Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Plasma miR-502-5p and coronary artery vasospasm: An exploratory study.","authors":"Lucía Matute-Blanco, Miguel Sánchez-Rodríguez, Juan Casanova-Sandoval, Marcos Garcia-Guimaraes, Kristian Rivera, Georgina Fuertes-Ferre, Ainhoa Pérez Guerrero, Raúl Millán Segovia, Thalía Belmonte, Iván D Benítez, Marta Molinero, Ferrán Barbè, Fernando Worner, Alfredo Bardají, Diego Fernández-Rodríguez, David de Gonzalo-Calvo","doi":"10.1016/j.arteri.2026.500947","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500947","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery vasospasm (CAV) is a major cause of myocardial ischemia in patients without obstructive coronary disease. Its detection remains challenging due to the lack of biomarkers. We investigated circulating microRNAs (miRNAs) as potential biomarkers for CAV.</p><p><strong>Methods: </strong>The ANFIBIO study is a prospective, multicenter cohort study that enrolled consecutive patients presenting with chest pain of presumed coronary origin (ClinicalTrials.gov identifier: NCT05374694). Patients were referred for invasive physiological evaluation. For this substudy, only those who underwent a coronary vasospasm test were included (n=70). Circulating miRNA profiling was performed using RT-qPCR.</p><p><strong>Results: </strong>The mean age of participants was 66.5 years and 40.0% were women. The prevalence of hypertension, dyslipidemia, and diabetes mellitus was 72.9%, 61.4% and 20.0%, respectively. Patients with CAV showed a higher use of oral nitrates. Notably, most individuals with undetectable plasma levels of miR-502-5p exhibited CAV (60%). Accordingly, detectability was used as the primary representation of miR-502-5p in further analyses. Adding miR-502-5p to a clinical model (age, sex, smoking status, nitrate use and transferrin concentration) was associated with a numerically higher AUC (0.74-0.81) and improved reclassification metrics (NRI=0.533; IDI=0.079).</p><p><strong>Conclusions: </strong>In this cohort, plasma miR-502-5p was associated with CAV and showed exploratory incremental value when added to a clinical model. These findings should be considered hypothesis-generating and require further validation in larger and independent cohorts.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500947"},"PeriodicalIF":1.9,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between adherence to the Mediterranean diet and metabolic syndrome in workers at a multinational company in Madrid. Cross-sectional study.","authors":"Luis Reinoso-Barbero, Pilar Muñoz-Dueñas, Marta Redondo-Lavirgen, Clara Ferrández, Laura Gómez-Paredes, Juan Muñoz-Gutiérrez, Cristina Pérez-Herreras, Félix Gómez-Gallego, Alejandro Fernández-Montero","doi":"10.1016/j.arteri.2026.500945","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500945","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>This study aimed to analyze the association between Mediterranean diet (MD) and cardiometabolic health in a working population.</p><p><strong>Methods: </strong>A cross-sectional study was conducted. 5,891 employees of a Spanish multinational company in Madrid. MEDAS (Mediterranean Diet Adherence Screener) questionnaire was completed to assess their adherence to the MD. Cardiovascular risk (CVR) prediction formulas using the European low-risk SCORE, body mass index (BMI), and the presence of metabolic syndrome (MS) were determined. Logistic regression, odds ratios (OR), and 95% confidence intervals (95%CI) were used.</p><p><strong>Results: </strong>42% were women. Mean age of 42.67±9.03 years. 89% showed medium or high adherence to MD, 99.5% had mild CVR, and 6.45% had MS. MD was not associated with the SCORE but was inversely associated with BMI and MS (P<.001). The association of MS with DM, showed an OR of 0.45 (95%CI: 0.31-0.68). Also significant with each of its isolated parameters: HDL cholesterol 0.63 (0.48-0.84), triglycerides 0.57 (0.43-0.78), abdominal circumference 0.62 (0.50-0.77) and blood glucose 0.67 (0.49-0.93), except for blood pressure 0.85 (0.70-1.04).</p><p><strong>Conclusions: </strong>Adherence to MD is associated with a lower prevalence of MS and a more favorable metabolic profile. Higher-quality studies are needed to provide more scientific evidence.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500945"},"PeriodicalIF":1.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) levels and their association with the severity and disability of ischemic stroke.","authors":"Àngels Pedragosa Vall, Alejandra Alija Martínez, Faunier Rios Jaramillo, Carolina Guerrero Buitrago, Marta Mauri Pont, Rosa Borrallo Almansa, Mamen Carmona Orozco","doi":"10.1016/j.arteri.2026.500941","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500941","url":null,"abstract":"<p><strong>Introduction: </strong>Lipoprotein(a) [Lp(a)] is a modified LDL particle with proatherogenic, proinflammatory, and antifibrinolytic properties, causally associated with vascular disease and ischemic stroke risk. Although evidence exists in Asian populations, few studies have analyzed the relationship between Lp(a) and stroke severity and disability in our population.</p><p><strong>Objective: </strong>Determine Lp(a) levels in patients with ischemic stroke or transient ischemic attack (TIA) and to explore their association with clinical characteristics, stroke subtypes, and functional outcomes.</p><p><strong>Methods: </strong>A total of 300 consecutive patients were included, excluding hemorrhagic strokes and alternative diagnoses. Clinical, anthropometric, and biochemical data were collected, including lipid profile and Lp(a), as well as stroke severity (NIHSS) and disability (mRS) scores at admission, discharge, and 90days.</p><p><strong>Results: </strong>Sixty percent of patients were men, with a mean age of 71years; 20% had a prior ischemic stroke, and nearly half were on lipid-lowering therapy. No significant differences were observed in traditional risk factors, lipid profile, or stroke subtypes according to Lp(a) levels. However, patients with Lp(a) ≥75nmol/l exhibited greater neurological deficit in the acute phase and at discharge, longer hospital stays, and worse functional outcomes according to mRS at discharge and 90days. A positive correlation was identified between Lp(a) and NIHSS/mRS scores.</p><p><strong>Conclusions: </strong>Elevated Lp(a) levels are associated with greater neurological severity and worse functional recovery after ischemic stroke, suggesting that Lp(a) could serve as an independent prognostic marker, useful for risk stratification and planning intensive rehabilitation strategies.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500941"},"PeriodicalIF":1.9,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early care of cardiovascular health. Descriptive review.","authors":"J Ildefonzo Arocha Rodulfo","doi":"10.1016/j.arteri.2026.500944","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500944","url":null,"abstract":"<p><p>Middle age is becoming an increasingly important focus for the prevention of cardiometabolic diseases in later life, as numerous published studies with decades of follow-up have shown that elevated blood glucose and insulin resistance in youth largely predict the risk of type 2 diabetes mellitus in individuals over 50 years of age. This descriptive literature review, based on numerous articles published in peer-reviewed journals since the beginning of this century and related to the spectrum of cardiovascular health care in early life, concludes that while adolescents and young adults have a lower average 10-year risk of atherosclerotic disease, they may derive greater benefits from preventive interventions due to a larger number of years of life at risk. Those who lose ideal cardiovascular health status in adolescence and early adulthood are at greater risk of cardiovascular disease compared to those who maintain ideal levels of cardiovascular health throughout their lives, which supports the importance of optimizing cardiovascular health starting in the early decades of life.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500944"},"PeriodicalIF":1.9,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global control of vascular risk in and from primary care. Regarding population screening.","authors":"Miguel Angel Maria Tablado","doi":"10.1016/j.arteri.2026.500948","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500948","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500948"},"PeriodicalIF":1.9,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between resistin and irisin and atherosclerotic plaque characteristics assessed by optical coherence tomography in patients with coronary artery disease.","authors":"Carlos Bobis Álvarez, Marcos Rodríguez Esteban, Nerea Torres González, Julio Hernández Afonso, Delia Almeida González, Antonio Cabrera de León","doi":"10.1016/j.arteri.2026.500942","DOIUrl":"https://doi.org/10.1016/j.arteri.2026.500942","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the relationship between serum resistin and irisin concentrations and the morphological characteristics of atherosclerotic plaques assessed by optical coherence tomography (OCT) in patients with coronary artery disease.</p><p><strong>Methods: </strong>A cross-sectional observational study was conducted on 51 patients. In addition to recording comorbidities, irisin and resistin levels were measured using ELISA, and structural plaque parameters (fibroatheroma, neovascularization, calcification, and macrophages) were assessed using OCT. Age- and sex-adjusted regression models were constructed to evaluate the associations of both biomarkers with comorbidities and plaque characteristics. Regression coefficients (β), 95% confidence intervals (95% CI), and p-values were reported.</p><p><strong>Results: </strong>In the overall patient population, irisin levels were significantly associated with the presence of fibroatheromas (β=8.98 [0.20-17.77]; p=0.045) and neovascularization (β=6.48 [0.47-12.49]; p=0.035). In patients with acute coronary syndrome (ACS), this biomarker showed a stronger association with fibroatheroma (β=11.25 [2.83-19.66]; p=0.010) and neovascularization (β=8.83 [2.38-15.29]; p=0.009). Resistin levels were higher in patients with diabetes mellitus (β=2.41 [0.10-4.72]; p=0.041) were not associated with plaque morphological characteristics.</p><p><strong>Conclusions: </strong>In patients with coronary artery disease, irisin is associated with fibroatheroma and neovascularization, particularly in the context of ACS. In these patients, resistin is related to diabetes mellitus but not to atherosclerotic plaque features. Both biomarkers may represent different pathophysiological pathways in atherosclerosis.</p>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":" ","pages":"500942"},"PeriodicalIF":1.9,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La edad vascular: una herramienta para facilitar la comunicación sobre el riesgo cardiovascular con los pacientes","authors":"Carlos Brotons ,&nbsp;Irene Moral","doi":"10.1016/j.arteri.2026.500936","DOIUrl":"10.1016/j.arteri.2026.500936","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 3","pages":"Article 500936"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential regulation of the HIF-1α/apoptosis axis by miR-126-5p in cardiac cells during ischemia/reperfusion injury","authors":"Lisaidy Ramos-Regalado ,&nbsp;Leonie Schoch ,&nbsp;Sebastià Alcover ,&nbsp;Marta Magaldi ,&nbsp;Ignacio Barriuso ,&nbsp;Teresa Padró ,&nbsp;María Borrell ,&nbsp;Lina Badimon ,&nbsp;Carlos Zaragoza ,&nbsp;Gemma Vilahur","doi":"10.1016/j.arteri.2025.500842","DOIUrl":"10.1016/j.arteri.2025.500842","url":null,"abstract":"<div><h3>Background</h3><div>MicroRNAs (miRs) regulate gene expression post-transcriptionally and are transported by high-density lipoproteins (HDL). Hypercholesterolemic HDL particles are enriched with miR-126-3p/5p, which can be delivered to endothelial cells, leading to the downregulation of hypoxia-inducible-factor-1α (HIF-1α), a key transcription factor involved in metabolic responses to hypoxia and cell survival during myocardial ischemia/reperfusion (I/R).</div></div><div><h3>Objective</h3><div>To investigate the effects of miR-126 mimic and inhibitor transfection on the HIF-1α/apoptosis axis in cardiac cell constituents under experimental I/R.</div></div><div><h3>Methods</h3><div>Firstly, specific durations of I/R were established for cardiac cells (cardiomyocytes, fibroblasts, endothelial cells, and macrophages) based on their susceptibility to metabolic changes and cell death. Then, we assessed the impact of transfecting these cells with mimic-miR-126-5p and anti-miR-126-5p to the selected timings of I/R on the HIF-1α/apoptosis axis.</div></div><div><h3>Results</h3><div>Endothelial cells were resistant to I/R and fibroblasts were sensitive to ischemia whereas cardiomyocytes displayed high metabolic flexibility. Endogenous miR-126 expression was exclusively found in endothelial cells. Transfection with anti-miR-126 increased HIF-1α transcription in endothelial cells and cardiomyocytes, while reducing HIF-1α levels in fibroblasts, resulted in decreased transcript levels of apoptotic markers. HIF-1α transcript levels remained unchanged in macrophages and transfection with mimic-miR-126 exerted no changes in the HIF-1α/apoptosis axis in all tested cells.</div></div><div><h3>Conclusions</h3><div>miR-126 differentially regulates HIF-1α/apoptosis expression in cardiac cells exposed to experimental I/R and may serve as a potential therapeutic target for enhancing myocardial resilience in the setting of myocardial infarction.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 3","pages":"Article 500842"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular age calculation from SCORE2 and SCORE2-OP cardiovascular risk tables","authors":"Jose I. Cuende ,&nbsp;Carlos Guijarro","doi":"10.1016/j.arteri.2025.500841","DOIUrl":"10.1016/j.arteri.2025.500841","url":null,"abstract":"<div><h3>Aims</h3><div>SCORE2 and SCORE2-OP cardiovascular risk tables were published in 2021 and incorporated into European cardiovascular prevention guidelines, replacing the previous SCORE tables. Since the 2012 version of these guidelines, the concept of vascular age has been included. Although there are vascular age tables derived from SCORE, there are no vascular age tables derived from SCORE2 and SCORE2-OP. The aim of this study is to construct new vascular age tables derived from SCORE2 and SCORE2-OP.</div></div><div><h3>Methods</h3><div>Based on the data from the SCORE2 and SCORE2-OP risk tables, 8 regressions between age and risk are calculated in baseline conditions for the 8 combinations of sex and cardiovascular risk zones. Another 248 regressions corresponding to the different non-baseline situations are calculated. By equating the risk in each box of the risk tables with the same risk in baseline conditions, the vascular age in each box of the risk tables can be obtained. Regression, determination and intraclass correlation coefficients are calculated to asses adjustment and agreement.</div></div><div><h3>Results</h3><div>Four vascular age tables have been obtained corresponding to countries with low, moderate, high and very high cardiovascular risk. The concordance in vascular age between the 4 tables is greater than 0.99, thus a universal vascular age table has been constructed. Vascular age does not need calibration unlike absolute risk.</div></div><div><h3>Conclusions</h3><div>Vascular age tables have been created from the SCORE2 and SCORE2-OP tables. A single vascular age table may be used for all European Countries.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 3","pages":"Article 500841"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfil lipídico y riesgo aterogénico en obesos metabólicamente sanos y no sanos: un análisis de cohortes por sexo y factores sociodemográficos","authors":"Miguel García Samuelsson ,&nbsp;Pedro Juan Tárraga López ,&nbsp;Ángel Arturo López González ,&nbsp;Carla Busquets-Cortés ,&nbsp;Joan Obrador de Hevia ,&nbsp;José Ignacio Ramírez Manent","doi":"10.1016/j.arteri.2025.500840","DOIUrl":"10.1016/j.arteri.2025.500840","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze lipid profiles and sociodemographic factors associated with atherogenic risk in obese workers classified as metabolically healthy (MHO) or unhealthy (MNHO).</div></div><div><h3>Methods</h3><div>Cross-sectional study of 68,884 obese workers. Atherogenic lipid indices (total cholesterol/HDL-c, LDL-c/HDL-c, triglycerides/HDL-c) and prevalence of atherogenic dyslipidemia were assessed. Multinomial logistic regression identified factors linked to lipid risk.</div></div><div><h3>Results</h3><div>MNHO individuals exhibited significantly higher atherogenic indices across sexes and diagnostic criteria. Atherogenic dyslipidemia and lipid triad were more prevalent in MNHO. Male sex, older age, lower educational level, lower social class, physical inactivity, low adherence to the Mediterranean diet, and smoking were associated with higher lipid risk.</div></div><div><h3>Conclusion</h3><div>Although MHO individuals show a more favorable lipid profile than MNHO, this advantage weakens with less stringent definitions. Sociodemographic and lifestyle factors strongly modulate atherogenic risk.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"38 3","pages":"Article 500840"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}