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Melanoma Management最新文献

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Knowledge and behavior of Lebanese parents regarding melanoma prevention in public and private school children 黎巴嫩家长在公立和私立学校儿童黑色素瘤预防方面的知识和行为
IF 3.6
Melanoma Management Pub Date : 2021-12-01 DOI: 10.2217/mmt-2021-0002
Léa El Haddad, Tarek Souaid, Diana Kadi, Joya-Rita Hindy, K. Souaid, H. Kourie, R. Tomb
{"title":"Knowledge and behavior of Lebanese parents regarding melanoma prevention in public and private school children","authors":"Léa El Haddad, Tarek Souaid, Diana Kadi, Joya-Rita Hindy, K. Souaid, H. Kourie, R. Tomb","doi":"10.2217/mmt-2021-0002","DOIUrl":"https://doi.org/10.2217/mmt-2021-0002","url":null,"abstract":"Aim: Assess the knowledge and behavior of Lebanese parents when it comes to melanoma and its prevention in children. Methods: A survey, to be completed by parents, was sent through children from three schools. Results: During sun exposure only 23.5% of 1012 respondents were always covering enough areas of their children's skin and 74.1% did not always apply sunscreen to their children. Parents of private school children were three times more likely to apply sunscreen to their children when exposed to sun, four times more likely to reapply sunscreen every 2–3 h and 21 times more likely to use a higher sun protection factor. Conclusion: Sun protection in children is insufficient and sunburns are frequent, illustrating the need for melanoma awareness campaigns.","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42588887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary metastatic melanoma: current state of diagnostic imaging and treatments. 肺转移性黑色素瘤:诊断、影像学和治疗的现状。
IF 3.6
Melanoma Management Pub Date : 2021-07-09 eCollection Date: 2021-09-01 DOI: 10.2217/mmt-2021-0001
Kermit S Zhang, Tomer Pelleg, Sabrina Campbell, Catalina Rubio, Anthony Lukas Loschner, Susanti Ie
{"title":"Pulmonary metastatic melanoma: current state of diagnostic imaging and treatments.","authors":"Kermit S Zhang,&nbsp;Tomer Pelleg,&nbsp;Sabrina Campbell,&nbsp;Catalina Rubio,&nbsp;Anthony Lukas Loschner,&nbsp;Susanti Ie","doi":"10.2217/mmt-2021-0001","DOIUrl":"https://doi.org/10.2217/mmt-2021-0001","url":null,"abstract":"<p><p>Melanoma is the deadliest form of skin cancer with an estimated incidence of over 160,000 cases annually and about 41,000 melanoma-related deaths per year worldwide. Malignant melanoma (MM) primarily occurs in the skin but has been described in other organs. Although the respiratory system is generally afflicted by tumors such as lung cancer, it is also rarely affected by primary MM. The estimated incidence of pulmonary MM of the lung accounts for 0.01% of all primary lung tumors. The current understanding of pulmonary MM of the lung pathophysiology and its management are not well established. We aim to survey current clinical modalities with a focus on diagnostic imaging and therapeutic intervention to guide providers in the management of patients with a high index of suspicion.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/ad/mmt-08-58.PMC8656320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39596634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Evolving treatments and future therapeutic targets in desmoplastic melanoma. 结缔组织增生性黑色素瘤的新疗法和未来治疗靶点。
IF 3.6
Melanoma Management Pub Date : 2021-06-17 eCollection Date: 2021-09-01 DOI: 10.2217/mmt-2020-0013
Matthew J Hadfield, Alla Turshudzhyan, Jane M Grant-Kels
{"title":"Evolving treatments and future therapeutic targets in desmoplastic melanoma.","authors":"Matthew J Hadfield,&nbsp;Alla Turshudzhyan,&nbsp;Jane M Grant-Kels","doi":"10.2217/mmt-2020-0013","DOIUrl":"https://doi.org/10.2217/mmt-2020-0013","url":null,"abstract":"Desmoplastic melanoma (DM) is a rare and histopathologically distinct type of melanoma that is a subvariant of spindle cell melanoma [1]. It has a strong association with chronic sun exposure and usually occurs later in life. Incidence is reported to be less than four percent of cutaneous melanomas. Early diagnosis can be challenging because DM is predominantly dermal and often amelanotic [2]. The diagnosis can be difficult not only clinically but also histologically, as DM can be mistaken for a variety of benign and malignant nonmelanocytic spindle cell tumors. Histology of DM is divided into pure and mixed types, and this classification plays an important role in prediction of clinical outcomes [3]. Pure DM tends to have less potential for metastasis and as a result has a more favorable prognosis than mixed DM [4]. DM commonly demonstrates local invasion with poor circumscription due to its infiltrative nature which results in a high recurrence rate. It primarily affects patients with fair skin with age distribution of 60–80 years old and male-to-female ratio of two–one [5]. The overall survival for patients with DM is relatively favorable despite its depth at diagnosis with median survival at 5 and 10 years of 84.8 and 79.2 %, respectively [6]. Advanced age of the patient, higher stage of the tumor as well as increased Breslow depth were found to be independent positive factors associated with DM [7]. While established DM treatment options are surgical excision, sentinel lymph node biopsy, systemic chemotherapy and radiation therapy, a number of genetic mutations associated with DM have shown it to be responsive to targeted therapies. This review will focus on the future of DM therapy, which lies in better targeted therapy approaches and better penetration into the tumor core leading to more robust responses to therapeutic agents.","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/23/mmt-08-56.PMC8656346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39582102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of rurality on melanoma diagnosis in Utah. 乡村性对犹他州黑色素瘤诊断的影响。
IF 3.6
Melanoma Management Pub Date : 2021-03-04 DOI: 10.2217/mmt-2020-0023
Tawnya L Bowles, Carol Sweeney, John Snyder, Jesse Gygi, Brad Bott, Daniel Wray, Timothy J Yeatman, William T Sause
{"title":"Impact of rurality on melanoma diagnosis in Utah.","authors":"Tawnya L Bowles,&nbsp;Carol Sweeney,&nbsp;John Snyder,&nbsp;Jesse Gygi,&nbsp;Brad Bott,&nbsp;Daniel Wray,&nbsp;Timothy J Yeatman,&nbsp;William T Sause","doi":"10.2217/mmt-2020-0023","DOIUrl":"https://doi.org/10.2217/mmt-2020-0023","url":null,"abstract":"<p><strong>Aim: </strong>To analyze trends in Utah melanoma diagnosis and study the impact of rurality.</p><p><strong>Patients & methods: </strong>State-wide melanoma incidence was calculated using Surveillance, Epidemiology, and End Results data (2005-2013). A subset of 5199 patients treated in an integrated healthcare system was further stratified for urban or rural residence.</p><p><strong>Results: </strong>Early-stage tumors accounted for most of the increase in melanoma incidence over time. Age-adjusted melanoma incidence rate was higher in rural counties (46.7 vs 39.4). Anatomic site and stage did not differ between rural and urban patients. Rural patients were more commonly diagnosed by a local primary care provider.</p><p><strong>Conclusion: </strong>Rurality had an impact on melanoma diagnosis in the specialty and location of the diagnosing provider.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/59/mmt-08-56.PMC8162144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39060449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
BRAF-MEK inhibitors as steroid-sparing bridge prior to checkpoint blockade therapy in symptomatic intracranial melanoma. BRAF-MEK抑制剂在症状性颅内黑色素瘤检查点阻断治疗前作为类固醇保留桥。
IF 3.6
Melanoma Management Pub Date : 2021-02-15 DOI: 10.2217/mmt-2020-0022
Karam Khaddour, Tanner M Johanns, George Ansstas
{"title":"BRAF-MEK inhibitors as steroid-sparing bridge prior to checkpoint blockade therapy in symptomatic intracranial melanoma.","authors":"Karam Khaddour,&nbsp;Tanner M Johanns,&nbsp;George Ansstas","doi":"10.2217/mmt-2020-0022","DOIUrl":"https://doi.org/10.2217/mmt-2020-0022","url":null,"abstract":"<p><p>The introduction of immune checkpoint blockade (ICB) and BRAF-MEK inhibitors has substantially improved outcomes in patients with metastatic melanoma. However, several challenging factors may hinder the efficacy of ICB in patients with symptomatic intracranial metastatic melanoma who are immunosuppressed due to the use of steroids prior to the administration of ICB. This has resulted in the exclusion of patients treated with high dose steroid at baseline from the majority of ICB clinical trials. In addition, despite the high efficacy of BRAF-MEK inhibitors in <i>BRAF</i>-mutant intracranial metastatic melanoma, most tumors will eventually progress. This demonstrates a gap in addressing the best management in such patients. Here, we present a case demonstrating our approach in this patient population.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/2a/mmt-08-55.PMC8162174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39059996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Metastatic melanoma causing recurrent intussusception and perforation of small bowel: case reports and literature review. 转移性黑色素瘤引起复发性肠套叠和小肠穿孔:病例报告和文献复习。
IF 3.6
Melanoma Management Pub Date : 2021-01-18 DOI: 10.2217/mmt-2020-0015
Yusuf Yagmur, Mehmet Ali Açıkgöz
{"title":"Metastatic melanoma causing recurrent intussusception and perforation of small bowel: case reports and literature review.","authors":"Yusuf Yagmur,&nbsp;Mehmet Ali Açıkgöz","doi":"10.2217/mmt-2020-0015","DOIUrl":"https://doi.org/10.2217/mmt-2020-0015","url":null,"abstract":"<p><strong>Aim: </strong>To present cases of recurred jejuno-jejunal intussusception and jejunal perforation due to melanoma.</p><p><strong>Materials & methods: </strong>Case 1: A 43-year-old male under treatment for malignant melanoma was presented with abdominal pain and distention. Ten centimeter intussuscepted jejunum was resected. Second exploration was done due to failure to pass gas and stool. The reintussusception was detected and resection of reintussuscepted jejunum was performed. Case 2: A 63-year-old male was presented with abdominal pain. Abdomen computed tomography showed free air in the abdomen suggesting intestinal perforations. Perforated area at 80 cm in the jejunum sutured.</p><p><strong>Conclusion: </strong>We present the seemingly first report of reintussusception of resected segment in a very short time. Surgeons should be aware of both intussusception and perforation in metastatic melanoma.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/19/mmt-08-54.PMC7849997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25343686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Increase of sentinel lymph node melanoma staging in The Netherlands: still room and need for further improvement. 荷兰前哨淋巴结黑色素瘤分期增加:仍有进一步改善的空间和需要。
IF 3.6
Melanoma Management Pub Date : 2020-12-14 DOI: 10.2217/mmt-2020-0018
Harmanjit Singh, Anjelli Wignakumar, Georgina J Williams, Shima Jamshidi, Daniel P Butler, Simon H Wood, Navid Jallali, Jonathan A Dunne
{"title":"Increase of sentinel lymph node melanoma staging in The Netherlands: still room and need for further improvement.","authors":"Harmanjit Singh,&nbsp;Anjelli Wignakumar,&nbsp;Georgina J Williams,&nbsp;Shima Jamshidi,&nbsp;Daniel P Butler,&nbsp;Simon H Wood,&nbsp;Navid Jallali,&nbsp;Jonathan A Dunne","doi":"10.2217/mmt-2020-0018","DOIUrl":"https://doi.org/10.2217/mmt-2020-0018","url":null,"abstract":"Harmanjit Singh‡ ,1, Anjelli Wignakumar‡ ,1, Georgina J Williams2, Shima Jamshidi3, Daniel P Butler2, Simon H Wood2, Navid Jallali2 & Jonathan A Dunne*,2 1Imperial College School of Medicine, Kensington, London SW7 2DD, UK 2Department of Plastic Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Rd, Hammersmith, London W6 8RF, UK 3Department of Plastic Surgery, Royal Free London NHS Foundation Trust, Pond St, Hampstead, London NW3 2QG, UK *Author for correspondence: jonathan.dunne1@nhs.net ‡Joint first authors","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/29/mmt-08-52.PMC7849948.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25343684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Letter in reply: increase of sentinel lymph node melanoma staging in The Netherlands; still room and need for further improvement. 回信：荷兰前哨淋巴结黑色素瘤分期的增加；仍有进一步改进的空间和必要。
IF 1
Melanoma Management Pub Date : 2020-11-23 DOI: 10.2217/mmt-2020-0021
Eric A Deckers, Marieke Wj Louwman, Schelto Kruijff, Harald J Hoekstra
{"title":"Letter in reply: increase of sentinel lymph node melanoma staging in The Netherlands; still room and need for further improvement.","authors":"Eric A Deckers, Marieke Wj Louwman, Schelto Kruijff, Harald J Hoekstra","doi":"10.2217/mmt-2020-0021","DOIUrl":"10.2217/mmt-2020-0021","url":null,"abstract":"","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/58/mmt-08-53.PMC7849923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25343685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The challenge of primary gastric melanoma: a systematic review. 原发性胃黑色素瘤的挑战：系统综述。
IF 1
Melanoma Management Pub Date : 2020-11-23 DOI: 10.2217/mmt-2020-0009
Gregory S Mellotte, Diya Sabu, Mary O'Reilly, Ray McDermott, Anthony O'Connor, Barbara M Ryan
{"title":"The challenge of primary gastric melanoma: a systematic review.","authors":"Gregory S Mellotte, Diya Sabu, Mary O'Reilly, Ray McDermott, Anthony O'Connor, Barbara M Ryan","doi":"10.2217/mmt-2020-0009","DOIUrl":"10.2217/mmt-2020-0009","url":null,"abstract":"<p><strong>Aim: </strong>Primary gastric melanoma is a rare clinical presentation. The purpose of this review was to compare the 1-year survival in patients who underwent surgery with patients who did not receive treatment.</p><p><strong>Patients & methods: </strong>A systematic search of databases for case reports and case series of primary gastric melanoma was conducted.</p><p><strong>Results: </strong>The mean survival of patients was 22 months. One-year survival was 56.5% with surgery, rising to 66% with adjuvant therapy. Mean survival of the surgical group was 21.05 months (±20.2) versus 4.5 months (±3.61) in the nonsurgical group.</p><p><strong>Conclusion: </strong>Primary gastric melanoma has a poor prognosis but early surgical intervention can have a significant impact on patient outcome. We reviewed the biology and clinical diagnosis of gastrointestinal melanoma and the current management options available.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/2a/mmt-07-51.PMC7724652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38709863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma. 瘤内淋巴细胞/单核细胞比值及M0巨噬细胞富集对黑色素瘤肿瘤免疫微环境的预后价值。
IF 3.6
Melanoma Management Pub Date : 2020-11-02 DOI: 10.2217/mmt-2020-0019
Neil K Jairath, Mark W Farha, Ruple Jairath, Paul W Harms, Lam C Tsoi, Trilokraj Tejasvi
{"title":"Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma.","authors":"Neil K Jairath,&nbsp;Mark W Farha,&nbsp;Ruple Jairath,&nbsp;Paul W Harms,&nbsp;Lam C Tsoi,&nbsp;Trilokraj Tejasvi","doi":"10.2217/mmt-2020-0019","DOIUrl":"https://doi.org/10.2217/mmt-2020-0019","url":null,"abstract":"<p><p>Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin cutaneous melanoma (n = 328) was utilized. CIBERSORT was used to identify immune cell type composition, on which unsupervised hierarchical clustering was performed. Analysis of overall survival was performed using Kaplan-Meier estimates and multivariate Cox regression analyses. Membership in the lymphocyte:monocyte<sup>low</sup>, monocyte<sup>hi</sup> <sup>gh</sup> and M0<sup>high</sup> cluster was an independently poor prognostic factor for survival (HR: 3.03; 95% CI: 1.12-8.20; p = 0.029) and correlated with decreased predicted response to immune checkpoint blockade. In conclusion, an M0-macrophage-enriched, lymphocyte-to-monocyte-ratio-low phenotype in the primary melanoma tumor site independently characterizes an aggressive phenotype that may differentially respond to treatment.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2020-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38710349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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