Annals of Geriatric Medicine and Research最新文献

{"title":"Healthcare Professionals' Perceptions of Decision-Making for Older Patients with Cancer Receiving Systemic Therapy: A Systematic Review and Qualitative Evidence Synthesis.","authors":"Kengo Hirayama, Honoka Tsumura, Sunka Kim, Moe Nemoto","doi":"10.4235/agmr.26.0051","DOIUrl":"10.4235/agmr.26.0051","url":null,"abstract":"<p><p>Decision-making about systemic therapy in older adults with cancer is complex due to frailty, clinical uncertainty, and competing treatment goals. Limited evidence exists synthesizing how healthcare professionals support decision-making in geriatric oncology. This qualitative systematic review searched four databases through November 2025 and conducted citation tracking. Thematic synthesis was performed, and confidence in findings was assessed using GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative research). Twelve studies involving 212 healthcare professionals were included. Two analytical and six descriptive themes were identified. Healthcare professionals sought to minimize treatment-related harm while respecting patients' values and life perspectives. Decision-making was shaped by clinical judgment integrating geriatric assessment findings, healthcare professionals' perspectives, ethical considerations regarding beneficence and autonomy, and structural factors such as resource limitations and interprofessional collaboration. These findings highlight the need for clinical expertise, collaboration across oncology, primary care, and geriatric care providers, and system-level support for geriatric-informed care.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"291-304"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulation of Biopsychosocial Risk Factors and Cognitive Impairment: The Impact of Slower Gait, Depression, and Low Education in Community-Dwelling Older Adults.","authors":"Hyunri Kim, Jong-Hwan Park, Tae Sung Park, Minwoo Jang, Myung-Jun Shin","doi":"10.4235/agmr.26.0020","DOIUrl":"10.4235/agmr.26.0020","url":null,"abstract":"<p><strong>Background: </strong>Cognitive decline in older adults, a prodromal stage of dementia, requires early preventive attention as a major public health concern. Cognitive decline in older adults involves complex interactions among physical, psychological, and social factors. This study applied the biopsychosocial model to examine how these multidimensional domains jointly influence cognitive function and to evaluate cumulative risks associated with multidimensional vulnerabilities.</p><p><strong>Methods: </strong>Data from 661 community-dwelling older adults aged 65 years or older who participated in a community health screening were analyzed. Cognitive function (Cognitive Impairment Screening Test), physical performance (Timed Up and Go test log-transformed [TUG_log]), depressive symptoms (Korean version of the Short Geriatric Depression Scale [SGDS-K]), and education were measured. Age-specific TUG_log cut-offs were obtained by ROC analysis. Dual- and triple-risk groups were defined based on TUG risk, low education (≤6 years), and depression (SGDS-K ≥8). Correlation, regression, and mediation analyses were performed.</p><p><strong>Results: </strong>Slower gait speed, lower education, and higher depressive symptoms were significantly associated with poorer cognitive function (p&lt;0.05). Compared with participants with no risk factors, those with two risk factors had 5.07-fold higher odds of cognitive impairment, while those with all three risk factors had 18.13-fold higher odds. Mediation analysis showed that depression did not directly affect cognition but had a significant indirect effect through impaired physical performance (bootstrap 95% confidence interval, -0.1765 to -0.0530).</p><p><strong>Conclusion: </strong>Cognitive function in older adults is shaped by interacting physical, psychological, and social factors. The accumulation of multidimensional vulnerabilities markedly increases cognitive decline risk, underscoring the need for integrated, multidomain prevention strategies.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"338-345"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Finger-Dexterity Dual Task and Neuropsychological Tests in Middle-Aged and Older Adults.","authors":"Ziheng Pan, Kenji Tsunoda, Jaehoon Seol, Taiki Inoue, Kyohei Shibuya, Koki Nagata, Iku Nishimura, Jieun Yoon, Miyuki Nemoto, Tetsuaki Arai, Tomohiro Okura","doi":"10.4235/agmr.26.0086","DOIUrl":"10.4235/agmr.26.0086","url":null,"abstract":"<p><strong>Background: </strong>Despite the importance of early cognitive impairment detection, standard screening tools have limitations. Motor-cognitive dual tasks such as the Digital Trail Making Peg Test (DTMP) are feasible objective alternatives. Nonetheless, most studies have focused on older adults, and whether these tasks are associated with cognitive performance in midlife remains unclear. This study investigated associations between DTMP performance and neuropsychological test performance in middle-aged and older adults.</p><p><strong>Methods: </strong>We analyzed 171 middle-aged (mean age, 54.5 years; female, 61.4%) and 173 older (mean age, 73.7 years; female, 41.6%) adults from the Tsukuba Happiness Life Study. Finger-dexterity dual-task performance was assessed using DTMP-A, requiring peg insertion in ascending numerical order, and DTMP-B, requiring alternating peg insertion between numbers and hiragana characters. Neuropsychological test performance was assessed using standardized measures of attention, executive function, memory, and language. Associations were examined using age-stratified multiple linear regression models after adjusting for covariates, with supportive domain-level models additionally adjusted for the Digit Symbol Substitution Test (DSST).</p><p><strong>Results: </strong>In age-stratified models, faster DTMP-B performance was significantly associated with better performance across attention, executive, memory, and language measures in both age groups, with standardized β coefficients ranging in absolute value from 0.22 to 0.64. Compared with DTMP-A, DTMP-B showed a broader and more consistent pattern of associations. In supportive DSST-adjusted models, DTMP-B remained associated with executive, memory, and language domains.</p><p><strong>Conclusion: </strong>The finger-dexterity dual task, particularly DTMP-B, showed consistent associations with neuropsychological test performance across cognitive domains, suggesting its potential as a practical performance-based indicator in middle-aged and older adults.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"360-370"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Correlation between Phase Angle and the Number of Medications in Older Inpatients: A Cross-Sectional Study.","authors":"Toshiyuki Moriyama, Mizuki Tokunaga, Ryoko Hori, Akiko Hachisuka, Hideaki Itoh, Mitsuhiro Ochi, Yasuyuki Matsushima, Satoru Saeki","doi":"10.4235/agmr.24.0096.c1","DOIUrl":"10.4235/agmr.24.0096.c1","url":null,"abstract":"","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"442"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Relationships between In-person and Digital Social Interactions with Family and Friends and Loneliness among Older Adults in Japan: A Cross-Sectional Analysis of the 2024 JACSIS.","authors":"Yu Koizumi, Takeshi Miura, Kazumi Kubota, Miya Aishima, Yukiko Matsumura, Yuka Kanoya, Takahiro Tabuchi","doi":"10.4235/agmr.25.0215.c1","DOIUrl":"10.4235/agmr.25.0215.c1","url":null,"abstract":"","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"443"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Prognostic Performance of Nutritional, Immuneinflammatory, and Anthropometric Indices for Cardiovascular and All-cause Mortality in Older Adults with Cardiovascular Disease (NHANES 2009-2018).","authors":"Hoang Le Huy Nguyen","doi":"10.4235/agmr.26.0021","DOIUrl":"10.4235/agmr.26.0021","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) in older adults is compounded by malnutrition and chronic inflammation. We compared the long-term prognostic performance of three categories of routinely available indices: nutritional (Prognostic Nutritional Index [PNI], Geriatric Nutritional Risk Index [GNRI], Controlling Nutritional Status [CONUT]); immune-inflammatory (Systemic Immune- Inflammation Index [SII]); and anthropometric (Weight-Adjusted Waist Index [WWI]).</p><p><strong>Methods: </strong>We analyzed 1,804 National Health and Nutrition Examintion Survey 2009-2018 participants aged ≥60 years with established CVD, linked to the National Death Index. Survey- weighted Cox models with restricted cubic splines estimated associations with cardiovascular and all-cause mortality, adjusted for demographic, socioeconomic, behavioral, and comorbid covariates. Sensitivity analyses included landmark exclusion of early deaths (6, 12, 24 months), a complete-case analysis, and additional adjustment for total energy and protein intake.</p><p><strong>Results: </strong>PNI and GNRI showed L-shaped associations with cardiovascular mortality, whereas CONUT showed a monotonic positive association. Each 1-point increase in PNI corresponded to an adjusted hazard ratio of 0.91 (95% confidence interval 0.87-0.95) for cardiovascular mortality; moderate-to-severe malnutrition by PNI carried a 4.61-fold higher hazard. PNI yielded the best model fit for cardiovascular mortality (lowest Akaike and Bayesian information criteria [AIC and BIC]); CONUT had the highest discrimination. The SII association attenuated when deaths within 24 months were excluded. The WWI predicted all-cause but not cardiovascular mortality.</p><p><strong>Conclusion: </strong>The nutritional indices (PNI, GNRI, CONUT) showed durable associations with cardiovascular mortality, whereas the SII signal was acute and the WWI predicted only all-cause mortality. These findings are hypothesis-generating; prospective external validation is required before routine clinical use.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"313-326"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment and Long-Term Cognitive Trajectories in Relation to Incident Sarcopenia.","authors":"Chao Li, Na Zeng, Fu-Shan Xue","doi":"10.4235/agmr.26.0026","DOIUrl":"10.4235/agmr.26.0026","url":null,"abstract":"<p><strong>Background: </strong>Although sarcopenia is a well-known risk factor for cognitive impairment, the evidence regarding whether cognitive dysfunction may be associated with sarcopenia remains limited. This prospective cohort study aimed to evaluate the association between mild cognitive impairment (MCI), long-term cognitive trajectories, and the development of sarcopenia. We also examined whether a healthy lifestyle could modify this risk.</p><p><strong>Methods: </strong>Using data from the China Health and Retirement Longitudinal Study, we conducted a 4-year longitudinal study with 7,548 participants. We used Cox proportional hazards regression to assess the link between baseline cognitive function and incident sarcopenia. Generalized estimating equation models explored the role of specific cognitive domains. Latent mixture modeling was used to identify long-term cognitive trajectories and evaluate the modifying effects of lifestyles.</p><p><strong>Results: </strong>Among the 7,548 included participants, the mean age was 63.5±6.6 years, and 44.7% were females. Over a 4-year follow-up, we identified 502 new cases of sarcopenia. Baseline MCI was significantly associated with a 57% increased risk of developing sarcopenia (hazard ratio=1.57; 95% confidence interval, 1.25-1.96; p&lt;0.001). Specific cognitive domains, including orientation, memory, and computation, were also significantly linked to sarcopenia. We identified three distinct cognitive trajectories: low (16.6%), moderate (45.6%), and normal (37.8%) function. Compared to the normal group, participants in the low and moderate cognitive function groups had a 2.02-fold and 1.51- fold higher risk of sarcopenia, respectively. A favorable lifestyle was found to significantly reduce the risk of sarcopenia.</p><p><strong>Conclusion: </strong>Both MCI and a persistent low-level decline in cognitive function are strongly associated with an increased risk of sarcopenia, but implementing timely healthy lifestyle interventions can significantly mitigate this risk and promote healthy aging.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"346-359"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between 1-Year Changes in Sarcopenia-Related Indicators and Subjective Well-being in Older Adults Requiring Support or Care under the Long-Term Care Insurance System.","authors":"Yohei Sawaya, Tamaki Hirose, Takahiro Shiba, Ryo Sato, Lu Yin, Shuntaro Tsuji, Tomohiko Urano","doi":"10.4235/agmr.26.0036","DOIUrl":"10.4235/agmr.26.0036","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence linking sarcopenia and subjective well-being among older adults requiring long-term care. This study examined longitudinal changes in sarcopenia-related indicators and their association with life satisfaction and happiness.</p><p><strong>Methods: </strong>This 1-year longitudinal study was conducted between 2023 and 2025. Participants were 101 older adults (mean age, 80.3±7.0 years; 55 males and 46 females) requiring support or care who used day-care rehabilitation services under the long-term care insurance system and had skeletal muscle mass index (SMI) and handgrip strength records at baseline and 1 year. Subjective well-being was assessed in terms of life satisfaction and happiness, and the participants were grouped accordingly. Group-by-time interactions in 1-year changes in SMI and handgrip strength were analyzed using two-way repeated-measures analysis of covariance adjusted for age and other relevant covariates.</p><p><strong>Results: </strong>For changes in SMI, a significant group-by-time interaction was observed between the satisfied (baseline, 6.29±1.07 kg/m²; follow-up, 6.24±1.12 kg/m²) and non-satisfied (baseline, 6.54±1.00 kg/m²; follow-up, 6.31±1.07 kg/m²) groups overall (p=0.048). In sex-stratified analyses, a significant group-by-time interaction was observed among females (p=0.0498) but not among males (p=0.665). No significant group-by-time interaction was observed for handgrip strength according to life satisfaction. When participants were classified by happiness, no significant group-by-time interactions were found for either SMI or handgrip strength.</p><p><strong>Conclusion: </strong>Life satisfaction, which reflects multidimensional factors including activities of daily living and psychological status, was suggested to be associated with less decline in skeletal muscle mass among older adults requiring support/care.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"390-399"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Walking Aid Selection in Patients with Vertebral Compression Fractures: A Retrospective Study.","authors":"Kodai Hosaka, Hiroshi Otao, Daisuke Matsumoto, Eri Nishi, Junpei Imamura, Junko Tanaka, Hajime Shibata","doi":"10.4235/agmr.26.0029","DOIUrl":"10.4235/agmr.26.0029","url":null,"abstract":"<p><strong>Background: </strong>Vertebral compression fractures (VCFs) are associated with reduced gait ability and functional impairment in older adults. Factors related to walking aid use at discharge remain unclear. This study examined associations between walking aid use and physical function at discharge.</p><p><strong>Methods: </strong>This cross-sectional study included 143 patients with VCFs discharged from Kurume Rehabilitation Hospital. Participants were classified into independent ambulation and walking aid groups, the latter subdivided into cane and walker users. Pain, cognitive function, handgrip strength, 30-second chair stand test, Berg Balance Scale (BBS), and skeletal muscle mass index (SMI) were assessed at discharge. Logistic regression identified factors associated with walking aid use, and exploratory analysis compared cane and walker users. Receiver operating characteristic (ROC) analysis was used to determine the BBS cutoff.</p><p><strong>Results: </strong>BBS at discharge was significantly associated with walking aid use (odds ratio [OR]=0.85; 95% confidence interval [CI] 0.77-0.93; p&lt;0.001). In exploratory analysis, pain (OR=1.43; 95% CI 1.03-1.96; p=0.029) and SMI (OR=0.40; 95% CI 0.20-0.79; p=0.010) were associated with cane versus walker use. The optimal BBS cutoff was 48.5 (area under the curve [AUC]=0.83).</p><p><strong>Conclusion: </strong>BBS was associated with the distinction between independent ambulation and walking aid use, while pain and SMI were associated with differences among walking aid users. These findings may inform clinical decision-making for walking aid selection at discharge.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"228-235"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of Smartphone-Based Cognitive Assessment in Older Adults.","authors":"Mokyung Jung, Fumiharu Togo","doi":"10.4235/agmr.25.0175","DOIUrl":"10.4235/agmr.25.0175","url":null,"abstract":"<p><strong>Background: </strong>This study examined the validity and reliability of two smartphone-based tasks, the Symbol Search Task (SST-SP) and the Dot Memory Task (DMT-SP), in cognitively healthy older adults.</p><p><strong>Methods: </strong>Sixty participants (32 older and 28 younger adults) completed two sessions approximately one week apart. In the first session, participants performed standardized cognitive tests (Symbol Digit Substitution Test and Visual Digit Span Test) on a personal computer (PC), PCbased Symbol Search Task (SST-PC), and Dot Memory Task (DMT-PC), followed by the SST-SP and DMT-SP. The second session included only SST-SP and DMT-SP.</p><p><strong>Results: </strong>In older adults, the correlation between the SST-SP and SST-PC was very strong (r=0.83). In addition, the SST-SP showed a moderate correlation with the Symbol Digit Substitution Test (r=0.50). A very strong correlation was observed between DMT-SP and DMT-PC (r=0.86). The DMT-SP also showed a moderate correlation with the Visual Digit Span Test (r=-0.47). The SST-SP demonstrated good test-retest reliability and high split-half reliability, whereas the DMT-SP showed moderate test- retest reliability and acceptable-to-good split-half reliability. Older adults scored lower than younger adults on both the SST-SP and DMT-SP.</p><p><strong>Conclusion: </strong>The SST-SP and DMT-SP are valid and reliable tools for assessing processing speed and working memory, respectively, in cognitively healthy older adults. These tools may provide new strategies for assessing the cognitive performance and/or ability in older adults in both research and clinical settings.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"246-254"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}