Journal of Neurorestoratology最新文献

{"title":"Predicting stroke risk: An effective stroke prediction model based on neural networks","authors":"Aakanshi Gupta ,&nbsp;Nidhi Mishra ,&nbsp;Nishtha Jatana ,&nbsp;Shaily Malik ,&nbsp;Khaled A. Gepreel ,&nbsp;Farwa Asmat ,&nbsp;Sachi Nandan Mohanty","doi":"10.1016/j.jnrt.2024.100156","DOIUrl":"10.1016/j.jnrt.2024.100156","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is the leading worldwide cause of disability and death. Effective stroke prevention and management depend on early identification of stroke risk.</div></div><div><h3>Methods</h3><div>Eight machine learning algorithms are applied to predict stroke risk using a well-curated dataset with pertinent clinical information. This paper describes a thorough investigation of stroke prediction using various machine learning methods.</div></div><div><h3>Results</h3><div>The empirical evaluation yields encouraging results, with the logistic regression, support vector machine, and K-nearest neighbors models achieving an impressive accuracy of 95.04%, and the random forest and neural network models scoring even better, with accuracies of 95.10% and 95.16%, respectively. The neural network exhibits slightly superior performance, indicating its potential as a reliable model for stroke risk assessment.</div></div><div><h3>Conclusions</h3><div>The empirical evaluation underscores the ability of neural networks to discern intricate data relationships. These findings offer valuable insights for healthcare professionals and researchers, aiding in the development of improved stroke prevention strategies and timely interventions, ultimately enhancing patient outcomes.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100156"},"PeriodicalIF":3.1,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Authors' response to “Respondence of ‘Brain iron deposition and whole-exome sequencing of non-Wilson's disease hypoceruloplasminemia in a family’”","authors":"Min Xu,&nbsp;Jian-Zhong Yi,&nbsp;Xiao-Ping Wang","doi":"10.1016/j.jnrt.2024.100155","DOIUrl":"10.1016/j.jnrt.2024.100155","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100155"},"PeriodicalIF":3.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000627/pdfft?md5=7c590c63c0cd37f723a13ec4acdef07b&pid=1-s2.0-S2324242624000627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviving consciousness: The impact of short-term spinal cord stimulation on patients with early-onset prolonged disorders of consciousness","authors":"Qiang Chen ,&nbsp;Weilong Huang ,&nbsp;Jianhong Tang ,&nbsp;Guohui Ye ,&nbsp;Hongliang Meng ,&nbsp;Qing Jiang ,&nbsp;Linying Ge ,&nbsp;HuiChen Li ,&nbsp;Lin Liu ,&nbsp;Qiuhua Jiang ,&nbsp;Dong Wang","doi":"10.1016/j.jnrt.2024.100143","DOIUrl":"10.1016/j.jnrt.2024.100143","url":null,"abstract":"<div><h3>Introduction</h3><div>Managing prolonged disorders of consciousness (pDoC) presents a significant clinical challenge despite numerous available therapies. While short-term spinal cord stimulation (st-SCS) for over 3 months has been recognized as an effective treatment for pDoC, its efficacy within the first 3 months remains unclear. This study explores st-SCS's impact on patients with pDoC for less than 3 months.</div></div><div><h3>Material and methods</h3><div>We enrolled 141 pDoC patients within 3 months of onset; 104 received st-SCS, and 37 underwent conservative treatment. Consciousness levels were assessed using the Coma Recovery Scale-Revised (CRS-R) before treatment, 2 weeks after, and at 3-month follow-up.</div></div><div><h3>Results</h3><div>Comparing the data from the 3-month follow-up, we found that, the st-SCS group showed significantly greater improvement in CRS-R scores compared to the control group (<em>p &lt;</em> 0.01), with more patients showing symptom amelioration (51/104 (49%)). Further analysis of the st-SCS treatment group showed significant improvement in CRS-R scores after 2 weeks (T1) and at the 3-month follow-up (T2) compared to baseline (T0). Both consciousness levels and specific CRS-R items improved notably post-treatment. Younger patients (&lt;40 years) with traumatic brain injury and higher initial CRS-R scores were more likely to experience positive outcomes. Additionally, multivariate logistic regression identified etiology, time since injury, and initial CRS-R score as significant predictors of the 3-month outcome (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>st-SCS is an effective treatment for pDoC within 3 months of onset, particularly for younger patients and those with trauma-induced conditions, significantly improving consciousness and outcomes.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100143"},"PeriodicalIF":3.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research hotspots and global trends in transcranial magnetic stimulation for stroke neurorestoration: A 30-year bibliometric analysis","authors":"Haozheng Li ,&nbsp;Chong Guan ,&nbsp;Dongxiang Fang ,&nbsp;Yang Yang ,&nbsp;Mengying Hsieh ,&nbsp;Zhiyuan Xu ,&nbsp;Qing Yang ,&nbsp;Yi Wu ,&nbsp;Ruiping Hu","doi":"10.1016/j.jnrt.2024.100148","DOIUrl":"10.1016/j.jnrt.2024.100148","url":null,"abstract":"<div><h3>Background</h3><div>Stroke patients often experience various functional impairments. Transcranial magnetic stimulation (TMS) has emerged as a novel non-invasive brain stimulation technique, and has gained widespread attention over the past 30 years for its application in stroke. The present study used bibliometric and content analysis methods to explore the research hotspots and future trends of TMS in stroke, with an aim to provide benefits for subsequent research.</div></div><div><h3>Methods</h3><div>Publications and reviews related to TMS in stroke from 1992 to 2022 were retrieved from the Web of Science Core Collection database. Data visualization and analysis were performed using CiteSpace, VOSviewer, and Scimago Graphica.</div></div><div><h3>Results</h3><div>We included 1666 papers in the analysis and noted an increasing trend in annual publication volume. Collaboration network analysis revealed close cooperation among scholars from these major countries and institutions. Emerging keywords included TMS, stroke, recovery, rehabilitation, rTMS, plasticity, cortex, excitability, upper limb, and tDCS. Keyword citation bursts appeared to be shifting toward clinical applications, including functional connectivity, systematic reviews, double-blind studies, connectivity, injury, and dysphagia.</div></div><div><h3>Conclusion</h3><div>Our study indicates substantial growth in TMS publications and citations in stroke rehabilitation since 2006, suggesting a maturing field that is advancing toward more sophisticated treatment protocols. The increasing relevance of TMS in neurological and rehabilitative applications highlights its potential for promoting post-stroke recovery. Emerging keywords such as brain functional connectivity, systematic reviews, and double-blind studies highlight a shift toward clinical applications. The future of TMS in stroke rehabilitation promises continued growth, interdisciplinary approaches, and improved patient outcomes.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100148"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review”","authors":"Xiumin Li,&nbsp;Bin Dong,&nbsp;Jie Wang","doi":"10.1016/j.jnrt.2024.100147","DOIUrl":"10.1016/j.jnrt.2024.100147","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100147"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000548/pdfft?md5=3450e83b01f2f476bd7e2a4fbf7cdaa6&pid=1-s2.0-S2324242624000548-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral hypertrophic olivary degeneration caused by unilateral midbrain infarction: A case report","authors":"Yuying Sun ,&nbsp;Yunfei Zhang ,&nbsp;Zhaoyang Lu ,&nbsp;Zijie Chen ,&nbsp;Jinggui Song ,&nbsp;Ping Zhang","doi":"10.1016/j.jnrt.2024.100141","DOIUrl":"10.1016/j.jnrt.2024.100141","url":null,"abstract":"<div><p>Hypertrophic olivary degeneration (HOD) arises from lesions of the dentato-rubro-olivary pathway (Guillain–Mollaret triangle), and bilateral HOD is the rarest. Our patient, a 42-year-old man with bilateral HOD caused by unilateral midbrain infarction, had both increased dizziness and ataxia as the first symptoms. HOD has no effective treatment and is easily misdiagnosed as other diseases in clinical practice. Our case demonstrated unique HOD symptomatology and emphasizes the important role of magnetic resonance imaging in diagnosing HOD. The use of gabapentin relieved nystagmus in our patient and may provide a reference for the future treatment of such patients.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100141"},"PeriodicalIF":3.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000482/pdfft?md5=38c01ecb7c1d8e58cf3f38b674e7ef85&pid=1-s2.0-S2324242624000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographic and temporal patterns of dyskinesia in multiple system atrophy with predominant parkinsonism","authors":"Hong Sun ,&nbsp;Chong Dong ,&nbsp;Yuan Li ,&nbsp;Miaomiao Li ,&nbsp;Hui Zhang ,&nbsp;Xitong Xu ,&nbsp;Wei Mao ,&nbsp;Piu Chan","doi":"10.1016/j.jnrt.2024.100145","DOIUrl":"10.1016/j.jnrt.2024.100145","url":null,"abstract":"<div><h3>Background</h3><p>Although dyskinesia is well recognized in Parkinson's disease, it is generally under acknowledged in multiple system atrophy (MSA). Reported cases of dyskinesia primarily manifest in patients with MSA with predominant parkinsonism (MSA-P), and characteristically present as orofacial dystonia. However, we have observed other manifestations of dyskinesia in our clinical practice. The current report aims to present the specific manifestations of dyskinesia in MSA-P, with videos.</p></div><div><h3>Methods</h3><p>We enrolled six patients with MSA-P with dyskinesia from Xuanwu Hospital. Of these, four had clinically established MSA-P and two had clinically probable MSA-P according to the 2022 Movement Disorder Society criteria for MSA diagnosis. All six patients underwent an acute levodopa challenge test, and videos were recorded during the process.</p></div><div><h3>Results</h3><p>Dyskinesia had a unilateral distribution in four patients. Three patients presented with peak-dose orofacial dystonia; of these, two were associated with blepharospasm and two were associated with limb dystonia. In addition, we observed that one patient had peak-dose distal lower limb dystonia with upper limb chorea, one patient had wearing-off dystonia of the eyelids, and one patient had diphasic generalized chorea mimicking that of Parkinson's disease.</p></div><div><h3>Conclusions</h3><p>In addition to orofacial dystonia, the topographic patterns of dyskinesia in MSA-P can manifest as limb dystonia, blepharospasm, and generalized chorea. Moreover, the temporal patterns of dyskinesia in MSA-P can be peak-dose, wearing-off, or diphasic.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100145"},"PeriodicalIF":3.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000524/pdfft?md5=43131876dd7e488e868ce0d326075d36&pid=1-s2.0-S2324242624000524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respondence to article “Brain iron deposition and whole-exome sequencing of non-Wilson's disease hypoceruloplasminemia in a family”","authors":"Hui Liu,&nbsp;Shu-Hong Wang","doi":"10.1016/j.jnrt.2024.100146","DOIUrl":"10.1016/j.jnrt.2024.100146","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100146"},"PeriodicalIF":3.1,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000536/pdfft?md5=2873dce26ff7a978a7c447004a09ae52&pid=1-s2.0-S2324242624000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GsMTx4 ameliorates spinal cord injury by regulating microglial polarization through the Piezo1/NFκB/STAT6 pathway","authors":"Weiwei Zheng ,&nbsp;Peng Zhang ,&nbsp;Hui Che ,&nbsp;Yu Zhang ,&nbsp;Xing Yang ,&nbsp;Yixin Shen","doi":"10.1016/j.jnrt.2024.100144","DOIUrl":"10.1016/j.jnrt.2024.100144","url":null,"abstract":"<div><h3>Objective</h3><p>Inflammatory reactions are recognized as pivotal in spinal cord injury (SCI), with the anti-inflammatory role of polarized microglia crucial in mitigating such injury. The present study aimed to determine the protective effects of GsMTx4 on functional recovery in a mouse model of SCI and investigate the role of GsMTx4 in cytokine-induced microglial activation and associated molecular mechanisms.</p></div><div><h3>Methods</h3><p>We assessed the effects of GsMTx4 on motor function in a mouse model of SCI, including neuronal survival and activated microglia in the vicinity of the injury after SCI. We also investigated the effects of GsMTx4 on expression of relevant inflammatory factors involved in cytokine-induced microglial activation and the associated signaling pathways.</p></div><div><h3>Results</h3><p>GsMTx4 effectively promoted functional recovery in mice and alleviated nerve damage after SCI. Additionally, GsMTx4 facilitated the transition of microglia from the M1 phenotype to the M2 phenotype, suppressed microglial activation, and reduced the expression of corresponding inflammatory mediators. These effects may involve modulation of neurogenic inflammation through the Piezo1/NFκB/STAT6 pathway, at least in part.</p></div><div><h3>Conclusion</h3><p>GsMTx4 safeguards against SCI by regulating microglial polarization, potentially via the Piezo1/NFκB/STAT6 pathway, offering initial evidence supporting the potential therapeutic efficacy of GsMTx4 for treatment of SCI.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100144"},"PeriodicalIF":3.1,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000512/pdfft?md5=bfe78d8fe1add4d4db5e0233b5e29251&pid=1-s2.0-S2324242624000512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of long non-coding RNAs in depression: Mechanisms and potential therapeutic targets","authors":"Zhanghua Ding ,&nbsp;Juntian Shen ,&nbsp;Chenlang Wei ,&nbsp;Zhuocao Liu ,&nbsp;Lina Huang ,&nbsp;Shouhong Zhou","doi":"10.1016/j.jnrt.2024.100142","DOIUrl":"10.1016/j.jnrt.2024.100142","url":null,"abstract":"<div><h3>Background</h3><p>Depression, also known as major depressive disorder, is a mental disorder caused by multiple factors. The cause of depression remains unclear, but a growing number of studies have reported a link between depression and long non-coding RNAs (lncRNAs). In the present study, we reviewed the relationships between depression and four lncRNAs, focusing on the differential expression of these lncRNAs in patients with depression, how to regulate depression, and how to use lncRNAs for the diagnosis, prevention, and treatment of clinical depression.</p></div><div><h3>Methods</h3><p>A systematic review of 23 studies published between 2011 and 2021 was conducted using Pubmed. Selection criteria included publication date and relevance to topic: Only articles published after 2010 were included to ensure the review reflects the most recent research, and all articles are selected strictly on their research topic.</p></div><div><h3>Results</h3><p>The short communication has summarized the relationships between depression and four lncRNAs, especially antisense lncRNAs and lincRNAs, and their potential in the diagnosis of depression and its targeted therapy.</p></div><div><h3>Conclusions</h3><p>The study found that these four lncRNAs, particularly antisense lncRNAs and lincRNAs, are closely associated with various aspects of depression. These findings suggest new therapeutic targets and could contribute to improving the accuracy of depression diagnosis.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100142"},"PeriodicalIF":3.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000494/pdfft?md5=708764b86b1cf3042edff88a03ceae08&pid=1-s2.0-S2324242624000494-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}