Surfactant protein D: a useful marker for differentiation of drug-induced pneumonia and bacterial pneumonia.

IF 8.5 Q1 RESPIRATORY SYSTEM

Pneumonia Pub Date : 2021-06-05 DOI:10.1186/s41479-021-00087-6

Yuko Waseda, Masahide Yasui, Kousuke Kurokawa, Ryo Chikazawa, Toshihiro Takeda, Miho Mitsui, Tomoaki Sonoda, Makiko Yamaguchi, Satoshi Watanabe, Hazuki Takato, Yukari Ichikawa, Yukihiro Umeda, Masaki Anzai, Hiroshi Ueda, Kazuo Kasahara, Tamotsu Ishizuka

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引用次数: 2

Abstract

Background: Drug-induced pneumonia (d-pneumonia) and bacterial pneumonia (b-pneumonia) are often difficult to differentiate; therefore, this study examined the possibility of differentiating them using serum biomarkers.

Methods: The study included 22 and 16 patients diagnosed with b- and d-pneumonia, respectively, at our institution or affiliated institutions. For d-pneumonia, the causative drug was minocycline hydrochloride in four patients, gefitinib in two patients, nivolumab in two patients, pembrolizumab in two patients, sulfasalazine in two patients, loxoprofen in one patient, Bouiougitou in one patient, edoxaban tosilate hydrate in one patient, and abemaciclib in one patient. White blood cell (WBC), C-reactive protein (CRP), Krebs von den Lungen-6 (KL-6), surfactant protein (SP)-D, and SP-A levels were measured in each patient and compared between the groups.

Results: Significant differences were noted in the WBC and SP-D levels between the two groups (P < 0.05, P < 0.001), but not in the CRP, KL-6, or SP-A levels.

Conclusion: The study results suggest that SP-D is a useful marker for differentiating b-pneumonia and d-pneumonia.

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表面活性剂蛋白D:鉴别药物性肺炎与细菌性肺炎的有用标志物。

背景:药物性肺炎(d型肺炎)和细菌性肺炎(b型肺炎)通常难以区分;因此，本研究探讨了使用血清生物标志物区分它们的可能性。方法:本研究纳入本院或附属机构分别诊断为b型和d型肺炎的22例和16例患者。对于d型肺炎，4例患者的病因药物为盐酸米诺环素，2例患者为吉非替尼，2例患者为纳武单抗，2例患者为派姆单抗，2例患者为柳氮磺胺吡啶，1例患者为loxoprofen, 1例患者为Bouiougitou, 1例患者为edoxaban tosilate hydrate, 1例患者为abemaciclib。测定各组患者白细胞(WBC)、c反应蛋白(CRP)、KL-6 (KL-6)、表面活性蛋白(SP)-D、SP- a水平，并进行组间比较。结果:两组患者WBC、SP-D水平差异有统计学意义(P)。结论:SP-D是鉴别b型肺炎和d型肺炎的有效标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pneumonia RESPIRATORY SYSTEM-

自引率

1.50%

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审稿时长

11 weeks

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