流感嗜血杆菌在社区获得性肺炎中的重要性:与肺炎链球菌相比,流感嗜血杆菌是一种新出现的老年人病原体,与合并症无关。

IF 8.5 Q1 RESPIRATORY SYSTEM
Linda Yamba Yamba, Karin Hansen, Lisa Wasserstrom, Yu-Ching Su, Jonas Ahl, Kristian Riesbeck
{"title":"流感嗜血杆菌在社区获得性肺炎中的重要性:与肺炎链球菌相比,流感嗜血杆菌是一种新出现的老年人病原体,与合并症无关。","authors":"Linda Yamba Yamba, Karin Hansen, Lisa Wasserstrom, Yu-Ching Su, Jonas Ahl, Kristian Riesbeck","doi":"10.1186/s41479-024-00136-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes.</p><p><strong>Methods: </strong>Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (≥ 18 years) from the prospective study \"Etiology of community acquired pneumonia in Sweden\" (ECAPS), which was established during the years 2016-2018.</p><p><strong>Results: </strong>Cases with H. influenzae CAP were significantly older compared to S. pneumoniae CAP (median 77 vs 70 years, p = 0.037) albeit similar comorbidities. Haemophilus influenzae was generally absent in the bloodstream compared to S. pneumoniae (18% vs 2%, p = 0.01) but clinical presentations were comparable. Only a minority of patients, 34% with H. influenzae and 41% with S. pneumoniae CAP had underlying lung disease.</p><p><strong>Conclusion: </strong>In the light of childhood immunization campaigns against S. pneumoniae and the increasing numbers of pneumococcal vaccinations among the elderly, coupled with an aging population, the incidence of CAP caused by H. influenzae may increase. Further research is needed to understand the impact of H. influenzae CAP and to a development of a vaccine against this emerging microbe.</p>","PeriodicalId":45120,"journal":{"name":"Pneumonia","volume":null,"pages":null},"PeriodicalIF":8.5000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344911/pdf/","citationCount":"0","resultStr":"{\"title\":\"The importance of Haemophilus influenzae in community-acquired pneumonia: an emerging pathogen in the elderly regardless of comorbidities compared to Streptococcus pneumoniae.\",\"authors\":\"Linda Yamba Yamba, Karin Hansen, Lisa Wasserstrom, Yu-Ching Su, Jonas Ahl, Kristian Riesbeck\",\"doi\":\"10.1186/s41479-024-00136-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes.</p><p><strong>Methods: </strong>Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (≥ 18 years) from the prospective study \\\"Etiology of community acquired pneumonia in Sweden\\\" (ECAPS), which was established during the years 2016-2018.</p><p><strong>Results: </strong>Cases with H. influenzae CAP were significantly older compared to S. pneumoniae CAP (median 77 vs 70 years, p = 0.037) albeit similar comorbidities. Haemophilus influenzae was generally absent in the bloodstream compared to S. pneumoniae (18% vs 2%, p = 0.01) but clinical presentations were comparable. Only a minority of patients, 34% with H. influenzae and 41% with S. pneumoniae CAP had underlying lung disease.</p><p><strong>Conclusion: </strong>In the light of childhood immunization campaigns against S. pneumoniae and the increasing numbers of pneumococcal vaccinations among the elderly, coupled with an aging population, the incidence of CAP caused by H. influenzae may increase. Further research is needed to understand the impact of H. influenzae CAP and to a development of a vaccine against this emerging microbe.</p>\",\"PeriodicalId\":45120,\"journal\":{\"name\":\"Pneumonia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.5000,\"publicationDate\":\"2024-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344911/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pneumonia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41479-024-00136-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pneumonia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41479-024-00136-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

摘要

背景:流感嗜血杆菌社区获得性肺炎(CAP)很常见,在某些情况下与肺炎链球菌同样常见。本研究旨在提供更多有关流感嗜血杆菌社区获得性肺炎患者及其治疗效果的数据:方法:将肺炎链球菌引起的 CAP(111 例)与流感嗜血杆菌引起的 CAP(53 例)进行比较。患者均为成人(≥ 18 岁),来自 2016-2018 年期间开展的前瞻性研究 "瑞典社区获得性肺炎病因学"(ECAPS):结果:尽管合并症相似,但流感嗜血杆菌 CAP 病例的年龄明显高于肺炎链球菌 CAP 病例(中位数 77 岁 vs 70 岁,p = 0.037)。与肺炎双球菌相比,流感嗜血杆菌一般不出现在血流中(18% 对 2%,p = 0.01),但临床表现相似。只有34%的流感嗜血杆菌和41%的肺炎双球菌CAP患者有潜在的肺部疾病:结论:鉴于肺炎双球菌的儿童免疫接种活动和老年人接种肺炎球菌疫苗的人数不断增加,再加上人口老龄化,由流感嗜血杆菌引起的 CAP 发病率可能会增加。要了解流感嗜血杆菌 CAP 的影响,并开发出针对这种新出现微生物的疫苗,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The importance of Haemophilus influenzae in community-acquired pneumonia: an emerging pathogen in the elderly regardless of comorbidities compared to Streptococcus pneumoniae.

Background: Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes.

Methods: Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (≥ 18 years) from the prospective study "Etiology of community acquired pneumonia in Sweden" (ECAPS), which was established during the years 2016-2018.

Results: Cases with H. influenzae CAP were significantly older compared to S. pneumoniae CAP (median 77 vs 70 years, p = 0.037) albeit similar comorbidities. Haemophilus influenzae was generally absent in the bloodstream compared to S. pneumoniae (18% vs 2%, p = 0.01) but clinical presentations were comparable. Only a minority of patients, 34% with H. influenzae and 41% with S. pneumoniae CAP had underlying lung disease.

Conclusion: In the light of childhood immunization campaigns against S. pneumoniae and the increasing numbers of pneumococcal vaccinations among the elderly, coupled with an aging population, the incidence of CAP caused by H. influenzae may increase. Further research is needed to understand the impact of H. influenzae CAP and to a development of a vaccine against this emerging microbe.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pneumonia
Pneumonia RESPIRATORY SYSTEM-
自引率
1.50%
发文量
7
审稿时长
11 weeks
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信