Journal of Neurorestoratology最新文献

{"title":"How to make the best use of scalp electroencephalography in clinical neurorestorative research and practice?","authors":"Yunfa Fu, Yuyu Cao, Yong Hu","doi":"10.1016/j.jnrt.2025.100249","DOIUrl":"10.1016/j.jnrt.2025.100249","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100249"},"PeriodicalIF":3.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 30° head position improves dynamic cerebral autoregulation in patients undergoing reperfusion therapy: A prospective self-controlled study","authors":"Yi Gao ,&nbsp;Ye Sun ,&nbsp;Zhuo Liu ,&nbsp;Yi Yang ,&nbsp;Jia-Xin Ren ,&nbsp;Qiu-Xia Deng ,&nbsp;Yang Qu ,&nbsp;Fan Chen ,&nbsp;Peng Zhang ,&nbsp;Zi-Duo Shen ,&nbsp;Xiu-Li Yan ,&nbsp;Zhen-Ni Guo","doi":"10.1016/j.jnrt.2025.100241","DOIUrl":"10.1016/j.jnrt.2025.100241","url":null,"abstract":"<div><h3>Background</h3><div>At present, the optimal head position for stroke patients undergoing reperfusion therapy remains unclear. Because different head positions may exert distinct effects on dynamic cerebral autoregulation (dCA).</div></div><div><h3>Methods</h3><div>In this self-controlled study, the cerebral blood flow velocity (CBFV) in the middle cerebral artery and finger blood pressure at the 0° and 30° head positions were continuously recorded using transcranial Doppler combined with servo-controlled finger plethysmography at 24 ​h, 3 days, and 7 days after reperfusion. These data were then used to calculate the dCA parameters (phase difference [PD], gain, and coherence function) through transfer function analysis. Meanwhile, 30 healthy controls were included.</div></div><div><h3>Results</h3><div>Finally, 83 patients who underwent reperfusion therapy were included in the final analysis. For both sides, the phase difference in the 30° head position was significantly higher at 24 ​h (affected side: <em>p</em> ​= ​0.047; unaffected side: <em>p</em> ​= ​0.003), 3 days (affected side: <em>p</em> ​= ​0.040, unaffected side: <em>p</em> ​= ​0.016)), and 7 days (affected side: <em>p</em> ​&lt; ​0.001; unaffected side: <em>p</em> ​&lt; ​0.001) than that in the 0° head position. There was no significant difference in cerebral blood flow velocity between the 0° and 30° head positions on both affected and unaffected sides. Additionally, no difference of dCA and cerebral blood flow velocity was found in different head positions among healthy controls.</div></div><div><h3>Conclusions</h3><div>The 30° head position for patients undergoing reperfusion therapy for acute ischemic stroke is beneficial for improving dCA.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100241"},"PeriodicalIF":3.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of repeated transcranial acupuncture stimulation on facial nerve compression injury-induced facial paralysis in rats via Janus kinase-signal transducer and activator of transcription pathway activation","authors":"Wan-Qing Yang ,&nbsp;Jian Shi ,&nbsp;Jia-Chao Qin ,&nbsp;Zhi-Jun Ye ,&nbsp;Bao-Kang Yu ,&nbsp;Meng-Ru Huang ,&nbsp;Shu-Qi Huang ,&nbsp;Jin Zhong ,&nbsp;Zhong-Wen Li ,&nbsp;Yu-Mei Zhang ,&nbsp;Chun-Fang Zhang","doi":"10.1016/j.jnrt.2025.100239","DOIUrl":"10.1016/j.jnrt.2025.100239","url":null,"abstract":"<div><h3>Background</h3><div>Facial nerve injury is a neurological condition that involves paralysis or weakness of the facial muscles. Repeated transcranial acupuncture stimulation (rTAS) is a specialized acupuncture technique that has shown effectiveness in clinical studies for treating facial nerve paralysis; however, its underlying mechanisms are incompletely understood. We aimed to clarify the therapeutic effects and mechanisms of rTAS on facial nerve compression injury-induced facial paralysis in rats.</div></div><div><h3>Methods</h3><div>Fifty rats were divided into five groups (<em>n</em> = 10 per group): control group (CG), model group (MG), and three rTAS groups: 0-min repeated transcranial acupuncture stimulation group (rTAS-0), 2-min repeated transcranial acupuncture stimulation group (rTAS-2), 5-min repeated transcranial acupuncture stimulation group (rTAS-5). The MG and rTAS groups underwent facial nerve compression to model paralysis, whereas CG underwent nerve exposure only. The rTAS groups then received acupuncture (30 min daily for 14 days) with varying twisting and rest durations. We assessed facial function, temperature, and electrophysiology, followed by serum and facial nerve collection for hematoxylin and eosin, Nissl, and Masson's staining, and for immunohistochemistry, enzyme-linked immunosorbent assay, and reverse transcription polymerase chain reaction to explore nerve repair factors.</div></div><div><h3>Results</h3><div>Compared with the CG, the MG showed reduced facial function, prolonged latency and decreased amplitude of compound muscle action potentials, and more severe nerve injury, including lower Nissl body counts and collagen fiber ratios (<em>p</em> &lt; 0.05). rTAS treatment alleviated facial nerve damage; rTAS-5 exhibited the greatest effects, with improved facial function, nerve activity, and electrophysiological indices and reduced pathological scores. rTAS-5 also enhanced histological features such as Nissl body density and collagen fiber ratios (<em>p</em> &lt; 0.05). Moreover, rTAS-5 upregulated JAK1 and STAT3 expression in the facial nerve, suggesting activation of the JAK/STAT pathway during the repair process.</div></div><div><h3>Conclusions</h3><div>rTAS may improve facial function in rats with facial paralysis, and a longer twisting time might yield better results. Our findings suggest that rTAS increases JAK1 and STAT3 expression to activate the JAK/STAT pathway, thereby promoting the regeneration and repair of damaged nerves.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100239"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing motor rehabilitation using a hybrid BCI paradigm: integrating high-frequency SSVEP with action observation and motor imagery","authors":"Zhaohui Li ,&nbsp;Meng Li ,&nbsp;Xiaorong Gao ,&nbsp;Hongyan Cui ,&nbsp;Xiaogang Chen","doi":"10.1016/j.jnrt.2025.100238","DOIUrl":"10.1016/j.jnrt.2025.100238","url":null,"abstract":"<div><h3>Background</h3><div>Both action observation (AO) and motor imagery (MI) can elicit activity in mirror neurons and the motor cortex. Therefore, brain–computer interface (BCI) systems based on AO and MI hold broad application prospects in the field of motor rehabilitation. An increasing number of studies have incorporated steady-state visual evoked potentials (SSVEP) into AO or MI paradigms to construct hybrid BCI systems and enhance robustness of the systems.</div></div><div><h3>Methods</h3><div>In this study, AO, MI, and AO combined with MI experiments were designed, based on a SSVEP paradigm. In the AO experiment, subjects were required to observe alternating and flickering fisted- and extended-hand pictures. In the MI task, subjects were required to perform MI tasks while focusing on flickering extended-hand pictures. In the AO combined with MI experiment, subjects were required to execute the same task for the AO experiment while simultaneously perform the MI task. Task-discriminant component analysis and Tikhonov regularizing common spatio-spectral pattern algorithms were used to separately process inputs from the two modalities, with the system ultimately outputting a fusion result.</div></div><div><h3>Results</h3><div>The results found that AO combined with MI and MI alone more effectively activated the motor cortex compared with AO alone. The fusion classification accuracy of the proposed hybrid paradigm reached 86.42% ​± ​8.42%, 88.54% ​± ​10.31%, and 88.91% ​± ​9.61% for AO, MI, and AO combined with MI, respectively.</div></div><div><h3>Conclusion</h3><div>This study provided an alternative for the construction of a more robust and comfortable rehabilitation system.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100238"},"PeriodicalIF":3.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal administration of edaravone attenuates brain injury by targeting neuroinflammation and oxidative stress following intracerebral hemorrhage in mice","authors":"Zhe Li ,&nbsp;Yang Liu ,&nbsp;Ruixue Wei ,&nbsp;Sara Xue ,&nbsp;V. Wee Yong ,&nbsp;Mengzhou Xue","doi":"10.1016/j.jnrt.2025.100230","DOIUrl":"10.1016/j.jnrt.2025.100230","url":null,"abstract":"<div><h3>Background</h3><div>Intracerebral hemorrhage (ICH) poses a significant global health burden, characterized by high mortality rates and long-term disability. Despite advancements in stroke management, effective therapeutic strategies targeting secondary brain injury mechanisms post-ICH remain elusive. In this study, we explored the neuroprotective potential of edaravone (EDA) in a mouse model of ICH, with particular focus on the innovative approach of intranasal administration.</div></div><div><h3>Methods</h3><div>A total of 96 C57BL/6 mice were randomly assigned to sham group (<em>n</em> ​= ​32), ICH ​+ ​vehicle group (<em>n</em> ​= ​32) and ICH ​+ ​EDA group (<em>n</em> ​= ​32). ICH was induced using 0.5 ​μL bacterial collagenase VII. EDA (3 ​mg/kg) was administered intranasally starting 2 ​h after ICH and every 12 ​h thereafter (20 ​μL per mouse; 5 ​μL per nostril every 5 ​min). The ICH ​+ ​vehicle group received the identical solvent at an equivalent volume as the EDA group via intranasal administration. We evaluated neurological functions through mNSS, corner turn, and forelimb placement tests. Additionally, brain water content, immunofluorescence staining, western blot analysis, Evans blue extravasation assay, and TUNEL staining were utilized to examine the neuroprotective effects of EDA in ICH.</div></div><div><h3>Results</h3><div>Our findings demonstrate that intranasal delivery of EDA significantly alleviated neurological deficits and reduced brain injury following ICH. This was evidenced by improvements in behavioral assessments, decreased brain water content, reduced lesion volume, and diminished cell death in the perihematomal region. Notably, intranasal EDA administration preserved blood-brain barrier integrity, suppressed microglia/macrophage activation, and mitigated oxidative stress, highlighting its multifaceted neuroprotective mechanisms.</div></div><div><h3>Conclusion</h3><div>These outcomes underscore the therapeutic promise of intranasal administration of EDA as a prospective intervention for alleviating secondary brain injury post-ICH and advocate for further translational and clinical investigations to validate its efficacy and safety in ICH patients.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100230"},"PeriodicalIF":3.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the evolution of meningeal lymphatic system research: A decade of bibliometric insights (2015–2025)","authors":"Changkai Hou ,&nbsp;Bangyue Wang ,&nbsp;Quanlei Liu ,&nbsp;Yang Dai ,&nbsp;Jinkun Xu ,&nbsp;Wen Ren ,&nbsp;Guoguang Zhao","doi":"10.1016/j.jnrt.2025.100229","DOIUrl":"10.1016/j.jnrt.2025.100229","url":null,"abstract":"<div><h3>Background</h3><div>The landmark discovery of the meningeal lymphatic system (MLS) has revolutionized our understanding of CNS waste clearance and immune surveillance. Despite a decade of transformative research since its identification in 2015, a comprehensive analysis of its developmental trajectory, current research landscape, and future directions is lacking. This bibliometric study systematically analyzes the first decade of MLS research (2015–2025), with a particular emphasis on neurorestoration potential.</div></div><div><h3>Methods</h3><div>We retrieved relevant publications from the Web of Science Core Collection (WoSCC) between 2015 and 2025. Data were processed using Microsoft Excel, while collaborative networks among countries, institutions, journals, and authors were analyzed via VOSviewer, CiteSpace, GraphPad Prism, Web of Science, and the online bibliometric platform (<span><span>http://bibliometric.com/</span><svg><path></path></svg></span>). The key metrics included article types, research trends, citation patterns, and keyword frequency.</div></div><div><h3>Results</h3><div>A total of 449 publications from 2546 authors across 703 institutions in 46 countries published in 230 academic journals were identified. <em>Nature communications</em> contributed the largest number of MLS-related articles, whereas <em>Nature</em> was the most cocited journal. The majority of publications focused on immunology and cell biology. The United States and China emerged as leading contributors, with the University of Virginia producing the largest number of publications. Kipnis Jonathan was the most prolific author, whereas Louveau Antoine received the greatest number of cocitations. Keyword co-occurrence and reference analysis revealed that the “glymphatic system” and “meningeal lymphatic vessels” were central research themes. Notably, neurodegenerative diseases emerged as a rapidly growing research hotspot in MLS studies.</div></div><div><h3>Conclusion</h3><div>This decade-spanning analysis reveals the potential of MLS research for clinically relevant neurorestorative applications. The recognition of MLS as a regulator of immune function and neural repair has positioned them as compelling therapeutic targets. Our study highlights key trends and predicts future directions in MLS research. These insights will help prioritize research efforts to harness MLS biology for central nervous system repair paradigms.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100229"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-citric acid hydrogels loaded with catalpol: A novel therapeutic strategy for spinal cord injury","authors":"Dapeng Zhao ,&nbsp;Hengrui Li ,&nbsp;Xiaoyu Wang ,&nbsp;Ailing Yu ,&nbsp;Lanhua Li ,&nbsp;Baoliang Sun ,&nbsp;Ying Wang ,&nbsp;Guojun Wang ,&nbsp;Jingyi Sun","doi":"10.1016/j.jnrt.2025.100228","DOIUrl":"10.1016/j.jnrt.2025.100228","url":null,"abstract":"<div><h3>Background</h3><div>Spinal cord injury (SCI), which often results from traumatic incidents, leads to neural damage and impaired sensory and motor functions and may pose a serious threat to life. Secondary injury mechanisms caused by persistent inflammation disrupt the local microenvironment, causing neuronal cell death and hindering neural regeneration. This study used a chitosan-citric acid (CS-CA) hydrogel as a carrier for Catalpol (CAT-CS-CA), which was directly applied to the injury site to promote SCI repair.</div></div><div><h3>Methods</h3><div>CAT-CS-CA and CS-CA hydrogels were characterized and implanted into rat SCI models. Fifty-four male Sprague-Dawley rats (230–250 g) rats were involved in the experiment. Six rats were randomly divided into two groups (<em>n</em> = 3 per group) for in vivo degradation of hydrogels. Forty-eight rats were randomly assigned into four groups (<em>n</em> = 12) using a randomization protocol: sham operation group (laminectomy only), SCI group, CS-CA hydrogel group, and CAT-CS-CA hydrogel group. From each group, 3 rats were randomly selected for serum and spinal cord tissue extraction, followed by ELISA and RT-qPCR assays to determine the expression levels of various inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10). Another 3 randomly selected rats were used for the evaluation of hindlimb motor function. The remaining 6 rats in each group were used to detect the expression of neuronal nuclei (NeuN), βIII-tubulin (Tuj1), glial fibrillary acidic protein (GFAP), and macrophage polarization (M1/M2 markers).</div></div><div><h3>Results</h3><div>The CAT-CS-CA hydrogel retains CS-CA hydrogel's advantages and gains enhanced neuroprotective and anti-inflammatory abilities. The implantation of CAT-CS-CA into injured rat spinal cords enhanced neuronal survival, stimulated axonal regeneration, and significantly suppressed glial proliferation at the injury site. In addition, it promoted macrophage polarization to the M2 phenotype and substantially enhanced hindlimb motor function in rats with SCI.</div></div><div><h3>Conclusion</h3><div>CAT-CS-CA hydrogel promotes neuronal survival, suppresses glial scarring, and improves motor function, offering a promising strategy for SCI repair.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100228"},"PeriodicalIF":3.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers in the diagnosis and prognosis of traumatic spinal cord injury: A systematic review and meta-analysis","authors":"Zhengwang Liu ,&nbsp;Haifeng Gao ,&nbsp;Yidi Man ,&nbsp;Xiaoyu Zhang ,&nbsp;Liang Chen ,&nbsp;Mingliang Yang ,&nbsp;Yingli Jing ,&nbsp;Jun Li","doi":"10.1016/j.jnrt.2025.100227","DOIUrl":"10.1016/j.jnrt.2025.100227","url":null,"abstract":"<div><div>Traumatic spinal cord injury (TSCI) is a severe neurological condition that frequently leads to permanent disability. Serum inflammatory markers and structural proteins may serve as potential biomarkers for TSCI. The present study aimed to evaluate the diagnostic and prognostic value of serum biomarkers in TSCI. In this article, a comprehensive literature search was conducted using databases such as Wanfang, VIP Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science. Meta-analysis was performed using RevMan 5.4 software to compare serum biomarker concentrations between TSCI patients and healthy controls (diagnostic group) and between patients with favorable and unfavorable prognoses (prognostic group). The quality of the included studies was evaluated using the Newcastle–Ottawa Scale. The results showed that: (1) In the diagnostic group, the meta-analysis revealed that serum levels of NSE, MIF, S100β, TNF-α, IL-1β, IL-4, IL-6, IL-16, CCL2, CCL4, CCL21, CXCL1, CXCL9, CXCL10, and CXCL12 were significantly elevated in TSCI patients compared with healthy controls, while IL-10 levels were decreased. (2) In the prognostic group, meta-analysis indicated that serum GFAP and NSE concentrations were significantly lower in patients with favorable prognoses than in those with poor prognoses. In conclusion, the serum levels of most structural proteins and inflammatory factors in patients with TSCI are elevated compared with healthy controls, and patients with poor prognosis exhibit even higher concentrations than those with favorable outcomes. These findings indicate the potential value of these markers for diagnosing TSCI and assessing prognosis.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100227"},"PeriodicalIF":3.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular radial peripapillary capillary: a potential optical coherence tomography angiography biomarker of cognitive impairment in patients with internal carotid artery stenosis","authors":"Panpan Shen ,&nbsp;Yili Lin ,&nbsp;Jiawei Ye ,&nbsp;Peiwen Wang ,&nbsp;Lujie Han ,&nbsp;Weitao Yu ,&nbsp;Xiang Yu ,&nbsp;Qiannan Hu ,&nbsp;Weifen Zhang ,&nbsp;Huiyuan Wang ,&nbsp;Pengfei Sun ,&nbsp;Xinchun Jin ,&nbsp;Sheng Zhang ,&nbsp;Yu Geng","doi":"10.1016/j.jnrt.2025.100225","DOIUrl":"10.1016/j.jnrt.2025.100225","url":null,"abstract":"<div><h3>Objective</h3><div>We investigated retinal and choroidal microvascular parameters as potential biomarkers for vascular cognitive impairment in patients with internal carotid artery stenosis (ICAS).</div></div><div><h3>Methods</h3><div>We enrolled 123 asymptomatic ICAS patients and categorized them into vascular mild cognitive impairment (VMCI) and vascular dementia (VaD) groups using the Montreal Cognitive Assessment. Optical coherence tomography angiography was used to evaluate vessel densities and perfusion areas in various retinal layers. Magnetic resonance imaging-based neuroimaging biomarkers for cerebral small vessel disease (CSVD) were also assessed. Least absolute shrinkage and selection operator logistic regression identified predictor variables, and receiver operating curve analysis assessed the ability of key parameters to distinguish between VMCI and VaD.</div></div><div><h3>Results</h3><div>Compared with VMCI patients, VaD patients had lower radial peripapillary capillary (RPC) perfusion area, higher CSVD burden score, and larger white matter hyperintensity volume (all <em>p</em> &lt; 0.05). Receiver operating curve analysis revealed that the RPC perfusion area of the affected eye had superior discriminatory power for distinguishing VaD from VMCI compared with both the CSVD burden score (<em>Z</em> = 1.99, <em>p</em> = 0.047) and white matter hyperintensity (<em>Z</em> = 1.97, <em>p</em> = 0.049). The optimal cutoff value for the 0–1 mm macular RPC perfusion area was determined as 0.068 mm².</div></div><div><h3>Conclusion</h3><div>The optical coherence tomography angiography-derived RPC perfusion area can effectively differentiate VaD from VMCI, suggesting its potential as a noninvasive diagnostic method to support clinical decision-making for ICAS patients.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100225"},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence to “Identification and validation of core genes associated with intracranial aneurysms through bioinformatics analysis and Mendelian randomization”","authors":"Shuya Jiao,&nbsp;Manjiang Cao","doi":"10.1016/j.jnrt.2025.100226","DOIUrl":"10.1016/j.jnrt.2025.100226","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 5","pages":"Article 100226"},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}