Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"LDL como objetivo terapéutico","authors":"Ángel Díaz Rodríguez ,&nbsp;Teresa Mantilla Morató","doi":"10.1016/j.arteri.2019.10.008","DOIUrl":"10.1016/j.arteri.2019.10.008","url":null,"abstract":"<div><p>The incidence of atherosclerotic cardiovsacular disease (ASCVC) has increased in the developed countries. Dyslipidemia is a primary major risk factor for ASCVD and LDL lowering is one of the main objectives. Although treatment goals for dyslipidemias should be personalized in every patient, statins are cost-effective in primary and secondary prevention of ASCVD. New treatments with higher power and greater decreases in LDL, PSCK9 inhibitors, have made a new breakthrough in ASCVD treatment. The 2019 Guidelines for de Management of Dyslipidaemias: Lipid Modification to reduce Cardiovascular Risk (European Society of Cardiology/European Atherosclerosis Society) with the level of evidence and the strength of the recommendations can facilitate the best decisions and benefits to our patients in clinical practice.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82481668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Índices aterogénicos: utilidad como predictores en enfermedad cardiovascular","authors":"Juan José Tamarit García","doi":"10.1016/j.arteri.2022.08.001","DOIUrl":"10.1016/j.arteri.2022.08.001","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Athrogenic indexes: Useful markers for predicting metabolic syndrome in axial spondyloarthritis","authors":"Maroua Slouma ,&nbsp;Khaoula Ben Ali ,&nbsp;Lobna Kharrat ,&nbsp;Chadia Zouaoui ,&nbsp;Haroun Ouertani ,&nbsp;Imen Gharsallah","doi":"10.1016/j.arteri.2022.03.005","DOIUrl":"10.1016/j.arteri.2022.03.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Metabolic syndrome is a pathological entity associated with a high risk of cardiovascular disease. Data regarding the frequency of this syndrome, lipid profile, and atherogenic index of plasma in patients with radiographic axial spondyloarthritis are scarce.</p><p>We aim to determine the prevalence of metabolic syndrome in patients with spondyloarthritis. We also aim to determine discriminative values of atherogenic indexes between patients with and without metabolic syndrome.</p></div><div><h3>Methods</h3><p><span>We conducted a cross-sectional study including 51 patients meeting the ASAS 2009 criteria for radiographic axial spondyloarthritis. We measured the following parameters: triglyceride (TG), high-density lipoproteins (HDL</span>_c), low-density lipoprotein cholesterol (LDL_c), and total cholesterol (TC). We calculated TC/HDL_c, TG/HDL_c, LDL_c/HDL_c ratios, and atherogenic index of plasma (LogTG/HDL_c).</p></div><div><h3>Results</h3><p>Metabolic syndrome was noted in 33% of cases. Patients with active disease had a higher body mass index (26.89<!--> <!-->±<!--> <!-->5.88 versus 23.63<!--> <!-->±<!--> <!-->4.47<!--> <!-->kg/m², <em>p</em> <!-->=<!--> <span>0.03), higher TG (1.41</span> <!-->±<!--> <!-->0.64 versus 0.89<!--> <!-->±<!--> <!-->0.5<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.05) and a lower HDL_c level (1<!--> <!-->±<!--> <!-->0.28 versus 1.31<!--> <!-->±<!--> <!-->0.22<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.01). However, the LogTG/HDL_c and TG/HDL_c were higher in patients under TNFα inhibitors. The ability of the TG/HDL_c ratio and LogTG/HDL_c to distinguish patients with or without metabolic syndrome were good at cut-offs of 1.33 and 0.22, respectively (specificity: 91.2% and sensitivity 70.6% for both ratios).</p></div><div><h3>Conclusion</h3><p>Our study showed that metabolic syndrome is frequent in patients with axial spondyloarthritis. Atherogenic indexes can be used for predicting metabolic syndrome in these patients.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75593536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Es necesario realizar un screening cardiovascular en los pacientes migrantes?","authors":"Ricardo Roa-Chamorro ,&nbsp;Pablo González-Bustos ,&nbsp;Lucía Torres-Quintero","doi":"10.1016/j.arteri.2022.06.003","DOIUrl":"10.1016/j.arteri.2022.06.003","url":null,"abstract":"<div><p>Migrant patients arriving in Spain often come from countries where there is no universal access to healthcare. Although the prevalence of arterial hypertension (HTN) is lower in West Africa than in Spain, there is a higher prevalence of masked HT due to the absence of health screening. Furthermore, patients with secondary hypertension may not be diagnosed. We present the case of a 36-year-old Senegalese man, with no known pathological history, resident for a year in Spain, who debuted with a hypertensive emergency. At the time of diagnosis, the patient had severe end-organ damage (hypertensive heart disease, hypertensive retinopathy). After the study, he was diagnosed with arterial hypertension secondary to malformation of the renal artery. After performing angioplasty, blood pressure normalized and, at 18 months, target organ damage had reduced. Migrants who arrive in our country must be incorporated into health screening systems to diagnose and treat possible unknown pathologies. In our case, the clue to secondary hypertension was the development of resistant hypertension with target organ damage in a young subject.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40509371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalencia de prediabetes y asociación con factores cardiometabólicos y renales. Estudio SIMETAP-PRED","authors":"Ezequiel Arranz-Martínez ,&nbsp;Antonio Ruiz-García ,&nbsp;Juan Carlos García Álvarez ,&nbsp;Teresa Fernández Vicente ,&nbsp;Nerea Iturmendi Martínez ,&nbsp;Montserrat Rivera-Teijido ,&nbsp;en representación del Grupo de Investigación del Estudio SIMETAP","doi":"10.1016/j.arteri.2021.12.002","DOIUrl":"10.1016/j.arteri.2021.12.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Prediabetes is a major public health problem. The aims of the SIMETAP-PRED study were to determine the prevalence rates of prediabetes according to two diagnostic criteria, and to compare the association of cardiometabolic and renal risk factors between populations with and without prediabetes.</p></div><div><h3>Methods</h3><p>Cross-sectional observational study conducted in Primary Care. Based random sample: 6,588 study subjects (response rate: 66%). Two diagnostic criteria for prediabetes were used: 1) prediabetes according to the Spanish Diabetes Society (PRED-SDS): Fasting plasma glucose (FPG) 110–125<!--> <!-->mg/dL or HbA1c 6.0% –6.4%; 2) prediabetes according to the American Diabetes Association (PRED-ADA): FPG 100–125<!--> <!-->mg/dL or HbA1c 5.7%–6.4%. The crude and sex- and age-adjusted prevalence rates, and cardiometabolic and renal variables associated with prediabetes were assessed.</p></div><div><h3>Results</h3><p>The crude prevalence rates of PRED-SDS and PRED-ADA were 7.9% (95% <span>C</span>I 7.3–8.6%), and 22.0% (95% CI 21.0–23.0%) respectively, their age-adjusted prevalence rates were 6.6% and 19.1 respectively. The high or very high cardiovascular risk of the PRED-SDS or PRED-ADA populations were 68.6% (95%CI 64.5–72.6%) and 61.7% (95%CI 59.1–64.1%) respectively. Hypertension, hypertriglyceridemia, overweight, obesity, and increased waist-to-height ratio were independently associated with PRED-SDS. In addition to these factors, low glomerular filtration rate and hypercholesterolemia were also independently associated with PRED-ADA.</p></div><div><h3>Conclusions</h3><p>The prevalence of PRED-ADA triples that of PRED-SDS. Two thirds of the population with prediabetes had a high cardiovascular risk. Several cardiometabolic and renal risk factors were associated with prediabetes. Compared to the SDS criteria, the ADA criteria make the diagnosis of prediabetes easier.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39890291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La microbiota intestinal: una herramienta indispensable en la lucha contra la enfermedad cardiovascular","authors":"Isabel Moreno-Indias","doi":"10.1016/j.arteri.2022.07.001","DOIUrl":"10.1016/j.arteri.2022.07.001","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40575859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comentario del CEIPV a las nuevas Guías Europeas de Prevención Cardiovascular 2021","authors":"Carlos Brotons ,&nbsp;Miguel Camafort ,&nbsp;María del Mar Castellanos ,&nbsp;Albert Clarà ,&nbsp;Olga Cortés ,&nbsp;Angel Diaz Rodriguez ,&nbsp;Roberto Elosua ,&nbsp;Manuel Gorostidi ,&nbsp;Antonio M. Hernández ,&nbsp;María Herranz ,&nbsp;Soledad Justo ,&nbsp;Carlos Lahoz ,&nbsp;Pilar Niño ,&nbsp;Vicente Pallarés-Carratalá ,&nbsp;Juan Pedro-Botet ,&nbsp;Antonio Pérez Pérez ,&nbsp;Miguel Angel Royo-Bordonada ,&nbsp;Rafael Santamaria ,&nbsp;Ricard Tresserras ,&nbsp;Alberto Zamora ,&nbsp;Pedro Armario","doi":"10.1016/j.arteri.2022.03.003","DOIUrl":"10.1016/j.arteri.2022.03.003","url":null,"abstract":"<div><p>We present the Spanish adaptation of the 2021 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice. The current guidelines besides the individual approach greatly emphasize on the importance of population level approaches to the prevention of cardiovascular diseases. Systematic global cardiovascular disease risk assessment is recommended in individuals with any major vascular risk factor. Regarding LDL-cholesterol, blood pressure, and glycemic control in patients with diabetes mellitus, goals and targets remain as recommended in previous guidelines. However, it is proposed a new, stepwise approach (steps 1 and 2) to treatment intensification as a tool to help physicians and patients pursue these targets in a way that fits patient profile. After step 1, considering proceeding to the intensified goals of step 2 is mandatory, and this intensification will be based on 10-year cardiovascular disease risk, lifetime cardiovascular disease risk and treatment benefit, comorbidities and patient preferences.</p><p>The updated SCORE algorithm ?SCORE2, SCORE2-OP? is recommended in these guidelines, which estimates an individual's 10-year risk of fatal and non-fatal cardiovascular disease events (myocardial infarction, stroke) in healthy men and women aged 40-89 years. Another new and important recommendation is the use of different categories of risk according to different age groups (&lt;<!--> <!-->50, 50-69, ≥<!--> <!-->70 years).</p><p>Different flow charts of cardiovascular disease risk and risk factor treatment in apparently healthy persons, in patients with established atherosclerotic cardiovascular disease, and in diabetic patients are recommended. Patients with chronic kidney disease are considered high risk or very high-risk patients according to the levels of glomerular filtration rate and albumin-to-creatinine ratio. New lifestyle recommendations adapted to the ones published by the Spanish Ministry of Health as well as recommendations focused on the management of lipids, blood pressure, diabetes and chronic renal failure are included.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40575861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relación entre la cuantificación de calcio coronario y la composición de la microbiota intestinal en sujetos sin enfermedad cardiovascular previa: estudio piloto","authors":"Isabel Ortega-Madueño ,&nbsp;Javier Modrego ,&nbsp;Rubén Gómez-Gordo ,&nbsp;Adriana Ortega-Hernández ,&nbsp;Leopoldo Pérez de Isla ,&nbsp;Juan Carlos Muñoz ,&nbsp;M. Luisa Nieto ,&nbsp;Dulcenombre Gómez-Garre","doi":"10.1016/j.arteri.2021.11.008","DOIUrl":"10.1016/j.arteri.2021.11.008","url":null,"abstract":"<div><h3>Aim</h3><p>To investigate the relationship between gut microbiota composition and the presence of coronary atherosclerosis assessed by coronary artery calcium (CAC) quantification in individuals without previous cardiovascular disease (CVD).</p></div><div><h3>Methods</h3><p>We included 20 patients over 18 years of age with no history of CVD who underwent multiple detector-computed tomography. From each patient, a stool sample was obtained to characterize gut microbiota composition by sequencing bacterial 16S ribosomal RNA gene. In addition, circulating levels of TNF-α and IL-1β, as well as trimethylamine N-oxide (TMAO) were determined in plasma samples by automated ELISA and capillary gas chromatography-mass spectrometry, respectively.</p></div><div><h3>Results</h3><p>The mean age of patients was 63.5 years and 60% were women. Half of patients had CAC &gt;100 (Agatston score), and were characterized by a higher abundance of the phylum <em>Proteobacteria</em>, mainly of bacteria belonging to the families <em>Enterobacteriaceae</em> and than patients with a CAC ≤ 100. Moreover, bacterial genera identified as biomarkers, such as <em>Enterobacter, Escherichia/Shigella</em> y <em>Klebsiella,</em> were positively associated with inflammation levels and with TMAO production.</p></div><div><h3>Conclusion</h3><p>Our data <strong>s</strong>hows a gut microbiota profile associated with the presence of coronary calcium in patients without previous CVD. Although there are no strategies to decrease the amount of coronary calcium, gut microbiota is highly malleable by several factors. The possibility of preventing and even intervening CVD progression through strategies targeted gut microbiota is a very attractive idea that deserves further studies.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0214916821001662/pdfft?md5=bab44869e4fa9a53da2dde3f4f24a626&pid=1-s2.0-S0214916821001662-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39596111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El receptor nuclear NOR-1 (Neuron-derived Orphan Receptor-1) en el remodelado vascular patológico","authors":"Carme Ballester-Servera ,&nbsp;Laia Cañes ,&nbsp;Judith Alonso ,&nbsp;Lidia Puertas ,&nbsp;Manel Taurón ,&nbsp;Cristina Rodríguez ,&nbsp;José Martínez-González","doi":"10.1016/j.arteri.2022.03.002","DOIUrl":"10.1016/j.arteri.2022.03.002","url":null,"abstract":"<div><p>Vascular cells and their interaction with inflammatory cells and the immune system play a key role in pathological vascular remodeling. A large number of genes and proteins regulated in a coordinated manner by a small number of transcription factors are involved in this process. In recent years, research on a small subfamily of transcription factors, the NR4A subfamily, has had a major impact on our understanding of vascular biology. The NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (NOR-1) receptors are products of early response genes whose expression is induced by multiple pathophysiological and physical stimuli. Their wide distribution in different tissues and cells places them in the control of numerous processes such as cell differentiation, proliferation, survival and apoptosis, as well as inflammation and the metabolism of lipids and carbohydrates. This review analyzes the role of these receptors, particularly NOR-1, in pathological vascular remodeling associated with atherosclerosis, abdominal aortic aneurysm and pulmonary arterial hypertension.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54194733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid intima-media thickness predicted the presence but not the severity or complexity of coronary artery disease in a South Asian population","authors":"Bhupendra Verma ,&nbsp;Deepak Katyal","doi":"10.1016/j.arteri.2021.12.001","DOIUrl":"10.1016/j.arteri.2021.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Carotid intima-media thickness (CIMT) is considered a marker of atherosclerosis<span>, but the data is lacking from the South Asian population. We aimed to study the relation of CIMT with the presence and severity of coronary artery disease (CAD) in this population.</span></p></div><div><h3>Methods</h3><p><span><span>This was a prospective, single-center study of consecutive patients undergoing elective coronary angiography. Participants with &gt;50% luminal stenosis in any major </span>coronary artery were included in the CAD group and those with normal coronaries in the non-CAD group. Multivariate </span>linear regression analysis<span> was done to determine independent predictors of CAD. Pearson's correlation coefficients assessed correlations between CIMT and Syntax and Gensini score.</span></p></div><div><h3>Results</h3><p>The mean CIMT was significantly much higher in the CAD group when compared to the non-CAD group (0.83<!--> <!-->±<!--> <!-->0.16 vs 0.61<!--> <!-->±<!--> <!-->0.14<!--> <!-->mm, <em>p</em> <!-->&lt;<!--> <!-->0.001). On multivariable linear regression analysis only diabetes (<em>β</em> <!-->=<!--> <!-->0.208 and <em>p</em> <!-->=<!--> <!-->0.024), waist–hip ratio (<em>β</em> <!-->=<!--> <!-->0.178 and <em>p</em> <!-->=<!--> <!-->0.043), current smoker (<em>β</em> <!-->=<!--> <!-->0.293 and <em>p</em> <!-->=<!--> <!-->&lt;0.001) and CIMT (<em>β</em> <!-->=<!--> <!-->0.217 and <em>p</em> <!-->=<!--> <!-->0.031) were independent predictors of CAD. The mean Gensini score in the CAD group was 48.59<!--> <!-->±<!--> <!-->34.25 and the mean Syntax score was 19.45<!--> <!-->±<!--> <!-->10.24. No significant relation was found between CIMT and Gensini score (<em>r</em> <!-->=<!--> <!-->0.009 and <em>p</em> <!-->=<!--> <!-->0.89), and Syntax score (<em>r</em> <!-->=<!--> <!-->−0.087 and <em>p</em> <!-->=<!--> <!-->0.171).</p></div><div><h3>Conclusion</h3><p>Mean CIMT is an independent predictor of CAD along with diabetes, waist–hip ratio, and smoking. However, CIMT was not related to the severity and complexity of the CAD as assessed by the Gensini score and Syntax score, respectively.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39783968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}