Journal of Neurorestoratology最新文献

{"title":"Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study","authors":"Dingyu Du ,&nbsp;Guipeng Zhao ,&nbsp;Yukai Huang ,&nbsp;Longyi Chen,&nbsp;Jinping Liu","doi":"10.1016/j.jnrt.2025.100203","DOIUrl":"10.1016/j.jnrt.2025.100203","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.</div></div><div><h3>Results</h3><div>In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR &gt; 1, <em>p</em> &lt; 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (<em>p</em> &gt; 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.</div></div><div><h3>Conclusion</h3><div>This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100203"},"PeriodicalIF":3.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroinflammation and neurorestoration following stroke: Molecular mechanisms and therapeutic approaches","authors":"Liang Cao ,&nbsp;Yi Zhang ,&nbsp;Wenjun Pi ,&nbsp;Voon Wee Yong ,&nbsp;Mengzhou Xue","doi":"10.1016/j.jnrt.2025.100201","DOIUrl":"10.1016/j.jnrt.2025.100201","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100201"},"PeriodicalIF":3.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Primed low frequency repetitive Transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial” [J Neurorestoratol 13 (2025) 100169]","authors":"Aliya Mufti ,&nbsp;Suman Jain ,&nbsp;Kanwal Preet Kochhar ,&nbsp;Sheffali Gulati ,&nbsp;Sanjay Wadhwa ,&nbsp;Kapil Sikka ,&nbsp;Rohit Saxena ,&nbsp;Md Iqbal Alam","doi":"10.1016/j.jnrt.2025.100192","DOIUrl":"10.1016/j.jnrt.2025.100192","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100192"},"PeriodicalIF":3.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal intranuclear inclusion disease with sudden visual impairment","authors":"Lili Liu ,&nbsp;Juanjuan Chen ,&nbsp;Zhijian Lin,&nbsp;Jun Hu,&nbsp;Yunong Li,&nbsp;Fenli Zhou","doi":"10.1016/j.jnrt.2025.100193","DOIUrl":"10.1016/j.jnrt.2025.100193","url":null,"abstract":"<div><div>Here we report a case of a 67-year-old female patient who presented with headache, limb tremors, and acute complete vision loss. Physical examination revealed bilateral miosis, and diffusion-weighted imaging sequences showed mild diffusion restriction in the subcortical regions of both occipital lobes. Genetic results revealed 85 GGC repeats in the 5′-untranslated region of the <em>NOTCH2NLC</em> gene. The therapeutic effect of dexamethasone and acyclovir was minimal. NIID must be considered in patients with acute onset and various clinical manifestations and imaging findings similar to encephalitis. We hope that our case presentation will enhance clinicians’ awareness of NIID.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100193"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in clinical neurorestorative treatments in brain trauma","authors":"Qian Zhou ,&nbsp;Wei Shen ,&nbsp;Liang Wen","doi":"10.1016/j.jnrt.2025.100191","DOIUrl":"10.1016/j.jnrt.2025.100191","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) is a significant cause of mortality and disability globally, imposing a considerable burden on society and individuals. In recent years, neurorestorative therapies for TBI have attracted widespread attention. Despite the rapid progress in clinical neurorestorative treatments for TBI, few relevant reviews have been published. This review addresses advances in these strategies for patients with TBI, covering cellular therapies, neurostimulation therapies, brain-computer interfaces, pharmacologic therapies, and multidisciplinary therapies. This review aims to serve as a reference for clinical professionals treating patients with TBI, improving neurologic rehabilitation and outcomes for patients with TBI.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100191"},"PeriodicalIF":3.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIF1α/SLC7A11 signaling attenuates 6-hydroxydopamine-induced ferroptosis in animal and cell models of Parkinson’s disease","authors":"Xuejia Liu ,&nbsp;Zhisheng Han ,&nbsp;Yuming Huang ,&nbsp;Mingzhi Li ,&nbsp;Jialu Tian ,&nbsp;Shan Zhao ,&nbsp;Yonghai Li ,&nbsp;Juntang Lin ,&nbsp;Han Li","doi":"10.1016/j.jnrt.2024.100171","DOIUrl":"10.1016/j.jnrt.2024.100171","url":null,"abstract":"<div><h3>Background</h3><div>The pathogenesis of Parkinson’s disease (PD) is associated with ferroptosis. The role of HIF1α is involved in several diseases, but its specific function in PD remains uncertain.</div></div><div><h3>Methods</h3><div>In this study, we generated animal and cellular models of PD using the neurotoxin 6-OHDA. The occurrence of ferroptosis was determined by measuring levels of ferroptosis-related proteins, Fe²⁺ amount and transmission electron microscopy analysis in the PD models, and was further confirmed by using a ferroptosis inhibitor. HIF1α overexpressing and HIF1α knockdown SH-SY5Y cells were constructed by lentivirus transfection. Then, the levels of lipid peroxide, ROS, SLC7A11, and GPX4 were detected to elucidate the relationship between HIF1α and ferroptosis. Luciferase assay was used to analyze the regulation between HIF1α and SLC7A11.</div></div><div><h3>Results</h3><div>We observed a significant downregulation of HIF1α in both animal and cellular PD models. Overexpression of HIF1α mitigated 6-OHDA-induced ferroptosis in SH-SY5Y cells, while, conversely, downregulation of HIF1α promoted ferroptosis in SH-SY5Y cells. BioEdit Sequence Alignment Editor software identified a hypoxia response element (HRE) within the promoter sequence of <em>SLC7A11</em>. The dual-luciferase reporter assays demonstrated that the co-expression of HIF1α and the <em>SLC7A11</em> promoter significantly augmented reporter activity in SH-SY5Y cells. Moreover, introduction of a mutation into the HRE of the <em>SLC7A11</em> promoter abolished the induction of SLC7A11 by HIF1α overexpression, resulted in a reduction in promoter activity compared with wild-type cells.</div></div><div><h3>Conclusions</h3><div>The collective findings of this study indicate that HIF1α can inhibit ferroptosis by positively regulating <em>SLC7A11</em>. This investigation has shed light on the crucial involvement of the HIF1α/SLC7A11 signaling axis in ferroptosis in PD models, thereby presenting patients with PD a promising therapeutic target.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100171"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The responsibility and mission of Neurorestoratology‒New year’s greetings for 2025","authors":"Hongyun Huang,&nbsp;Paul R. Sanberg,&nbsp;Hari Shanker Sharma,&nbsp;Sang Ryong Jeon","doi":"10.1016/j.jnrt.2024.100174","DOIUrl":"10.1016/j.jnrt.2024.100174","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100174"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primed low frequency repetitive transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial","authors":"Aliya Mufti ,&nbsp;Suman Jain ,&nbsp;Kanwal Preet Kochhar ,&nbsp;Sheffali Gulati ,&nbsp;Sanjay Wadhwa ,&nbsp;Kapil Sikka ,&nbsp;Rohit Saxena ,&nbsp;Md Iqbal Alam","doi":"10.1016/j.jnrt.2024.100169","DOIUrl":"10.1016/j.jnrt.2024.100169","url":null,"abstract":"<div><h3>Background</h3><div>Multiple prenatal and postnatal etiologies in cerebral palsy (CP) patients cause neural tissue damage and alterations in cortical neuronal activity and plasticity, leading to motor and cognitive deficits early in life. Repetitive transcranial magnetic stimulation (rTMS) to the lesioned or contralesional hemisphere has been shown to alleviate these functional deficits. However, the underlying mechanisms of the beneficial effects of rTMS via realigning intracortical and interhemispheric circuitry and excitability remain unclear. The present study explored the ability of primed low-frequency rTMS to modulate intracortical excitatory-inhibitory circuitry, interhemispheric and corticospinal integrity, and plasticity in infantile hemiplegic CP.</div></div><div><h3>Methods</h3><div>The current study was a randomized, placebo-controlled trial with infantile hemiplegic CP patients. The active group received 6 Hz primed low-frequency 1Hz rTMS delivered to the contralesional primary motor cortex for 4 weeks, in 10 sessions. The placebo group received sham stimulation. Both groups also underwent 10 sessions of modified-constraint induced movement therapy (mCIMT). Pre- and post-intervention assessments were conducted using the Quality of Upper Extremity Skills Test to evaluate sensory and motor function, and the Modified Ashworth Scale (MAS) to assess spasticity. Additionally, cortical excitability and plasticity were measured using single- and paired-pulse TMS.</div></div><div><h3>Results</h3><div>We found a significant increase in Quality of Upper Extremity Skills Test scores, CP Quality of Life Child (CP QOL-Child) scores, and grip strength, and a decrease in MAS scores in the active rTMS group compared with the sham group. Single- and paired-pulse paradigms revealed a significant decrease in resting and active motor threshold, a reduction in the cortical silent period, and short- and long-interval intracortical inhibition in the intervention group compared with the sham group.</div></div><div><h3>Conclusion</h3><div>Primed low-frequency rTMS in the contralesional hemisphere combined with mCIMT shows potential for modulating motor neuronal excitability, rebalancing intracortical excitatory-inhibitory circuitry, and enhancing functional outcomes in children with infantile hemiparetic CP.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100169"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top cited articles of 2023 in Journal of Neurorestoratology","authors":"Yong Hu","doi":"10.1016/j.jnrt.2024.100172","DOIUrl":"10.1016/j.jnrt.2024.100172","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100172"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of single-event multilevel surgical interventions on long-term motor outcomes in children and adolescents with cerebral palsy: A systematic review and meta-analysis","authors":"Weihong Wang ,&nbsp;Qiang Tang ,&nbsp;Hua Liu ,&nbsp;Rong Xu ,&nbsp;Lijun Zhang","doi":"10.1016/j.jnrt.2024.100170","DOIUrl":"10.1016/j.jnrt.2024.100170","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this meta-analysis was to evaluate the impact of the timing of single-event multilevel surgery (SEMLS) on long-term motor outcomes in children and adolescents with cerebral palsy (CP).</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted by searching PubMed, Cochrane Library, Embase, and Web of Science databases for studies up to April 2024. Twelve eligible studies were included, from which we examined patients’ gait, stride length, walking speed, and the gross motor function measure (GMFM66).</div></div><div><h3>Results</h3><div>Gait analysis showed significant improvements in CP patients after SEMLS, which included an increased gait deviation index (<em>p</em> &lt; 0.001), reduced Gillette gait index (<em>p</em> &lt; 0.001), and reduced gait profile score (<em>p</em> &lt; 0.001). Subgroup analysis showed that age at surgery (&lt;12 years old vs. 12−18 years old) was not a factor affecting patients’ gait. Spatial and temporal parameters such as stride length (<em>p</em> &lt; 0.001) and walking velocity (<em>p</em> = 0.02) also improved significantly after surgery. However, there were only trends towards broader motor function gains measured by the GMFM66 (<em>p</em> = 0.39).</div></div><div><h3>Conclusions</h3><div>SEMLS effectively improved key gait and mobility parameters in children and adolescents with CP, and was not affected by younger or older surgical ages (&lt;12 years old or 12−18 years old). However, these gait improvements do not uniformly translate into broader motor function gains.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100170"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}