Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Reorganización en red del sistema vascular en la hipertensión: rigidez arterial, hemodinamia y arquitectura aórtica","authors":"Alberto Guevara-Tirado","doi":"10.1016/j.arteri.2026.500895","DOIUrl":"10.1016/j.arteri.2026.500895","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertension is associated with vascular remodeling and hemodynamic alterations; however, the global interaction of these processes remains insufficiently understood.</div></div><div><h3>Objective</h3><div>To analyze the structure of physiological networks integrating arterial stiffness, hemodynamic parameters, and aortic architecture in patients with and without hypertension.</div></div><div><h3>Materials and methods</h3><div>An analytical study based on a secondary dataset (n<!--> <!-->=<!--> <!-->801) including clinical and hemodynamic measurements, arterial stiffness assessed by the left and right cardio-ankle vascular index (CAVI-L and CAVI-R), and aortic diameters measured by computed tomography. Physiological networks were estimated for hypertensive and non-hypertensive groups using the Extended Bayesian Information Criterion Graphical LASSO (EBIC-GLASSO). Centrality metrics (degree, strength, betweenness) and global network metrics (density, modularity, and communities) were computed. Networks were visualized using the Fruchterman–Reingold algorithm and compared through a permutation-based procedure reproducing the Network Comparison Test (NCT).</div></div><div><h3>Results</h3><div>Network analysis revealed topological differences between patients with hypertension and those without hypertension. In the hypertensive group, CAVI-L, body mass index, and diastolic blood pressure showed higher degree and strength values. Aortic segments such as the sinus of Valsalva, mid aortic arch, and proximal descending thoracic aorta exhibited higher betweenness values. The hypertensive network showed higher density and lower effective functional differentiation. Permutation analysis confirmed greater global network strength in the hypertensive group, with formal statistical significance observed only for diastolic blood pressure.</div></div><div><h3>Conclusions</h3><div>Hypertension is associated with global changes in vascular organization, characterized by increased arterial stiffness, higher network connectivity, and a functional predominance of diastolic blood pressure within the physiological network.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 5","pages":"Article 500895"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La inteligencia artificial en la práctica clínica: una revolución inevitable que transformará la atención sanitaria","authors":"Joan-Carles Vallvé","doi":"10.1016/j.arteri.2026.500939","DOIUrl":"10.1016/j.arteri.2026.500939","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 5","pages":"Article 500939"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoyetic deficiency in polymeric immunoglobulin receptor attenuates experimental atherosclerosis.","authors":"Isabel Cerro-Pardo, Belén Picatoste, Cristina Márquez-Gálvez, Lucía Ortega-Villanueva, Joan Carles Escolà-Gil, Estefanía Núñez, Jesús Vázquez, Luis Miguel Blanco-Colio, José Luis Martín-Ventura","doi":"10.1016/j.arteri.2026.500960","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500960","url":null,"abstract":"<p><strong>Background: </strong>Polymeric immunoglobulin receptor (PIGR) is a transmembrane protein involved in the transcytosis of polymeric IgA and IgM immunoglobulins. Recent data from our group described that systemic deficiency of Pigr reduces atherosclerosis development, which is associated with increased plasma IgA and IgM levels.</p><p><strong>Purpose: </strong>To analyse the role of Pigr deficiency in hematopoietic cells in an experimental model of atherosclerosis in mice.</p><p><strong>Methods: </strong>We analyzed PIGR distribution in early atherosclerotic plaques compared to healthy aortic samples, as well as PIGR expression in macrophages derived from human peripheral blood mononuclear cells (PBMCs). The contribution of hematopoietic Pigr to experimental atherosclerosis was assessed by performing bone marrow transplantation in Ldlr^-/- mice fed an atherogenic diet for 10weeks.</p><p><strong>Results: </strong>PIGR expression was observed in the intima of early human atherosclerotic lesions, showing colocalization with macrophages. In addition, PIGR levels increased during the in vitro differentiation of human PBMCs into macrophages. Analysis of the hematopoietic lineage-specific Pigr deficiency in atherosclerosis revealed that Pigr^-/- mice displayed significantly reduced plaque size in the aortic sinuses as well as a strong decrease in macrophage infiltration, while no changes in contractile vascular smooth muscle cells and collagen content were observed. These effects occurred independently of systemic changes in lipids, IgA and IgM levels.</p><p><strong>Conclusions: </strong>Hematopoietic Pigr deficiency attenuates experimental atherosclerosis, although the molecular mechanisms underlying this protective effect remain to be fully elucidated.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500960"},"PeriodicalIF":1.9,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of the impact of weekend sleep restriction and recovery sleep on metabolic and cardiovascular risk indicators: Results from a randomized crossover clinical trial.","authors":"José Vicente Sorlí, María Milagros Raybaud, Adelina Pastor, Xinran Xion, Vicent Beltrán, Carolina Ortega-Azorín, Eva María Asensio, Dolores Corella, Eva Cristina Pascual-Castelló, Laura Viviana Villamil, Rebeca Fernández-Carrión, Andrea Álvarez-Sala, Rocío Barragán","doi":"10.1016/j.arteri.2026.500959","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500959","url":null,"abstract":"<p><p>Insufficient sleep (<7h/night) affects approximately one-third of the adult population and is associated with cardiometabolic alterations. A common strategy to compensate for sleep debt accumulated during the workweek is extending sleep duration during the weekend, although its effects remain controversial. The aim of this study was to preliminarily evaluate the impact of 5 days of sleep restriction followed by 2 days of recovery sleep on sleep parameters and cardiometabolic biomarkers. A randomized crossover clinical trial was conducted in 10 healthy adults under two conditions: 1) adequate habitual sleep for 7 days (HS), and 2) 5 days of sleep restriction (-1h 30min/night) followed by 2 days of ad libitum recovery sleep (RS). Sleep duration was reduced by 102min during weekdays in the RS condition (P<.001), with no differences during the weekend. After the recovery period, sleep quality worsened in the RS condition, with increased wake after sleep onset and a higher number of awakenings. In addition, triglyceride levels and blood pressure were higher in RS compared with HS. These preliminary findings suggest that weekend recovery sleep does not fully compensate for the effects of partial sleep restriction.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500959"},"PeriodicalIF":1.9,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spanish Atherosclerosis Society Dyslipidaemia Registry: Evolution, real-world evidence, and its role in precision medicine. Current status in 2026.","authors":"Victoria Marco-Benedí, Ana M Bea, Emilio Ortega, Alberto Zamora, José Antonio Gimeno, Carlos Guijarro, Begoña Cortés, Aurora González, Alcibíades Segundo Díaz Vera, Rosa M Sánchez-Hernández","doi":"10.1016/j.arteri.2026.500958","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500958","url":null,"abstract":"<p><strong>Introduction: </strong>The National Dyslipidemia Registry of the Spanish Atherosclerosis Society (SEA) represents a major source of real-world evidence on lipid metabolism disorders in Spain. This study aims to describe the evolution of the registry, its main scientific contributions, and its current role in the development of precision medicine strategies.</p><p><strong>Methods: </strong>A descriptive study was conducted based on the analysis of the SEA National Dyslipidemia Registry, complemented by a structured review of the main scientific publications derived from it. Studies related to familial hypercholesterolemia, rare dyslipidemias, response to lipid-lowering therapy, artificial intelligence, and lipoprotein(a) were included. Updated data on the number of patients and participating centers were also incorporated.</p><p><strong>Results: </strong>As of March 2026, the registry includes 10,073 patients from 113 lipid units across Spain. The studies derived from the registry have enabled a detailed characterization of the clinical and genetic profile of familial hypercholesterolemia, identified a significant gap in lipid control in routine clinical practice, and demonstrated substantial variability in response to lipid-lowering therapy. In addition, the role of lipoprotein(a) as an independent cardiovascular risk factor has been further elucidated, including its interaction with other lipid parameters and sex-related differences. The registry has also improved the characterization of rare dyslipidemias, such as familial chylomicronemia syndrome and homozygous familial hypercholesterolemia. The incorporation of artificial intelligence models has enhanced cardiovascular risk stratification.</p><p><strong>Conclusions: </strong>The SEA National Dyslipidemia Registry has become a reference platform for cardiovascular research in real-world settings, supporting the transition toward precision medicine through the integration of clinical, genetic, and analytical data.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500958"},"PeriodicalIF":1.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First real-world experience with inclisiran in Spain: Efficacy, safety, and prescription patterns in clinical practice.","authors":"Alvaro Velasco, Ramón Costa, Jesús Alonso-Carrillo, Marta de Castro, Cristina Hayes Meizoso, Agustín Blanco-Echevarria, Rocío Tello, Jorge Solís","doi":"10.1016/j.arteri.2026.500957","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500957","url":null,"abstract":"<p><strong>Background: </strong>Low-density lipoprotein cholesterol (LDL-C) is a key causal factor in atherosclerotic cardiovascular disease. Although statins remain the cornerstone of treatment, their use is limited by adverse effects, variable response and poor adherence. Inclisiran, a small interfering RNA that inhibits hepatic PCSK9 synthesis, has demonstrated marked LDL-C reductions in clinical trials. However, real-world evidence remains limited.</p><p><strong>Methods: </strong>Observational longitudinal study in a Spanish tertiary hospital including all patients prescribed inclisiran since its approval. Baseline characteristics were analysed. LDL-C target achievement and safety outcomes were assessed.</p><p><strong>Results: </strong>Seventy-seven patients were included (median age 59 years), most of whom were at high or very high cardiovascular risk; 82% were treated for secondary prevention and 41% had statin intolerance. Median baseline LDL-C was 115 [103-133]mg/dL. Mean LDL-C reductions were 52% at 3 months, 61% at 9 months and 52% at 15 months. Greater reductions were observed in patients receiving concomitant high-potency statins. Individualised LDL-C targets were achieved in 59%, 52% and 56% of patients at 3, 9 and 15 months, respectively. Adverse events were infrequent (5%) and limited to mild injection-site reactions. Eleven per cent of patients were lost to follow-up, mainly due to poor adherence.</p><p><strong>Conclusions: </strong>In routine clinical practice, inclisiran was effective and well tolerated, producing substantial and sustained reductions in LDL-C in a predominantly high-cardiovascular-risk population. Its favourable safety profile and twice-yearly administration make it a practical therapeutic option, particularly for patients with statin intolerance or adherence difficulties, and support its integration into real-world care pathways.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500957"},"PeriodicalIF":1.9,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papel de los inhibidores del factor xi como nueva estrategia anticoagulante en la prevención y tratamiento de la trombosis arterial.","authors":"José A Páramo","doi":"10.1016/j.arteri.2026.500956","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500956","url":null,"abstract":"<p><p>Oral anticoagulants, namely vitamin K antagonists, have been key agents for the prevention and treatment of thrombosis. Limitations of these drugs have been supplanted by direct oral anticoagulants (DOACs), with better safety profile, lack of routine monitoring and very limited drug-drug interactions, but still with increased risk of bleeding. A new class of antithrombotics that inhibit factor XI, which is positioned in the intirnsic pathway of blood coagulation, is under development. Various types of factor XI inhibitors have been studied in clinical studies, including antisense oligonucleotides, small molecules, monoclonal antibodies and aptamers. Recently data from clinical trials have shown promising results regarding their safety and efficacy in preventing and treating arterial thrombosis, and in the short-term they can replace the traditional antithrombotic agents.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500956"},"PeriodicalIF":1.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consenso de la Sociedad Española de Arteriosclerosis y la Sociedad Española de Medicina Interna sobre Dieta Mediterránea y salud: un enfoque integral más allá de los nutrientes","authors":"Javier Delgado-Lista,&nbsp;Juana Carretero Gómez,&nbsp;Francisco Gómez Delgado,&nbsp;Vicente Pascual,&nbsp;José Luis Díaz,&nbsp;Carlos Guijarro,&nbsp;Juan Pedro-Botet,&nbsp;Antonio Pérez,&nbsp;Ana María Piera Carbonell,&nbsp;Cristina Soler Ferrer,&nbsp;Mercedes Sotos Prieto,&nbsp;Manuel Suarez Tembra,&nbsp;Estefanía Toledo Atucha,&nbsp;Pablo Pérez-Martínez","doi":"10.1016/j.arteri.2026.500910","DOIUrl":"10.1016/j.arteri.2026.500910","url":null,"abstract":"<div><div>Mediterranean Diet has proven to be one of the most effective dietary patterns for preventing cardiovascular disease and other cardiometabolic outcomes, however, scientific research has historically tended to focus on the composition of foods and their nutrients, neglecting other essential components of this dietary pattern. These non-nutritional factors, including commensality and conviviality, food seasonality and sustainability, culinary practices, and the temporal synchronization of food intake, are integral to the conceptual framework of Mediterranean Diet and were a key criterion for its recognition as an Intangible Cultural Heritage of Humanity. Despite their relevance, their systematic treatment in the scientific literature has been limited.</div><div>This consensus statement reviews and synthesizes recent evidence on these non-nutritional factors, identifying the mechanisms by which they influence adherence to the pattern and biological determinants relevant to vascular health, such as metabolic regulation, low-grade inflammation, and circadian function. Furthermore, highlighting these elements contributes to the implementation and adaptation of MediterraneanDiet in other sociocultural contexts, promoting the adoption of a comprehensive pattern that preserves its conceptual foundations beyond the mere replication of foods, and allows these individuals to access the additional benefits conferred by these non-nutritional factors.</div><div>This holistic approach proposes that the Mediterranean Diet, conceived as a lifestyle pattern, can be coherently adapted to different cultural and geographical realities, thus optimizing its transfer to clinical practice and to strategies for the prevention of arteriosclerosis and its risk factors.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 4","pages":"Article 500910"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La dieta mediterránea es mucho más que comida: el cómo, con quién y cuándo se come influencian la salud tanto como qué y cuánto se come","authors":"Emilio Ros","doi":"10.1016/j.arteri.2026.500938","DOIUrl":"10.1016/j.arteri.2026.500938","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 4","pages":"Article 500938"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress and inflammation link Life's Essential 8 with adverse cardiovascular events in adults with diabetes mellitus: NHANES 2011–2018","authors":"Ronghao Li ,&nbsp;Mengfan Li ,&nbsp;Xinyi Wang ,&nbsp;Zhongyun Zhou","doi":"10.1016/j.arteri.2025.500844","DOIUrl":"10.1016/j.arteri.2025.500844","url":null,"abstract":"<div><h3>Background</h3><div>The American Heart Association has modified Life's Essential 8 (LE8) as a new algorithm for evaluating cardiovascular health (CVH). However, the relationship between LE8 and cardiovascular disease (CVD) incidence among diabetic patients, and the potential effect of oxidative stress and inflammation within these associations remain to be elucidated.</div></div><div><h3>Methods</h3><div>Three thousand eight hundred twenty-eight diabetic patients were selected from the National Health and Nutrition Examination Survey (NHANES). The weighted logistic regression was employed to examine the association between LE8 with CVD, and the quantitative relationship was investigated with a restricted cubic spline (RCS). Mediation analyses explored the mediating role of oxidative stress and inflammation in the above relationship.</div></div><div><h3>Results</h3><div>In the 3828 diabetic patients, a total of 977 people were diagnosed with CVD, and the LE8 was significantly and linearly negatively associated with CVD incidence. After all covariates were adjusted, the medium CVH group had a 25% lower risk of CVD (OR: 0.75, 95% CI: 0.58, 0.95) than the low CVH group, and the high CVH group had a 66% lower risk (OR: 0.34, 95% CI: 0.12, 0.94). Furthermore, oxidative stress and inflammation explained 11.57% and 10.89% of the connection, respectively (<em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>Elevated LE8 is negatively associated with adverse cardiovascular events in diabetes mellitus and the association appeared to be partially mediated through oxidative stress and inflammation pathways. Those results indicate the necessity of maintaining at least moderate cardiovascular health and the LE8 help make lifestyle self-management more targeted for diabetes patients.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 4","pages":"Article 500844"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}