PneumoniaPub Date : 2014-12-01DOI: 10.1007/BF03399440
T. Luong, S. Lee, S. Pyo, D. Rhee, K. Matsubara, N. Ishiwada, J. Nishi, B. Chang, Y. Akeda, N. Iwanaga, T. Kajihara, T. Takazono, Y. Imamura, K. Yanagihara, S. Kohno
{"title":"Man versus Microbe---who gets pneumococcal disease and why?","authors":"T. Luong, S. Lee, S. Pyo, D. Rhee, K. Matsubara, N. Ishiwada, J. Nishi, B. Chang, Y. Akeda, N. Iwanaga, T. Kajihara, T. Takazono, Y. Imamura, K. Yanagihara, S. Kohno","doi":"10.1007/BF03399440","DOIUrl":"https://doi.org/10.1007/BF03399440","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"3 1","pages":"80 - 91"},"PeriodicalIF":6.8,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03399440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52101354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-12-01DOI: 10.1007/BF03399441
M. Alderson, R. Malley, P. Anderson, C. Thompson, R. Morrison, D. Briles, J. King, N. Green, J. Hural, J. Flores, A. Tate, J. Maisonneuve, C. Keech, R. Prymula, S. Silfverdal, J. Wysocki, P. Albrecht, N. François, A. Gardev, D. Borys
{"title":"Next generation vaccines","authors":"M. Alderson, R. Malley, P. Anderson, C. Thompson, R. Morrison, D. Briles, J. King, N. Green, J. Hural, J. Flores, A. Tate, J. Maisonneuve, C. Keech, R. Prymula, S. Silfverdal, J. Wysocki, P. Albrecht, N. François, A. Gardev, D. Borys","doi":"10.1007/BF03399441","DOIUrl":"https://doi.org/10.1007/BF03399441","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"3 1","pages":"92 - 121"},"PeriodicalIF":6.8,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03399441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52101369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-12-01DOI: 10.1007/BF03399439
W. Albrich, M. Pride, S. Madhi, J. Callahan, P. Adrian, R. French, N. V. Niekerk, V. Souza, K. Jansen, K. Klugman
{"title":"New Pneumococcal Diagnostics---further ahead or more confused?","authors":"W. Albrich, M. Pride, S. Madhi, J. Callahan, P. Adrian, R. French, N. V. Niekerk, V. Souza, K. Jansen, K. Klugman","doi":"10.1007/BF03399439","DOIUrl":"https://doi.org/10.1007/BF03399439","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"3 1","pages":"61 - 79"},"PeriodicalIF":6.8,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03399439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52101341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-12-01DOI: 10.1007/BF03399446
D. Murdoch, V. Picot, M. Messaoudi, J. Telles
{"title":"Pneumococcal Pneumonia---Risky Business","authors":"D. Murdoch, V. Picot, M. Messaoudi, J. Telles","doi":"10.1007/BF03399446","DOIUrl":"https://doi.org/10.1007/BF03399446","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"41 1","pages":"246 - 281"},"PeriodicalIF":6.8,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03399446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52101719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-10-14DOI: 10.15172/pneu.2014.5/482
K. F. O'Grady, P. Torzillo, K. Frawley, A. Chang
{"title":"The radiological diagnosis of pneumonia in children","authors":"K. F. O'Grady, P. Torzillo, K. Frawley, A. Chang","doi":"10.15172/pneu.2014.5/482","DOIUrl":"https://doi.org/10.15172/pneu.2014.5/482","url":null,"abstract":"Despite the importance of paediatric pneumonia as a cause of short and long-term morbidity and mortality worldwide, a reliable gold standard for its diagnosis remains elusive. The utility of clinical, microbiological and radiological diagnostic approaches varies widely within and between populations and is heavily dependent on the expertise and resources available in various settings. Here we review the role of radiology in the diagnosis of paediatric pneumonia. Chest radiographs (CXRs) are the most widely employed test, however, they are not indicated in ambulatory settings, cannot distinguish between viral and bacterial infections and have a limited role in the ongoing management of disease. A standardised definition of alveolar pneumonia on a CXR exists for epidemiological studies targeting bacterial pneumonias but it should not be extrapolated to clinical settings. Radiography, computed tomography and to a lesser extent ultrasonography and magnetic resonance imaging play an important role in complicated pneumonias but there are limitations that preclude their use as routine diagnostic tools. Large population-based studies are needed in different populations to address many of the knowledge gaps in the radiological diagnosis of pneumonia in children, however, the feasibility of such studies is an important barrier.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"5 1","pages":"38 - 51"},"PeriodicalIF":6.8,"publicationDate":"2014-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2014.5/482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67244702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-09-22DOI: 10.15172/pneu.2014.5/481
J. Rylance, P. Waitt
{"title":"Pneumonia severity scores in resource poor settings","authors":"J. Rylance, P. Waitt","doi":"10.15172/pneu.2014.5/481","DOIUrl":"https://doi.org/10.15172/pneu.2014.5/481","url":null,"abstract":"Clinical prognostc scores are increasingly used to streamline care in well-resourced setngs. The potental benefts of identfying patents at risk of clinical deterioraton and poor outcome, delivering appropriate higher level clinical care, and increasing efciency are clear. In this focused review, we examine the use and applicability of severity scores applied to patents with community acquired pneumonia in resource poor setngs. We challenge clinical researchers working in such systems to consider the generalisability of existng severity scores in their populatons, and where performance of scores is suboptmal, to promote eforts to develop and validate new tools for the beneft of patents and healthcare systems.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"5 1","pages":"30 - 37"},"PeriodicalIF":6.8,"publicationDate":"2014-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2014.5/481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67244877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-09-11DOI: 10.15172/pneu.2014.4/463
F. Lim, D. Lehmann, Aoiffe McLoughlin, C. Harrison, Judith Willis, C. Giele, A. Keil, H. Moore
{"title":"Risk factors and comorbidities for invasive pneumococcal disease in Western Australian Aboriginal and non-Aboriginal people","authors":"F. Lim, D. Lehmann, Aoiffe McLoughlin, C. Harrison, Judith Willis, C. Giele, A. Keil, H. Moore","doi":"10.15172/pneu.2014.4/463","DOIUrl":"https://doi.org/10.15172/pneu.2014.4/463","url":null,"abstract":"Australian Aboriginal people have among the highest rates of invasive pneumococcal disease (IPD) worldwide. We investigated clinical diagnosis, risk factors, comorbidities and vaccine coverage in Aboriginal and non-Aboriginal IPD cases. Using enhanced surveillance, we identified IPD cases in Western Australia, Australia, between 1997 and 2007. We calculated the proportion with risk factors and comorbidities in children (<5 years) and adults (=15 years), as well as adults living in metropolitan and non-metropolitan regions. We then calculated the proportion of cases eligible for vaccination who were vaccinated before contracting IPD. Of the 1,792 IPD cases that were reported, 355 (20%) were Aboriginal and 1,155 (65%) were adults. Pneumonia was the most common diagnosis (61% of non-Aboriginal and 49% of Aboriginal adult IPD cases in 2001–2007). Congenital abnormality was the most frequent comorbidity in non-Aboriginal children (11%). In Aboriginal children, preterm delivery was most common (14%). Ninety-one percent of non-Aboriginal and 96% of Aboriginal adults had one or more risk factors or comorbidities. In non-Aboriginal adults, cardiovascular disease (34%) was the predominant comorbidity whilst excessive alcohol use (66%) was the most commonly reported risk factor in Aboriginal adults. In adults, comorbidities were more frequently reported among those in metropolitan regions than those in non-metropolitan regions. Vaccination status was unknown for 637 of 1,082 cases post-July 2001. Forty-one percent of non-Aboriginal and 60% of Aboriginal children were eligible for vaccination but were not vaccinated. Among adults with risk factors who were eligible for vaccination and with known vaccination status, 75% Aboriginal and 94% non-Aboriginal were not vaccinated. An all-of-life immunisation register is needed to evaluate vaccine coverage and effectiveness in preventing IPD in adults.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"4 1","pages":"24 - 34"},"PeriodicalIF":6.8,"publicationDate":"2014-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2014.4/463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67244936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2014-03-16DOI: 10.15172/pneu.2014.4/416
M. Alpers
{"title":"Reflections on pneumonia in the tropics","authors":"M. Alpers","doi":"10.15172/pneu.2014.4/416","DOIUrl":"https://doi.org/10.15172/pneu.2014.4/416","url":null,"abstract":"This review of pneumonia in the tropics is based on experience with respiratory infectons in Papua New Guinea since the 1970s. It discusses ideas, principles, historical aspects of pneumonia research and the need to work with people in the community. In order to understand pneumonia in a tropical setng and evaluate new interventons it is essental to study the ecosystem of the causatve infectons, within the host and the community and between interactng microorganisms. Vaccines are much-needed preventve tools, and for pneumonia in a highly endemic setng the preventon of severe and fatal disease takes priority over the preventon of infecton. In this setng mild infecton plays an important role in preventng severe disease. For achieving long-term sustainable outcomes, sometmes ‘less is more’. A multpronged approach is required to control and prevent pneumonia, and in devising new ways of doing so. This includes appropriate and accessible clinical care, a clean, smoke-free environment, good nutriton and a range of vaccines. Also required are persistent advocacy from the global scientfc community and strong engagement with and by the communites that bear the burden of disease. Beter health care must be pursued in conjuncton with raising literacy rates and reducing poverty.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"4 1","pages":"1 - 7"},"PeriodicalIF":6.8,"publicationDate":"2014-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2014.4/416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67244720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumoniaPub Date : 2013-07-27eCollection Date: 2013-01-01DOI: 10.15172/pneu.2013.2/264
Penelope L Chapman
{"title":"Pneumonia - Forgotten no more.","authors":"Penelope L Chapman","doi":"10.15172/pneu.2013.2/264","DOIUrl":"https://doi.org/10.15172/pneu.2013.2/264","url":null,"abstract":"Commentary Pneumonia - Forgotten No More Chapman, P.L. Pneumonia is the leading cause of death in children worldwide and kills an estimated 1.2 million children under the age of five every year; more than AIDS, malaria and tuberculosis combined. Relatively few resources have been committed to addressing the problem of childhood pneumonia, particularly in resource poor settings. Yet effective interventions are available but reach too few children.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"2 ","pages":"33-36"},"PeriodicalIF":6.8,"publicationDate":"2013-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2013.2/264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}