Annals of Geriatric Medicine and Research最新文献

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Predicting Mortality Risks Using Body Mass Index and Weight Loss at Admission in Patients with Heart Failure. 利用入院时的体重指数和体重下降情况预测心力衰竭患者的死亡风险。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.4235/agmr.23.0213
Yuria Ishida, Keisuke Maeda, Kenta Murotani, Akio Shimizu, Junko Ueshima, Ayano Nagano, Tatsuro Inoue, Naoharu Mori
{"title":"Predicting Mortality Risks Using Body Mass Index and Weight Loss at Admission in Patients with Heart Failure.","authors":"Yuria Ishida, Keisuke Maeda, Kenta Murotani, Akio Shimizu, Junko Ueshima, Ayano Nagano, Tatsuro Inoue, Naoharu Mori","doi":"10.4235/agmr.23.0213","DOIUrl":"10.4235/agmr.23.0213","url":null,"abstract":"<p><strong>Background: </strong>The association of the combination of body mass index (BMI) and weight change at admission with prognoses in patients with heart failure (HF) is unclear. Therefore, we investigated whether BMI and weight changes at admission affect mortality in patients with HF.</p><p><strong>Methods: </strong>This retrospective cohort study lasted 99 months, starting in April 2014, and included 4,862 patients with HF from a Japanese real-world database. Cubic and thin-plate smoothing spline analyses were performed to investigate the association of BMI and weight changes with mortality. The percentage weight change was calculated every 6 months. The study outcome was the presence or absence of death.</p><p><strong>Results: </strong>The patients' mean age was 81.5±9.6 years, and 1,239 (25.5%) patients died. Cubic spline analysis revealed a negative correlation of BMI with mortality hazard ratio (HR) (BMI of 18.5 kg/m2 and 25 kg/m2; HR=1.3 [1.2-1.4] and 0.8 [0.7-0.9], respectively). Cubic spline analysis of weight change showed that weight loss tended to increase the mortality HR (each 6% decrease in weight change rate was associated with a 1.1 times higher mortality risk (95% CI [1.0-1.2]) Thin-plate smoothing spline analysis showed that the odds ratio (OR) negatively correlated with BMI (1-year mortality: BMI of 18.5 kg/m2, 22 kg/m2, and 25 kg/m2; OR at 0% weight change=1.5, 1.0, and 0.7, respectively; 2-year mortality: BMI=18.5 kg/m2, 22 kg/m2, and 25 kg/m2; OR at 0% weight change=1.4, 0.9, and 0.7, respectively).</p><p><strong>Conclusion: </strong>A low BMI in patients with HF was associated with a higher risk of mortality. Weight loss in patients, regardless of BMI, was associated with a higher OR for mortality.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"171-177"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Olfactory and Gustatory Function with Memory among Community-Dwelling Independent Older Adults. 居住在社区的独立老年人的嗅觉和味觉功能与记忆力的关系。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.4235/agmr.23.0217
Hyuma Makizako, Yuki Nakai, Shoma Akaida, Yoshiaki Taniguchi, Takaki Miwa, Shigeto Morimoto
{"title":"Association of Olfactory and Gustatory Function with Memory among Community-Dwelling Independent Older Adults.","authors":"Hyuma Makizako, Yuki Nakai, Shoma Akaida, Yoshiaki Taniguchi, Takaki Miwa, Shigeto Morimoto","doi":"10.4235/agmr.23.0217","DOIUrl":"10.4235/agmr.23.0217","url":null,"abstract":"<p><strong>Background: </strong>This study examined the association between memory function and reduced olfactory and gustatory function among independent community-dwelling older adults.</p><p><strong>Methods: </strong>This cross-sectional study included 127 older adults (65.4% women). We assessed their memory, odor, and taste identification skills. Open essence (OE) test and taste strips (TS) were used to identify hyposmia (OE test ≤6) and hypogeusia (TS test ≤8), respectively.</p><p><strong>Results: </strong>Participants with severe hyposmia had significantly poorer memory functions compared to participants without severe hyposmia. After adjusting for covariates, multivariate logistic regression models revealed a significant association between immediate recognition performance and a decreased likelihood of severe hyposmia (odds ratio=0.65; 95% confidence interval 0.47-0.90). We observed no significant association between taste function and memory.</p><p><strong>Conclusion: </strong>Memory function may be associated with olfactory impairment in older adults.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"178-183"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Podocyte Disease Following Treatment with Intravenous Ibandronate in an Older Patient. 一名老年患者接受伊班膦酸钠静脉注射治疗后出现荚膜细胞病变。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-02-22 DOI: 10.4235/agmr.23.0195
Ye Rin Chung, Hyun Soon Lee, Dong Young Lee, Sang Hee Lee, Jin Seon Jeong, Beom Kim
{"title":"Podocyte Disease Following Treatment with Intravenous Ibandronate in an Older Patient.","authors":"Ye Rin Chung, Hyun Soon Lee, Dong Young Lee, Sang Hee Lee, Jin Seon Jeong, Beom Kim","doi":"10.4235/agmr.23.0195","DOIUrl":"10.4235/agmr.23.0195","url":null,"abstract":"<p><p>Bisphosphonates are commonly used to treat osteoporosis. While renal toxicity is common with pamidronate and zoledronate, few ibandronate-related cases are reported. We describe a rare case of ibandronate-associated nephrotoxicity. An 88-year-old woman was admitted for edema. She had been receiving intravenous ibandronate treatment for postmenopausal osteoporosis and had no other diagnosed diseases. She was presented with proteinuria, hypoalbuminemia (1.9 g/dL), and an elevated serum creatinine level (1.8 mg/dL). Renal biopsy revealed podocyte disease, favoring a diagnosis of focal segmental glomerulosclerosis. She was treated with diuretics, tacrolimus, and fimasartan. Steroids were avoided due to severe osteoporosis. Three months later, the edema had subsided and the laboratory findings had improved (serum albumin 3.5 g/dL, serum creatinine 0.97 mg/dL). This case emphasizes the importance of careful monitoring of proteinuria and renal function during ibandronate treatment. In older adult patients, kidney biopsy and immunosuppressive treatment may be considered based on physical activity and underlying diseases.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"228-230"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Phase Angle Dynamics with Sarcopenia and Activities of Daily Living in Osteoporotic Fracture Patients. 骨质疏松性骨折患者的相角动态与肌肉疏松症和日常生活活动的关系。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI: 10.4235/agmr.23.0212
Yusuke Ito, Yoshihiro Yoshimura, Fumihiko Nagano, Ayaka Matsumoto, Hidetaka Wakabayashi
{"title":"Association of Phase Angle Dynamics with Sarcopenia and Activities of Daily Living in Osteoporotic Fracture Patients.","authors":"Yusuke Ito, Yoshihiro Yoshimura, Fumihiko Nagano, Ayaka Matsumoto, Hidetaka Wakabayashi","doi":"10.4235/agmr.23.0212","DOIUrl":"10.4235/agmr.23.0212","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine whether changes in phase angle during rehabilitation are associated with clinical outcomes such as activities of daily living (ADL), skeletal muscle mass index (SMI), and strength in patients with osteoporotic fractures.</p><p><strong>Methods: </strong>This retrospective observational study included patients with osteoporotic fractures admitted to convalescent rehabilitation wards. Changes in phase angle were defined as the difference between the phase angle values at discharge and on admission. The primary outcome was the Functional Independence Measure motor (FIM-motor) score at discharge. The secondary outcomes were SMI and handgrip strength at discharge. We used multivariate analysis to adjust for confounding factors and examine the association between changes in the phase angle and outcomes.</p><p><strong>Results: </strong>We analyzed a total of 115 patients (97 women, mean age of 81.0±10.0 years), with a median change in phase angle of 0° during hospitalization. We observed increased phase angles in 49 patients (43%), with a median increase of 0.2°. Multiple regression analysis showed that changes in phase angle were independently associated with FIM-motor score at discharge (β=0.238, p=0.027). Changes in phase angle were not significantly associated with SMI (β=0.059, p=0.599) or handgrip strength (β=-0.032, p=0.773) at discharge.</p><p><strong>Conclusion: </strong>An increased phase angle during rehabilitation was positively associated with ADL improvement in patients with osteoporotic fractures. These findings may help clinicians make informed decisions regarding patient care and treatment strategies for better outcomes.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"192-200"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Different Extubation Strategies on Atelectasis in Older Adults after Major Abdominal Surgery: A Prospective Randomized Controlled Trial. 不同拔管策略对腹部大手术后老年患者气胸的影响:前瞻性随机对照试验。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.4235/agmr.23.0180
Rahul Madhukar Kashyap, Pradeep Bhatia, Tanvi M Meshram, Swati Chhabra, Rakesh Kumar
{"title":"Effects of Different Extubation Strategies on Atelectasis in Older Adults after Major Abdominal Surgery: A Prospective Randomized Controlled Trial.","authors":"Rahul Madhukar Kashyap, Pradeep Bhatia, Tanvi M Meshram, Swati Chhabra, Rakesh Kumar","doi":"10.4235/agmr.23.0180","DOIUrl":"10.4235/agmr.23.0180","url":null,"abstract":"<p><strong>Background: </strong>Older patients are particularly vulnerable to age-related respiratory changes. This prospective randomized controlled trial studied the effects of high and low fractions of inspired oxygen (FiO2) with the recruitment maneuver (RM) during extubation on lung atelectasis postoperatively in older patients undergoing major abdominal surgery.</p><p><strong>Methods: </strong>We randomized a total of 126 patients aged &gt;60 years who underwent both elective and emergency major abdominal surgeries and met the inclusion criteria into three groups (H, HR, and LR) using computer-generated block randomization. Group H received high FiO2 (1), Group HR received high FiO2 (1) with RM followed by a positive end-expiratory pressure of 5 cm H2O, and Group LR received low FiO2 (0.4) with RM followed by a positive end-expiratory pressure of 5 cm H2O 10 minutes before extubation. Oxygenation and atelectasis were measured using the arterial partial pressure of oxygen (PaO2)/FiO2 ratios and lung ultrasound score. Postoperative pulmonary complications were recorded up to 24 hours postoperatively.</p><p><strong>Results: </strong>The mean PaO2/FiO2 at 30 minutes post-extubation was significantly higher in Groups LR and HR compared to that in Group H (390.71±29.55, 381.97±24.97, and 355.37±31.70; p&lt;0.001). In the immediate postoperative period, the median lung ultrasound score was higher in Group H than that in Groups LR and HR (6 [5-7], 3 [3-5], and 3.5 [2.25-4.75]; p&lt;0.001). The incidence of oxygen desaturation and oxygen requirements was higher in Group H during the postoperative period.</p><p><strong>Conclusion: </strong>The RM before extubation is beneficial in reducing atelectasis and postoperative pulmonary complications, irrespective of the FiO2 concentration used in older adults undergoing major abdominal surgeries. (Trail registration number: Reference No. CTRI/2022/04/042115; date of CTRI registration 25/02/2022; and date of enrolment of the first research participant 05/05/2022).</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"201-208"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Factors Influencing Handgrip Strength Asymmetry in Older Peruvian Adults. 评估影响秘鲁老年人手握力不对称的因素。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI: 10.4235/agmr.23.0194
Alba Zevallos, Renzo Pajuelo-Vásquez, Kiara Camacho-Caballero, Rodrigo Corcuera-Ciudad, Paola Goicochea-Romero, Wendy Gutiérrez-Baca, Diego Chambergo-Michilot, José F Parodi, Fernando M Runzer-Colmenares
{"title":"Evaluation of Factors Influencing Handgrip Strength Asymmetry in Older Peruvian Adults.","authors":"Alba Zevallos, Renzo Pajuelo-Vásquez, Kiara Camacho-Caballero, Rodrigo Corcuera-Ciudad, Paola Goicochea-Romero, Wendy Gutiérrez-Baca, Diego Chambergo-Michilot, José F Parodi, Fernando M Runzer-Colmenares","doi":"10.4235/agmr.23.0194","DOIUrl":"10.4235/agmr.23.0194","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a musculoskeletal disease involving the reduction of muscle mass, strength, and performance. Handgrip strength (HGS) measurements included in frailty assessments are great biomarkers of aging and are related to functional deficits. We assessed the association between potential influencing factors and HGS asymmetry in older Peruvian adults.</p><p><strong>Methods: </strong>We used a database of the Peruvian Naval Medical Center &quot;Cirujano Santiago Távara&quot; located in Callao, Peru. All the patients included were ≥60 years old and had an HGS measurement in the dominant and non-dominant hand.</p><p><strong>Results: </strong>From a total of 1,468 patients, 74.66% had HGS asymmetry. After adjustment, calf circumference weakness (adjusted prevalence ratio [aPR]=1.08; 95% confidence interval [CI], 1.01-1.15), falls risk (aPR = 1.08; 95% CI, 1.02-1.16), and an altered Lawton index (aPR=0.92; 95% CI, 0.84-0.99) were associated with HGS asymmetry.</p><p><strong>Conclusion: </strong>Our findings suggest that HGS asymmetry should be measured along with other geriatric assessments used to evaluate health outcomes in the elderly to enhance health promotion and prevention aimed at preserving muscle strength to curb functional limitations in the elderly.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"184-191"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Network Typologies and Digital Literacy Differences among Korean Older Adults: A Latent Class Analysis. 韩国老年人的社交网络类型与数字素养差异:潜类分析
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-02-22 DOI: 10.4235/agmr.23.0174
Hamin Lee, Mi Kyeong Kim, Hae Yean Park, Kang-Hyun Park
{"title":"Social Network Typologies and Digital Literacy Differences among Korean Older Adults: A Latent Class Analysis.","authors":"Hamin Lee, Mi Kyeong Kim, Hae Yean Park, Kang-Hyun Park","doi":"10.4235/agmr.23.0174","DOIUrl":"10.4235/agmr.23.0174","url":null,"abstract":"<p><strong>Background: </strong>This study categorized older Korean adults' social networks and analyzed their characteristics and digital literacy differences based on type.</p><p><strong>Methods: </strong>We analyzed data from 9,377 Korean older adult participants of the 2020 National Survey of Older Koreans, and performed latent class analysis (LCA) chi-square and Welch's F analyses to understand the characteristics of each social network type. The Games-Howell post-hoc test was applied to determine the significance of differences between groups.</p><p><strong>Results: </strong>The three social network types derived using LCA were \"child-centered,\" \"child-friend,\" and \"friend-centered.\" The digital literacy levels differed significantly according to social network type.</p><p><strong>Conclusion: </strong>The results of this study can be used to propose intervention programs and services associated with older adults' social networks by examining their social network types and the corresponding differences in digital literacy.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"134-143"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Associated with the Deterioration of Intrinsic Capacity among Older Adults in Mexico and Colombia. 墨西哥和哥伦比亚老年人内在能力退化的相关因素。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.4235/agmr.23.0182
Claudia Liliana Valencia Rico, Nora Hilda González Quirarte, Lidia Guadalupe Compeán Ortiz, Hortensia Castañeda Hidalgo, Sandra Milena Campiño Valderrama, Lilia Fletes Rayas
{"title":"Factors Associated with the Deterioration of Intrinsic Capacity among Older Adults in Mexico and Colombia.","authors":"Claudia Liliana Valencia Rico, Nora Hilda González Quirarte, Lidia Guadalupe Compeán Ortiz, Hortensia Castañeda Hidalgo, Sandra Milena Campiño Valderrama, Lilia Fletes Rayas","doi":"10.4235/agmr.23.0182","DOIUrl":"10.4235/agmr.23.0182","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) is defined as &quot;all the physical and mental attributes possessed by the older person.&quot; This concept has gained momentum in recent years because it provides insights into the changes in the functional capacity of individuals during their life. This study examined common factors associated with IC decline among older adults in Mexico and Colombia.</p><p><strong>Methods: </strong>This cross-sectional, correlational study included 348 community-dwelling older adults. Sociodemographic, clinical, and family conditions were assessed as possible associated factors, and IC was analyzed across five domains: cognitive, locomotor, psychological, vitality (malnutrition through deficiency and excess), and sensory (visual and auditory). Parametric and non-parametric statistical analyses were performed.</p><p><strong>Results: </strong>The common factors associated with impairment according to domain were family dysfunctionality (cognitive domain); myocardial infarction, family dysfunctionality, age &gt;80 years, home occupation, and not having a partner (locomotor domain); dysfunctional family and risk of falls (psychological domain); age &gt;80 years and not having a partner (malnutrition by deficiency domain); age 60-79 years, walking &lt;7,500 steps/day, and peripheral vascular disease (malnutrition by excess domain); risk of falling and being female (visual sensory domain); risk of falling (auditory sensory domain); and dysfunctional family and risk of falling (total intrinsic capacity).</p><p><strong>Conclusion: </strong>Both populations had common sociodemographic, clinical, and familial factors that directly affected total IC stocks and their domains.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"156-163"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series. 同型半胱氨酸水平升高和脑萎缩变化是筛查阿尔茨海默病的标志--病例系列。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-03-01 Epub Date: 2023-12-13 DOI: 10.4235/agmr.23.0135
Ram Prakash Sah, C S Vidya, Pratibha Pereira, Shubha Jayaram, Anshu Kumar Yadav, P Sujatha
{"title":"Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series.","authors":"Ram Prakash Sah, C S Vidya, Pratibha Pereira, Shubha Jayaram, Anshu Kumar Yadav, P Sujatha","doi":"10.4235/agmr.23.0135","DOIUrl":"10.4235/agmr.23.0135","url":null,"abstract":"<p><p>Alzheimer disease (AD) is the most common cause of dementia worldwide. Its clinical manifestations include a progressive loss of memory and other cognitive domains, as well as brain atrophy. An elevated homocysteine level (&gt;15 µmol/L), known as hyperhomocysteinemia, is also an attributing risk factor for AD, vascular pathologies, and brain atrophy. Neuroimaging studies including T2-weighted magnetic resonance imaging scans revealed white matter hyperintensities in the periventricular and deep white matter, enlarged ventricles, widened sulci, and decreased white matter mass, which are features of aging, as well as cerebrovascular changes. This case series investigated changes in biochemical marker levels including serum homocysteine, folate, and vitamin B12, and the degree of atrophic variations in cortical-subcortical white matter in AD. The present study hypothesized that serum homocysteine levels might be used as a surrogate marker to screen for AD at an earlier stage.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"116-120"},"PeriodicalIF":2.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case-Finding for Sarcopenia in Community-Dwelling Older Adults: Comparison of Mini Sarcopenia Risk Assessment with SARC-F and SARC-CalF. 在社区居住的老年人中寻找 Sarcopenia 的病例:迷你 Sarcopenia 风险评估与 SARC-F 和 SARC-CalF 的比较。
IF 2.8
Annals of Geriatric Medicine and Research Pub Date : 2024-03-01 Epub Date: 2024-01-12 DOI: 10.4235/agmr.23.0190
Shiyun Chua, Jia Qian Chia, Jun Pei Lim, Justin Chew, Wee Shiong Lim
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