Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Exploring the link between fibrates therapy and diabetes mellitus following primary acute pancreatitis with hypertriglyceridemia.","authors":"Jiali Xu, Nana Deng, Zhouyue Zhang, Mingming Deng, Gang Luo","doi":"10.1016/j.arteri.2025.500800","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500800","url":null,"abstract":"<p><strong>Objective: </strong>Post-acute pancreatitis diabetes mellitus (PPDM-A) is a type of diabetes linked to pancreatic exocrine dysfunction, which increases the risk of pancreatic cancer and mortality. Hyperlipidemia, or high blood lipid levels, is the third leading cause of acute pancreatitis (AP) and is associated with a higher diabetes risk. However, the link between lipid-lowering treatments and PPDM-A is unclear. This study aims to explore this relationship.</p><p><strong>Methods: </strong>A cohort of 223 patients diagnosed with AP and hyperlipidemia was categorized into PPDM-A and non-PPDM-A groups. Binary logistic regression was utilized to analyze the correlation between fibrate therapy and PPDM-A incidence. Mendelian randomization (MR) was used to determine whether there was a causal relationship between triglyceride levels and diabetes.</p><p><strong>Results: </strong>Elevated blood glucose levels (GLU) (OR=1.360, p<0.001), female (OR=0.091, p=0.030), severity of AP [moderately severe AP (MASP) (OR=5.585, p=0.019)], recurrent acute pancreatitis (RAP) (OR=6.399, p=0.007), and fibrate use (OR=0.109, p=0.001) emerged as independent influencing factors of PPDM-A. MR evidence suggests a causal relationship between triglyceride levels and diabetes risk (OR=1.088, p<0.001), with a two-step MR showing that pancreatitis partially mediates this effect with a mediated proportion of 1.55% (p=0.048).</p><p><strong>Conclusion: </strong>Fibrates demonstrate the potential to lower the risk of PPDM-A among individuals with AP and hypertriglyceridemia. Furthermore, the effect of triglyceride levels on diabetes risk was partly mediated by pancreatitis.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500800"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of lipoprotein (a) determination in a selection of Spanish Clinical Laboratories. Batary study.","authors":"Teresa Arrobas Velilla, Salomon Martin Perez, Carla Fernández Prendes, Maria Jose Castro Castro, Silvia Camos Anguila, Antonio Leon Justel","doi":"10.1016/j.arteri.2025.500798","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500798","url":null,"abstract":"<p><strong>Introduction: </strong>Lipoprotein a is considered an independent factor of atherosclerotic cardiovascular disease with high prevalence, but the availability of real and updated data in Spain as well as determination protocols are limited.</p><p><strong>Main objective: </strong>Analyze the current state of the pre-analytical, analytical and post-analytical process of Lp (a) and assess the relationship with other variables.</p><p><strong>Material and method: </strong>Retrospective, observational, multicenter, anonymized study carried out in 2022 by survey of clinical laboratories.</p><p><strong>Results: </strong>21,926 determinations were obtained corresponding to 49 Laboratories. The values obtained were: Lp(a)>30mg/dl=46.87%, Lp(a)>50mg/dl 35.31%, Lp(a)>70mg/dl=26.8% Lp(a)>90mg/dl=19.3% with predominance of superiority in female gender in all established cut-off points. Almost 30% of primary care doctors do not have access to their application. 56.9% do not have a rejection criterion. 70.6% do not have protocols for its determination. There are two predominant analytical techniques, Immunophelometry (40%) and immunoturbidimetry (60%), 24% use nmon/L, 68% mg/dL and 8% report both.</p><p><strong>Conclusions: </strong>There is a low number of patients who have Lp(a) measured and of them the percentage of patients according to risk cut-off points are higher than those described. There is a lack of uniformity in pre-analytical, analytical and post-analytical processes in which it is necessary to work in a multidisciplinary manner to avoid future cardiovascular events.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500798"},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of therapeutic inertia in lipid-lowering therapy in patients at very high cardiovascular risk.","authors":"Juan Cosín Sales, Carlos Escobar Cervantes, José Javier Gómez-Barrado, José Manuel Andreu Cayuelas, Abel García Del Egido, Jorge Joaquín Castro Martín, Ana Isabel Huelmos Rodrigo, Miguel Corbi-Pascual, Ariana Varela Cancelo, Rafael Vidal-Pérez, Leticia Fernandez-Friera, Enrique Santas Olmeda, Almudena Aguilera-Saborido, Antonio Fernández Romero, Antonio Sánchez Hidalgo, Francisco Pérez-Sádaba, Román Freixa-Pamias","doi":"10.1016/j.arteri.2025.500773","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500773","url":null,"abstract":"<p><strong>Aims: </strong>A high number of patients do not achieve the therapeutic goals set by clinical practice guidelines, despite the therapeutic alternatives that currently exist in lipid-lowering treatment (LLT). This study aimed to estimate the proportion of patients who have recently suffered an acute coronary syndrome (ACS) who do not meet the therapeutic goal with LLT and the proportion of routine follow-up visits where therapeutic inertia (TI) occurs.</p><p><strong>Methods: </strong>A retrospective study chart review was conducted in 13 Spanish centres. Patients aged ≥18 years who suffered an ACS event in the last two years and had received LLT were included. Sociodemographic, clinical, treatment and participating centre/physician-related variables were collected. TI was considered when a visit did not result in a change in the patient's therapy despite the non-achievement of therapeutic goals. Descriptive analysis was performed, and factors associated with TI were evaluated using logistic regression.</p><p><strong>Results: </strong>159 patients were included (mean age 63.08 years old, 80.5% male) and 338 follow-up visits were analysed. Over 50% of the patients did not meet the therapeutic target and TI was estimated in 39.13% of visits. Some factors were associated with a lower risk of TI: professional experience, number of vessels affected, and diabetes. And others with higher risk: being female, previous CV pathology and a complete revascularisation.</p><p><strong>Conclusion: </strong>The management of patients after ACS is still suboptimal. The importance of clinical inertia in ACS remains a real awareness and active strategies will help mitigate this phenomenon due to the risk of recurrent ACS.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500773"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of body and visceral fat determined by bioimpedancemetry versus body mass index and waist circumference in the identification of elevated values of different atherogenesis risk scales.","authors":"María Gordito Soler, José Ignacio Ramírez-Manent, Pedro Juan Tárraga López, Emilio Martínez-Almoyna Rifá, Hernán Paublini, Ángel Arturo López González","doi":"10.1016/j.arteri.2025.500772","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500772","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity and atherogenesis are two highly prevalent pathological processes worldwide that also share several pathophysiological mechanisms.</p><p><strong>Objectives: </strong>Descriptive and cross-sectional study in 8,590 Spanish workers (4,104 men and 4,486 women) with an average age of 41.5years, in which the usefulness of four scales of overweight and obesity such as body mass index (BMI), waist circumference and percentages of body and visceral fat determined by bioimpedance measurement to identify high levels of atherogenic risk determined by atherogenic dyslipidemia (AD), lipid triad (LT) and several atherogenic indices is assessed.</p><p><strong>Results: </strong>All the overweight and obesity scales show a predictive value between moderate and good, determined by the AUC of the ROC curves, with values ranging from 0.727 to 0.886 in women and 0.676 to 0.885 in men. Of all of them, the one with the highest AUC is visceral fat with values exceeding 0.800 and the lowest are for BMI. In all cases, the AUC is higher in women.</p><p><strong>Conclusions: </strong>The overweight and obesity scales analysed (BMI, waist circumference and percentage of body and visceral fat) show AUCs for predicting atherogenic risk between moderate and high, with visceral fat being the most useful of all.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500772"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 inhibitors tug of war: Compliance, adverse events and LDL-cholesterol target","authors":"Francesco Sbrana,&nbsp;Beatrice Dal Pino","doi":"10.1016/j.arteri.2025.500771","DOIUrl":"10.1016/j.arteri.2025.500771","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 500771"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sICAM-1 concentrations are associated with inflammation in contralateral carotid plaque in patients with ischemic stroke","authors":"Núria Puig ,&nbsp;Pol Camps-Renom ,&nbsp;Eduardo Garcia ,&nbsp;Aleyda Benítez-Amaro ,&nbsp;Ana Aguilera-Simón ,&nbsp;Alejandro Fernández-León ,&nbsp;Jose Luis Sanchez Quesada ,&nbsp;Vicenta Llorente-Cortés ,&nbsp;Sonia Benitez","doi":"10.1016/j.arteri.2024.07.002","DOIUrl":"10.1016/j.arteri.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerotic plaques in the internal carotid artery are responsible for more than 15% of ischemic strokes. Carotid ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) detects plaque inflammation. Plasma ICAM-1 and LRP1 concentrations have been associated with inflammation in ipsilateral carotid plaque. The aim of the present study was to test the association between the soluble (s) form of these biomarkers and contralateral carotid plaques.</div></div><div><h3>Methods</h3><div>Prospective study conducted in 53 patients with a recent ischemic stroke and at least one atherosclerotic plaque in both carotid arteries. All of the patients underwent an early carotid ¹⁸F-FDG PET, and a blood sample was obtained at 7<!--> <!-->±<!--> <!-->1 days. Several plasma inflammatory markers were evaluated by Multiplex and sLRP1 levels were measured by commercial ELISA. Bivariate and multivariable linear regression was used to assess the association between inflammatory markers and the clinical variables, including contralateral maximum standardized uptake value (SUVmax) and mean SUVmax (mean of contralateral and ipsilateral SUVmax) of ¹⁸F-FDG uptake. Hazard ratio (HR) was estimated with Cox models adjusted for potential confounding factors to evaluate recurrence.</div></div><div><h3>Results</h3><div>Multivariable linear regression analysis showed an independent association between sICAM-1 and sVCAM-1 and mean SUVmax (CI<!--> <!-->=<!--> <!-->−0.064–0.325, <em>p</em> <!-->=<!--> <!-->0.004; CI<!--> <!-->=<!--> <!-->0.079–0.554, <em>p</em> <!-->=<!--> <!-->0.010). In addition, in bivariate regression analysis, sICAM-1 was associated with contralateral SUVmax (CI<!--> <!-->=<!--> <!-->0.049–0.382, <em>p</em> <!-->=<!--> <!-->0.012). Cox regression showed that mean SUVmax was associated with stroke recurrence (HR<!--> <!-->=<!--> <!-->5.604, <em>p</em> <!-->=<!--> <!-->0.044).</div></div><div><h3>Conclusions</h3><div>sICAM-1 was independently associated with mean carotid plaque inflammation and with inflammation in contralateral plaque. sICAM-1 could be an indicator of plaque inflammation even in asymptomatic plaques.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 100729"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in atherosclerosis: Current and forthcoming impact.","authors":"José A. Páramo ,&nbsp;Ana Cenarro ,&nbsp;Fernando Civeira ,&nbsp;Carmen Roncal","doi":"10.1016/j.arteri.2024.03.006","DOIUrl":"10.1016/j.arteri.2024.03.006","url":null,"abstract":"<div><div>Atherosclerosis is the main pathogenic substrate for cardiovascular diseases (CVDs). Initially categorized as a passive cholesterol storage disease, nowadays, it is considered an active process, identifying inflammation among the key players for its initiation and progression. Despite these advances, patients with CVDs are still at high risk of thrombotic events and death, urging to deepen into the molecular mechanisms underlying atherogenesis, and to identify novel diagnosis and prognosis biomarkers for their stratification. In this context, extracellular vesicles (EVs) have been postulated as an alternative in search of novel biomarkers in atherosclerotic diseases, as well as to investigate the crosstalk between the cells participating in the processes leading to arterial remodelling. EVs are nanosized lipidic particles released by most cell types in physiological and pathological conditions, that enclose lipids, proteins, and nucleic acids from parental cells reflecting their activation status. First considered cellular waste disposal systems, at present, EVs have been recognized as active effectors in a myriad of cellular processes, and as potential diagnosis and prognosis biomarkers also in CVDs. This review summarizes the role of EVs as potential biomarkers of CVDs, and their involvement into the processes leading to atherosclerosis.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 100718"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo poligénico y aterosclerosis subclínica en individuos asintomáticos de mediana edad. Estudio ILERVAS","authors":"Emilio Ortega ,&nbsp;Amanda Jiménez ,&nbsp;Sheila López-Ruiz ,&nbsp;Eva Castro-Boqué ,&nbsp;José Manuel Valdivielso ,&nbsp;Marcelino Bermúdez-López ,&nbsp;Gemma Chiva-Blanch","doi":"10.1016/j.arteri.2024.11.004","DOIUrl":"10.1016/j.arteri.2024.11.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>More than 50% of first cardiovascular events (CVE) occur in populations identified as at low or intermediate risk by the risk equations, so the inclusion of additional variables, such as polygenic risk scores (PRS), has been proposed to improve the predictive capacity of these equations. The aim of this study was to assess whether a PRS, independently or with clinical risk equations, is associated with the presence, severity and extent of subclinical atherosclerosis.</div></div><div><h3>Methods</h3><div>109 subjects with atherosclerosis were selected from the ILERVAS cohort (primary prevention) and matched with 109 participants without atherosclerosis of the same age, sex and SCORE2 risk level. Atherosclerosis was assessed and quantified by arterial wall vascular ultrasound in 12 territories, and PRS was estimated using the Cardio inCode Score®. The predictive capacity of the presence of subclinical atherosclerosis was estimated, as well as the association between the extent and severity of atherosclerosis with PRS and clinical risk (SCORE2).</div></div><div><h3>Results</h3><div>PRS was similar between participants with or without atherosclerosis <em>(P</em> <!-->=<!--> <!-->0.525). We did not find an association between PRS and SCORE2 (r<!--> <!-->=<!--> <!-->-0.29, <em>P</em> <!-->=<!--> <!-->0.709), and the addition of PRS to SCORE2 did not improve the prediction of atherosclerosis [AUC (95% CI)<!--> <!-->=<!--> <!-->0.566 (0.477, 0.654), <em>P</em> <!-->=<!--> <!-->0.148]. The extent of atherosclerosis was related to SCORE2 (<em>P</em> <!-->=<!--> <!-->0.009), but not to PRS (<em>P</em> <!-->=<!--> <!-->0.709).</div></div><div><h3>Conclusions</h3><div>The Selected PRS is not associated with the presence of atherosclerosis or clinical risk, suggesting that its additional contribution to CVE risk would be mediated by mechanisms independent of the development of atherosclerosis. Additional biomarkers are needed to improve the prediction of subclinical atherosclerosis without using imaging tests as a first step in personalized assessment.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 100751"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Los niveles plasmáticos elevados de TNF-R1 predicen el desarrollo de eventos isquémicos agudos en pacientes coronarios con diabetes","authors":"Sebastián Mas-Fontao ,&nbsp;Nieves Tarín ,&nbsp;Carmen Cristóbal ,&nbsp;Manuel Soto-Catalán ,&nbsp;Ana Pello ,&nbsp;Alvaro Aceña ,&nbsp;Jairo Lumpuy-Castillo ,&nbsp;Carmen Garces ,&nbsp;Carmen Gomez-Guerrero ,&nbsp;Carlos Gutiérrez-Landaluce ,&nbsp;Luis M. Blanco-Colio ,&nbsp;José Luis Martín-Ventura ,&nbsp;Ana Huelmos ,&nbsp;Joaquín Alonso ,&nbsp;Lorenzo López Bescós ,&nbsp;Juan A. Moreno ,&nbsp;Ignacio Mahíllo-Fernández ,&nbsp;Óscar Lorenzo ,&nbsp;María Luisa González-Casaus ,&nbsp;Jesús Egido ,&nbsp;José Tuñón","doi":"10.1016/j.arteri.2024.08.004","DOIUrl":"10.1016/j.arteri.2024.08.004","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the relationship between inflammatory biomarkers and the occurrence of cardiovascular events in patients with type 2 diabetes mellitus (DM2) and stable coronary artery disease.</div></div><div><h3>Methods</h3><div>A total of 964 patients with stable coronary artery disease were included. Plasma levels of inflammatory markers, including tumour necrosis factor receptors 1 and 2 (TNF-R1 and TNF-R2), growth differentiation factor-15 (GDF-15), soluble suppression of tumorigenicity 2 (sST2), and high-sensitivity C-reactive protein (hsCRP) were measured. The primary endpoint was the development of acute ischaemic events (any type of acute coronary syndrome, stroke, or transient ischaemic attack).</div></div><div><h3>Results</h3><div>There were 232 diabetic patients and 732 non-diabetic patients. Patients with coronary artery disease and DM2 (232, 24%) had higher levels of TNF-R1, TNF-R2, GDF-15, sST2 (<em>P</em>&lt;.001), and hsCRP compared to patients without DM2, indicating a higher inflammatory state. After a median follow-up of 5.39 (2.81-6.92) years, patients with DM2 more frequently developed the primary endpoint (15.9% vs 10.8%; <em>P</em>=.035). Plasma levels of TNF-R1 were independent predictors of the primary endpoint in patients with DM2, along with male gender, triglyceride levels, and the absence of treatment with angiotensin-converting enzyme inhibitors. None of these inflammatory markers predicted the development of this event in non-diabetic patients.</div></div><div><h3>Conclusions</h3><div>Patients with stable coronary artery disease and DM2 exhibit elevated levels of the proinflammatory markers TNF-R1, TNF-R2, GDF-15, and sST2. Moreover, TNF-R1 is an independent predictor of acute ischaemic events only in diabetic patients.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 100735"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hábitos nutricionales en los pacientes con enfermedad arterial periférica: adherencia a la dieta mediterránea","authors":"Elena Vilalta Doñate ,&nbsp;Francisca García Fernández ,&nbsp;Salvador Martínez Meléndez ,&nbsp;Consuelo Castillo Castillo ,&nbsp;Pablo Salas Medina ,&nbsp;Isabel Almodóvar Fernández","doi":"10.1016/j.arteri.2024.06.002","DOIUrl":"10.1016/j.arteri.2024.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Adherence to the Mediterranean diet (Dietmed) exerts protective effects on cardiovascular disease (CVD). In the Lower Extremity Peripheral Arterial Disease (PAD) there are fewer studies that analyze these data.</div></div><div><h3>Objective</h3><div>To determine adherence to Dietmed and dietary habits in patients with PAD, according to a history of CVD (coronary and/or cerebral ischaemic pathology) and according to the ankle-brachial index (ABI ≥ or &lt;0,5).</div></div><div><h3>Material and methods</h3><div>Cross-sectional analytical study carried out in a tertiary hospital. The sample was collected consecutively. Sociodemographic and clinical history, ankle-brachial index (ABI) and a 14-point Dietmed adherence dietary questionnaire were included. The analysis of categorical variables was carried out using the Pearson's Chi-Square test, the T-Student's statistic test for independent samples was used for parametric variables and the U. Mann-Whitney test for non-parametric variables.</div></div><div><h3>Results</h3><div>Of the 97 patients, 87,6% had low adherence to Dietmed, with no differences according to the severity of PAD. However, when we analysed the data according to whether or not they had a history of CVD, we observed a high adherence to some items included in Dietmed, specifically, in the CVD group, the consumption of lean meat (95,5% vs 64%; <em>P</em>=.004). In addition, we observed a significant difference in the consumption in the group without a history of CVD (32% vs 9,1%; <em>P</em>=.033).</div></div><div><h3>Conclusion</h3><div>In our population, patients with PAD, regardless of the stage of the disease and whether they had associated coronary or cerebral ischaemic pathology, had low adherence to Dietmed. Therefore, it is important to implement nutritional education programmes in patients with PAD in all stages, as well as in those patients who have already suffered a vascular event, so that they maintain adherence to healthy dietary habits in the long term.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 2","pages":"Article 100726"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141628054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}