Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Differential regulation of the HIF-1α/apoptosis axis by miR-126-5p in cardiac cells during ischemia/reperfusion injury.","authors":"Lisaidy Ramos-Regalado, Leonie Schoch, Sebastià Alcover, Marta Magaldi, Ignacio Barriuso, Teresa Padró, María Borrell, Lina Badimon, Carlos Zaragoza, Gemma Vilahur","doi":"10.1016/j.arteri.2025.500842","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500842","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRs) regulate gene expression post-transcriptionally and are transported by high-density lipoproteins (HDL). Hypercholesterolemic HDL particles are enriched with miR-126-3p/5p, which can be delivered to endothelial cells, leading to the downregulation of hypoxia-inducible-factor-1α (HIF-1α), a key transcription factor involved in metabolic responses to hypoxia and cell survival during myocardial ischemia/reperfusion (I/R).</p><p><strong>Objective: </strong>To investigate the effects of miR-126 mimic and inhibitor transfection on the HIF-1α/apoptosis axis in cardiac cell constituents under experimental I/R.</p><p><strong>Methods: </strong>Firstly, specific durations of I/R were established for cardiac cells (cardiomyocytes, fibroblasts, endothelial cells, and macrophages) based on their susceptibility to metabolic changes and cell death. Then, we assessed the impact of transfecting these cells with mimic-miR-126-5p and anti-miR-126-5p to the selected timings of I/R on the HIF-1α/apoptosis axis.</p><p><strong>Results: </strong>Endothelial cells were resistant to I/R and fibroblasts were sensitive to ischemia whereas cardiomyocytes displayed high metabolic flexibility. Endogenous miR-126 expression was exclusively found in endothelial cells. Transfection with anti-miR-126 increased HIF-1α transcription in endothelial cells and cardiomyocytes, while reducing HIF-1α levels in fibroblasts, resulted in decreased transcript levels of apoptotic markers. HIF-1α transcript levels remained unchanged in macrophages and transfection with mimic-miR-126 exerted no changes in the HIF-1α/apoptosis axis in all tested cells.</p><p><strong>Conclusions: </strong>miR-126 differentially regulates HIF-1α/apoptosis expression in cardiac cells exposed to experimental I/R and may serve as a potential therapeutic target for enhancing myocardial resilience in the setting of myocardial infarction.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500842"},"PeriodicalIF":1.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neutrophil percentage-to-albumin ratio (NPAR) and long-term mortality in community-dwelling adults with chest pain: Evidence from US NHANES 2001-2018.","authors":"Qiyun Long, Zejiang Liu, Qin Guo, Xuhui Song, Yongcan Guo","doi":"10.1016/j.arteri.2025.500843","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500843","url":null,"abstract":"<p><strong>Objective: </strong>The neutrophil percentage-to-albumin ratio (NPAR) is a readily available biomarker with prognostic significance across various disease conditions. However, its role in predicting mortality among community patients with chest pain remains underexplored. This study examined NPAR's association with long-term mortality in adults with chest pain using NHANES 2001-2018 data.</p><p><strong>Methods: </strong>We analyzed data from 6846 community-dwelling adults reporting chest pain. Cox proportional hazards regression models, restricted cubic spline (RCS) analysis, and Kaplan-Meier survival curves were employed to evaluate the relationship between NPAR and the risk of all-cause and cardiovascular mortality. Models were adjusted for demographic, clinical, and laboratory covariates.</p><p><strong>Results: </strong>Participants were categorized into tertiles based on NPAR values: T1 (<13.0), T2 (13.0-15.0), and T3 (>15.0). Multivariable analysis revealed that the T3 cohort demonstrated significantly increased risks of all-cause mortality (HR 1.56, 95% CI 1.32-1.84, P<0.001) and cardiovascular mortality (HR 1.86, 95% CI 1.37-2.51, P<0.001) relative to T1. RCS analysis identified a J-shaped relationship between NPAR and mortality risk, with a significant inflection point at NPAR >13.5 (P for non-linearity <0.001). Incremental analysis showed that each unit increase in NPAR was associated with an 11% higher risk of all-cause mortality (HR 1.11, 95% CI 1.07-1.14, P<0.001) and a 14% increased risk of cardiovascular mortality (HR 1.14, 95% CI 1.08-1.20, P<0.001).</p><p><strong>Conclusions: </strong>Elevated NPAR levels are independently associated with increased long-term mortality in adults with chest pain. These findings position NPAR as a promising prognostic biomarker in this patient population.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500843"},"PeriodicalIF":1.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular age calculation from SCORE2 and SCORE2-OP cardiovascular risk tables.","authors":"Jose I Cuende, Carlos Guijarro","doi":"10.1016/j.arteri.2025.500841","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500841","url":null,"abstract":"<p><strong>Aims: </strong>SCORE2 and SCORE2-OP cardiovascular risk tables were published in 2021 and incorporated into European cardiovascular prevention guidelines, replacing the previous SCORE tables. Since the 2012 version of these guidelines, the concept of vascular age has been included. Although there are vascular age tables derived from SCORE, there are no vascular age tables derived from SCORE2 and SCORE2-OP. The aim of this study is to construct new vascular age tables derived from SCORE2 and SCORE2-OP.</p><p><strong>Methods: </strong>Based on the data from the SCORE2 and SCORE2-OP risk tables, 8 regressions between age and risk are calculated in baseline conditions for the 8 combinations of sex and cardiovascular risk zones. Another 248 regressions corresponding to the different non-baseline situations are calculated. By equating the risk in each box of the risk tables with the same risk in baseline conditions, the vascular age in each box of the risk tables can be obtained. Regression, determination and intraclass correlation coefficients are calculated to asses adjustment and agreement.</p><p><strong>Results: </strong>Four vascular age tables have been obtained corresponding to countries with low, moderate, high and very high cardiovascular risk. The concordance in vascular age between the 4 tables is greater than 0.99, thus a universal vascular age table has been constructed. Vascular age does not need calibration unlike absolute risk.</p><p><strong>Conclusions: </strong>Vascular age tables have been created from the SCORE2 and SCORE2-OP tables. A single vascular age table may be used for all European Countries.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500841"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profile and atherogenic risk in metabolically healthy and unhealthy obese individuals: A cohort analysis by sex and sociodemographic factors.","authors":"Miguel García Samuelsson, Pedro Juan Tárraga López, Ángel Arturo López González, Carla Busquets-Cortés, Joan Obrador de Hevia, José Ignacio Ramírez Manent","doi":"10.1016/j.arteri.2025.500840","DOIUrl":"https://doi.org/10.1016/j.arteri.2025.500840","url":null,"abstract":"<p><strong>Objective: </strong>To analyze lipid profiles and sociodemographic factors associated with atherogenic risk in obese workers classified as metabolically healthy (MHO) or unhealthy (MNHO).</p><p><strong>Methods: </strong>Cross-sectional study of 68,884 obese workers. Atherogenic lipid indices (total cholesterol/HDL-c, LDL-c/HDL-c, triglycerides/HDL-c) and prevalence of atherogenic dyslipidemia were assessed. Multinomial logistic regression identified factors linked to lipid risk.</p><p><strong>Results: </strong>MNHO individuals exhibited significantly higher atherogenic indices across sexes and diagnostic criteria. Atherogenic dyslipidemia and lipid triad were more prevalent in MNHO. Male sex, older age, lower educational level, lower social class, physical inactivity, low adherence to the Mediterranean diet, and smoking were associated with higher lipid risk.</p><p><strong>Conclusion: </strong>Although MHO individuals show a more favorable lipid profile than MNHO, this advantage weakens with less stringent definitions. Sociodemographic and lifestyle factors strongly modulate atherogenic risk.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500840"},"PeriodicalIF":1.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planificación del tratamiento hipolipemiante en la enfermedad vascular ateroesclerótica. Consenso SEC/SEA/SEEN/SEMFYC/SEMERGEN/SEMG/SEN/SEACV/S.E.N","authors":"Rosa Fernández-Olmo ,&nbsp;Alberto Cordero ,&nbsp;Armando Oterino ,&nbsp;Agustín Blanco-Echevarría ,&nbsp;David Vivas ,&nbsp;Carlos Escobar ,&nbsp;Emilio Ortega ,&nbsp;Mónica Torres-Fonseca ,&nbsp;Carmen Sánchez-Peinador ,&nbsp;Borja Quiroga ,&nbsp;Vicente Pascual ,&nbsp;Pedro Martínez-Losas ,&nbsp;Daniel Escribano ,&nbsp;María del Mar Freijo ,&nbsp;Rosa María Sánchez Hernández ,&nbsp;Ana Viana ,&nbsp;Román Freixa-Pamias ,&nbsp;Almudena Castro ,&nbsp;Juan José Gómez Doblas","doi":"10.1016/j.arteri.2025.500799","DOIUrl":"10.1016/j.arteri.2025.500799","url":null,"abstract":"<div><div>In recent years we have been experiencing an advance in lipid-lowering therapies, with the appearance of new drugs that act on the different metabolic pathways, reducing both the levels of cholesterol associated with low-density lipoproteins (LDL-C) containing apoprotein<!--> <!-->B (ApoB), and vascular risk. However, the results in achieving goals are still scarce, as well as the use of the different therapies that help us to achieve them. Among the reasons that justify this situation are: the inadequate identification of vascular risk, the underuse of therapies, poor adherence to the recommended treatment, the lack of organization in terms of the assignment of roles and algorithms of action in the follow-up of patients and the need for improved education and psychosocial interventions that influence both adherence and consolidation of Healthy lifestyle habits. This consensus document aims to improve the approach and follow-up of dyslipidemia in a comprehensive way, defining the planning of lipid-lowering therapies as a control strategy (SEC/SEA/SEEN/SEMFYC/SEMERGEN/SEMG/SEN/SEACV/S.E.N.).</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 500799"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlación de la adhesión de los elementos del ateroma y las causas de la trombosis","authors":"Irving Mauricio Lecona Licona ,&nbsp;José María Rodríguez Lelis ,&nbsp;Joaquín Pérez Ortega ,&nbsp;José Alfredo Rodríguez Ramírez","doi":"10.1016/j.arteri.2025.500801","DOIUrl":"10.1016/j.arteri.2025.500801","url":null,"abstract":"<div><h3>Introduction</h3><div>Ischemic diseases are the second leading cause of death in Mexico and account for over 30% of deaths worldwide. Atherosclerosis, in particular, obstructs arteries and impairs blood circulation, contributing to increased mortality and reduced quality of life. <em>Objective</em> In this study, adhesion energies and their influence on the structural arrangement of an atheroma were determined.</div></div><div><h3>Methodology</h3><div>Adhesion energies were measured for each main component of the atheroma, including arteries and plaque components such as cholesterol, calcium, collagen, glucose, and elastin. The relationship between adhesion and atheroma formation is demonstrated, highlighting the significant interaction of adhesion energies between fibrinogen and cholesterol. Numerical results showed that fibrinogen and cholesterol have the highest adhesion energy, followed by collagen-glucose and cholesterol-elastin combinations.</div></div><div><h3>Results</h3><div>Additionally, interactions with the highest adhesion energy, such as Fib-Fib with an energy value of <span><math><mrow><mn>9.60</mn><mi>x</mi><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>5</mn></mrow></msup><mi>J</mi><mo>/</mo><msup><mi>m</mi><mn>2</mn></msup></mrow></math></span>, CML-GB with a value of <span><math><mrow><mn>2.76</mn><mi>x</mi><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>9</mn></mrow></msup><mi>J</mi><mo>/</mo><msup><mi>m</mi><mn>2</mn></msup></mrow></math></span>, along with LDL-LDL with an adhesion value of <span><math><mrow><mn>6.35</mn><mi>x</mi><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>5</mn></mrow></msup><mi>J</mi><mo>/</mo><msup><mi>m</mi><mn>2</mn></msup></mrow></math></span> and Elas-LDL with a J value of <span><math><mrow><mn>3.40</mn><mi>x</mi><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>5</mn></mrow></msup><mi>J</mi><mo>/</mo><msup><mi>m</mi><mn>2</mn></msup></mrow></math></span>, influence the atheroma structure formation.</div></div><div><h3>Conclusions</h3><div>These results demonstrate the association between adhesion energy in forming an atheroma that obstructs arteries, reduces blood flow, and the pathology of thrombus formation.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 500801"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of metabolic syndrome on coronary artery severity in patients with acute myocardial infarction: A perspective from a developing country","authors":"Hai Phuong Nguyen Tran ,&nbsp;Tai Nhat Nguyen ,&nbsp;Kha Minh Nguyen ,&nbsp;Sang Quang Ly ,&nbsp;Sy Van Hoang","doi":"10.1016/j.arteri.2024.08.006","DOIUrl":"10.1016/j.arteri.2024.08.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic syndrome (MetS) has been frequently observed in patients with acute myocardial infarction (AMI). However, there is limited research assessing the impact of metabolic syndrome on coronary artery severity in patients with acute myocardial infarction.</div></div><div><h3>Methods</h3><div>We analyzed 199 patients with AMI who underwent invasive coronary angiography. This study aimed to determine the impact of MetS, MetS score and its components on coronary artery severity.</div></div><div><h3>Results</h3><div>The study comprised 199 eligible patients, with an average age of 64.5<!--> <!-->±<!--> <!-->11.3 years. Among the entire cohort, 136 patients (68.3%) were diagnosed with MetS. The MetS 3 subgroup with three components exhibited the highest percentage at 29.2%. The proportion of one-vessel, two-vessel, three-vessel, multi-vessel disease, or left main disease did not differ between the MetS and non-MetS groups (<em>p</em> <!-->&gt;<!--> <!-->0.05). Our study revealed that the MetS group had a higher median Gensini score compared to the non-MetS group (<em>p</em> <!-->=<!--> <!-->0.002). Furthermore, the Gensini score was significantly correlated with the MetS score (Spearman correlation 0.2, <em>p</em> <!-->&lt;<!--> <!-->0.05). Among metabolic syndrome components, elevated waist circumference and elevated blood glucose were associated with the Gensini score.</div></div><div><h3>Conclusions</h3><div>Our study revealed that MetS, MetS score and two components of MetS, elevated waist circumference and elevated blood glucose, were associated with the severity of angiographic coronary artery in patients with AMI.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 100737"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrategias de mejora en la salud cardiovascular y el tratamiento de la dislipidemia en España. Proyecto Expert Insights","authors":"Juan Pedro-Botet ,&nbsp;Román Freixa ,&nbsp;Juan José Tamarit ,&nbsp;José López-Miranda ,&nbsp;Rosa Fernández-Olmo ,&nbsp;Ovidio Muñiz-Grijalvo ,&nbsp;Rafael Vázquez-García ,&nbsp;Carlos Guijarro ,&nbsp;Luis Rodríguez-Padial ,&nbsp;José Luis Díaz-Díaz ,&nbsp;Marisol Bravo-Amaro ,&nbsp;José Luís Hernández ,&nbsp;José Antonio Alarcón-Duque ,&nbsp;José Alfredo Martin-Armas ,&nbsp;Martín García-López ,&nbsp;Juan Cosín-Sales","doi":"10.1016/j.arteri.2024.08.007","DOIUrl":"10.1016/j.arteri.2024.08.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To gather opinions, recommendations, and proposals for improvement from Spanish clinicians on cardiovascular (CV) health, with particular focus on dyslipidemia management.</div></div><div><h3>Methods</h3><div>The Expert Insights project involved 8<!--> <!-->face-to-face sessions held throughout Spain, attended by 138 CV health experts. Clinicians answered to 25 questions survey related to CV health and dyslipidemia control. Each session included an analysis and a discussion on the perceived realities and areas for improvement.</div></div><div><h3>Results</h3><div>72% of centers have a standardized process for monitoring patients after a CV episode at discharge, but only 37% during their clinical follow-up. Patient care and management are dependent on the physician, with a lack of coordination between hospital specialties and primary care (PC). 95% of clinicians believe it is necessary to standarize treatment optimization. 65% of centers prescribe combined lipid-lowering treatment after a CV episode. Updating cLDL levels in the Therapeutic Positioning Report and standardizing and globalizing the prescription document would reduce iPCSK9 prescription barriers and lead to more equitable access.</div></div><div><h3>Conclusions</h3><div>In Spain, there are significant deficiencies in the management of dyslipidemia, with a great need for a consensus on standardizing management processes and optimizing patient treatment. The opinions, recommendations, and improvement proposals from Spanish clinicians on CV health are an important starting point to improve the situation.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 100738"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanisms underlying the cardiac effects of modified citrus pectin in obese rats with myocardial ischemia: Role of galectin-3","authors":"Sara Jiménez-González ,&nbsp;Beatriz Delgado-Valero ,&nbsp;Ana Romero-Miranda ,&nbsp;Fabian Islas ,&nbsp;María Luaces ,&nbsp;Bunty Ramchandani ,&nbsp;María Cuesta-Corral ,&nbsp;Alejandro Montoro-Garrido ,&nbsp;María Luisa Nieto ,&nbsp;Ernesto Martínez-Martínez ,&nbsp;Victoria Cachofeiro","doi":"10.1016/j.arteri.2024.10.007","DOIUrl":"10.1016/j.arteri.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Modified citrus pectin (MCP) is used as a nutritional supplement that inhibits galectin-3 activity, a central player in the cardiac damage associated with different pathological situations. In fact, we have previously observed that MCP improved cardiac function in obese infarcted rats that was associated with a reduction in cardiac fibrosis. Therefore, the aim of the present study was to further explore whether this effect could involve the modulation of gene expression of ECM components and their mediators as well as whether it could affect another two mechanisms involved in cardiac damage: mitochondrial dynamics and autophagic flux.</div></div><div><h3>Methods</h3><div>Male Wistar rats were fed an atherogenic diet with a high content of saturated fat (35%). MI was induced by the ligation of left anterior descendant (LAD) coronary artery 6 weeks after and MCP (100<!--> <!-->mg/kg/day) or vehicle were administered for 4 weeks more. A group of rats fed a standard diet (5.3% fat) and subjected to a sham operation was used as controls.</div></div><div><h3>Results</h3><div>Obese infarcted animals presented an increase in cross-linked collagen that was not affected by the administration of galectin-3 inhibitor. However, MCP reduced the increase in gene expression observed in obese infarcted rats of ECM components and mediators (collagen I, fibronectin, transforming growth factor-β and connective tissue growth factor), of components of endoplasmic reticulum stress (binding immunoglobulin protein, CCAAT-enhancer-binding homologous protein and activating transcription factor 4), of oxidative stress mediator (NADPH oxidase-4) and normalized those of the interleukin 33/ST2 system. MCP is also able to increase the levels of the mitochondrial protein Dynamin-1-like and those of both proteins involved in autophagic flux (p62 and LC3) that were reduced by the myocardial ischemia in the context of obesity.</div></div><div><h3>Conclusions</h3><div>The data show that the beneficial effect of the nutritional supplement MCP on the cardiac consequences associated with myocardial ischemia in the context of obesity could rely on its capacity to inhibit galectin-3 and to consequently modulate different downstream mechanisms, including inflammation, ER stress, oxidative stress, autophagy and mitochondrial function, which can facilitate fibrosis and cardiac remodeling in this pathological context.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 100750"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carga acumulada de colesterol: el tiempo perdido no se recupera","authors":"Pablo Pérez-Martínez ,&nbsp;José López-Miranda","doi":"10.1016/j.arteri.2025.500805","DOIUrl":"10.1016/j.arteri.2025.500805","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 4","pages":"Article 500805"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}