重度抑郁症与颈椎病的关系:一项双样本双向孟德尔随机化研究

IF 3.1 4区 医学 Q2 CLINICAL NEUROLOGY
Dingyu Du , Guipeng Zhao , Yukai Huang , Longyi Chen, Jinping Liu
{"title":"重度抑郁症与颈椎病的关系:一项双样本双向孟德尔随机化研究","authors":"Dingyu Du ,&nbsp;Guipeng Zhao ,&nbsp;Yukai Huang ,&nbsp;Longyi Chen,&nbsp;Jinping Liu","doi":"10.1016/j.jnrt.2025.100203","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.</div></div><div><h3>Results</h3><div>In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR &gt; 1, <em>p</em> &lt; 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (<em>p</em> &gt; 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.</div></div><div><h3>Conclusion</h3><div>This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100203"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study\",\"authors\":\"Dingyu Du ,&nbsp;Guipeng Zhao ,&nbsp;Yukai Huang ,&nbsp;Longyi Chen,&nbsp;Jinping Liu\",\"doi\":\"10.1016/j.jnrt.2025.100203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.</div></div><div><h3>Results</h3><div>In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR &gt; 1, <em>p</em> &lt; 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (<em>p</em> &gt; 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.</div></div><div><h3>Conclusion</h3><div>This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.</div></div>\",\"PeriodicalId\":44709,\"journal\":{\"name\":\"Journal of Neurorestoratology\",\"volume\":\"13 3\",\"pages\":\"Article 100203\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurorestoratology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2324242625000257\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurorestoratology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2324242625000257","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在通过双向孟德尔随机化(MR)分析探讨颈椎病(CS)与重度抑郁症(MD)之间的因果关系。方法利用综合流行病学单位开放全基因组关联研究(GWAS)数据库的汇总数据,采用双向磁共振验证CS与MD之间的双向因果关系。采用MR Egger、加权中位数、逆方差加权(IVW)和简单模式方法,IVW结果优先考虑。进行敏感性分析,包括异质性试验、水平多效性试验和留一法,以确认MR结果的稳定性。结果在正向磁共振分析中,MD与CS之间存在因果关系(IVW: OR >;1、p <;0.05)。然而,反向MR分析显示CS和MD之间没有因果关系(p >;0.05)。敏感性分析未发现样本异质性,无水平多效效应,无显著偏倚,支持MR分析结果的可靠性。结论本研究提供的证据表明MD与CS有因果关系,而CS与MD没有因果关系。这些发现为这两种流行疾病的发病机制提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study

Background

This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.

Methods

Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.

Results

In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR > 1, p < 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (p > 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.

Conclusion

This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Neurorestoratology
Journal of Neurorestoratology CLINICAL NEUROLOGY-
CiteScore
2.10
自引率
18.20%
发文量
22
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信