{"title":"Psychosocial Determinants of Knee Osteoarthritis Progression: Results from the Promoting Independence in Our Seniors with Arthritis Study.","authors":"Guo Jeng Tan, Sheng Hui Kioh, Sumaiyah Mat, Maw Pin Tan, Shirley Huey Ling Chan, Jacintha Mei Ying Lee, Yee Wen Tan","doi":"10.4235/agmr.23.0011","DOIUrl":"10.4235/agmr.23.0011","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (OA) is a common cause of physical disability among older adults. While established risk factors for knee OA include age and increased body weight, few studies have examined psychosocial risk factors or progression of knee OA.</p><p><strong>Methods: </strong>The Promoting Independence in our Seniors with Arthritis study recruited participants aged 65 years and over from orthopedic outpatients and community engagement events. Participants were invited to annual visits during which knee OA symptoms were assessed with the Knee Injury and Osteoarthritis Outcome Score (KOOS), social network using the 6-item Lubben Social Network Scale and anxiety and depression using the Hospital Anxiety and Depression scale. Knee OA worsening was defined by a 5% reduction in mean KOOS scores at the last visit compared to the first visit.</p><p><strong>Results: </strong>Data were available from 148 participants, mean age 66.2±6.5 years and 74.1% female, of whom 28 (18.9%) experienced OA worsening over a median follow-up period of 29 months. Univariate analyses revealed that age, sex, height, grip strength, and social network were associated with OA worsening. Social network remained statistically significantly associated with OA worsening after adjustment for age and sex difference (odds ratio=0.924; 95% confidence interval, 0.857-0.997). The relationship between social network and OA worsening were attenuated by both depression and handgrip strength at baseline.</p><p><strong>Conclusion: </strong>Psychological status and muscle strength may be modifiable risk factors for social network which may in turn prevent knee OA worsening and should be targeted in future intervention studies.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"346-352"},"PeriodicalIF":3.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta-Analysis on the Association between Echo Intensity, Muscle Strength, and Physical Function in Older Individuals.","authors":"Han Yuan, Maengkyu Kim","doi":"10.4235/agmr.23.0101","DOIUrl":"10.4235/agmr.23.0101","url":null,"abstract":"<p><strong>Background: </strong>The use of ultrasonographic echo intensity (EI) to evaluate skeletal muscle quality and its effects on strength, explosive power, and physical function (PF) in older individuals remains unclear. This meta-analysis evaluated the associations among EI, muscle strength (MS), and PF in older individuals.</p><p><strong>Methods: </strong>We conducted a systematic search of the PubMed, Embase, Web of Science, SPORT Discus, and CINAHL databases through October 2022 to identify primary studies examining the association between EI and MS/PF. Effect sizes were computed using a random-effects model and presented using forest plots. Pearson correlation coefficient (r) and I2 statistics were used to measure heterogeneity.</p><p><strong>Results: </strong>This meta-analysis included 24 patients. EI demonstrated a negative association with maximal strength (r=-0.351; 95% confidence interval [CI], -0.411 to -0.288; p<0.001) and explosive power (r=-0.342; 95% CI, -0.517 to -0.139; p=0.001) in older individuals. Handgrip strength also showed a significant negative correlation with EI (r=-0.361; 95% CI, -0.463 to -0.249; p<0.001). However, we observed only a small and non-significant negative association between EI and gait speed (r=-0.003; 95% CI, -0.083 to -0.077; p=0.943), and a weak non-significant correlation with the chair stand test (r=0.072; 95% CI, -0.045 to 0.187; p=0.227).</p><p><strong>Conclusion: </strong>Increased EI was associated with lower strength and power but not with gait speed or chair test performance in older individuals. Further large-sample studies with long-term follow-up are needed to improve frailty prediction and risk assessment in this population.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"329-337"},"PeriodicalIF":3.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Gusti Putu Suka Aryana, Sandra Surya Rini, Siti Setiati
{"title":"Retraction: Denosumab's Therapeutic Effect for Future Osteosarcopenia Therapy: A Systematic Review and Meta-Analysis.","authors":"I Gusti Putu Suka Aryana, Sandra Surya Rini, Siti Setiati","doi":"10.4235/agmr.22.0139.r1","DOIUrl":"10.4235/agmr.22.0139.r1","url":null,"abstract":"","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"27 4","pages":"361"},"PeriodicalIF":3.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship between Chronic Musculoskeletal Pain and Sarcopenia Risk in Community-Dwelling Older Adults: A Cross-Sectional Study.","authors":"Ulku Kezban Sahin, Aysun Yağci Şentürk","doi":"10.4235/agmr.23.0081","DOIUrl":"10.4235/agmr.23.0081","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to better understand the relationship between chronic musculoskeletal pain and the risk of sarcopenia in older adults.</p><p><strong>Methods: </strong>The risk of sarcopenia was assessed in 210 older adults using the SARC-F (strength, assistance with walking, rising from a chair, ascending stairs, and falls) questionnaire. Geriatric pain measures were used to assess pain. We also recorded the pain sites (ankles/feet, wrists/hands, upper back, lower back, neck, shoulder, hips, and knees).</p><p><strong>Results: </strong>Participant mean age was 72.4±7 years, and 109 (51.9%) of the participants were female. The prevalence rates of sarcopenia and chronic musculoskeletal pain were 60% and 92.9%, respectively. Older adults at risk of sarcopenia had a higher mean age, body mass index (BMI), number of comorbidities and falls, presence of chronic pain, pain intensity, and pain sites. Sarcopenia risk was correlated with chronic pain intensity (current and last 7 days) (r=0.506, p<0.001 and r=0.584, p< 0.001, respectively), multisite pain (r=0.442, p< 0.001), and Geriatric Pain Measure score (r=0.730; p< 0.001). Age (odds ratio [OR]=1.1; 95% confidence interval [CI], 1.0-1.2), BMI (OR=1.1; 95% CI, 1.0-1.2), and geriatric pain (OR=1.1; 95% Cl, 1.0-1.1) were associated with sarcopenia risk.</p><p><strong>Conclusions: </strong>The risk of sarcopenia is linked to chronic pain, which frequently occurs in geriatric populations. Our study results also showed that higher pain intensity was associated with a higher risk of sarcopenia. Older adults at risk for sarcopenia often experience chronic musculoskeletal pain, which must be better recognized. Moreover, its significance must be noted in the treatment process.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"250-257"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/e7/agmr-23-0081.PMC10556709.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10081881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between Support after Dementia Diagnosis and Subsequent Decrease in Social Participation.","authors":"Hiroshige Matsumoto, Shuji Tsuda, Shun Takehara, Tomoyuki Yabuki, Satoko Hotta","doi":"10.4235/agmr.23.0091","DOIUrl":"10.4235/agmr.23.0091","url":null,"abstract":"We are writing this letter to accelerate research and discussion on the nature of post-diagnostic support for dementia. Accurate diagnosis of dementia provides a gateway to care and support for people living with dementia and their relatives. 1) The reasons for recommending early diagnosis is that cognitive rehabilitation in the milder stages of dementia was suggested to be effective in preventing further impairment. 2) National plans focused on early diagnosis of dementia have been initiated in many countries. 3) However, the stigma and anxiety associated with diagnosis of dementia without care and support may reduce social participation. 4) Also, post-diagnostic support is supposed to moderate the negative impact, but little is known about the delivery and effectiveness of the support. Therefore, we have analyzed the association between post-diagnosis support and subsequent changes in social participation using data from an online survey.","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"27 3","pages":"274-276"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/12/agmr-23-0091.PMC10556721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with Improvement in Activities of Daily Living during Hospitalization: A Retrospective Study of Older Patients with Hip Fractures.","authors":"Kazuya Takeda, Mineko Wada, Kyosuke Yorozuya, Yuhei Hara, Toyoaki Watanabe, Hideaki Hanaoka","doi":"10.4235/agmr.23.0040","DOIUrl":"10.4235/agmr.23.0040","url":null,"abstract":"<p><strong>Background: </strong>In this study, we aimed to examine the changes in delirium during hospitalization of patients and its association with behavioral and psychological symptoms of dementia (BPSD), as well as improvements in activities of daily living (ADL).</p><p><strong>Methods: </strong>A longitudinal, retrospective cohort study was conducted involving 83 older adults (≥65 years) with hip fractures. We collected Mini-Mental State Examination (MMSE) and Functional Independence Measure-motor domain (m-FIM) assessment results from the medical charts at two time points: baseline (first week of hospitalization) and pre-discharge (final week before discharge). Additionally, we collected data on delirium and BPSD at three points: baseline, week 2 post-admission, and pre-discharge. We performed univariate logistic regression analysis using changes in m-FIM scores as the dependent variable and MMSE and m-FIM scores at baseline and pre-discharge, along with delirium and BPSD subtypes at baseline, week 2 post-admission, and pre-discharge, as the explanatory variables. Finally, we performed a multivariate logistic regression analysis incorporating the significant variables from the univariate analysis to identify factors associated with ADL improvement during hospitalization.</p><p><strong>Results: </strong>We observed significant correlations between ADL improvement during hospitalization and baseline m-FIM and MMSE scores, hypoactive delirium state, and BPSD subtype pre-discharge. Notably, all participants with hypoactive symptoms before discharge exhibited some subtype of delirium and BPSD at baseline.</p><p><strong>Conclusion: </strong>Besides ADL ability and cognitive function at admission, the presence of hypoactive delirium and BPSD subtype before discharge may hinder ADL improvement during hospitalization.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"220-227"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/7b/agmr-23-0040.PMC10556722.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10087647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sung-Ae Cho, Jun-Ho Kim, Choon-Kyu Cho, Tae-Yun Sung
{"title":"The Effect of Neuromuscular Blockade Reversal Agents on Postoperative Pulmonary Complications in Patients undergoing Femur Fracture Repair Surgery: A Retrospective Observational Study.","authors":"Sung-Ae Cho, Jun-Ho Kim, Choon-Kyu Cho, Tae-Yun Sung","doi":"10.4235/agmr.23.0060","DOIUrl":"10.4235/agmr.23.0060","url":null,"abstract":"<p><strong>Background: </strong>Femoral fracture repair surgery under general anesthesia is associated with postoperative pulmonary complications (PPCs). However, information on PPCs caused by residual neuromuscular blockade following perioperative use of neuromuscular blockers is limited. This study aimed to identify the differences in the incidence of PPCs according to the type of neuromuscular blockade reversal agent used in femoral fracture repair surgery, as well as the risk factors for PPCs.</p><p><strong>Methods: </strong>We retrospectively analyzed the electronic medical records of 604 patients aged >18 years who underwent general anesthesia for femoral fracture repair surgery at a single university hospital between March 2017 and March 2022. Patients in whom sugammadex or anticholinesterase was used to reverse the neuromuscular block were subjected to propensity score matching. Multivariate logistic regression analysis was performed to identify risk factors for PPCs.</p><p><strong>Results: </strong>Among the 604 patients, 108 were matched in each group. The incidence rates of PPCs overall and in the anticholinesterase and sugammadex groups were 7.0%, 8.3%, and 5.6%, respectively, with no significant differences between the groups. Older age, higher ASA (American Society of Anesthesiologists) physical status, and lower preoperative oxygen saturation were risk factors, whereas emergency surgery was a preventive factor.</p><p><strong>Conclusions: </strong>Our results demonstrated that the incidence of PPC did not differ significantly between sugammadex and anticholinesterase in patients undergoing femur fracture repair under general anesthesia. Identifying the risk factors and confirming complete recovery from neuromuscular blockade might be more important.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"212-219"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/02/agmr-23-0060.PMC10556711.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tiara Octary, Made Satya Nugraha Gautama, Hai Duong
{"title":"Effectiveness of Vitamin D Supplements in Reducing the Risk of Falls among Older Adults: A Meta-Analysis of Randomized Controlled Trials.","authors":"Tiara Octary, Made Satya Nugraha Gautama, Hai Duong","doi":"10.4235/agmr.23.0047","DOIUrl":"10.4235/agmr.23.0047","url":null,"abstract":"<p><strong>Background: </strong>The role of vitamin D in reducing the risk of falls in older adults has not been clearly demonstrated. This study examined the effectiveness of vitamin D supplementation in reducing the risk of falls in older adults.</p><p><strong>Methods: </strong>Four databases (Cochrane Library, Embase, PubMed, and CINAHL) were searched without language restrictions or time limitations. These articles were comprehensively screened using EndNote version 20.1 software. A manual search of the reference lists of the identified studies was also performed. The analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The pooled evidence was analyzed using RevMan software version 5.4.</p><p><strong>Results: </strong>Seventeen studies met inclusion criteria among 550 potentially relevant studies. The pooled analysis of 38,598 older adults showed that vitamin D supplementation decreased the odds of having at least one fall by 1% (odds ratio [OR]=1.01; 95% confidence interval [CI], 0.92-1.11; p=0.86); however, the difference was not statistically significant. Of eight studies with 19,946 older adults, the pooled analysis showed a 12% (OR=1.12; 95% CI, 0.97-1.29; p=0.11) decrease in the odds of having at least one fracture among older adults; however, the difference was also not statistically significant. Pooled subgroup analysis showed that neither low (<2,000 IU/day) nor high (≥2,000 and <4,000 IU/day) doses of vitamin D supplementation had any significant effect on the incidence of falls and fractures.</p><p><strong>Conclusion: </strong>Vitamin D supplementation had no beneficial effect in reducing fall and fracture incidence among older adults.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"192-203"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/76/agmr-23-0047.PMC10556715.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10129951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra Piscitelli, Stefano Cacciatore, Fiorella Ambrosio, Rosa Ragozzino, Francesco Maria Pasquini, Francesco Incordino, Emanuela D'Angelo, Laura Gerardino, Loredana Maggi, Francesco Landi
{"title":"Clostridium tetani Infection in a Geriatric Patient: Do Not Let Your Guard Off!","authors":"Alessandra Piscitelli, Stefano Cacciatore, Fiorella Ambrosio, Rosa Ragozzino, Francesco Maria Pasquini, Francesco Incordino, Emanuela D'Angelo, Laura Gerardino, Loredana Maggi, Francesco Landi","doi":"10.4235/agmr.23.0067","DOIUrl":"10.4235/agmr.23.0067","url":null,"abstract":"<p><p>Tetanus is an infectious disease caused by Clostridium tetani toxin. Although easily preventable through vaccination, over 73,000 new infections and 35,000 deaths due to tetanus occurred worldwide in 2019, with higher rates in countries with healthcare barriers. Here, we present a clinical case of C. tetani infection in an 85-year-old patient. Patient robustness and high functional reserve before infection are favorable predictors of survival for an otherwise fatal disease. However, the patient did not experience any severe complications. Therefore, this report is a strong call for tetanus vaccination.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"269-273"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/5c/agmr-23-0067.PMC10556716.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Océane Babin de Lignac, Priscille Carvalho, Marion Carrette, Lucie Cellier, Philippe Courville, Billal Tedbirt
{"title":"Mucous Membrane Pemphigoid in a Nonagenarian: A Case Report.","authors":"Océane Babin de Lignac, Priscille Carvalho, Marion Carrette, Lucie Cellier, Philippe Courville, Billal Tedbirt","doi":"10.4235/agmr.23.0038","DOIUrl":"10.4235/agmr.23.0038","url":null,"abstract":"<p><p>Mucous membrane pemphigoid is a rare autoimmune blistering disease characterized by post-bullous erosion of mucous membranes. Herein, we present a case of a nonagenarian man who was referred to our department of dermatology presenting with painful erosion of the buccal mucosa. Physical examination revealed palate erosion associated with erosion of the buccal mucosa. A diagnosis of mucous membrane pemphigoid was confirmed, and the patient was successfully treated with topical corticosteroids.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"266-268"},"PeriodicalIF":3.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/08/agmr-23-0038.PMC10556713.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}