Journal of Kidney Cancer and VHL最新文献_第7页

High-Resolution Ultrasonography of Renal Oncocytoma Presenting with Symptomatic Hematuria and Urinary Bladder Clot Retention-A Rare Occurrence. 以症状性血尿和膀胱血栓潴留为表现的肾嗜瘤瘤的高分辨率超声检查——罕见的病例。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-01-01 DOI: 10.15586/jkcvhl.v9i1.200

Reddy Ravikanth

引用次数: 2

Von Hippel-Lindau Syndrome: Medical Syndrome or Surgical Syndrome? A Surgical Perspective. 冯希佩尔-林道综合征:内科综合征还是外科综合征?外科视角。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-12-05 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i1.206

Danilo Coco, Silvana Leanza

{"title":"Von Hippel-Lindau Syndrome: Medical Syndrome or Surgical Syndrome? A Surgical Perspective.","authors":"Danilo Coco, Silvana Leanza","doi":"10.15586/jkcvhl.v9i1.206","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i1.206","url":null,"abstract":"Von Hippel-Lindau syndrome (VHL) is an autosomal dominant disease caused by a genetic aberration of the tumor suppressor gene VHL and characterized by multi-organ tumors. The most common neoplasm is retinal or cerebral hemangioblastoma, although spinal hemangioblastomas, Renal Clear Cell Carcinoma (RCCC), pheochromocytomas (Pheo), paragangliomas, Pancreatic Neuroendocrine Tumors (PNETs), cystadenomas of the epididymis, and tumors of the lymphatic sac can also be found. Neurological complications from retinal or CNS hemangioblastoma and metastases of RCCC are the most common causes of death. There is a strong association between pheochromocytoma and VHL syndrome, and pheochromocytoma is often a classic manifestation of the syndrome. RCCCs are often incidental and identified during other tests. Between 35 and 70% of patients with VHL have pancreatic cysts. These can manifest as simple cysts, serous cysto-adenomas, or PNETs with a risk of malignant degeneration or metastasis of no more than 8%. The objective of this retrospective study is to analyze abdominal manifestations of VHL from a surgical point of view.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"27-32"},"PeriodicalIF":1.6,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39770523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients 肾癌患者抑郁、焦虑和应激关系的研究

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-11-28 DOI: 10.15586/jkcvhl.v9i1.199

T. Demirtas, Zekeriya Temircan

{"title":"Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients","authors":"T. Demirtas, Zekeriya Temircan","doi":"10.15586/jkcvhl.v9i1.199","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i1.199","url":null,"abstract":"Cancer of the kidney is one of the 10 most common cancers found globally. Overall, it is the fourth most common cancer in men and the eighth most common cancer in women. Many kidney cancer patients experience psychologic problems and reactions. The present study examined relationship between anxiety, depression, and perceived stress symptoms in kidney cancer patients. Cross-sectional data were obtained from the patients diagnosed with kidney cancer. All participants completed sociodemographic form, Hospital Anxiety and Depression form, and Perceived Stress Scale. Statistical analysis was exercised using the Student’s t-test, Chi-squared test (χ2), Fischer’s exact test, ANOVA, Mann–Whitney U test, and Kruskal–Wallis one-way variance analysis. A total of 250 patients participated in the study. The mean age was 57.4 years (SD 6.4, range = 25–76 years). The majority of patients were males (73%) and married (218). Anxiety symptoms were determined in 91.2% patients, depression symptoms in 87.2% patients, and perceived stress symptoms in 93.6% patients. The mean scores of Hospital Depression and Anxiety Scale (HADS)-Anxiety, HADS-Depression, and HADS-Perceived Stress were significantly different between age (P < 0.05), gender (P < 0.05), and income groups (P < 0.001). Kidney cancer patients showed poorer psychologic health. The overall levels of anxiety, depression, and perceived stress symptoms were higher among the studied kidney cancer patients. Findings of the current study could improve both psychologic well-being of patients and health-related quality of life.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"19 - 26"},"PeriodicalIF":1.6,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43396361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Benign Renal Masses that Were Exposed after Nephron-Sparing Surgery: "Postsurgical Fatty Tumor." Is It Related to the Surgical Technique? 保留肾脏手术后暴露的良性肾肿块:“术后脂肪瘤”。与手术技术有关吗?

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-11-28 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i1.195

Mehmet Balasar, Mehmet Serkan Özkent, Arif Aydin, Hakan Hakkı Taskapu, Ahmet Atici, Gokhan Ecer, Mehmet Giray Sonmez

{"title":"The Benign Renal Masses that Were Exposed after Nephron-Sparing Surgery: \"Postsurgical Fatty Tumor.\" Is It Related to the Surgical Technique?","authors":"Mehmet Balasar, Mehmet Serkan Özkent, Arif Aydin, Hakan Hakkı Taskapu, Ahmet Atici, Gokhan Ecer, Mehmet Giray Sonmez","doi":"10.15586/jkcvhl.v9i1.195","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i1.195","url":null,"abstract":"After nephron-sparing surgery (NSS), postsurgical fatty tumor could be mistakenly reported as angiomyolipoma during radiologic imaging of some patients. In the present paper, we studied the postsurgical fatty tumor detected after NSS but not covered before in the literature. In addition, we also evaluated whether the postsurgical fatty tumor was related to the surgical technique employed. Patients admitted to the urology department of our university hospital from 2014 to 2019 and operated with open NSS were evaluated retrospectively. We detected those 156 patients were operated with NSS. Nine patients with angiomyolipoma as primary pathology and four patients with surgical border positivity were excluded from the study. The patients were divided into two groups based on the repair of tumor extraction region. In Group 1, fatty tissue was used for repair, and Group 2 is the primary repair group. In all, 143 patients (Group 1 = 79, and Group 2 = 64) were included in the study. No demographic and radiologic differences, such as number of patients, age, gender, positioning of tumor, mass localization, tumor diameter, and RENAL nephrometry scoring system, were detected between the two groups. Postsurgical fatty tumors were detected in 28 patients in Group 1 and in two patients in Group 2 (P < 0.001). In patients with negative surgical margins after partial nephrectomy, lesions that were radiologically detected mimicking as angiomyolipoma were defined as \"postsurgical fatty tumor.\" This mass containing adipose tissue only neither depicted vascularization and enhancement nor increase in size for at least 1 year. We assumed that these lesions must be followed as benign lesions not requiring additional treatment.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39710122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients. 肾癌患者抑郁、焦虑和应激关系的研究。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-11-28 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i5.199

Türev Demirtaş, Zekeriya Temircan

{"title":"Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients.","authors":"Türev Demirtaş, Zekeriya Temircan","doi":"10.15586/jkcvhl.v9i5.199","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i5.199","url":null,"abstract":"Cancer of the kidney is one of the 10 most common cancers found globally. Overall, it is the fourth most common cancer in men and the eighth most common cancer in women. Many kidney cancer patients experience psychologic problems and reactions. The present study examined relationship between anxiety, depression, and perceived stress symptoms in kidney cancer patients. Cross-sectional data were obtained from the patients diagnosed with kidney cancer. All participants completed sociodemographic form, Hospital Anxiety and Depression form, and Perceived Stress Scale. Statistical analysis was exercised using the Student's t-test, Chi-squared test (χ2), Fischer's exact test, ANOVA, Mann-Whitney U test, and Kruskal-Wallis one-way variance analysis. A total of 250 patients participated in the study. The mean age was 57.4 years (SD 6.4, range = 25-76 years). The majority of patients were males (73%) and married (218). Anxiety symptoms were determined in 91.2% patients, depression symptoms in 87.2% patients, and perceived stress symptoms in 93.6% patients. The mean scores of Hospital Depression and Anxiety Scale (HADS)-Anxiety, HADS-Depression, and HADS-Perceived Stress were significantly different between age (P < 0.05), gender (P < 0.05), and income groups (P < 0.001). Kidney cancer patients showed poorer psychologic health. The overall levels of anxiety, depression, and perceived stress symptoms were higher among the studied kidney cancer patients. Findings of the current study could improve both psychologic well-being of patients and health-related quality of life.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"19-26"},"PeriodicalIF":1.6,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma. 免疫治疗肾肉瘤样细胞癌患者的持续缓解。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-10-26 eCollection Date: 2021-01-01 DOI: 10.15586/jkcvhl.v8i4.168

Anusim Nwabundo, Gbadebo Damilola, Afolayan-Oloye Olabisi, Jaiyesimi Ishmael

引用次数: 0

Different Treatments of Symptomatic Angiomyolipomas of the Kidney: Two Case Reports. 症状性肾血管平滑肌脂肪瘤的不同治疗方法:附2例报告。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-10-19 eCollection Date: 2021-01-01 DOI: 10.15586/jkcvhl.v8i4.181

Giuseppina Pacella, Eliodoro Faiella, Carlo Altomare, Flavio Andresciani, Gennaro Castiello, Caterina Bernetti, Marina Sarli, Bruno Beomonte Zobel, Rosario Francesco Grasso

{"title":"Different Treatments of Symptomatic Angiomyolipomas of the Kidney: Two Case Reports.","authors":"Giuseppina Pacella, Eliodoro Faiella, Carlo Altomare, Flavio Andresciani, Gennaro Castiello, Caterina Bernetti, Marina Sarli, Bruno Beomonte Zobel, Rosario Francesco Grasso","doi":"10.15586/jkcvhl.v8i4.181","DOIUrl":"https://doi.org/10.15586/jkcvhl.v8i4.181","url":null,"abstract":"Development of more sensitive imaging techniques has caused an increase in the number of diagnosed small renal tumors. Approximately 2-3% of these lesions are proved to be angiomyolipomas (AML), a rare benign tumor of the kidney sometimes causing pain and hematuria. The most required approach is observation, but in the case of recurrent symptoms or larger tumors, which may cause bleeding, a more active treatment is required. We present two cases of symptomatic AML tumors of different sizes in the kidney: one treated with transarterial embolization (TAE), and the other with percutaneous cryoablation (CRA). The lesions were diagnosed on the basis of contrast-enhanced computed tomography (CT) scan and magnetic resonance imaging (MRI). Both treatments proved to be effective and safe for treating renal AMLs. A follow-up carried out, based on contrast-enhanced CT scan, confirmed complete treatment of AML and decreased lesion size. There are myriad minimally invasive approaches for the treatment of renal AMLs, and the preservation of renal function remains a priority. The most popular treatment option is the selective renal artery embolization. Owing to its limited invasiveness, CRA could be an attractive option for the preventive treatment of AML.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"8 4","pages":"32-37"},"PeriodicalIF":1.6,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39832693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genetic Polymorphisms of the TGFB1 Signal Peptide and Promoter Region: Role in Wilms Tumor Susceptibility? TGFB1信号肽和启动子区域的遗传多态性:在Wilms肿瘤易感性中的作用?

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-10-16 eCollection Date: 2021-01-01 DOI: 10.15586/jkcvhl.v8i4.182

Cintya Mayumi Ishibashi, Carlos Eduardo Coral de Oliveira, Roberta Losi Guembarovski, Bruna Karina Banin Hirata, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Marla Karine Amarante, Karen Brajão de Oliveira, Marina Okuyama Kishima, Carolina Batista Ariza, Maria Angelica Ehara Watanabe

{"title":"Genetic Polymorphisms of the TGFB1 Signal Peptide and Promoter Region: Role in Wilms Tumor Susceptibility?","authors":"Cintya Mayumi Ishibashi, Carlos Eduardo Coral de Oliveira, Roberta Losi Guembarovski, Bruna Karina Banin Hirata, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Marla Karine Amarante, Karen Brajão de Oliveira, Marina Okuyama Kishima, Carolina Batista Ariza, Maria Angelica Ehara Watanabe","doi":"10.15586/jkcvhl.v8i4.182","DOIUrl":"https://doi.org/10.15586/jkcvhl.v8i4.182","url":null,"abstract":"The aim of the present study was to investigate the rs1800468 (G-800A), rs1800469 (C-509T), rs1800470 (C29T), and rs1800471 (G74C) TGFB1 genetic polymorphisms and their haplotype structures in patients with Wilms Tumor (WT) and neoplasia-free controls. The genomic DNA was extracted from 35 WT patients and 160 neoplasia-free children, and the TGFB1 polymorphisms were genotyped by polymerase chain reaction, followed by restriction fragment length polymorphism. The haplotype structures were inferred, and permutation and logistic regression tests were performed to check for differences in haplotype distribution between the control and WT individuals. Positive associations were found in the recessive model for rs1800469 T allele (OR: 8.417; 95% CI: 3.177 to 22.297; P < 0.001) and for the rs1800470 C allele (OR: 3.000; 95% CI: 1.296 to 6.944; P = 0.01). Haplotype analysis revealed a significant negative association between GCTG and WT (OR: 0.236, 95% CI: 0.105 to 0.534; P = 0.0002); by contrast, the GTTG haplotype was associated with increased risk for WT (OR: 12.0; 95% CI: 4.202 to 34.270; P < 0.001). Furthermore, rs1800469 was negatively correlated with tumor size and a trend toward a positive correlation for capsular invasion was observed in the dominant model (Tau-b: -0.43, P = 0.02 and tau-b: 0.5, P = 0.06, respectively). This is the first study with rs1800468, rs1800469, rs1800470, and rs1800471 TGFB1 polymorphisms in WT, and our results suggest that the TGFB1 promoter and signal peptide region polymorphisms may be associated with WT susceptibility and clinical presentation.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"8 4","pages":"22-31"},"PeriodicalIF":1.6,"publicationDate":"2021-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39832692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Routine Bone Imaging for Metastatic Renal Cell Carcinoma: Is it Time? 转移性肾细胞癌的常规骨成像：是时候了吗？

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-10-14 eCollection Date: 2021-01-01 DOI: 10.15586/jkcvhl.v8i4.207

Mamta Parikh

引用次数: 0

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging? 肾细胞癌转移模式的演变:我们是否需要进行常规骨成像?

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2021-10-13 eCollection Date: 2021-01-01 DOI: 10.15586/jkcvhl.v8i4.202

Justin Lin, Yue Zhang, Wei Hou, Qian Qin, Matthew D Galsky, William K Oh, Che-Kai Tsao

{"title":"Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?","authors":"Justin Lin, Yue Zhang, Wei Hou, Qian Qin, Matthew D Galsky, William K Oh, Che-Kai Tsao","doi":"10.15586/jkcvhl.v8i4.202","DOIUrl":"https://doi.org/10.15586/jkcvhl.v8i4.202","url":null,"abstract":"Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs. A systematic literature review was performed to identify all publicly available prospective clinical trials in metastatic renal cell carcinoma (mRCC) from 1990 to 2018. A total of 16,899 mRCC patients from 127 qualified phase I-III clinical trials with metastatic site documentations were included for analysis for incidence of metastases to lung, liver, bone, and lymph nodes (LNs) over time. Studies were categorized into three treatment eras based on the timing of regulatory approval: Cytokine Era (1990-2004), vascular endothelial growth factor/tyrosine kinase inhibitor (TKI) Era (2005-2016), and immune checkpoint inhibitor/TKI Era (ICI-TKI, 2017-2018) and also classified as first-line only (FLO) or second-line and beyond (SLB). Overall, an increase in the incidence of bone and LNs metastases in FLO and SLB, and lung metastases in FLO, was seen over the three treatment eras. Generally, the burden of disease is higher in SLB when compared with FLO. Importantly, in the ICI-TKI era, the incidences of bone metastasis are 28% in FLO and 29% in SLB settings. The disease burden in patients with mRCC has increased steadily over the past three decades. Given the unexpectedly high rate of bone metastasis, routine dedicated bone imaging should be considered in all patients with mRCC.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"8 4","pages":"13-19"},"PeriodicalIF":1.6,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39832690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2