Patterns in progression from early-stage melanoma to late-stage melanoma: implications for survivorship follow-up.

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI:10.1080/20450885.2024.2424708

David J Savage, Benjamin Switzer, Rujul Parikh, Jung Min Song, Carolyn Stanek, Joshua Arbesman, Lucy Boyce Kennedy, Pauline Funchain

引用次数: 0

Abstract

Aim: This study determined the characteristics of patients with early-stage melanoma (IA-IIA) who later had stage IV recurrence.Patients & methods: We retrospectively examined 880 melanoma patients and identified those who progressed to stage IV disease from an initial early-stage (n = 50).Results: We observed a median latent period of 4 years between early-stage diagnosis and metastatic disease. More patients (54%) developed metastatic disease 4 years or later from the initial diagnosis. 34% had regular dermatology appointments, and 30% had regular oncology follow-up. Lung and brain were the most common metastatic sites.Conclusion: Long term monitoring beyond 4 years and a low threshold for performing symptom-guided imaging, particularly if pulmonary or neurologic symptoms occur, may be prudent after early-stage melanoma diagnosis.

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从早期黑色素瘤发展到晚期黑色素瘤的模式：对幸存者随访的影响。

目的：本研究确定了早期黑色素瘤（IA-IIA）晚期IV期复发患者的特征。患者和方法：我们回顾性检查了880例黑色素瘤患者，并确定了从最初的早期发展到IV期疾病的患者（n = 50）。结果：我们观察到早期诊断和转移性疾病之间的中位潜伏期为4年。更多的患者（54%）在最初诊断后4年或更晚发生转移性疾病。34%的人有定期的皮肤科预约，30%的人有定期的肿瘤随访。肺和脑是最常见的转移部位。结论：4年以上的长期监测和较低的症状引导成像阈值，特别是如果出现肺部或神经系统症状，在早期黑色素瘤诊断后可能是谨慎的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.