Risk factors and assessment of subclinical atherosclerosis in patients with psoriatic arthritis

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis Pub Date : 2024-11-01 DOI:10.1016/j.arteri.2024.04.001

Zhoulan Zheng , Qianru Liu , Zhenan Zhang , Qianyu Guo , Liyun Zhang , Gailian Zhang

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引用次数: 0

Abstract

Objective

To understand the prevalence of subclinical atherosclerosis (SCA) in psoriatic arthritis (PsA) patients; to explore the correlation between PsA combined with SCA and traditional cardiovascular risk factors and disease activity; to compare the role of Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) scores.

Methods

We included 50 PsA patients who met the CASPAR classification criteria, 50 diabetes patients and 50 healthy people. Clinical data were collected from all patients, minimal disease activity (MDA), disease activity index for psoriatic arthritis (DAPSA), ASCVD, FRS were assessed in patients with PsA, and carotid artery intima–media thickness was measured.

Results

The prevalence of SCA in PsA patients was significantly higher than that in healthy controls (44% vs 24%, P < 0.05). Smoking, drinking, ASCVD, FRS were the risk factors of PsA with SCA (P < 0.05). Psoriasis (PsO) duration, PtGA, VAS and DAPSA were the risk factors for PsA with SCA (P < 0.05). FRS and ASCVD scores underestimated SCA risk in PsA patients.

Conclusion

Compared with healthy controls, patients with PsA have higher prevalence of SCA. High DAPSA is a risk factor for PsA with SCA. Carotid ultrasound can monitor SCA in patients with PsA, improve stratification of cardiovascular risk.

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银屑病关节炎患者亚临床动脉粥样硬化的风险因素和评估。

目的了解亚临床动脉粥样硬化（SCA）在银屑病关节炎（PsA）患者中的发病率；探讨PsA合并SCA与传统心血管风险因素和疾病活动之间的相关性；比较弗雷明汉风险评分（FRS）和动脉粥样硬化性心血管疾病（ASCVD）评分的作用：我们纳入了50名符合CASPAR分类标准的PsA患者、50名糖尿病患者和50名健康人。收集了所有患者的临床数据，评估了PsA患者的最小疾病活动度（MDA）、银屑病关节炎疾病活动度指数（DAPSA）、ASCVD和FRS，并测量了颈动脉内中膜厚度：结果：PsA 患者的 SCA 患病率明显高于健康对照组（44% 对 24%）：与健康对照组相比，PsA患者的SCA患病率更高。高DAPSA是PsA伴SCA的一个危险因素。颈动脉超声可监测PsA患者的SCA，改善心血管风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

40 days

期刊介绍： La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.