Pneumonia最新文献

{"title":"Meningococcal pneumonia: a review","authors":"C. Feldman, R. Anderson","doi":"10.1186/s41479-019-0062-0","DOIUrl":"https://doi.org/10.1186/s41479-019-0062-0","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41479-019-0062-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49444171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Standardisation and evaluation of a quantitative multiplex real-time PCR assay for the rapid identification of Streptococcus pneumonia","authors":"Feroze A. Ganaie, V. Govindan, K. R. Ravi Kumar","doi":"10.1186/s41479-017-0034-1","DOIUrl":"https://doi.org/10.1186/s41479-017-0034-1","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"9 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2017-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41479-017-0034-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65785941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination for the control of childhood bacterial pneumonia - <i>Haemophilus influenzae</i> type b and pneumococcal vaccines.","authors":"Diana C Otczyk, Allan W Cripps","doi":"10.15172/pneu.2013.2/229","DOIUrl":"10.15172/pneu.2013.2/229","url":null,"abstract":"<p><p>Pneumonia in childhood is endemic in large parts of the world and in particular, in developing countries, as well as in many indigenous communities within developed nations. <i>Haemophilus influenzae</i> type b and <i>Streptococcus pneumoniae</i> conjugate vaccines are currently available against the leading bacterial causes of pneumonia. The use of the vaccines in both industrialised and developing countries have shown a dramatic reduction in the burden of pneumonia and invasive disease in children. However, the greatest threat facing pneumococcal conjugate vaccine effectiveness is serotype replacement. The current vaccines provide serotype-specific, antibody-mediated protection against only a few of the 90+ capsule serotypes. Therefore, there has been a focus in recent years to rapidly advance technologies that will result in broader disease coverage and more affordable vaccines that can be used in developing countries. The next generation of pneumococcal vaccines have advanced to clinical trials.</p>","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"2 ","pages":"2-15"},"PeriodicalIF":8.5,"publicationDate":"2016-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical site-specific contributions of pneumococcal virulence determinants","authors":"A. Shenoy, C. Orihuela","doi":"10.1186/s41479-016-0007-9","DOIUrl":"https://doi.org/10.1186/s41479-016-0007-9","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"8 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2016-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41479-016-0007-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65785901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The respiratory microbiota during health and disease: a paediatric perspective","authors":"I. Koppen, A. A. Bosch, E. Sanders, M. V. van Houten, D. Bogaert","doi":"10.15172/pneu.2015.6/656","DOIUrl":"https://doi.org/10.15172/pneu.2015.6/656","url":null,"abstract":"Recent studies investigating the relationship between the microbiota and disease are demonstrating novel concepts that could significantly alter the way we treat disease and promote health in the future. It is suggested that the microbiota acquired during childhood may shape the microbial community and affect immunological responses for later life, and could therefore be important in the susceptibility towards disease. Several diseases, including asthma, pneumonia, and otitis media, are associated with changes in composition and diversity of the respiratory microbiota. This review summarises current literature, focusing on the composition and development of the respiratory microbiota in children and its relationship with respiratory diseases.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"6 1","pages":"90 - 100"},"PeriodicalIF":6.8,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2015.6/656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67245413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella empyema: a case report","authors":"S. Pathmanathan, Suminda Welagedara, Petra Dorrington, Siddhartha Sharma","doi":"10.1007/BF03371465","DOIUrl":"https://doi.org/10.1007/BF03371465","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"22 1","pages":"120 - 124"},"PeriodicalIF":6.8,"publicationDate":"2015-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03371465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51683039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FREO2: An electricity free oxygen concentrator","authors":"B. Sobott, D. Peake, James F. P. Black, R. Rassool","doi":"10.15172/pneu.2015.6/529","DOIUrl":"https://doi.org/10.15172/pneu.2015.6/529","url":null,"abstract":"The World Health Organization recommends oxygen therapy for children with severe pneumonia, but this essential medicine is unavailable in many health centres in limited-resource settings. To address this need, an appropriate means of oxygen provision will need to be low-cost and robust, require little maintenance and not compete for fuel with other vital functions, and be environmentally sustainable. This report presents the preliminary results of the Fully Renewable Energy Oxygen (FREO2) system, confirming the viability of a novel means of producing medical grade oxygen without any electricity. The approach relies on exploiting the reduction in pressure of water flowing through a raised siphon to create a source of vacuum. This is used to power a customised vacuum-pressure-swing-adsorption system and produce medical grade oxygen. The FREO2 system has been designed to meet the criteria for successful oxygen delivery in small health facilities. It is ideally suited for deployment in tropical or mountainous regions with proximity to flowing water. Importantly, the oxygen generating capacity of FREO2 rises with the increased demand commonly observed during the rainy season in such climates.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"6 1","pages":"115 - 119"},"PeriodicalIF":6.8,"publicationDate":"2015-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2015.6/529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67245439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress towards understanding the pathology of the pneumococcus","authors":"A. Cox, A. B. Brueggemann, T. Mitchell, Jeremy S. Brown","doi":"10.1007/BF03371466","DOIUrl":"https://doi.org/10.1007/BF03371466","url":null,"abstract":"","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"7 1","pages":"1-2"},"PeriodicalIF":6.8,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03371466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51683532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The upper respiratory tract microbiome of hospitalised patients with community-acquired pneumonia of unknown aetiology: a pilot study","authors":"T. Wiemken, V. Jala, R. Kelley, P. Peyrani, William A. Mattingly, F. Arnold, Patricio W. Cabral, R. Cavallazzi, B. Haribabu, J. Ramirez","doi":"10.15172/pneu.2015.6/682","DOIUrl":"https://doi.org/10.15172/pneu.2015.6/682","url":null,"abstract":"The composition of the upper respiratory tract microbiome may play an important role in the development of lower respiratory tract infections. Here, we characterised the microbiome of the nasopharynx and oropharynx of hospitalised patients with community-acquired pneumonia (CAP) with unknown aetiology in an attempt to obtain insight into the aetiology of CAP. A random sample of 10 patients hospitalised with CAP previously enrolled in a separate clinical trial (ClinicalTrials.gov registry, Study ID: NCT01248715) in which a complete microbiological workup was not able to define an aetiology were analysed in this pilot study. This larger trial (n = 1,221) enrolled patients from 9 adult hospitals in Louisville, Kentucky, USA. Nasopharyngeal and oropharyngeal swabs were obtained for metagenomic analysis. Polymerase chain reaction (PCR) for Streptococcus pneumoniae was performed in all patients. One patient had a distinct nasophararyngeal microbiome consisting largely of Haemophilus influenzae. This was the only patient with a negative PCR for S. pneumoniae in both nasophararyngeal and oropharyngeal specimens. Overall, substantial differences were found between nasophararyngeal and oropharyngeal microbiomes. The upper respiratory tract microbiome of only one patient suggested H. influenzae as a probable aetiology of CAP. Although this was a pilot study of only 10 patients, the presence of S. pneumoniae in the upper respiratory tract of the other 9 patients warrants further investigation.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"6 1","pages":"83 - 89"},"PeriodicalIF":6.8,"publicationDate":"2015-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2015.6/682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67245491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer patients with community-acquired pneumonia treated in intensive care have poorer outcomes associated with increased illness severity and septic shock at admission to intensive care: a retrospective cohort study","authors":"R. José, Ali O. Mohammed, J. Goldring, R. Chambers, Jeremy S. Brown, B. Agarwal","doi":"10.15172/pneu.2015.6/645","DOIUrl":"https://doi.org/10.15172/pneu.2015.6/645","url":null,"abstract":"Patients with community-acquired pneumonia (CAP) and an underlying diagnosis of cancer have worse outcomes. However, the characteristics of cancer patients with CAP admitted to intensive care units (ICUs) are not well established. In a retrospective observational study, patients admitted to a London university hospital ICU between January 2006 and October 2011 with a primary diagnosis of CAP were included. Demographic, clinical, laboratory, and outcome data were collected from the ICU and hospital pathology databases. The analysis included 96 patients with CAP, 19 of whom had an existing diagnosis of cancer. Patients with cancer had a longer median time interval between hospital and ICU admission (1 vs 2 days, p = 0.049). On admission to ICU, there were no differences in white cell count, C-reactive protein, clotting, renal function, liver function, heart rate, temperature, systolic blood pressure or oxygenation index between patients with or without cancer. However, patients with cancer had significantly lower haemoglobin levels (median 8.6 vs 10.0 g/dl, p = 0.010) and lowest diastolic blood pressure (median 40 vs 50 mmHg, p = 0.026), and higher sodium levels (median 142 vs 139 mmol/l), p = 0.020), APACHE II (median 25 vs 20, p = 0.009), SAPS II (median 51 vs 43, p = 0.039) and SOFA (median 12 vs 9, p = 0.018) scores. There were no statistically significant differences in the proportion of patients receiving mechanical ventilation or renal support, the duration of mechanical ventilation or ICU or hospital length of stay. Patients with cancer were more likely to receive vasopressors (89.5% vs 63.6%, p = 0.030) and had increased ICU (68.4% vs 31.2%, p = 0.004) and hospital (78.9% vs 33.8%, p = 0.001) mortality. The limitations of this study are its relatively small sample size and those associated with the retrospective study design. In conclusion, cancer patients with CAP had an increased risk of death that was associated with increased illness severity and prevalence of septic shock at the time of ICU admission, suggesting there may be a delay in recognition for the need for intensive care support in these patients.","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":"6 1","pages":"77 - 82"},"PeriodicalIF":6.8,"publicationDate":"2015-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15172/pneu.2015.6/645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67245118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}