Muhammad Anas Kudsi, Anas Alsheikh Hamdoun, Osama Haj Osman, Lina Ghabreau, Nour Hakim, Aladdin Etr
{"title":"A rare and challenging case of amelanotic subungual melanoma from Syria.","authors":"Muhammad Anas Kudsi, Anas Alsheikh Hamdoun, Osama Haj Osman, Lina Ghabreau, Nour Hakim, Aladdin Etr","doi":"10.1080/20450885.2024.2442874","DOIUrl":null,"url":null,"abstract":"<p><p>Subungual melanoma accounts for 1.9% of cutaneous melanomas. Amelanotic cases, comprising 15-25%, poses a significant diagnostic challenge because it can be misdiagnosed as other traumatic, inflammatory, or neoplastic conditions. This often leads to delayed diagnosis and subsequently, a poor prognosis. We present a case of an 83-year-old woman with a bleeding, painful and progressive lesion on the nail area of her right middle finger initially misdiagnosed as paronychia at a rural clinic four months ago. An incisional biopsy confirmed the diagnosis of amelanotic subungual melanoma. Amputation of the affected finger was performed successfully. Imaging studies showed no metastatic disease. This case underscores the importance of early recognition and management of subungual melanoma, particularly in remote rural areas, to optimize patient outcomes.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"11 1","pages":"2442874"},"PeriodicalIF":1.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703459/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Melanoma Management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20450885.2024.2442874","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
A rare and challenging case of amelanotic subungual melanoma from Syria.
Subungual melanoma accounts for 1.9% of cutaneous melanomas. Amelanotic cases, comprising 15-25%, poses a significant diagnostic challenge because it can be misdiagnosed as other traumatic, inflammatory, or neoplastic conditions. This often leads to delayed diagnosis and subsequently, a poor prognosis. We present a case of an 83-year-old woman with a bleeding, painful and progressive lesion on the nail area of her right middle finger initially misdiagnosed as paronychia at a rural clinic four months ago. An incisional biopsy confirmed the diagnosis of amelanotic subungual melanoma. Amputation of the affected finger was performed successfully. Imaging studies showed no metastatic disease. This case underscores the importance of early recognition and management of subungual melanoma, particularly in remote rural areas, to optimize patient outcomes.
期刊介绍：
Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.
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