Journal of Public Health in Africa最新文献

筛选
英文 中文
Infection prevention knowledge and practices among healthcare workers at a health facility in Makurdi, Benue State, Nigeria. 尼日利亚贝努埃州马库尔迪一家卫生机构卫生保健工作者的感染预防知识和做法。
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2599
Owoicho Oko Amali, Renay Helouise VAN Wyk
{"title":"Infection prevention knowledge and practices among healthcare workers at a health facility in Makurdi, Benue State, Nigeria.","authors":"Owoicho Oko Amali, Renay Helouise VAN Wyk","doi":"10.4081/jphia.2023.2599","DOIUrl":"https://doi.org/10.4081/jphia.2023.2599","url":null,"abstract":"<p><p>The ongoing COVID-19 pandemic has highlighted the critical importance of infection prevention practices among healthcare workers. Prioritizing this crucial aspect of healthcare can mitigate the spread of infectious diseases and ensure the well-being of our healthcare heroes and their communities. The purpose of the research was to investigate the knowledge and practice of infection prevention and control. The study was a cross-sectional study that used self-administered paper-based questionnaires. The study sample of 316 eligible healthcare workers was selected using stratified sampling. Data was entered into EPI Info version 7.2 and exported to SPSS version 27 for analysis. The ethics committees of the university and the hospital approved the study. The majority of participants 116 (36.7%) were nurses. The mean age was 34.79 years ± 8.37, 118 (37.30%) were male while 198 (62.7%) were female. Only 169 (53.9%) knew the recommended duration for hand washing. 132 (41.8%) of healthcare workers believed needles should be recapped following use. Healthcare workers were twice as likely to wash their hands before contact and five times more likely to wash their hands after contact with a patient, their bedding, or after a procedure (AOR 1.82, 95% CI 1.04-3.20), (AOR 4.51, 95% CI 1.76-11.54) respectively. Personal protective equipment (PPEs) were twice as likely to be unavailable (AOR 2.39, 95% CI 1.31-4.37). The findings revealed suboptimal knowledge and practice of hand hygiene indicating the need for healthcare workers to be trained on Infection Prevention and Control. PPE(s) must be provided for healthcare workers to improve compliance with IPC practices.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The public healthcare sector of Mauritius: knowledge of and attitudes toward hearing loss among community health workers. 毛里求斯的公共保健部门:社区保健工作者对听力损失的知识和态度。
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2497
Taslima Foondun, Lidia Pottas, Maggi Soer
{"title":"The public healthcare sector of Mauritius: knowledge of and attitudes toward hearing loss among community health workers.","authors":"Taslima Foondun, Lidia Pottas, Maggi Soer","doi":"10.4081/jphia.2023.2497","DOIUrl":"https://doi.org/10.4081/jphia.2023.2497","url":null,"abstract":"<p><p>Mauritius does not have community health workers trained in identifying risk factors for hearing loss or in referring patients for diagnostic testing. It is crucial to gather information about the knowledge of and attitudes toward hearing loss among community health workers before involving them in the identification and intervention of hearing loss in Mauritius. To describe the knowledge of and attitudes toward hearing loss among community health workers in Mauritius. A descriptive survey design with quantitative analysis was used. Using non-probability purposive sampling, 125 community health workers which included 94 community health officers and 31 community-based rehabilitation officers were recruited from the five catchment areas of the public healthcare sector. Participants filled in a 15-item paper-based questionnaire on the knowledge of and attitudes toward hearing loss. The questionnaire was internally consistent, with Cronbach alpha scores of 0.759 and 0.863. The overall knowledge of community health workers regarding risk factors and the identification of hearing loss was poor (38.3%). 92.6% of community health workers reported positive attitudes toward hearing loss. General knowledge of hearing loss (P=0.015) and knowledge of risk factors and identification of hearing loss (P=0.005) were significant predictors of attitudes toward hearing loss. Knowledge of and attitudes toward hearing loss were significantly associated with working experience and practice setting (P=0.004). There remains a need to educate community health workers about the risk factors and identification of hearing loss to ensure timely diagnosis and management of hearing loss at the community level.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practices of pregnant women regarding tobacco and alcohol use during pregnancy at one primary health care clinic in Southern Namibia. 纳米比亚南部一家初级保健诊所孕妇在怀孕期间使用烟草和酒精的做法。
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2652
Selma Hamutenya, Emma Maano Nghitanwa
{"title":"Practices of pregnant women regarding tobacco and alcohol use during pregnancy at one primary health care clinic in Southern Namibia.","authors":"Selma Hamutenya, Emma Maano Nghitanwa","doi":"10.4081/jphia.2023.2652","DOIUrl":"https://doi.org/10.4081/jphia.2023.2652","url":null,"abstract":"<p><p>Tobacco and alcohol use during pregnancy has negative consequences, to the fetus. The study purpose was to investigate the practices of pregnant women regarding the use of tobacco and alcohol during pregnancy. A quantitative research approach with a descriptive, cross-sectional, analytical design was used. The population were all pregnant women aged 18 years and above attending antenatal care at Mariental clinic. Written informed consent was obtained from all respondents prior to data collection. Data was collected from 211 respondents selected through a systematic sampling. Data was analysed using Statistical Package of the Social Sciences version 27. Descriptive statistics were used for frequencies and percentages. Fisher's Exact test at 0.05 alpha level was used to determine the association between variables. The mean age was 28.8 with a standard deviation of 6.9 years. Most participants, 92 (43.6%) were aged between 18 and 24 years. Majority, 186 (88.15%) were in third trimester of pregnancy and 154 (73%) were single. Most 148 (70.14%) respondents have good practices towards alcohol use during pregnancy. Moreover, 190 (90%) of the respondents were classified as having good practices towards tobacco use in pregnancy. Educational levels showed a significant association with practices towards tobacco smoking (P=0.042). The study concluded good practices among pregnant women on alcohol and tobacco smoking during pregnancy. It is recommended that health facilities should introduce awareness campaign on the dangers of alcohol and tobacco use during pregnancy. Moreover, educational materials should be developed in local languages and distributed to community.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To be seen, heard, and valued. Active engagement as the next frontier for global health conference equity: a view from the global South. 被看到,被听到,被重视。积极参与是全球卫生会议公平的下一个前沿:来自全球南方的观点。
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2810
Barnabas Tobi Alayande
{"title":"To be seen, heard, and valued. Active engagement as the next frontier for global health conference equity: a view from the global South.","authors":"Barnabas Tobi Alayande","doi":"10.4081/jphia.2023.2810","DOIUrl":"10.4081/jphia.2023.2810","url":null,"abstract":"","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitudes, and practices of healthcare workers regarding human immunodeficiency virus index testing in 2021, Burkina Faso. 2021年布基纳法索医护人员对人体免疫缺陷病毒指数检测的知识、态度和做法。
IF 0.6
Journal of Public Health in Africa Pub Date : 2023-10-01 DOI: 10.4081/jphia.2023.2459
Smaïla Ouédraogo, Ahmed Kabore, Ismaël Diallo, Maurice Sarigda, Désiré Lucien Dahourou, Kuilga Benjamin Kabre, Issa Romba, Bapougouni Philippe Christian Yonli, Ter Tiero Elias Dah, Nicolas Meda
{"title":"Knowledge, attitudes, and practices of healthcare workers regarding human immunodeficiency virus index testing in 2021, Burkina Faso.","authors":"Smaïla Ouédraogo, Ahmed Kabore, Ismaël Diallo, Maurice Sarigda, Désiré Lucien Dahourou, Kuilga Benjamin Kabre, Issa Romba, Bapougouni Philippe Christian Yonli, Ter Tiero Elias Dah, Nicolas Meda","doi":"10.4081/jphia.2023.2459","DOIUrl":"10.4081/jphia.2023.2459","url":null,"abstract":"<p><p>Although knowing one's HIV status is a necessary step in initiating antiretroviral treatment, more than a quarter of Burkinabe who are HIV-positive do not know their status. To reach the target of screening at least 95% of people living with HIV (PLHIV), the country has opted for HIV index testing (screening of sexual partners, children and partners of intravenous drug users). This study assessed the knowledge, attitudes and practices of health workers on HIV index testing. A cross-sectional study was conducted among health workers on index testing pilot sites in Burkina Faso. We constructed scores of health workers' knowledge, attitudes and practices regarding HIV index testing. A total of 132 health workers were surveyed, 62.8% of whom were female. Regarding profiles, 44.7% of the participants were nurses and 5.3% were midwives; physicians and psychosocial counselors accounted for 16.7 and 33.3%, respectively. Most of the participants worked in public health centers (60.6%). Overall, the majority of the participants had poor or average knowledge (85.6%) of the index testing strategy and harmful or inadequate practices (87.1%). Less than half (40.9%) had favorable attitudes toward the strategy. Our study showed that the knowledge of health workers was generally average, their attitudes were not very favorable and their practices were mostly inadequate with regard to HIV index testing. In order to increase the chances of reaching the first 95% of UNAIDS, trainings on the topic must be designed for health workers.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors contributing to changes in contraceptive use among adolescent girls in Zambia: a decomposition analysis. 影响赞比亚少女避孕药具使用变化的因素:分解分析
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 DOI: 10.4081/jphia.2023.2261
Mumbi Chola, Khumbulani Hlongwana, Themba G Ginindza
{"title":"Factors contributing to changes in contraceptive use among adolescent girls in Zambia: a decomposition analysis.","authors":"Mumbi Chola, Khumbulani Hlongwana, Themba G Ginindza","doi":"10.4081/jphia.2023.2261","DOIUrl":"10.4081/jphia.2023.2261","url":null,"abstract":"<p><p>Despite its documented benefits, contraceptive use among adolescents remains low, particularly in low-and middle-income countries. This study aimed to decompose the main factors contributing to the changes in contraceptive use among adolescent girls in Zambia over the period 1996 to 2014. Data on adolescent girls aged 15-19 years from Zambia Demographic and Health Survey data were analysed using multivariate decomposition analysis of change. Stata 15/MP (Stata-Corp LLC) was used for analysis, at a 95% confidence level. A P-value of 0.05 was used to determine statistical significance. The sample included 9,072 adolescent girls. Contraceptive use increased by 3% from 7.6% in 1996 to 10.6% in 2013/14. Change in modern contraceptive use among adolescents was mainly due to differences in coefficients (changes in population behaviour). Increases in age contributed to the change in contraceptive use, resulting in 2.94 and 9.33% increases for 17- and 18-year-olds respectively. Marriage or living with a partner contributed the largest change (44%) while living in a rural area accounted for approximately 20%. Interventions targeting improving contraceptive use in adolescents should be responsive to the needs of various age groups, places of residence, and educational levels for maximum benefits.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sub-optimal satisfaction of people living with HIV and AIDS regarding their care in Burkina Faso, West Africa. 西非布基纳法索艾滋病毒和艾滋病感染者对其护理的满意度不理想
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 DOI: 10.4081/jphia.2023.2432
Smaïla Ouédraogo, Ter Tiero Elias Dah, Ismaël Diallo, Maurice Sarigda, Désiré Lucien Dahourou, Issa Romba, Fatogoma Bertrand Sanon, Pengdwendé Anne Lygie Kabore, Bapougouni Philippe Christian Yonli, Léon Gueswendé Blaise Savadogo
{"title":"Sub-optimal satisfaction of people living with HIV and AIDS regarding their care in Burkina Faso, West Africa.","authors":"Smaïla Ouédraogo,&nbsp;Ter Tiero Elias Dah,&nbsp;Ismaël Diallo,&nbsp;Maurice Sarigda,&nbsp;Désiré Lucien Dahourou,&nbsp;Issa Romba,&nbsp;Fatogoma Bertrand Sanon,&nbsp;Pengdwendé Anne Lygie Kabore,&nbsp;Bapougouni Philippe Christian Yonli,&nbsp;Léon Gueswendé Blaise Savadogo","doi":"10.4081/jphia.2023.2432","DOIUrl":"10.4081/jphia.2023.2432","url":null,"abstract":"<p><p>People living with HIV (PLHIV) satisfaction regarding to care could play an important role in the elimination of HIV epidemic by 2030. We assessed Burkina Faso PLHIV satisfaction regarding to their care, and identified its associated factors. A representative nationwide cross-sectional study was performed in 2021-2022 in 30 HIV/AIDS care sites. PLHIV aged at least 18 years, receiving ART for six months or plus were included. Individual and structural data were collected using a questionnaire administered by trained investigators. Satisfaction with HIV/AIDS care was explored using six components (reception, waiting time to medical visit, care environment, sharing updated information on HIV AIDS, answering to PLHIV questions, and providing tailored care and advice to PLHIV needs). Factors associated with satisfaction were identified using logistic regressions. 448 PLHIV were considered in this analysis. Median age was 46 years. Overall satisfaction regarding to care was 40,8% (95% confidence interval 95% CI 36.2-45.6). Specifically, it was 90.6, 54.9, 85.3, 75.7, 90.8, and 93.3% regarding to reception, waiting time, care environment, sharing updated information, answering to PLHIV questions, and providing tailored care and advice to PLHIV needs, respectively. Attending to medical visits in community-based organization (CBO) and private clinics (adjusted odds ratio aOR 1.82, 95% CI 1.14-2.93, P#x003C;0.001), as well as in tertiary hospitals (aOR 2.37, 95% CI 1.45-3.87, P=0.001) were positively associated with PLHIV satisfaction. Burkina Faso PLHIV are generally unsatisfied with care. HIV national authorities should promote HIV care in CBO clinics model in the delivery of HIV services in others public sites.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49028371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The loneliness caused by globalization after the COVID-19 pandemic needs to be redefined. 新冠肺炎疫情后全球化带来的孤独需要重新定义
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 DOI: 10.4081/jphia.2023.2378
Masoud Mohammadi
{"title":"The loneliness caused by globalization after the COVID-19 pandemic needs to be redefined.","authors":"Masoud Mohammadi","doi":"10.4081/jphia.2023.2378","DOIUrl":"10.4081/jphia.2023.2378","url":null,"abstract":"Dear Editor, Loneliness is a common experience and is often a complex and unpleasant response to isolation or lack of companionship [1]. About 80% of people under the age of 18 and 40% of adults over the age of 65 reports feeling lonely at least sometimes [1]. Loneliness represents perceived social isolation, so we can say that people can live relatively solitary life and not feel lonely, and on the contrary, they can have a seemingly rich social life and still feel lonely. [...]","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48959438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Configuring a computer-based nursing process form to support nursing diagnosis in rural healthcare clinics in Nigeria. 配置基于计算机的护理流程表格,以支持尼日利亚农村医疗保健诊所的护理诊断。
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2359
Chinemerem Eleke, Ada C Nwaneri, Joy C Samuel, Sabinah Ngbala-Okpabi, Ifeyinwa S Agu, Damiete M Amachree, Tex-Jack Dokuba
{"title":"Configuring a computer-based nursing process form to support nursing diagnosis in rural healthcare clinics in Nigeria.","authors":"Chinemerem Eleke, Ada C Nwaneri, Joy C Samuel, Sabinah Ngbala-Okpabi, Ifeyinwa S Agu, Damiete M Amachree, Tex-Jack Dokuba","doi":"10.4081/jphia.2023.2359","DOIUrl":"https://doi.org/10.4081/jphia.2023.2359","url":null,"abstract":"<p><p>Poor internet infrastructure limits the use of computer-based nursing process forms in rural areas. This study aimed to configure a computer-based nursing process form to support nursing diagnosis and care evaluation in rural healthcare clinics in Africa. This study utilized a methodological design. The design process utilized a three-stage procedure involving planning, configuration, and testing. Seven faculty members volunteered to participate in the laboratory verification process. Each simulation session lasted 45 min and span from patient admission to exit. The experts independently scored the software functionality dichotomously as Not Suitable (score 0) and Suitable (score 1) for nursing practice. The agreement between the faculty volunteers was 0.857. The configuration of a readily available Microsoft Access computer application to support nursing diagnosis without internet service is possible. Health facilities in rural areas without internet connectivity should resort to such local configurations to maximize the benefits of electronic-based documentation.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotypic resistance testing improves antiretroviral treatment outcomes in a cohort of adolescents in Cameroon: Implications in the dolutegravir-era. 基因型耐药检测改善了喀麦隆一组青少年的抗逆转录病毒治疗结果:妊娠前期的影响
IF 0.8
Journal of Public Health in Africa Pub Date : 2023-10-01 eCollection Date: 2023-10-31 DOI: 10.4081/jphia.2023.2612
Willy LE Roi Togna Pabo, Debimeh Njume, Roland Ndip Ndip, Désiré Takou, Maria-Mercedes Santoro, Collins Chenwi, Grace Beloumou, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Aude Christelle Ka'e, Georges Teto, Beatrice Dambaya, Sandrine Djupsa, Raymond Babila Nyasa, Davy Hyacinthe Gouissi Anguechia, Cedric Kamta, Lionel Bala, Virginie Lambo, Samuel Martin Sosso, Vittorio Colizzi, Carlo Federico Perno, Joseph Fokam, Alexis Ndjolo
{"title":"Genotypic resistance testing improves antiretroviral treatment outcomes in a cohort of adolescents in Cameroon: Implications in the dolutegravir-era.","authors":"Willy LE Roi Togna Pabo, Debimeh Njume, Roland Ndip Ndip, Désiré Takou, Maria-Mercedes Santoro, Collins Chenwi, Grace Beloumou, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Aude Christelle Ka'e, Georges Teto, Beatrice Dambaya, Sandrine Djupsa, Raymond Babila Nyasa, Davy Hyacinthe Gouissi Anguechia, Cedric Kamta, Lionel Bala, Virginie Lambo, Samuel Martin Sosso, Vittorio Colizzi, Carlo Federico Perno, Joseph Fokam, Alexis Ndjolo","doi":"10.4081/jphia.2023.2612","DOIUrl":"https://doi.org/10.4081/jphia.2023.2612","url":null,"abstract":"<p><p>Acquired drug resistance (ADR) is common among adolescents living with perinatal HIV (APHI) in sub-Saharan Africa (SSA). Personalized management has the potential to improve pediatric antiretroviral therapy (ART), even in the presence of long-term treatment and HIV-1 subtype diversity. We sought to evaluate the effect of HIV-1 mutational profiling on immuno-virological response and ADR among APHI. A cohort-study was conducted from 2018-2020 among 311 APHI receiving ART in Cameroon. Clinical, immunological and virological responses were measured at enrolment (T1), 6-months (T2) and 12-months (T3). Immunological failure (IF: CD4 #x003C;250 cells/mm<sup>3</sup>), VF (viremia ≥1,000 copies/ml), and ADR were analyzed, with P#x003C;0.05 considered significant. Mean age was 15(±3) years; male-female ratio was 1:1; median [IQR] ART-duration was 36[21-81] months. At T1, T2, and T3 respectively, adherence-level was 66.4, 58.3 and 66.5%; 14 viral clades were found, driven by CRF02_AG (58.6%); ADR-mutations favored increased switch to second-line ART (16.1, 31.2, and 41.9%, P#x003C;0.0001). From T1-T3 respectively, there were declining rates of IF (25.5, 18.9, and 9.83%, P#x003C;0.0001), VF (39.7, 39.9, and 28.2%, P=0.007), and HIVDR (96.4, 91.7, and 85.0%, P=0.099). Predictors of ADR were being on first-line ART (P=0.045), high viremia at enrolment (AOR=12.56, P=0.059), and IF (AOR=5.86, P=0.010). Of note, optimized ART guided by mutational profile (AOR=0.05, P=0.002) was protective. Moreover, full Tenofovir+Lamivudine+Dolutegravir efficacy was predicted in 77 and 62% of APHI respectively after first- and second-line failure. Among APHI in this SSA setting, viral mutational profiling prompts the use of optimized Dolutegravir-based ART regimens, leading to improved immuno-virological response and declining ADR burdens. Thus, implementing personalized HIV medicine in this vulnerable population would substantially improve ART response and the achievement of the 95-95-95 goals in these underserved populations.</p>","PeriodicalId":44723,"journal":{"name":"Journal of Public Health in Africa","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信