Journal of Neurorestoratology最新文献

{"title":"The efficacy of hyperbaric oxygen therapy in stroke patients: a real-world study","authors":"Linguo Zhang,&nbsp;Yue Hu,&nbsp;Xiao Han,&nbsp;Li Fan,&nbsp;Hong Zhang,&nbsp;Qiuzhen Zhang,&nbsp;Zhongfei Bai,&nbsp;Lingjing Jin,&nbsp;Danmei Lan","doi":"10.1016/j.jnrt.2026.100315","DOIUrl":"10.1016/j.jnrt.2026.100315","url":null,"abstract":"<div><h3>Background</h3><div>Hyperbaric oxygen therapy (HBOT) is widely used as an adjunctive intervention in stroke rehabilitation; however, its therapeutic benefit remains uncertain. This study investigated the clinical effectiveness of HBOT in improving recovery among patients with subacute-to-chronic stroke.</div></div><div><h3>Methods</h3><div>A total of 564 patients (14 days to 6 months after stroke onset) treated at Shanghai Yangzhi Rehabilitation Hospital between January 2017 and December 2024 were enrolled. Patients were assigned to either the HBOT group (<em>n</em> = 250), which received 15–40 HBOT sessions at 1.8 ATA in addition to routine rehabilitation, or the non-HBOT group (<em>n</em> = 314), which received routine rehabilitation alone. Propensity score matching (PSM) and inverse probability weighting (IPW) were used to balance baseline characteristics between groups. The primary outcome was the change in National Institutes of Health Stroke Scale (NIHSS) score from baseline (ΔNIHSS). Secondary outcomes included changes in Functional Test for the Hemiplegic Upper Extremity–Hong Kong (FTHUE-HK), Berg Balance Scale (BBS), and Modified Rankin Scale (mRS) scores, expressed as ΔFTHUE-HK, ΔBBS, and ΔmRS, respectively.</div></div><div><h3>Results</h3><div>After 1:1 PSM, 83 matched pairs were included. No significant between-group differences were observed in ΔNIHSS, ΔFTHUE-HK, ΔBBS, or ΔmRS. Sensitivity analyses confirmed these findings. IPW applied to the original cohort demonstrated a modest but statistically significant reduction in NIHSS score (<em>β</em> = −0.3428, <em>p</em> = 0.040); however, the observed improvement was well below the established 2-point minimal clinically important difference. Post hoc subgroup analyses suggested that patients who completed 15–24 HBOT sessions experienced greater neurological improvement (interaction <em>p</em> = 0.004). Disease duration was not associated with treatment response.</div></div><div><h3>Conclusions</h3><div>HBOT was not associated with clinically meaningful improvements in overall functional recovery among patients with subacute-to-chronic stroke. Although weighted analyses identified a small statistically significant reduction in NIHSS score, the effect was not clinically meaningful. Exploratory subgroup analyses suggested a possible dose-related benefit that warrants confirmation in prospective studies.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 4","pages":"Article 100315"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148658550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined high-frequency rTMS and rPMS for upper limb motor recovery in subacute stroke: A randomized sham-controlled trial","authors":"Tianyu Ma,&nbsp;Zhichao Liu,&nbsp;Yajuan Su,&nbsp;Shan Lu,&nbsp;Qiguang Li,&nbsp;Qing Xu,&nbsp;Rui Zhang,&nbsp;Bin Su,&nbsp;Hewei Wang,&nbsp;Limin Sun","doi":"10.1016/j.jnrt.2026.100314","DOIUrl":"10.1016/j.jnrt.2026.100314","url":null,"abstract":"<div><h3>Background</h3><div>Impaired upper limb motor function remains a significant and enduring clinical challenge in the post-stroke recovery phase. The combination of repetitive transcranial magnetic stimulation (rTMS) and repetitive peripheral magnetic stimulation (rPMS) may improve recovery via complementary central-peripheral modulation. However, its clinical efficacy remains to be fully elucidated. This study investigated the effects of sequential dual-modality stimulation (rPMS followed by high frequency (HF)-rTMS) on improving upper limb motor function and basic activities of daily living in individuals during the subacute phase of stroke.</div></div><div><h3>Methods</h3><div>In this three-arm, randomized, sham-controlled, evaluator-blinded trial, 60 patients with subacute stroke with upper limb motor deficits were randomly assigned to: Combined HF-rTMS and rPMS (Combined Group, <em>n</em> = 20), rTMS alone (Central Group, <em>n</em> = 20), or sham stimulation (Control Group, <em>n</em> = 20). All participants received 10 sessions of neuromodulation (5 days/week for 2 weeks) in addition to conventional rehabilitation. The primary endpoint was the Fugl–Meyer Assessment of Upper Extremity (FMA-UE) score, while the secondary endpoints were the Action Research Arm Test (ARAT) performance and Barthel Index (BI) score for functional independence. Analysis of covariance was used to account for baseline differences and to assess the efficacy of the intervention at the post-treatment time point.</div></div><div><h3>Results</h3><div>The Combined Group demonstrated superior motor recovery, achieving significantly higher adjusted mean FMA-UE scores than the Control Group (Bonferroni-adjusted <em>p = </em>0.028). The subscale analysis revealed that these gains were primarily driven by improvements in distal motor function (<em>F</em> = 5.236, <em>p</em> = 0.008), with the Combined Group significantly outperforming the Control Group (Bonferroni-adjusted <em>p = </em>0.007). Regarding secondary outcomes, the between-group analysis did not reveal any statistically significant differences in manual dexterity (measured by the ARAT; <em>p</em> = 0.207) or activities of daily living (assessed by the BI; <em>p</em> = 0.072; not significant after Bonferroni correction).</div></div><div><h3>Conclusions</h3><div>Combined HF-rTMS and rPMS represent a promising therapeutic approach to improve upper limb motor recovery during the subacute phase of stroke, with therapeutic benefits predominantly localized to the distal motor domain. These findings support the clinical value of integrating central and peripheral neuromodulation strategies to optimize functional independence following stroke.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 4","pages":"Article 100314"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148740534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative multi-phase transcriptomics for precision diagnostics and therapeutic target discovery in amyotrophic lateral sclerosis","authors":"Rabia Sultan,&nbsp;Ren-Jing Liu,&nbsp;Safa Rafique,&nbsp;Liu Li,&nbsp;Zuncheng Zheng,&nbsp;Hui Lv,&nbsp;Xiaoyu Wang,&nbsp;Jiao Wang","doi":"10.1016/j.jnrt.2026.100313","DOIUrl":"10.1016/j.jnrt.2026.100313","url":null,"abstract":"<div><h3>Background</h3><div>Amyotrophic lateral sclerosis (ALS) lacks routine molecular diagnostics, and diagnostic delays averaging twelve to fifteen months from symptom onset substantially erode the therapeutic window. Peripheral blood transcriptomics offers a minimally invasive route toward earlier diagnosis, yet discovery is heavily challenged by cross-platform inconsistency, small peripheral transcriptomic signals, and a lack of biologically grounded validation. Most published signatures are evaluated only against healthy controls, leaving their performance against clinically similar mimic conditions uncharacterized. This study aimed to develop a computational framework for peripheral blood biomarker discovery in ALS and validate the resulting signature across independent cohorts and disease mimics.</div></div><div><h3>Methods</h3><div>We developed a systems-integrated, leakage-free transcriptomic framework using GSE112676 (<em>n</em> = 702) as the sole discovery cohort. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed, followed by a triple-consensus machine learning pipeline combining Random Forest, LASSO regression, and SVM-RFE. A novel Biomarker Priority Score (BPS) integrating cross-cohort diagnostic stability with network centrality was developed for biomarker ranking. The trained model was validated across five independent arms spanning three external cohorts on two microarray platforms and one RNA-seq dataset.</div></div><div><h3>Results</h3><div>Differential expression analysis identified 976 ALS-associated genes, and WGCNA resolved nine co-expression modules with the brown module showing the strongest disease association (<em>r</em> = 0.368, <em>p</em> &lt; 0.0001). The pipeline yielded a six-gene diagnostic signature (<em>BRI3</em>, <em>ABCA1</em>, <em>QPCT</em>, <em>PPP2R5A</em>, <em>ETFRF1</em>, and <em>SLC37A3</em>) with a discovery area under the curve (AUC) of 0.868 (95% CI: 0.835–0.897) and an independent validation AUC of 0.746 (GSE112680, <em>n</em> = 301). The BPS ranked <em>ABCA1</em> as the lead candidate. Application of the trained model to ALS mimic patients showed that the signature detects a shared peripheral immune-metabolic response across motor neuron disease conditions rather than an ALS-specific signal (ALS vs mimic: AUC = 0.525; mimic vs control: AUC = 0.717). Furthermore, peripheral immune deconvolution identified two distinct ALS immune subtypes, and drug repurposing analysis nominated clonidine and fingolimod as candidate therapeutic agents.</div></div><div><h3>Conclusion</h3><div>This study identifies a reproducible peripheral blood transcriptomic signature for ALS and shows that its performance against mimic disorders is reduced, consistent with prior blood transcriptomic studies indicating that mimic discrimination is substantially more difficult than ALS-versus-control classification.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 4","pages":"Article 100313"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148658549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate localization in expedited accelerated transcranial magnetic stimulation for disorders of consciousness","authors":"Yunfei Sang","doi":"10.1016/j.jnrt.2026.100316","DOIUrl":"10.1016/j.jnrt.2026.100316","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 4","pages":"Article 100316"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148644635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the locus coeruleus–glymphatic axis in Alzheimer’s disease: From neuromelanin MRI to DTI-ALPS","authors":"Jiayu Liu ,&nbsp;Yuxin Wang ,&nbsp;Gang Cheng,&nbsp;Hulin Zhao,&nbsp;Rui Hui,&nbsp;Mei Li,&nbsp;Yuanyuan Dang,&nbsp;Meijing Liu,&nbsp;Baorui Guo,&nbsp;Shichao Su,&nbsp;Wenxuan Li,&nbsp;Wenying Lv,&nbsp;Jianning Zhang","doi":"10.1016/j.jnrt.2026.100301","DOIUrl":"10.1016/j.jnrt.2026.100301","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is increasingly recognized as a disorder not only of cortical amyloid-β and tau deposition, but also of upstream neuromodulatory and clearance systems that shape when and where pathology emerges. Among these, the locus coeruleus (LC) noradrenergic nucleus and the brain’s perivascular “glymphatic” network have attracted particular attention. In this review, we synthesize converging evidence that positions the LC–glymphatic interplay as a mechanistically relevant “axis” in AD, and evaluate two magnetic resonance imaging (MRI)-based proxies of this axis: neuromelanin-sensitive LC imaging and diffusion tensor image analysis along the perivascular space (DTI-ALPS). We first summarize neuropathological and experimental data demonstrating that the LC is an early and vulnerable tau node whose degeneration perturbs synaptic plasticity, neuroinflammation, sleep–wake regulation and vascular dynamics. The evidence base spans post-mortem neuropathology, animal mechanistic studies, and predominantly cross-sectional human MRI/PET observational cohorts, with fewer longitudinal studies and very limited interventional imaging datasets. We then review acquisition protocols, reliability and clinical findings for LC neuromelanin MRI, highlighting robust associations with cognitive performance and downstream tau burden. In parallel, we describe the physiological basis and methodological implementation of DTI-ALPS as an indirect marker of perivascular CSF–interstitial fluid transport, and collate studies linking reduced ALPS indices to amyloid/tau biomarkers, small vessel disease and cognitive decline. Integrating these literatures, we propose an in-vivo “LC–glymphatic axis” framework in which LC degeneration and impaired perivascular transport co-evolve and jointly influence AD risk and progression. We discuss how this framework can inform biomarker development, risk stratification and trial enrichment, and outline neuromodulatory strategies—such as transcutaneous vagus nerve stimulation and closed-loop slow-wave sleep enhancement—that could be used to experimentally engage this axis with LC MRI and ALPS as mechanism-proximal endpoints. Finally, we critically appraise methodological limitations, conceptual uncertainties and key gaps in longitudinal, multimodal and interventional evidence. Overall, imaging the LC–glymphatic axis offers a promising route to move beyond purely cortical markers and to test whether targeting upstream neuromodulation and clearance can contribute to genuine disease modification in AD.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 3","pages":"Article 100301"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for clinical diagnosis and neurorestorative treatment of intracerebral hemorrhage (2024 Chinese version)","authors":"Lukui Chen ,&nbsp;Chuan Hong ,&nbsp;Xiaoling Guo ,&nbsp;Jing Liu ,&nbsp;Jinquan Cai ,&nbsp;Lin Chen ,&nbsp;Gengsheng Mao ,&nbsp;Mengzhou Xue ,&nbsp;Jiangbo Pu ,&nbsp;Dezhi Kang ,&nbsp;Dezhong Liu ,&nbsp;Jinbiao Luo ,&nbsp;Chao You ,&nbsp;Shujie Sun ,&nbsp;Zhouping Tang ,&nbsp;Hongtian Zhang ,&nbsp;Chao He ,&nbsp;Guojian Wu ,&nbsp;Hongyun Huang","doi":"10.1016/j.jnrt.2026.100295","DOIUrl":"10.1016/j.jnrt.2026.100295","url":null,"abstract":"<div><div>Intracerebral hemorrhage (ICH) is a leading cause of mortality and disability in the Chinese population. Neurorestorative treatments represent effective therapeutic strategies for patients with ICH. In recent years, significant advancements have been achieved in ICH neurorestoration. However, the absence of established standards and guidelines presents a major challenge in both clinical practice and fundamental research. To address this issue, the Chinese Association of Neurorestoratology (CANR; Preparatory), together with the China Committee of the International Association of Neurorestoratology (IANR-China Committee), convened a panel of experts to consolidate various neurorestorative approaches and develop comprehensive clinical guidelines for the diagnosis and management of ICH neurorestoration. These guidelines provide diagnostic criteria and staging for ICH, as well as therapeutic strategies for neurorestoration at different stages of the condition, aiming to improve patient survival rates and quality of life.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 3","pages":"Article 100295"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK/eIF2α signaling pathways” [J Neurorestoratol 11 (2023) 100081]","authors":"Fang Wang ,&nbsp;Chengyi Zhang ,&nbsp;Qiongchi Zhang ,&nbsp;Jiaxi Li ,&nbsp;Yuewen Xue ,&nbsp;Xijing He ,&nbsp;Fengtao Li","doi":"10.1016/j.jnrt.2026.100291","DOIUrl":"10.1016/j.jnrt.2026.100291","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 3","pages":"Article 100291"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Ischemic stroke treatment by vagus nerve stimulation: A comprehensive review of mechanisms, clinical efficacy, and future directions” [Journal of Neurorestoratology 13 (2025) 100209]","authors":"Penglang Fan ,&nbsp;Chao Wu ,&nbsp;Bin Liu","doi":"10.1016/j.jnrt.2026.100288","DOIUrl":"10.1016/j.jnrt.2026.100288","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 3","pages":"Article 100288"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the therapeutic efficacy of human umbilical cord mesenchymal stromal cells for cerebral palsy in children","authors":"Sai Wang ,&nbsp;Yachen Wang ,&nbsp;Jing Liu","doi":"10.1016/j.jnrt.2025.100266","DOIUrl":"10.1016/j.jnrt.2025.100266","url":null,"abstract":"<div><div>Cerebral palsy (CP) is a non-progressive disorder of the central nervous system resulting from brain damage in the developing fetus or infant. It is primarily characterized by motor and postural abnormalities that severely impair motor function, speech, cognition, and mental health. Current comprehensive treatment approaches—including rehabilitation, pharmacotherapy, and surgical interventions—offer only limited symptomatic relief and fail to address the underlying neurodevelopmental deficits. Therefore, there remains an urgent clinical need for innovative therapies capable of fundamentally repairing neural damage and restoring functional neural circuitry. In recent years, umbilical cord mesenchymal stromal cells (UC-MSCs) have emerged as a promising therapeutic strategy for CP due to their unique biological properties, including low immunogenicity and potent paracrine activity. Preclinical studies have demonstrated that UC-MSCs can promote structural and functional reconstruction of damaged neural networks through multiple synergistic mechanisms, such as immunomodulation to reshape the immune microenvironment, neurotrophic support and neuroregeneration, and proliferative potential for cellular replacement. Notably, a recent study in Poland (<em>n</em> = 152) provided large-sample validation of these effects. Following infusion of Human UC-MSCs (HUC-MSCs), the median increase in the Gross Motor Function Measure (GMFM) score was 1.9 points, with a significant negative correlation with age (Spearman's <em>R</em> = −0.38, <em>p</em> &lt; 0.05). The median improvement in the 6-Minute Walk Test((6-MWT) was 75 m, which correlated with GMFM improvement (Spearman's <em>R</em> = 0.47, <em>p</em> &lt; 0.05). The median reduction in Timed Up and Go test time was 2 s, and the magnitude of improvement was significantly correlated with baseline GMFM, 6-MWT gain, and age. The findings suggest that the functional benefits of HUC-MSCs are more pronounced in younger children and those with better baseline motor function. However, larger sample sizes and long-term follow-up studies are still required to validate the durability of these effects and establish long-term safety. This review systematically integrates the neurorestorative mechanisms of UC-MSCs, preclinical evidence, and the latest clinical data to provide a theoretical foundation and practical guidance for the future development of novel UC-MSC-based therapeutic strategies.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 2","pages":"Article 100266"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of a hybrid SSVEP–AO–MI paradigm for motor rehabilitation: Considerations for clinical translation","authors":"Parth Aphale,&nbsp;Himanshu Shekhar,&nbsp;Shashank Dokania","doi":"10.1016/j.jnrt.2026.100268","DOIUrl":"10.1016/j.jnrt.2026.100268","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"14 2","pages":"Article 100268"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}