Journal of Neurorestoratology最新文献

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Enhancing motor rehabilitation using a hybrid BCI paradigm: integrating high-frequency SSVEP with action observation and motor imagery 使用混合脑机接口模式增强运动康复:将高频SSVEP与动作观察和运动想象相结合
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-12-01 Epub Date: 2025-07-18 DOI: 10.1016/j.jnrt.2025.100238
Zhaohui Li , Meng Li , Xiaorong Gao , Hongyan Cui , Xiaogang Chen
{"title":"Enhancing motor rehabilitation using a hybrid BCI paradigm: integrating high-frequency SSVEP with action observation and motor imagery","authors":"Zhaohui Li ,&nbsp;Meng Li ,&nbsp;Xiaorong Gao ,&nbsp;Hongyan Cui ,&nbsp;Xiaogang Chen","doi":"10.1016/j.jnrt.2025.100238","DOIUrl":"10.1016/j.jnrt.2025.100238","url":null,"abstract":"<div><h3>Background</h3><div>Both action observation (AO) and motor imagery (MI) can elicit activity in mirror neurons and the motor cortex. Therefore, brain–computer interface (BCI) systems based on AO and MI hold broad application prospects in the field of motor rehabilitation. An increasing number of studies have incorporated steady-state visual evoked potentials (SSVEP) into AO or MI paradigms to construct hybrid BCI systems and enhance robustness of the systems.</div></div><div><h3>Methods</h3><div>In this study, AO, MI, and AO combined with MI experiments were designed, based on a SSVEP paradigm. In the AO experiment, subjects were required to observe alternating and flickering fisted- and extended-hand pictures. In the MI task, subjects were required to perform MI tasks while focusing on flickering extended-hand pictures. In the AO combined with MI experiment, subjects were required to execute the same task for the AO experiment while simultaneously perform the MI task. Task-discriminant component analysis and Tikhonov regularizing common spatio-spectral pattern algorithms were used to separately process inputs from the two modalities, with the system ultimately outputting a fusion result.</div></div><div><h3>Results</h3><div>The results found that AO combined with MI and MI alone more effectively activated the motor cortex compared with AO alone. The fusion classification accuracy of the proposed hybrid paradigm reached 86.42% ​± ​8.42%, 88.54% ​± ​10.31%, and 88.91% ​± ​9.61% for AO, MI, and AO combined with MI, respectively.</div></div><div><h3>Conclusion</h3><div>This study provided an alternative for the construction of a more robust and comfortable rehabilitation system.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100238"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2024 yearbook of Neurorestoratology 2024年神经修复学年鉴
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-12-01 Epub Date: 2025-09-11 DOI: 10.1016/j.jnrt.2025.100250
Hongyun Huang , Paul R. Sanberg , Hari Shanker Sharma , John R. Bach , Hooshang Saberi , Ashok K. Shetty , Ali Otom , Almudena Ramon-Cueto , Damien Kuffler , Xiaoling Guo , Mengzhou Xue , Dario Siniscalco , Edgardo O. Alvarez , Ziad Alhawamdeh , Russell J. Andrews , Gustavo A. Moviglia , Shiqing Feng , Liyan Qiao
{"title":"The 2024 yearbook of Neurorestoratology","authors":"Hongyun Huang ,&nbsp;Paul R. Sanberg ,&nbsp;Hari Shanker Sharma ,&nbsp;John R. Bach ,&nbsp;Hooshang Saberi ,&nbsp;Ashok K. Shetty ,&nbsp;Ali Otom ,&nbsp;Almudena Ramon-Cueto ,&nbsp;Damien Kuffler ,&nbsp;Xiaoling Guo ,&nbsp;Mengzhou Xue ,&nbsp;Dario Siniscalco ,&nbsp;Edgardo O. Alvarez ,&nbsp;Ziad Alhawamdeh ,&nbsp;Russell J. Andrews ,&nbsp;Gustavo A. Moviglia ,&nbsp;Shiqing Feng ,&nbsp;Liyan Qiao","doi":"10.1016/j.jnrt.2025.100250","DOIUrl":"10.1016/j.jnrt.2025.100250","url":null,"abstract":"<div><div>In the year 2024, the continuous novel advances in the field of Neurorestoratology have reflected the exploring pathogenesis and neurorestorative mechanisms of the neurodegenerative diseases. Clinical therapeutic neurorestorative explorations have demonstrated exciting results benefiting patients with neuro-psychiatric diseases through various therapeutic strategies, including neuromodulation and brain-computer interfaces, cell therapies, neurorestorative surgery as well as pharmaceutical therapy, and intensive training. More randomized clinical trials of neurorestorative treatments have been conducted and demonstrated positive results, which will be further translated into routine clinical practice. Here we compile the most relevant studies with the sole idea of contributing to the improvement of quality of life of people suffering from neurological disorders. This yearbook emphasizes and summarizes some of the most relevant reserach in the field of Neurorestoratology, evidenced by published articles in original impact journals during 2024.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100250"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the evolution of meningeal lymphatic system research: A decade of bibliometric insights (2015–2025) 解码脑膜淋巴系统研究的演变:十年文献计量学见解(2015-2025)
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1016/j.jnrt.2025.100229
Changkai Hou , Bangyue Wang , Quanlei Liu , Yang Dai , Jinkun Xu , Wen Ren , Guoguang Zhao
{"title":"Decoding the evolution of meningeal lymphatic system research: A decade of bibliometric insights (2015–2025)","authors":"Changkai Hou ,&nbsp;Bangyue Wang ,&nbsp;Quanlei Liu ,&nbsp;Yang Dai ,&nbsp;Jinkun Xu ,&nbsp;Wen Ren ,&nbsp;Guoguang Zhao","doi":"10.1016/j.jnrt.2025.100229","DOIUrl":"10.1016/j.jnrt.2025.100229","url":null,"abstract":"<div><h3>Background</h3><div>The landmark discovery of the meningeal lymphatic system (MLS) has revolutionized our understanding of CNS waste clearance and immune surveillance. Despite a decade of transformative research since its identification in 2015, a comprehensive analysis of its developmental trajectory, current research landscape, and future directions is lacking. This bibliometric study systematically analyzes the first decade of MLS research (2015–2025), with a particular emphasis on neurorestoration potential.</div></div><div><h3>Methods</h3><div>We retrieved relevant publications from the Web of Science Core Collection (WoSCC) between 2015 and 2025. Data were processed using Microsoft Excel, while collaborative networks among countries, institutions, journals, and authors were analyzed via VOSviewer, CiteSpace, GraphPad Prism, Web of Science, and the online bibliometric platform (<span><span>http://bibliometric.com/</span><svg><path></path></svg></span>). The key metrics included article types, research trends, citation patterns, and keyword frequency.</div></div><div><h3>Results</h3><div>A total of 449 publications from 2546 authors across 703 institutions in 46 countries published in 230 academic journals were identified. <em>Nature communications</em> contributed the largest number of MLS-related articles, whereas <em>Nature</em> was the most cocited journal. The majority of publications focused on immunology and cell biology. The United States and China emerged as leading contributors, with the University of Virginia producing the largest number of publications. Kipnis Jonathan was the most prolific author, whereas Louveau Antoine received the greatest number of cocitations. Keyword co-occurrence and reference analysis revealed that the “glymphatic system” and “meningeal lymphatic vessels” were central research themes. Notably, neurodegenerative diseases emerged as a rapidly growing research hotspot in MLS studies.</div></div><div><h3>Conclusion</h3><div>This decade-spanning analysis reveals the potential of MLS research for clinically relevant neurorestorative applications. The recognition of MLS as a regulator of immune function and neural repair has positioned them as compelling therapeutic targets. Our study highlights key trends and predicts future directions in MLS research. These insights will help prioritize research efforts to harness MLS biology for central nervous system repair paradigms.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100229"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurorestoration treatment for post-stroke cognitive impairment (PSCI) 脑卒中后认知障碍(PSCI)的神经修复治疗
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-12-01 Epub Date: 2025-08-20 DOI: 10.1016/j.jnrt.2025.100240
Zuohui Yang , Hongbing Wu , Haiyan Wang , Xia Yu , Jingzheng Zhu , Ming Xie , Siyuan Chen , Yingfei Wu , Xinglei Zhou , Shuxin Song , Hongbo Zhang
{"title":"Neurorestoration treatment for post-stroke cognitive impairment (PSCI)","authors":"Zuohui Yang ,&nbsp;Hongbing Wu ,&nbsp;Haiyan Wang ,&nbsp;Xia Yu ,&nbsp;Jingzheng Zhu ,&nbsp;Ming Xie ,&nbsp;Siyuan Chen ,&nbsp;Yingfei Wu ,&nbsp;Xinglei Zhou ,&nbsp;Shuxin Song ,&nbsp;Hongbo Zhang","doi":"10.1016/j.jnrt.2025.100240","DOIUrl":"10.1016/j.jnrt.2025.100240","url":null,"abstract":"<div><div>Stroke can lead to extensive neurological dysfunction and is a leading cause of disability worldwide, primarily leading to cognitive and motor dysfunction. Within 6 months after a stroke, more than 60% of stroke survivors experience various cognitive impairments, such as post-stroke memory decline, visuospatial dysfunction, calculation difficulties, and orientation disorders. In recent years, numerous studies have shown that new technologies such as cell therapy, drug therapy, music therapy, and brain–computer interfaces have demonstrated positive effects on cognitive recovery. These technologies may enhance neural network repair and improve cognitive function in patients with post-stroke cognitive impairment, reducing the harm that it causes.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100240"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical guideline for neurorestorative therapy in pediatric cerebral palsy (2024 China version) 小儿脑瘫神经修复治疗临床指南(2024中文版)
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-12-01 Epub Date: 2025-10-19 DOI: 10.1016/j.jnrt.2025.100253
Zhonghai Li , Kwok-Fai So , Lin Chen , Shiqing Feng , Yong Hu , Liming Cheng , Xinlin Hou , Dong Li , Weimin Huang , Jiujun Qiu , Guoqiang Cheng , Jun Wang , Tonghuan Li , Weipeng Liu , Chao Han , Xin Guan , Yachen Wang , Lili Du , Hongyun Huang , Jing Liu
{"title":"Clinical guideline for neurorestorative therapy in pediatric cerebral palsy (2024 China version)","authors":"Zhonghai Li ,&nbsp;Kwok-Fai So ,&nbsp;Lin Chen ,&nbsp;Shiqing Feng ,&nbsp;Yong Hu ,&nbsp;Liming Cheng ,&nbsp;Xinlin Hou ,&nbsp;Dong Li ,&nbsp;Weimin Huang ,&nbsp;Jiujun Qiu ,&nbsp;Guoqiang Cheng ,&nbsp;Jun Wang ,&nbsp;Tonghuan Li ,&nbsp;Weipeng Liu ,&nbsp;Chao Han ,&nbsp;Xin Guan ,&nbsp;Yachen Wang ,&nbsp;Lili Du ,&nbsp;Hongyun Huang ,&nbsp;Jing Liu","doi":"10.1016/j.jnrt.2025.100253","DOIUrl":"10.1016/j.jnrt.2025.100253","url":null,"abstract":"<div><div>Cerebral palsy (CP) is a common pediatric neuromotor disorder that is characterized by persistent impairments in movement, muscle tone, and posture. It is frequently associated with sensory, cognitive, and behavioral comorbidities. This guideline presents evidence-based recommendations for neurorestorative therapy in pediatric CP, developed through a systematic review of 44 studies (including randomized controlled trials, cohort studies, and systematic reviews) published up to December 31, 2024. Recommendations were graded according to the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Key recommendations include the use of the Gross Motor Function Classification System for precise motor dysfunction grading, neuroimaging-supported diagnostic criteria, and a multidisciplinary neurorestorative treatment approach. This approach encompasses cell therapy <em>(Grade B)</em>, pharmacological management <em>(Grades B–C)</em>, surgical interventions <em>(Grade B)</em>, neuromodulation <em>(Grade B)</em>, structured rehabilitation <em>(Grade B)</em>, and psychological support <em>(Grade C)</em>. The guideline also advocates for a multi-tiered prevention strategy targeting primary, secondary, and tertiary levels. By emphasizing evidence-based, individualized, and multidisciplinary care, this guideline aims to optimize neurorestorative outcomes and improve quality of life for children with CP, while encouraging ongoing research and periodic updates as new evidence emerges.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100253"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural stem/progenitor cell transplantation therapy for chronic spinal cord injury 神经干细胞/祖细胞移植治疗慢性脊髓损伤
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1016/j.jnrt.2025.100223
Jun Zhang , Xiaolong Zheng , Zitao Wu , Yu Wang , Hong Chen
{"title":"Neural stem/progenitor cell transplantation therapy for chronic spinal cord injury","authors":"Jun Zhang ,&nbsp;Xiaolong Zheng ,&nbsp;Zitao Wu ,&nbsp;Yu Wang ,&nbsp;Hong Chen","doi":"10.1016/j.jnrt.2025.100223","DOIUrl":"10.1016/j.jnrt.2025.100223","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is a severely disabling neurological condition that results in impaired mobility, sensory disruption, and autonomic dysfunction. Transplantation of neural stem/progenitor cells (NSPCs) is considered a promising candidate for promoting functional recovery, and most research has focused on the early stages of SCI. However, most SCI patients are in the chronic phase, and clinical trials for patients with chronic SCI will be able to detect additional potential treatment effects. Therefore, this review focuses on the study of advances in the transplantation of NSPCs obtained or derived from different sources for chronic SCI. We first summarize the progress in the use of rodent NSPC transplantation for chronic SCI. Rodent NSPCs can survive, differentiate, and support histological regeneration at the site of injury but only with cellular combination therapy can they induce functional motor recovery. Next, we review research advances in human NSPC transplantation alone or in combination therapies for chronic SCI, demonstrating a high potential therapeutic effect. Finally, we discuss clinical trials of human NSPC transplantation for chronic SCI, focusing on safety and feasibility as the main clinical outcome measures. The long-term follow-up data also show optimistic clinical therapeutic efficacy.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100223"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macular radial peripapillary capillary: a potential optical coherence tomography angiography biomarker of cognitive impairment in patients with internal carotid artery stenosis 黄斑放射状乳头周围毛细血管:内颈动脉狭窄患者认知障碍的潜在光学相干断层扫描血管造影生物标志物
IF 3.1 4区 医学
Journal of Neurorestoratology Pub Date : 2025-10-01 Epub Date: 2025-06-19 DOI: 10.1016/j.jnrt.2025.100225
Panpan Shen , Yili Lin , Jiawei Ye , Peiwen Wang , Lujie Han , Weitao Yu , Xiang Yu , Qiannan Hu , Weifen Zhang , Huiyuan Wang , Pengfei Sun , Xinchun Jin , Sheng Zhang , Yu Geng
{"title":"Macular radial peripapillary capillary: a potential optical coherence tomography angiography biomarker of cognitive impairment in patients with internal carotid artery stenosis","authors":"Panpan Shen ,&nbsp;Yili Lin ,&nbsp;Jiawei Ye ,&nbsp;Peiwen Wang ,&nbsp;Lujie Han ,&nbsp;Weitao Yu ,&nbsp;Xiang Yu ,&nbsp;Qiannan Hu ,&nbsp;Weifen Zhang ,&nbsp;Huiyuan Wang ,&nbsp;Pengfei Sun ,&nbsp;Xinchun Jin ,&nbsp;Sheng Zhang ,&nbsp;Yu Geng","doi":"10.1016/j.jnrt.2025.100225","DOIUrl":"10.1016/j.jnrt.2025.100225","url":null,"abstract":"<div><h3>Objective</h3><div>We investigated retinal and choroidal microvascular parameters as potential biomarkers for vascular cognitive impairment in patients with internal carotid artery stenosis (ICAS).</div></div><div><h3>Methods</h3><div>We enrolled 123 asymptomatic ICAS patients and categorized them into vascular mild cognitive impairment (VMCI) and vascular dementia (VaD) groups using the Montreal Cognitive Assessment. Optical coherence tomography angiography was used to evaluate vessel densities and perfusion areas in various retinal layers. Magnetic resonance imaging-based neuroimaging biomarkers for cerebral small vessel disease (CSVD) were also assessed. Least absolute shrinkage and selection operator logistic regression identified predictor variables, and receiver operating curve analysis assessed the ability of key parameters to distinguish between VMCI and VaD.</div></div><div><h3>Results</h3><div>Compared with VMCI patients, VaD patients had lower radial peripapillary capillary (RPC) perfusion area, higher CSVD burden score, and larger white matter hyperintensity volume (all <em>p</em> &lt; 0.05). Receiver operating curve analysis revealed that the RPC perfusion area of the affected eye had superior discriminatory power for distinguishing VaD from VMCI compared with both the CSVD burden score (<em>Z</em> = 1.99, <em>p</em> = 0.047) and white matter hyperintensity (<em>Z</em> = 1.97, <em>p</em> = 0.049). The optimal cutoff value for the 0–1 mm macular RPC perfusion area was determined as 0.068 mm<sup>2</sup>.</div></div><div><h3>Conclusion</h3><div>The optical coherence tomography angiography-derived RPC perfusion area can effectively differentiate VaD from VMCI, suggesting its potential as a noninvasive diagnostic method to support clinical decision-making for ICAS patients.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100225"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan-citric acid hydrogels loaded with catalpol: A novel therapeutic strategy for spinal cord injury 载梓醇壳聚糖-柠檬酸水凝胶:一种新的脊髓损伤治疗策略
IF 3.4 4区 医学
Journal of Neurorestoratology Pub Date : 2025-10-01 Epub Date: 2025-06-28 DOI: 10.1016/j.jnrt.2025.100228
Dapeng Zhao , Hengrui Li , Xiaoyu Wang , Ailing Yu , Lanhua Li , Baoliang Sun , Ying Wang , Guojun Wang , Jingyi Sun
{"title":"Chitosan-citric acid hydrogels loaded with catalpol: A novel therapeutic strategy for spinal cord injury","authors":"Dapeng Zhao ,&nbsp;Hengrui Li ,&nbsp;Xiaoyu Wang ,&nbsp;Ailing Yu ,&nbsp;Lanhua Li ,&nbsp;Baoliang Sun ,&nbsp;Ying Wang ,&nbsp;Guojun Wang ,&nbsp;Jingyi Sun","doi":"10.1016/j.jnrt.2025.100228","DOIUrl":"10.1016/j.jnrt.2025.100228","url":null,"abstract":"<div><h3>Background</h3><div>Spinal cord injury (SCI), which often results from traumatic incidents, leads to neural damage and impaired sensory and motor functions and may pose a serious threat to life. Secondary injury mechanisms caused by persistent inflammation disrupt the local microenvironment, causing neuronal cell death and hindering neural regeneration. This study used a chitosan-citric acid (CS-CA) hydrogel as a carrier for Catalpol (CAT-CS-CA), which was directly applied to the injury site to promote SCI repair.</div></div><div><h3>Methods</h3><div>CAT-CS-CA and CS-CA hydrogels were characterized and implanted into rat SCI models. Fifty-four male Sprague-Dawley rats (230–250 g) rats were involved in the experiment. Six rats were randomly divided into two groups (<em>n</em> = 3 per group) for in vivo degradation of hydrogels. Forty-eight rats were randomly assigned into four groups (<em>n</em> = 12) using a randomization protocol: sham operation group (laminectomy only), SCI group, CS-CA hydrogel group, and CAT-CS-CA hydrogel group. From each group, 3 rats were randomly selected for serum and spinal cord tissue extraction, followed by ELISA and RT-qPCR assays to determine the expression levels of various inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10). Another 3 randomly selected rats were used for the evaluation of hindlimb motor function. The remaining 6 rats in each group were used to detect the expression of neuronal nuclei (NeuN), βIII-tubulin (Tuj1), glial fibrillary acidic protein (GFAP), and macrophage polarization (M1/M2 markers).</div></div><div><h3>Results</h3><div>The CAT-CS-CA hydrogel retains CS-CA hydrogel's advantages and gains enhanced neuroprotective and anti-inflammatory abilities. The implantation of CAT-CS-CA into injured rat spinal cords enhanced neuronal survival, stimulated axonal regeneration, and significantly suppressed glial proliferation at the injury site. In addition, it promoted macrophage polarization to the M2 phenotype and substantially enhanced hindlimb motor function in rats with SCI.</div></div><div><h3>Conclusion</h3><div>CAT-CS-CA hydrogel promotes neuronal survival, suppresses glial scarring, and improves motor function, offering a promising strategy for SCI repair.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100228"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum biomarkers in the diagnosis and prognosis of traumatic spinal cord injury: A systematic review and meta-analysis 血清生物标志物在外伤性脊髓损伤诊断和预后中的作用:一项系统综述和荟萃分析
IF 3.1 4区 医学
Journal of Neurorestoratology Pub Date : 2025-10-01 Epub Date: 2025-06-25 DOI: 10.1016/j.jnrt.2025.100227
Zhengwang Liu , Haifeng Gao , Yidi Man , Xiaoyu Zhang , Liang Chen , Mingliang Yang , Yingli Jing , Jun Li
{"title":"Serum biomarkers in the diagnosis and prognosis of traumatic spinal cord injury: A systematic review and meta-analysis","authors":"Zhengwang Liu ,&nbsp;Haifeng Gao ,&nbsp;Yidi Man ,&nbsp;Xiaoyu Zhang ,&nbsp;Liang Chen ,&nbsp;Mingliang Yang ,&nbsp;Yingli Jing ,&nbsp;Jun Li","doi":"10.1016/j.jnrt.2025.100227","DOIUrl":"10.1016/j.jnrt.2025.100227","url":null,"abstract":"<div><div>Traumatic spinal cord injury (TSCI) is a severe neurological condition that frequently leads to permanent disability. Serum inflammatory markers and structural proteins may serve as potential biomarkers for TSCI. The present study aimed to evaluate the diagnostic and prognostic value of serum biomarkers in TSCI. In this article, a comprehensive literature search was conducted using databases such as Wanfang, VIP Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science. Meta-analysis was performed using RevMan 5.4 software to compare serum biomarker concentrations between TSCI patients and healthy controls (diagnostic group) and between patients with favorable and unfavorable prognoses (prognostic group). The quality of the included studies was evaluated using the Newcastle–Ottawa Scale. The results showed that: (1) In the diagnostic group, the meta-analysis revealed that serum levels of NSE, MIF, S100β, TNF-α, IL-1β, IL-4, IL-6, IL-16, CCL2, CCL4, CCL21, CXCL1, CXCL9, CXCL10, and CXCL12 were significantly elevated in TSCI patients compared with healthy controls, while IL-10 levels were decreased. (2) In the prognostic group, meta-analysis indicated that serum GFAP and NSE concentrations were significantly lower in patients with favorable prognoses than in those with poor prognoses. In conclusion, the serum levels of most structural proteins and inflammatory factors in patients with TSCI are elevated compared with healthy controls, and patients with poor prognosis exhibit even higher concentrations than those with favorable outcomes. These findings indicate the potential value of these markers for diagnosing TSCI and assessing prognosis.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100227"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence to “Identification and validation of core genes associated with intracranial aneurysms through bioinformatics analysis and Mendelian randomization” 对应于“通过生物信息学分析和孟德尔随机化鉴定和验证颅内动脉瘤相关的核心基因”
IF 3.1 4区 医学
Journal of Neurorestoratology Pub Date : 2025-10-01 Epub Date: 2025-06-19 DOI: 10.1016/j.jnrt.2025.100226
Shuya Jiao, Manjiang Cao
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