Journal of Neurorestoratology最新文献

{"title":"Brain-computer interface (BCI) in clinical neurorestorative practices","authors":"Yunfa Fu , Yuhang Xue , Xiaogang Chen , Yong Hu","doi":"10.1016/j.jnrt.2025.100188","DOIUrl":"10.1016/j.jnrt.2025.100188","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100188"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental phases of Neurorestoratology and current key tasks","authors":"Hongyun Huang , Paul R. Sanberg , Hari Shanker Sharma , Sang Ryong Jeon","doi":"10.1016/j.jnrt.2025.100189","DOIUrl":"10.1016/j.jnrt.2025.100189","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100189"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-ray-based ultra-high dose rate FLASH radiotherapy mitigates acute radiation-induced hippocampal injury and inflammation","authors":"Renke He ,&nbsp;Jiayu Liu ,&nbsp;Bingxian Wang ,&nbsp;Hanbo Zhang ,&nbsp;Shengqiang Xie ,&nbsp;Yiyuan Zhang ,&nbsp;Xianhong Liu ,&nbsp;Jianxin Wang ,&nbsp;Dai Wu ,&nbsp;Lehui Du ,&nbsp;Baolin Qu ,&nbsp;Gang Cheng ,&nbsp;Jianning Zhang","doi":"10.1016/j.jnrt.2025.100186","DOIUrl":"10.1016/j.jnrt.2025.100186","url":null,"abstract":"<div><h3>Background</h3><div>To compare neural damage induced by ultra-high dose rate FLASH radiotherapy (FLASH-RT) with that induced by conventional dose rate radiotherapy (CONV-RT) in healthy mice.</div></div><div><h3>Methods</h3><div>Eighty adult male C57BL/6J mice were divided into five groups: Sham, CONV-RT10Gy, CONV-RT20Gy, FLASH-RT10Gy, and FLASH-RT20Gy. Three days post-irradiation, morphological changes in neurons within the dentate gyrus (DG), CA1, and CA3 were observed using hematoxylin and eosin and Nissl staining. The malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), catalase (CAT), and hydroxyl radical (OH⁻) levels were measured using assay kits. Quantitative reverse transcription PCR was used to assess interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF)-α mRNA expression levels in hippocampus. Immunofluorescence was employed to observe microglial activation in the DG.</div></div><div><h3>Results</h3><div>Compared with Sham, CONV-RT10Gy and CONV-RT20Gy exhibited disorganized neuronal arrangements and blurred nucleoli in the DG; the number of Nissl body was reduced, but FLASH-RT10Gy and FLASH-RT20Gy alleviated these abnormalities. Moreover, FLASH-RT20Gy mitigated the upregulation of MDA and downregulation of GSH, GSH-PX, SOD, CAT, and OH⁻ levels in the hippocampus of mice subjected to CONV-RT20Gy. Additionally, FLASH-RT20Gy attenuated the upregulation of IL-1β, IL-6, iNOS, and TNF-α mRNA levels in hippocampus of mice subjected to CONV-RT20Gy and diminished microglial activation in the DG.</div></div><div><h3>Conclusion</h3><div>FLASH-RT mitigate the structural and functional disruptions in hippocampal neurons induced by CONV-RT and alleviate oxidative stress and inflammation in hippocampal tissue by reducing microglial activation.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100186"},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound B vitamins mitigate post-traumatic stress disorder-like behaviors induced by single prolonged stress in rats by inhibiting hippocampal mitochondrial DNA methylation","authors":"Yanteng Li ,&nbsp;Runzi Wang ,&nbsp;Fang Xie ,&nbsp;Lingjia Qian ,&nbsp;Yong Zhang ,&nbsp;Jianning Zhang","doi":"10.1016/j.jnrt.2025.100187","DOIUrl":"10.1016/j.jnrt.2025.100187","url":null,"abstract":"<div><h3>Background</h3><div>Post-traumatic stress disorder (PTSD) is a serious mental disorder. Current treatments, typically using serotonin reuptake inhibitors, have limited effectiveness and often cause severe adverse effects. In the present study, we investigated whether Compound B vitamins (VBco) have protective effects in improving PTSD-like behaviors and the possible related molecular mechanisms in a rat model of single prolonged stress (SPS).</div></div><div><h3>Methods</h3><div>Eighty adult male rats were randomly divided into four groups (<em>n</em> = 20): control (CTRL), SPS, VBco control (CTRL-VBco), and SPS and VBco (SPS-VBco). After modeling, behavioral tests (including open field test, forced swimming test, sucrose preference test, fear conditioning test) were conducted. Blood was collected to detect plasma homocysteine (Hcy) concentrations. Brain tissue was collected for mitochondrial function analysis, western blotting, and quantitative real-time Polymerase Chain Reaction (PCR).</div></div><div><h3>Results</h3><div>VBco reduced plasma Hcy levels significantly 1 week post-SPS. The SPS-VBco group showed decreased grooming times and increased movement speed in the open field test, less resting time in the forced swim test, increased sucrose preference ratios in the sucrose preference test, and less freezing time in the fear conditioning test. VBco increased the expression of mRNA for subunits of respiratory chain-related protein in hippocampal mitochondria and improved mitochondrial complex I and IV activity and membrane potential in hippocampus. VBco reversed SPS-induced mtND1 and mtND3 methylation in hippocampal mitochondria. VBco downregulated the levels of methyltransferases (DNMT1, DNMT3A, DNMT3B) in hippocampal mitochondria.</div></div><div><h3>Conclusion</h3><div>VBco can inhibit hippocampal mitochondrial DNA methylation effectively. This may be one of the mechanisms by which it attenuates PTSD-like behaviors.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100187"},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making smiles and eye closure natural! Application of acupoint injection therapy in facial paralysis comorbidities: A case report","authors":"Yuxin Liu ,&nbsp;Xixi Han ,&nbsp;Lin Chen ,&nbsp;Bin Ma","doi":"10.1016/j.jnrt.2025.100185","DOIUrl":"10.1016/j.jnrt.2025.100185","url":null,"abstract":"<div><div>Facial paralysis comorbidities is now understood to include two distinct forms: synkinesis and micro-entrapment syndrome of nerves innervating the face (MESNIF). These disorders manifest as oromandibular synkinesis, stiffness and atrophy of facial muscles on one side, which affect activities of daily living. Acupoint Injection is a treatment for facial paralysis, combining the meridian theory of traditional Chinese medicine, with the injection of specific drugs into acupuncture points of the face. In recent years, the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects. We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100185"},"PeriodicalIF":3.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroanatomical characteristics of late-onset essential tremors: Implications for stereotactic targeting of the ventral intermediate nucleus of the thalamus","authors":"Junhyung Kim ,&nbsp;Sungyang Jo ,&nbsp;Sun Ju Chung ,&nbsp;Seok Ho Hong ,&nbsp;Sang Ryong Jeon","doi":"10.1016/j.jnrt.2024.100178","DOIUrl":"10.1016/j.jnrt.2024.100178","url":null,"abstract":"<div><h3>Background</h3><div>Essential tremor is the most prevalent movement disorder in older adults, yet its association with aging-related anatomical changes has not been well explored. This study aimed to identify the clinical and neuroanatomical characteristics of medically refractory essential tremor in individuals who are potential candidates for surgical intervention.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional descriptive analysis of a population with essential tremors at a single tertiary-level center. Morphometric analysis of structural MRI was performed for 96 samples, and volumetric measurements were compared across four age/sex-matched groups (beta-blocker monotherapy, combination therapy, surgical intervention, and healthy controls).</div></div><div><h3>Results</h3><div>Individuals with essential tremors had greater ventricular volume than healthy controls. The lateral ventricle volume was 1.57-fold (95% confidence interval, 1.39 to 1.77) larger in the essential tremor subjects, while no significant differences between treatment groups were observed. In terms of stereotactic target coordinate of the ventral intermediate nucleus (Vim) of the thalamus, the width of the third ventricle at the intercommissural plane level was 8.0 ± 2.2 mm in the surgical intervention group, compared with 5.7 ± 2.3 mm in healthy controls. The Vim target coordinates averaged 13.8 ± 1.6 mm laterally from the midline in this cohort; however, one-quarter of candidates had coordinates exceeding 16 mm, substantially differing from previously established atlas-based coordinates of the Vim.</div></div><div><h3>Conclusions</h3><div>Our findings suggest the potential association between late-onset essential tremor and hydrocephalus, which necessitates careful consideration in stereotactic procedures with regard to the anatomical variability of the third ventricle.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100178"},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic identification of risk factors from an immunological viewpoint in idiopathic Parkinson's disease","authors":"Zhenshan Sun ,&nbsp;Pengfei Fu ,&nbsp;Shiqing Zhang ,&nbsp;Ken Kin Lam Yung","doi":"10.1016/j.jnrt.2024.100177","DOIUrl":"10.1016/j.jnrt.2024.100177","url":null,"abstract":"<div><h3>Background</h3><div>In the present study, we focused on uncovering stable genetic alterations associated with idiopathic Parkinson's disease (IPD) in blood samples. We aimed to identify factors that connect IPD to the peripheral immune system, thereby deepening our understanding of the pathophysiology of this disease.</div></div><div><h3>Methods</h3><div>A gene expression microarray dataset (GSE99039) was selected from the National Center for Biotechnology Information Gene Expression Omnibus database to screen for differentially expressed genes (DEGs). Subsequent analyses included Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. A protein–protein interaction network was then constructed to identify hub genes within these DEGs. Additionally, we used a verification dataset (GSE160299) to test the consistency of the expression level changes of the hub genes.</div></div><div><h3>Results</h3><div>We identified 277 DEGs, comprising 270 downregulated genes and 7 upregulated genes. The functional enrichment results revealed a close association between IPD and changes in peripheral immune status. Five hub genes—<em>HLA-F</em>, <em>HLA-E</em>, <em>KIR3DL2</em>, <em>KIR3DL1</em>, and <em>TYROBP</em>—were identified, and the expression level changes remained stable in the verification set.</div></div><div><h3>Conclusions</h3><div>Our findings help to clarify the regulatory pathways that connect peripheral immunity to IPD pathogenesis. We identified five key hub genes in the blood as IPD-related factors; all five genes were also significantly altered in an independent clinical dataset.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100177"},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in neurodegenerative diseases: Pathogenesis and novel neurorestorative interventions","authors":"Wenyong Gao ,&nbsp;Shiyuan Jing ,&nbsp;Chao He ,&nbsp;Hooshang Saberi ,&nbsp;Hari Shanker Sharma ,&nbsp;Fabin Han ,&nbsp;Lin Chen","doi":"10.1016/j.jnrt.2024.100176","DOIUrl":"10.1016/j.jnrt.2024.100176","url":null,"abstract":"<div><div>Progressive neurodegenerative diseases (NDs) that lack effective disease-modifying treatments, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), represent significant global health challenges. In recent years, key research findings have included the role of neuroinflammation driven by microglia and astrocytes, the impact of genetic mutations, and the importance of autophagy and mitochondrial quality control in maintaining neuronal health. In this review, we summarize recent advancements of the pathogenesis of NDs, the cellular and animal models that have provided valuable insights into disease mechanisms, and the development of blood-based biomarkers for early diagnosis and monitoring of disease progression. We also highlight emerging neurorestorative therapeutic strategies involving stem cell therapy, antisense oligonucleotides, and induced pluripotent stem cells. Additionally, we cover recent clinical trials of promising drugs, such as lecanemab and donanemab for AD, and tavapadon for PD. Finally, we propose future research directions, emphasizing the need for combination therapies that target multiple pathways, the development of more precise animal models, and the integration of nanotechnology for improved drug delivery across the blood–brain barrier.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100176"},"PeriodicalIF":3.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal MRI and artificial intelligence: Shaping the future of glioma","authors":"Yiqin Yan ,&nbsp;Chenxi Yang ,&nbsp;Wensheng Chen ,&nbsp;Zhaoxing Jia ,&nbsp;Haiying Zhou ,&nbsp;Zhong Di ,&nbsp;Longbiao Xu","doi":"10.1016/j.jnrt.2024.100175","DOIUrl":"10.1016/j.jnrt.2024.100175","url":null,"abstract":"<div><div>Gliomas are the most common malignant tumors in the central nervous system and are known for their inherent diversity and propensity to invade surrounding tissue. These features pose significant challenges in diagnosing and treating these tumors. Magnetic resonance imaging (MRI) has not only remained at the forefront of glioma management but has also evolved significantly with the advent of multimodal MRI. The rise of multimodal MRI represents a pivotal leap forward, as it seamlessly integrates diverse MRI sequences and advanced techniques to offer an unprecedented, comprehensive, and multidimensional glimpse into the complexities of glioma pathology, including encompassing structural, functional, and even molecular imaging. This holistic approach empowers clinicians with a deeper understanding of tumor characteristics, enabling more precise diagnoses, tailored treatment strategies, and enhanced monitoring capabilities, ultimately improving patient outcomes. Looking ahead, the integration of artificial intelligence (AI) with MRI data heralds a new era of unparalleled precision in glioma diagnosis and therapy. This integration holds the promise to revolutionize the field, enabling more sophisticated analyses that fully leverage all aspects of multimodal MRI. In summary, with the continuous advancement of multimodal MRI techniques and future deep integrations with artificial intelligence, glioma care is poised to evolve toward increasingly personalized, precise, and efficacious strategies.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100175"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical association of habitual breakfast skipping with cognitive decline and neurodegeneration among older adults","authors":"Jun Zhang ,&nbsp;Ya-Jun Li ,&nbsp;Shu Yang ,&nbsp;Bing-Hu Li ,&nbsp;Duo-Zi Wang ,&nbsp;Lei Liu ,&nbsp;Jian-Hong Wang","doi":"10.1016/j.jnrt.2024.100173","DOIUrl":"10.1016/j.jnrt.2024.100173","url":null,"abstract":"<div><h3>Background</h3><div>Unhealthy lifestyles have a considerable impact on the incidence of dementia. Skipping breakfast disturbs energy homeostasis and impairs brain function. In this study, we investigated the association between breakfast skipping and cognitive performance among community-dwelling adults.</div></div><div><h3>Methods</h3><div>We recruited 859 community-dwelling adults aged ≥60 years from January 1 to December 31, 2021. Participants’ sociodemographic information and breakfast skipping habits were self-reported. Participants were followed up for 36 months and cognitive function was assessed using the Mini-Mental State Examination (MMSE) with an interval of 18 months. Trajectories of cognitive change were compared between individuals with and without breakfast skipping. To reduce the risk of bias owing to unmatched sample sizes between the groups, we conducted 1:1 propensity score matching (PSM) based on age, sex, education level, and ApoE genotype.</div></div><div><h3>Results</h3><div>At baseline and 18-month follow-up, no difference was found in MMSE scores between participants with and without breakfast skipping. However, those who habitually skipped breakfast had significantly lower MMSE scores than those who did not at 36-month follow-up. Individuals with habitual breakfast skipping had a steeper rate of cognitive decline than those without habitual breakfast skipping during follow-up. Breakfast skipping was a risk factor for longitudinal cognitive decline, defined as a decrease in MMSE scores of ≥3, adjusted for age, sex, education, body mass index, ApoE ε4 carrier status, hypertension, diabetes, and hyperlipidemia. At the last follow-up, participants who habitually skipped breakfast had significantly higher levels of ptau181 and NfL than those who did not. In the PSM cohort, similar findings were obtained regarding cognitive trajectories and plasma biomarkers.</div></div><div><h3>Conclusion</h3><div>Breakfast skipping was linked to an increased risk of long-term cognitive decline and neurodegeneration among older adults. The link between unhealthy dietary habits and cognitive decline may be attributed to a deficiency in neurorestoration resulting from inadequate energy consumption.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100173"},"PeriodicalIF":3.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}