soler ,&nbsp;José Ignacio Ramírez-Manent ,&nbsp;Pedro Juan Tárraga López ,&nbsp;Emilio Martínez-Almoyna Rifá ,&nbsp;Hernán Paublini ,&nbsp;Ángel Arturo López González","doi":"10.1016/j.arteri.2025.500772","DOIUrl":"10.1016/j.arteri.2025.500772","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity and atherogenesis are two highly prevalent pathological processes worldwide that also share several pathophysiological mechanisms.</div></div><div><h3>Objectives</h3><div>Descriptive and cross-sectional study in 8,590 Spanish workers (4,104 men and 4,486 women) with an average age of 41.5<!--> <!-->years, in which the usefulness of four scales of overweight and obesity such as body mass index (BMI), waist circumference and percentages of body and visceral fat determined by bioimpedance measurement to identify high levels of atherogenic risk determined by atherogenic dyslipidemia (AD), lipid triad (LT) and several atherogenic indices is assessed.</div></div><div><h3>Results</h3><div>All the overweight and obesity scales show a predictive value between moderate and good, determined by the AUC of the ROC curves, with values ranging from 0.727 to 0.886 in women and 0.676 to 0.885 in men. Of all of them, the one with the highest AUC is visceral fat with values exceeding 0.800 and the lowest are for BMI. In all cases, the AUC is higher in women.</div></div><div><h3>Conclusions</h3><div>The overweight and obesity scales analysed (BMI, waist circumference and percentage of body and visceral fat) show AUCs for predicting atherogenic risk between moderate and high, with visceral fat being the most useful of all.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 6","pages":"Article 500772"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloproliferative neoplasms: A model of the journey from clonal hematopoiesis to cardiovascular disease and cancer","authors":"Santiago Redondo","doi":"10.1016/j.arteri.2025.500767","DOIUrl":"10.1016/j.arteri.2025.500767","url":null,"abstract":"<div><div>In the last decade, the coming of next-generation sequencing and its application to large human populations is breaking the barrier between inflammation and cancer. Indeed, acquired mutations in key genes that regulate hematopoiesis and thus confer a selective advantage in the proliferation of hematopoietic progenitors have established the concept of clonal hematopoiesis of indeterminate potential or CHIP. A growing body of clinical and experimental evidence is highlighting the link between CHIP and adverse outcomes, in particular atherosclerotic cardiovascular disease and cancer. The apparent surprise about how these two different entities share common mechanisms can be explained by myeloproliferation and inflammation. These mechanisms are involved not only in the development of myeloid tumors but also in atherogenesis. Myeloproliferative neoplasms or MPN are a type of myeloid tumors where thrombotic risk is increased not only by higher blood counts but also by means of an accelerated atherosclerosis. Therefore, myeloproliferative neoplasms are a model of the link between clonal hematopoiesis and atherosclerotic cardiovascular disease. The concept of CHIP has important clinical applications. A deeper understanding of these mechanisms may pave the way for the future early diagnosis and potential pre-emptive treatments of these two major causes of death.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 6","pages":"Article 500767"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of therapeutic inertia in lipid-lowering therapy in patients at very high cardiovascular risk","authors":"Juan Cosín Sales ,&nbsp;Carlos Escobar Cervantes ,&nbsp;José Javier Gómez-Barrado ,&nbsp;José Manuel Andreu Cayuelas ,&nbsp;Abel García del Egido ,&nbsp;Jorge Joaquín Castro Martín ,&nbsp;Ana Isabel Huelmos Rodrigo ,&nbsp;Miguel Corbi-Pascual ,&nbsp;Ariana Varela Cancelo ,&nbsp;Rafael Vidal-Pérez ,&nbsp;Leticia Fernandez-Friera ,&nbsp;Enrique Santas Olmeda ,&nbsp;Almudena Aguilera-Saborido ,&nbsp;Antonio Fernández Romero ,&nbsp;Antonio Sánchez Hidalgo ,&nbsp;Francisco Pérez-Sádaba ,&nbsp;Román Freixa-Pamias","doi":"10.1016/j.arteri.2025.500773","DOIUrl":"10.1016/j.arteri.2025.500773","url":null,"abstract":"<div><h3>Aims</h3><div>A high number of patients do not achieve the therapeutic goals set by clinical practice guidelines, despite the therapeutic alternatives that currently exist in lipid-lowering treatment (LLT). This study aimed to estimate the proportion of patients who have recently suffered an acute coronary syndrome (ACS) who do not meet the therapeutic goal with LLT and the proportion of routine follow-up visits where therapeutic inertia (TI) occurs.</div></div><div><h3>Methods</h3><div>A retrospective study chart review was conducted in 13 Spanish centres. Patients aged ≥18 years who suffered an ACS event in the last two years and had received LLT were included. Sociodemographic, clinical, treatment and participating centre/physician-related variables were collected. TI was considered when a visit did not result in a change in the patient's therapy despite the non-achievement of therapeutic goals. Descriptive analysis was performed, and factors associated with TI were evaluated using logistic regression.</div></div><div><h3>Results</h3><div>159 patients were included (mean age 63.08 years old, 80.5% male) and 338 follow-up visits were analysed. Over 50% of the patients did not meet the therapeutic target and TI was estimated in 39.13% of visits. Some factors were associated with a lower risk of TI: professional experience, number of vessels affected, and diabetes. And others with higher risk: being female, previous CV pathology and a complete revascularisation.</div></div><div><h3>Conclusion</h3><div>The management of patients after ACS is still suboptimal. The importance of clinical inertia in ACS remains a real awareness and active strategies will help mitigate this phenomenon due to the risk of recurrent ACS.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 6","pages":"Article 500773"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}