Journal of Neurorestoratology最新文献

{"title":"Research progress on the therapeutic efficacy of human umbilical cord mesenchymal stromal cells for cerebral palsy in children","authors":"Sai Wang ,&nbsp;Yachen Wang ,&nbsp;Jing Liu","doi":"10.1016/j.jnrt.2025.100266","DOIUrl":"10.1016/j.jnrt.2025.100266","url":null,"abstract":"<div><div>Cerebral palsy (CP) is a non-progressive disorder of the central nervous system resulting from brain damage in the developing fetus or infant. It is primarily characterized by motor and postural abnormalities that severely impair motor function, speech, cognition, and mental health. Current comprehensive treatment approaches—including rehabilitation, pharmacotherapy, and surgical interventions—offer only limited symptomatic relief and fail to address the underlying neurodevelopmental deficits. Therefore, there remains an urgent clinical need for innovative therapies capable of fundamentally repairing neural damage and restoring functional neural circuitry. In recent years, umbilical cord mesenchymal stromal cells (UC-MSCs) have emerged as a promising therapeutic strategy for CP due to their unique biological properties, including low immunogenicity and potent paracrine activity. Preclinical studies have demonstrated that UC-MSCs can promote structural and functional reconstruction of damaged neural networks through multiple synergistic mechanisms, such as immunomodulation to reshape the immune microenvironment, neurotrophic support and neuroregeneration, and proliferative potential for cellular replacement. Notably, a recent study in Poland (<em>n</em> = 152) provided large-sample validation of these effects. Following infusion of Human UC-MSCs (HUC-MSCs), the median increase in the Gross Motor Function Measure (GMFM) score was 1.9 points, with a significant negative correlation with age (Spearman's <em>R</em> = −0.38, <em>p</em> &lt; 0.05). The median improvement in the 6-Minute Walk Test((6-MWT) was 75 m, which correlated with GMFM improvement (Spearman's <em>R</em> = 0.47, <em>p</em> &lt; 0.05). The median reduction in Timed Up and Go test time was 2 s, and the magnitude of improvement was significantly correlated with baseline GMFM, 6-MWT gain, and age. The findings suggest that the functional benefits of HUC-MSCs are more pronounced in younger children and those with better baseline motor function. However, larger sample sizes and long-term follow-up studies are still required to validate the durability of these effects and establish long-term safety. This review systematically integrates the neurorestorative mechanisms of UC-MSCs, preclinical evidence, and the latest clinical data to provide a theoretical foundation and practical guidance for the future development of novel UC-MSC-based therapeutic strategies.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 2","pages":"Article 100266"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of a hybrid SSVEP–AO–MI paradigm for motor rehabilitation: Considerations for clinical translation","authors":"Parth Aphale,&nbsp;Himanshu Shekhar,&nbsp;Shashank Dokania","doi":"10.1016/j.jnrt.2026.100268","DOIUrl":"10.1016/j.jnrt.2026.100268","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 2","pages":"Article 100268"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology analysis of energy metabolism-related genes in ischemic stroke targeted by Herba Siegesbeckiae","authors":"Wenjuan Cong ,&nbsp;Xiaojing Yuan ,&nbsp;Yuwen Hao ,&nbsp;Huimin Jia ,&nbsp;Wenjun Jiang ,&nbsp;Qiang Gao ,&nbsp;Xiaoqian Lv ,&nbsp;Hongyou Yang ,&nbsp;Yaoting Zheng ,&nbsp;Hao Zhang ,&nbsp;Haoyue Chen ,&nbsp;Ling Zheng ,&nbsp;Chao Pang ,&nbsp;Yilin Sun ,&nbsp;Yi Zhang ,&nbsp;Xuanxuan Ge ,&nbsp;Zuncheng Zheng ,&nbsp;Xiaoyu Wang","doi":"10.1016/j.jnrt.2025.100254","DOIUrl":"10.1016/j.jnrt.2025.100254","url":null,"abstract":"<div><h3>Objective</h3><div>Ischemic stroke (IS), a leading cause of disability and mortality worldwide, results from cerebral vascular occlusion and is associated with profound energy metabolism disorders, including oxidative phosphorylation, glycolysis, and fatty acid metabolism. <em>Herba Siegesbeckiae</em> (HS), a traditional Chinese medicinal herb, has shown neuroprotective potential by modulating metabolic and inflammatory pathways,but its mechanisms in IS remain unclear.</div></div><div><h3>Methods</h3><div>Active compounds of HS were identified from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Potential targets were predicted using GeneCards, DisGeNET, and SwissTargetPrediction and filtered for genes related to energy metabolism in IS. A protein-protein interaction network was constructed using STRING and analyzed with Cytoscape 3.9.1 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed with the clusterProfiler package in R,and molecular docking with AutoDock Vina evaluated compounds-target affinities.</div></div><div><h3>Results</h3><div>Nine active compounds and 252 potential target genes were identified. Among 21 core targets, IL6, CYP3A4, and PPARG showed the highest network centrality. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated enrichment in inflammatory regulation, lipid metabolism, and oxidative stress-related pathways. Molecular docking showed strong binding affinities, with hederagenin demonstrating the most stable interaction with CYP3A4.</div></div><div><h3>Conclusion</h3><div>HS may regulate energy metabolism in IS through multi-target, multi-pathway mechanisms, exerting neuroprotective effects via anti-inflammatory and metabolic regulation.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100254"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spring of China's national policy in clinical cell (somatic cell) therapy for neurorestoration","authors":"Hongyun Huang","doi":"10.1016/j.jnrt.2026.100267","DOIUrl":"10.1016/j.jnrt.2026.100267","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100267"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asynchronous co-culture enhances neuronal differentiation in CRISPR/Cas9-engineered NURR1 reporter induced neural stem cells","authors":"Deqiang Han ,&nbsp;Xueyao Wang ,&nbsp;Shuili Jing ,&nbsp;Tianqi Zheng ,&nbsp;Yuan Wang ,&nbsp;Yuanzhang Tang ,&nbsp;Zhiguo Chen","doi":"10.1016/j.jnrt.2025.100252","DOIUrl":"10.1016/j.jnrt.2025.100252","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is caused by the gradual degeneration of dopaminergic neurons in the midbrain, resulting in severe motor impairments. Stem cell-based neurorestorative therapies present considerable therapeutic promise; however, major challenges remain, such as variability in lineage specification, limited long-term graft survival, and the absence of effective real-time techniques to monitor differentiation processes. Overcoming these obstacles necessitates innovative strategies to address cellular heterogeneity and enhance the efficacy of neurorestorative interventions.</div></div><div><h3>Methods</h3><div>We engineered a NURR1-driven dopaminergic reporter in induced neural stem cells (iNSCs) through CRISPR/Cas9-mediated knock-in of ZsGreen. The differentiation capacity of reporter iNSCs was validated via <em>in vitro</em> spontaneous differentiation. Transcriptomic profiling was performed to compare fluorescence-sorted differentiation-committed (ZsGreen⁺) and non-committed (ZsGreen^–) subpopulations with biological triplicates. To enhance neuronal differentiation efficiency, we developed a stage-specific asynchronous co-culture system that combined early-stage (day 5) and mid-stage (day 8) differentiating iNSC populations. Optimized iNSC-derived dopaminergic precursors were transplanted into striatum of sixteen male SCID-Beige mice (6–8 weeks old), which were randomly assigned to two groups: one receiving co-cultured cells (<em>n</em> ​= ​8) and the other receiving non-co-cultured cells (<em>n</em> ​= ​8). Graft survival and differentiation were subsequently assessed.</div></div><div><h3>Results</h3><div>The reporter system allowed real-time tracking of dopaminergic differentiation from iNSCs without affecting their differentiation potential. Transcriptome analysis showed specific activation of neurorestorative pathways in ZsGreen⁺ ​cells, including processes such as neurogenesis, neuronal maturation, axonal guidance, and cell projection organization. Asynchronous co-culture markedly enhanced the neuronal yield from iNSC-derived dopaminergic precursors compared with standard approaches. Transplantation <em>in vivo</em> confirmed stable engraftment and differentiation into TH-positive cells within the host striatal tissue.</div></div><div><h3>Conclusion</h3><div>The NURR1-ZsGreen reporter system provides a functional platform to resolve lineage specification heterogeneity and optimize differentiation protocols. The identified neurorestorative pathways, together with the asynchronous co-culture strategy, collectively address critical barriers in cell replacement-based neurorestorative therapy.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100252"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical diagnostic and therapeutic guidelines for ischemic stroke neurorestoration (2024 China version)","authors":"Xiaoling Guo ,&nbsp;Qun Xue ,&nbsp;Jianhua Zhao ,&nbsp;Yang Yu ,&nbsp;Yi Yang ,&nbsp;HanCheng Qiu ,&nbsp;Wei Zhang ,&nbsp;Lin Chen ,&nbsp;Liqun Ren ,&nbsp;Jing Liu ,&nbsp;Ping Zhang ,&nbsp;Siquan Liang ,&nbsp;Gengsheng Mao ,&nbsp;Linsen Mu ,&nbsp;Dezhong Liu ,&nbsp;Chuanqiang Qu ,&nbsp;Haitao Xi ,&nbsp;Hongyan Han ,&nbsp;Zhenchuan Liu ,&nbsp;Juehua Zhu ,&nbsp;Hongyun Huang","doi":"10.1016/j.jnrt.2025.100263","DOIUrl":"10.1016/j.jnrt.2025.100263","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100263"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycium barbarum polysaccharide promotes motor function recovery in rats after spinal cord injury by regulating macrophage /microglial polarization","authors":"Dun-Xu Hu ,&nbsp;Er-Ke Gao ,&nbsp;Jia-Yi Zhang ,&nbsp;Jun-Bo Chen ,&nbsp;De-Jing Zhang ,&nbsp;Peng-Tian Zhao ,&nbsp;Zhi-Qi Wang ,&nbsp;Jun-Jin Li ,&nbsp;Zhi-Jian Wei ,&nbsp;Tao Zhang","doi":"10.1016/j.jnrt.2025.100264","DOIUrl":"10.1016/j.jnrt.2025.100264","url":null,"abstract":"<div><h3>Background</h3><div>Macrophage and microglial polarization are key drivers of localised inflammatory responses following spinal cord injury (SCI). The equilibrium between the anti-inflammatory and pro-inflammatory effects mediated by polarised cells plays a critical role in influencing neurological recovery post-SCI. Lycium barbarum polysaccharide (LBP), a bioactive compound derived from Lycium barbarum, has shown potential in modulating inflammatory responses and enhancing neurofunctional recovery, yet its underlying mechanisms are still not fully understood.</div></div><div><h3>Methods</h3><div>We selected 48 adult female rats as the experimental subjects for the <em>in vivo</em> study. Random assignment placed the rats into three distinct groups (<em>n</em> ​= ​16): Sham, SCI, and SCI ​+ ​LBP. A rat spinal cord contusion model was utilised to evaluate the therapeutic effects of LBP on histological repair and locomotor recovery following SCI. Inflammatory cytokine levels at the injury site were quantified. <em>In vitro</em>, a lipopolysaccharide (LPS)-induced bone marrow-derived macrophage (BMDM) model was employed to assess the anti-inflammatory effects of LBP, with subsequent analysis of inflammatory mediator profiles and macrophage M1/M2 polarization status.</div></div><div><h3>Results</h3><div>LBP treatment significantly improved hindlimb motor function and enhanced nerve conduction capacity in SCI rats, accompanied by reduced histological damage. Moreover, LBP substantially downregulated pro-inflammatory cytokine expression at the injury site. Mechanistically, LBP suppressed M1 polarization while promoting M2 polarization of macrophages and microglia.</div></div><div><h3>Conclusion</h3><div>LBP offers neuroprotective effects by mitigating post-SCI inflammatory responses via modulation of macrophage and microglial polarization to an anti-inflammatory phenotype. These results provide preclinical evidence for the potential application of LBP as a treatment for SCI.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100264"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of argatroban in acute branch atheromatous disease: A retrospective observational study","authors":"Min Chang,&nbsp;Ruifang Ren,&nbsp;Dewei Zhu,&nbsp;Jun Zhao,&nbsp;Xu Li,&nbsp;Meiyang Yu,&nbsp;Ping Zhang,&nbsp;Haiqing Yan","doi":"10.1016/j.jnrt.2025.100251","DOIUrl":"10.1016/j.jnrt.2025.100251","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the efficacy and safety of argatroban combined with dual antiplatelet therapy (DAPT) for treating acute branch atheromatous disease-related cerebral infarction.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted of 127 stroke patients admitted to the Department of Neurology at the First Affiliated Hospital of Xinxiang Medical University from January 2022 to December 2023. Patients were divided into two groups: the argatroban group with 44 individuals (who initially received argatroban therapy and subsequently received DAPT) and the DAPT group with 83 individuals (who received treatment with aspirin combined with clopidogrel). Therapeutic effects were evaluated using the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale, and Activities of Daily Living scores before and after treatment.</div></div><div><h3>Results</h3><div>After propensity score matching, 37 patients were included per group. The argatroban group showed higher rates of “basic cure,” 3-month modified Rankin Scale score ≤1, and NIHSS score reduction ≥2, and had a lower recurrence rate (<em>p</em> ​&lt; ​0.05). No adverse events were observed. Multivariate logistic regression confirmed a lower recurrence rate in the argatroban group. Subgroup analysis revealed better outcomes in older patients (higher NIHSS reduction ≥2) and in young/middle-aged patients with mild branch atheromatous disease (higher cure rate, lower incidence of early neurological deterioration) (<em>p</em> ​&lt; ​0.05).</div></div><div><h3>Conclusion</h3><div>Argatroban combined with DAPT in the acute phase improves cure rates, promotes neurological recovery, enhances short-term prognosis, reduces recurrence, and does not increase adverse reactions such as bleeding.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100251"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCL14–CXCR4-mediated platelet migration across the blood–brain barrier and subsequent microglia and astrocyte activation in arterial baroreflex dysfunction","authors":"Ruimin Chen ,&nbsp;Fengbao Chen ,&nbsp;Rui Tan ,&nbsp;Bowen Shen ,&nbsp;Lili Yang ,&nbsp;Yunting Wang ,&nbsp;Tianyang Guo ,&nbsp;Xiuli Jing ,&nbsp;Xiaoli Lu ,&nbsp;Xinbo Li ,&nbsp;Yongfeng Gao ,&nbsp;Xiaomin Zhao","doi":"10.1016/j.jnrt.2025.100255","DOIUrl":"10.1016/j.jnrt.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>Arterial baroreflex (ABR) dysfunction is linked to various central nervous system disorders and is associated with platelet accumulation in the brain, contributing to neuroinflammation. However, the mechanisms for platelets crossing the blood–brain barrier (BBB) and the role of platelets in ABR dysfunction remain poorly understood. We hypothesize that CXCL14–CXCR4 signaling facilitates platelet migration across the BBB and promotes glial activation in the context of ABR dysfunction.</div></div><div><h3>Methods</h3><div>ABR dysfunction was induced in Sprague Dawley rats via sinoaortic denervation (SAD). Four weeks post-surgery, 12 rats were randomly divided into two groups (<em>n</em> ​= ​6 per group; Sham and SAD). An additional 18 were divided into three groups (<em>n</em> ​= ​6 per group; Sham, SAD, and SAD ​+ ​clopidogrel). Platelet infiltration in the brain was assessed by immunohistochemistry. Levels of CXCL14 in the brain were evaluated using immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays. CXCR4 levels on platelets was detected by flow cytometry. We constructed an <em>in vitro</em> BBB model to study platelet migration across the BBB. Platelets were co-cultured with BV2 cells and C6 cells, and the levels of inflammatory factors were measured using enzyme-linked immunosorbent assays. Polarization was assessed by immunofluorescence.</div></div><div><h3>Results</h3><div>Immunofluorescence revealed significant platelet infiltration in ABR dysfunction model rat brains. <em>In vitro</em> BBB models and <em>in vivo</em> experiments confirmed increased platelet migration in ABR-dysfunctional rats. Further analysis showed elevated levels of the chemokine CXCL14 in brain tissue and increased CXCR4 abundance on platelets. <em>In vitro</em> assays demonstrated that platelet migration across the model BBB was driven by CXCL14 and was significantly reduced by inhibitors targeting CXCL14 (neutralizing antibody), CXCR4 (AMD3100), G-protein signaling (pertussis toxin), PI3K signaling (LY294002), and actin polymerization (cytochalasin B). Moreover, CXCL14 stimulation enhanced the phosphorylation of neural Wiskott–Aldrich syndrome protein (N-WASP), a key regulator of cytoskeletal dynamics. Migrating platelets also promoted the polarization of microglia and astrocytes toward pro-inflammatory M1 and A1 phenotypes, respectively. Treatment with clopidogrel, a platelet inhibitor, suppressed platelet migration and glial activation.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that the CXCL14–CXCR4 axis mediates platelet migration across the BBB in states of ABR dysfunction via G-protein and PI3K-dependent pathways, ultimately triggering glial activation. Our study provides new insights into the mechanisms of platelet migration and neuroinflammation associated with ABR dysfunction.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 1","pages":"Article 100255"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 30° head position improves dynamic cerebral autoregulation in patients undergoing reperfusion therapy: A prospective self-controlled study","authors":"Yi Gao ,&nbsp;Ye Sun ,&nbsp;Zhuo Liu ,&nbsp;Yi Yang ,&nbsp;Jia-Xin Ren ,&nbsp;Qiu-Xia Deng ,&nbsp;Yang Qu ,&nbsp;Fan Chen ,&nbsp;Peng Zhang ,&nbsp;Zi-Duo Shen ,&nbsp;Xiu-Li Yan ,&nbsp;Zhen-Ni Guo","doi":"10.1016/j.jnrt.2025.100241","DOIUrl":"10.1016/j.jnrt.2025.100241","url":null,"abstract":"<div><h3>Background</h3><div>At present, the optimal head position for stroke patients undergoing reperfusion therapy remains unclear. Because different head positions may exert distinct effects on dynamic cerebral autoregulation (dCA).</div></div><div><h3>Methods</h3><div>In this self-controlled study, the cerebral blood flow velocity (CBFV) in the middle cerebral artery and finger blood pressure at the 0° and 30° head positions were continuously recorded using transcranial Doppler combined with servo-controlled finger plethysmography at 24 ​h, 3 days, and 7 days after reperfusion. These data were then used to calculate the dCA parameters (phase difference [PD], gain, and coherence function) through transfer function analysis. Meanwhile, 30 healthy controls were included.</div></div><div><h3>Results</h3><div>Finally, 83 patients who underwent reperfusion therapy were included in the final analysis. For both sides, the phase difference in the 30° head position was significantly higher at 24 ​h (affected side: <em>p</em> ​= ​0.047; unaffected side: <em>p</em> ​= ​0.003), 3 days (affected side: <em>p</em> ​= ​0.040, unaffected side: <em>p</em> ​= ​0.016)), and 7 days (affected side: <em>p</em> ​&lt; ​0.001; unaffected side: <em>p</em> ​&lt; ​0.001) than that in the 0° head position. There was no significant difference in cerebral blood flow velocity between the 0° and 30° head positions on both affected and unaffected sides. Additionally, no difference of dCA and cerebral blood flow velocity was found in different head positions among healthy controls.</div></div><div><h3>Conclusions</h3><div>The 30° head position for patients undergoing reperfusion therapy for acute ischemic stroke is beneficial for improving dCA.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 6","pages":"Article 100241"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}