Journal of Neurorestoratology最新文献_第5页

Therapeutic effects of glial cell-derived extracellular vesicles on ischemic stroke in rodent models: A systematic review and meta-analysis 神经胶质细胞来源的细胞外囊泡对缺血性脑卒中啮齿动物模型的治疗作用：系统回顾和荟萃分析

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.1016/j.jnrt.2025.100222

Na Li , Ying Qian , Hongrui Zhang , Chenxi Tao , Ying Li , Rufan Xu , Yikun Sun , Yannan He , Yonghong Gao , Zhenhong Liu

{"title":"Therapeutic effects of glial cell-derived extracellular vesicles on ischemic stroke in rodent models: A systematic review and meta-analysis","authors":"Na Li , Ying Qian , Hongrui Zhang , Chenxi Tao , Ying Li , Rufan Xu , Yikun Sun , Yannan He , Yonghong Gao , Zhenhong Liu","doi":"10.1016/j.jnrt.2025.100222","DOIUrl":"10.1016/j.jnrt.2025.100222","url":null,"abstract":"<div><div>Treating ischemic stroke (IS) presents significant challenges; however, recent advancements suggest that glial cell-derived extracellular vesicles (GD-EVs) may offer a promising therapeutic strategy. This systematic review and meta-analysis evaluated the potential benefits of GD-EVs in IS by synthesizing data from preclinical studies. The review protocol was pre-registered with PROSPERO (CRD42024541149). Comprehensive literature searches were conducted across multiple databases, including PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang Database, and SinoMed, until April 10, 2024, to identify relevant studies. Preclinical studies investigating the utilization of GD-EVs in animal models of IS were included. Study quality was assessed using the risk of bias tool from the Systematic Review Center for Laboratory Animal Experimentation. From an initial pool of 3028 studies, 11 studies met the inclusion criteria. The analysis demonstrated that GD-EVs significantly improved neurological function, as evidenced by a reduction in the modified neurological severity score (standardized mean difference [SMD]: −1.69, 95% confidence interval [CI]: −2.15 to −1.22, <em>p</em> < 0.00001, and I<sup>2</sup> = 0%). GD-EVs also significantly reduced infarct volume in rodent models (SMD: −4.78, 95% CI: −6.91 to −2.66, <em>p</em> < 0.0001, Tau<sup>2</sup> = 0.99, and I<sup>2</sup> = 42%) and decreased brain water content and the release of pro-inflammatory factors post-stroke.</div><div>The methodological rigor of the included studies indicated sufficiently high overall quality. These findings suggest that GD-EVs hold significant promise as a novel therapeutic approach for IS and warrant further preclinical investigations before translation into clinical trials.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 4","pages":"Article 100222"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in clinical neurorestorative treatments of Parkinson's disease 帕金森病神经修复治疗的临床进展

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1016/j.jnrt.2025.100204

Yixuan Yin , Dongning Su , Joyce S.T. Lam , Tao Feng

引用次数: 0

The effects of weight training and Aklil-ol-Malek on histopathology and C-reactive protein, nuclear factor erythroid-derived 2-like 2 beta-site Amyloid Precursor protein cleaving enzyme1 genes expression in Alzheimer's disease model rats 重量训练和Aklil-ol-Malek对阿尔茨海默病模型大鼠组织病理学及c反应蛋白、核因子红细胞源性2-样2 β -位点淀粉样前体蛋白切割酶1基因表达的影响

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-04-08 DOI: 10.1016/j.jnrt.2025.100206

Farah Nameni , Mohammad Reza Amir Khan Dehkordi

{"title":"The effects of weight training and Aklil-ol-Malek on histopathology and C-reactive protein, nuclear factor erythroid-derived 2-like 2 beta-site Amyloid Precursor protein cleaving enzyme1 genes expression in Alzheimer's disease model rats","authors":"Farah Nameni , Mohammad Reza Amir Khan Dehkordi","doi":"10.1016/j.jnrt.2025.100206","DOIUrl":"10.1016/j.jnrt.2025.100206","url":null,"abstract":"<div><h3>Background</h3><div>Oxidative stress and neuroinflammation are key factors in the pathophysiology of Alzheimer's disease (AD). Exercise and Aklil-ol-Malek may reduce AD symptoms. Therefore, the current study investigated the effect of weight training and Aklil-ol-Malek consumption on histopathological and inflammatory changes in hippocampal tissue of male AD model rats.</div></div><div><h3>Method</h3><div>We prepared 55 8-week-old male Wistar rats and transferred them to an animal laboratory. The rats were randomly divided into five groups: healthy control group, Alzheimer's control group, Alzheimer's group + weight training, Alzheimer's group + Aklil-ol-Malek supplement, and Alzheimer's group + Aklil-ol-Malek supplement + weight training. AD was induced in the 4 groups. The weight training protocol and Aklil-ol-Malek supplementation were examined as an intervention. The designated groups were administered Aklil-ol-Malek supplements. The anesthetized rats' hippocampi were extracted for further analysis 72 hours after the last session of the protocol. After the induction of AD and supplementation, two-way analysis of variance was used to examine the differences between groups (<em>p <</em> 0.05).</div></div><div><h3>Results</h3><div>The results showed a decrease in the expression of CRP and NFE2L2 genes in rats in the Aklil-ol-Malek and weight training group compared with the findings in rats in the Alzheimer's group. Changes in the expression of BACE1 were not significant in rats in the weight training with Aklil-ol-Malek group.</div></div><div><h3>Conclusion</h3><div>An intervention receiving exercise and Aklil-ol-Malek extract positively improved health and reduced AD progression. These results were likely to have been caused by the physiological effects of exercise and the antioxidant properties of Aklil-ol-Malek.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100206"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of transcutaneous auricular vagus nerve stimulation for patients with mild cognitive impairment and depressive symptoms: A case report and fMRI study 经皮耳迷走神经刺激对轻度认知障碍伴抑郁症状患者的疗效：1例报告及fMRI研究

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.jnrt.2025.100202

Chunlei Guo , Jifei Sun , Yue Ma , Shanshan Gao , Tianjiao Xu , Qingyan Chen , Lei Zhang , Jiudong Cao , Guolei Zhang , Yang Hong , Hua Yan , Ge Yang , Jiliang Fang

引用次数: 0

Application and progress of magnetic field therapy for spinal cord injury 磁场治疗脊髓损伤的应用与进展

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.1016/j.jnrt.2025.100205

Zicai Liu , Zhanxiang Lin , Xuejin Liu , Xiuying Xie , Cheng Tan

{"title":"Application and progress of magnetic field therapy for spinal cord injury","authors":"Zicai Liu , Zhanxiang Lin , Xuejin Liu , Xiuying Xie , Cheng Tan","doi":"10.1016/j.jnrt.2025.100205","DOIUrl":"10.1016/j.jnrt.2025.100205","url":null,"abstract":"<div><div>Spinal cord injury (SCI), which results in severe neurological loss and multiple complications, remains a global health problem. Although SCI is a central nervous system injury, the field of related therapies has shown great promise, with breakthroughs regarding the theory of central nervous system irreparability. However, from the perspective of neuroprosthetics, the relevant basic theories are not always fully recognized or clearly understood, which poses a challenge to clinical practice guidance. Magnetic therapy technology has developed rapidly in recent years, and various magnetic therapy methods have emerged. Magnetic field therapy (MFT), with applications in SCI treatment, is considered a promising strategy for nerve repair and provides a theoretical foundation for subsequent research. MFT, including transcranial magnetic stimulation, static magnetic field, and pulsed electromagnetic field, has been used preclinically, and clinical studies have shown potential efficacy in SCI. Moreover, preclinical studies have revealed that MFT promotes nerve repair, reduces inflammatory responses, improves motor function, and enhances bladder control. They have also demonstrated that MFT is safe in human SCI patients and may improve motor function and pain control. However, its translation from preclinical studies to clinical application faces many challenges, including biological differences, determination of dose and treatment parameters, assessment of safety and side effects, and ethical and regulatory compliance. The present article aims to provide a comprehensive review of the applications and advances of MFT in SCI, to guide future research and provide a reference for clinical treatment. An in-depth discussion of MFT in the field of SCI may provide new ideas and directions for neural repair in SCI.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100205"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study 重度抑郁症与颈椎病的关系：一项双样本双向孟德尔随机化研究

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1016/j.jnrt.2025.100203

Dingyu Du , Guipeng Zhao , Yukai Huang , Longyi Chen, Jinping Liu

{"title":"Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study","authors":"Dingyu Du , Guipeng Zhao , Yukai Huang , Longyi Chen, Jinping Liu","doi":"10.1016/j.jnrt.2025.100203","DOIUrl":"10.1016/j.jnrt.2025.100203","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.</div></div><div><h3>Results</h3><div>In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR > 1, <em>p</em> < 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (<em>p</em> > 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.</div></div><div><h3>Conclusion</h3><div>This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100203"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in clinical neurorestorative treatments in brain trauma 脑外伤神经修复治疗的临床进展

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-02-14 DOI: 10.1016/j.jnrt.2025.100191

Qian Zhou , Wei Shen , Liang Wen

引用次数: 0

Neuroinflammation and neurorestoration following stroke: Molecular mechanisms and therapeutic approaches 脑卒中后的神经炎症和神经恢复：分子机制和治疗方法

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1016/j.jnrt.2025.100201

Liang Cao , Yi Zhang , Wenjun Pi , Voon Wee Yong , Mengzhou Xue

引用次数: 0

Corrigendum to “Primed low frequency repetitive Transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial” [J Neurorestoratol 13 (2025) 100169] “启动低频重复经颅磁刺激重新平衡大脑皮层兴奋抑制回路和改善婴儿脑瘫患者的功能预后：一项随机对照试验”[J]中华神经医学杂志13(2025):1009。

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-14 DOI: 10.1016/j.jnrt.2025.100192

Aliya Mufti , Suman Jain , Kanwal Preet Kochhar , Sheffali Gulati , Sanjay Wadhwa , Kapil Sikka , Rohit Saxena , Md Iqbal Alam

引用次数: 0

Neuronal intranuclear inclusion disease with sudden visual impairment 突发性视力损害的神经元核内包涵病

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.1016/j.jnrt.2025.100193

Lili Liu , Juanjuan Chen , Zhijian Lin, Jun Hu, Yunong Li, Fenli Zhou

引用次数: 0