Journal of Kidney Cancer and VHL最新文献_第7页

Synchronized Laparoscopic Bilateral Adrenalectomy for Pheochromocytoma in Multiple Endocrine Neoplasia Syndrome: A Case Report. 同步腹腔镜双侧肾上腺切除术治疗多发性内分泌瘤综合征嗜铬细胞瘤1例。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-09-02 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i3.239

Ali Eslahi, Shahryar Zeighami, Faisal Ahmed, Seyed Hossein Hosseini, Bahareh Ebrahimi, Mohammad Hossein Anbardar

{"title":"Synchronized Laparoscopic Bilateral Adrenalectomy for Pheochromocytoma in Multiple Endocrine Neoplasia Syndrome: A Case Report.","authors":"Ali Eslahi, Shahryar Zeighami, Faisal Ahmed, Seyed Hossein Hosseini, Bahareh Ebrahimi, Mohammad Hossein Anbardar","doi":"10.15586/jkcvhl.v9i3.239","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i3.239","url":null,"abstract":"<p><p>Pheochromocytomas are tumors producing catecholamines that arise from chromaffin cells in the adrenal medulla. They are usually benign in multiple endocrine neoplasia type 2 (MEN2) syndrome, but they tend to present bilaterally in 50-80% of the patients. Few researchers have reported success with simultaneous laparoscopic bilateral adrenalectomy. Hence, we report a 48-year-old woman who presented with a panic attack, headache, and abdominal discomfort that had started 10 years ago. The computed tomography (CT) scan showed a large bilateral cystic lesion in both adrenal glands in favor of pheochromocytomas (30 × 22 mm and 18 × 15 mm on the right side and 40 × 33 mm and 35 × 28 mm on the left side). The patient underwent bilateral laparoscopic adrenalectomy without intraoperative or postoperative complications. The total blood loss was 50 cc, and the operative time was 4 h. The histopathology of the specimen revealed pheochromocytomas of adrenal masses. In conclusion, our case demonstrates that synchronized laparoscopic bilateral adrenalectomy can be a safe and feasible treatment option for pheochromocytomas in MEN2 patients.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 3","pages":"24-28"},"PeriodicalIF":1.6,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33467023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary Leiomyomatosis and Renal Cell Cancer 遗传性平滑肌瘤病与肾细胞癌症

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-05-26 DOI: 10.1007/978-3-642-16483-5_2682

Catarina Machado, Maria Sofia Quental, J. R. Brandão, M. Silva‐Ramos

引用次数: 0

Massive Malignant Epithelioid Angiomyolipoma of the Kidney 肾脏大量恶性上皮样血管平滑肌脂肪瘤

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-04-22 DOI: 10.15586/jkcvhl.v9i2.210

Isaac M. Tessone, Benjamin Lichtbroun, A. Srivastava, Alexandra L. Tabakin, Charles F Polotti, R. Groisberg, Evita T. Sadimin, E. Singer, M. Grandhi

引用次数: 2

Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry 新发肾细胞癌病例的发病率和分布:来自全国癌症登记的27年趋势

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-04-18 DOI: 10.15586/jkcvhl.v9i2.219

Ahmad Alzubaidi, Stephen P Sekoulopoulos, J. Pham, Vonn Walter, Jay G. Fuletra, J. Raman

{"title":"Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry","authors":"Ahmad Alzubaidi, Stephen P Sekoulopoulos, J. Pham, Vonn Walter, Jay G. Fuletra, J. Raman","doi":"10.15586/jkcvhl.v9i2.219","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i2.219","url":null,"abstract":"Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"7 - 12"},"PeriodicalIF":1.6,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43355062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

High Levels of PD-L1+ and Hyal2+ Myeloid-derived Suppressor Cells in Renal Cell Carcinoma 肾细胞癌中高水平的PD-L1+和Hyal2+髓源性抑制细胞

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-04-16 DOI: 10.15586/jkcvhl.v9i2.208

S. Kusmartsev, Elizabeth P. Kwenda, Paul R. Dominguez-Gutierrez, P. Crispen, P. O'Malley

{"title":"High Levels of PD-L1+ and Hyal2+ Myeloid-derived Suppressor Cells in Renal Cell Carcinoma","authors":"S. Kusmartsev, Elizabeth P. Kwenda, Paul R. Dominguez-Gutierrez, P. Crispen, P. O'Malley","doi":"10.15586/jkcvhl.v9i2.208","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i2.208","url":null,"abstract":"Renal cell carcinoma (RCC) patients frequently have increased number of immunosuppressive myeloid cells in circulation. High number of myeloid-derived suppressor cells (MDSCs) in the blood are associated with immune suppression as well as with cancer-related inflammation which drives the mobilization of myeloid cells to tumor tissue. Here, we show that peripheral blood from a previously untreated RCC patient has increased the number of monocytic CD33+CD11b+ MDSCs, which also co-expressed PD-L1 and membrane-bound enzyme hyaluronidase 2 (Hyal2). PD-L1 expression is associated with immune suppression, whereas expression of Hyal2 is associated with inflammation, because Hyal2+ myeloid cells can degrade the extracellular hyaluronan (HA), leading to the accumulation of pro-inflammatory HA fragments with low molecular weight. These findings implicate the potential involvement of monocytic MDSCs in both tumor-associated immune suppression and cancer-related inflammation. Analysis of organotypic tumor-tissue slice cultures prepared from cancer tissue of the same patient revealed the significant presence of PD-L1+ HLA-DR+ macrophage-like or dendritic cell-like antigen-presenting cells in tumor stroma. Interestingly, stroma-associated PD-L1+ cells frequently have intracellular hyaluronan. Collectively, data presented in this study suggest that the interplay between tumor-recruited myeloid cells and stromal HA may contribute to the inflammation and immune tolerance in kidney cancer.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"1 - 6"},"PeriodicalIF":1.6,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46108715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Primary Rhabdomyosarcoma of Kidney with Local Recurrence and Liver Metastasis in Adults: A Case Report 成人原发性肾横纹肌肉瘤伴局部复发及肝转移1例报告

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-04-14 DOI: 10.15586/jkcvhl.v9i1.218

H. Nasrollahi, Ali Eslahi, Ali Ariafar, F. Ahmed, A. Monabati

{"title":"Primary Rhabdomyosarcoma of Kidney with Local Recurrence and Liver Metastasis in Adults: A Case Report","authors":"H. Nasrollahi, Ali Eslahi, Ali Ariafar, F. Ahmed, A. Monabati","doi":"10.15586/jkcvhl.v9i1.218","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i1.218","url":null,"abstract":"Primary rhabdomyosarcoma (RMS) of the kidney in an adult is rare, with only a few cases published in the literature. It is a mesenchymal tumor associated with an aggressive and rapid clinical progression course. We present a case of primary renal RMS in a 58-year-old female who presented with intermittent abdominal pain in the past year. The computed tomography (CT) scan revealed a 20×25×8 cm heterogeneous solid mass in the middle pole extended to the lower pole of the right kidney. Therefore, the patient underwent a right radical nephroureterectomy. Histopathology examination and immunohistochemistry studies confirmed the diagnosis of RMS with pleomorphic components. Postoperatively, the patient was discharged without any complications and was referred to an oncologist for chemotherapy. However, a follow-up CT scan in 2 months showed widespread liver metastasis and local recurrence. The patient received Gemcitabine and Docetaxel, but her condition worsened, and she passed away 5 months later. Primary renal RMS is rare in adults. In addition, liver metastasis is uncommon and poorly understood. Hence, we describe the clinicopathologic characteristics, including clinical follow-up of our case, focusing on the disease progression, treatment, and outcome.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"55 - 58"},"PeriodicalIF":1.6,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67104234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Renal Leiomyosarcoma, a Rare Presentation 肾脏平滑肌肉瘤，一种罕见的表现

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-03-21 DOI: 10.15586/jkcvhl.v9i1.216

T. Djiwa, K. Sabi, P. Simgban, Mayi Bombonne, B. Sama, Mazamaesso Tchaou, T. Darré

引用次数: 1

Inflammatory Hibernoma of the Renal Hilum Mimicking a Renal Pelvis Tumor 类似肾盂肿瘤的肾门炎性冬眠瘤

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-03-16 DOI: 10.15586/jkcvhl.v9i1.225

Kelsey Larkin, Kevin J. Chua, S. Doppalapudi, Colton Smith, Evita T. Sadimin, V. Fitzhugh, E. Singer

引用次数: 0

Spectrum of Presentations and Management Strategies in Renal Angiomyolipoma. 肾血管肌脂肪瘤的表现范围和处理策略

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-01-28 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i1.221

Sinan Khaddam, Shuchi Gulati

引用次数: 0

New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature. 肾血管平滑肌脂肪瘤治疗的新趋势和新证据:文献综述。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2022-01-21 eCollection Date: 2022-01-01 DOI: 10.15586/jkcvhl.v9i1.177

Juan Camilo Álvarez Restrepo, David Andres Castañeda Millan, Carlos Andres Riveros Sabogal, Andres Felipe Puentes Bernal, Wilfredo Donoso Donoso

{"title":"New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature.","authors":"Juan Camilo Álvarez Restrepo, David Andres Castañeda Millan, Carlos Andres Riveros Sabogal, Andres Felipe Puentes Bernal, Wilfredo Donoso Donoso","doi":"10.15586/jkcvhl.v9i1.177","DOIUrl":"https://doi.org/10.15586/jkcvhl.v9i1.177","url":null,"abstract":"Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized tomography is the standard diagnostic method for renal AML, while definitive diagnosis is made by histopathology. The management of choice in most cases is active surveillance (AS), with a clinical and imaging follow-up protocol. In high-risk cases, therapeutic management should be considered, with alternatives such as selective arterial embolization (SAE), nephron-sparing surgery (NSS), and mTOR inhibitors in selected patients. Renal AML in women of childbearing age, those with growth >0.25 cm/year, intralesional aneurysms >5 mm, and clinically significant symptoms may qualify for active treatment. Despite the limitations derived from the available evidence, it is possible to consider SAE, NSS, and the use of mTOR inhibitors as management alternatives for selected patients.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"9 1","pages":"33-41"},"PeriodicalIF":1.6,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6