Audiology Research最新文献

{"title":"Variability of Vestibular Function in Pediatric Patients with Auditory Neuropathy Spectrum Disorder.","authors":"Guangwei Zhou, Kaitlyn Butler","doi":"10.3390/audiolres16030089","DOIUrl":"10.3390/audiolres16030089","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Auditory neuropathy spectrum disorder (ANSD) is a well-established hearing disorder in the pediatric population and is estimated to account for at least 10% of children with sensorineural hearing loss. Compared to auditory function, vestibular function in children with ANSD has not been well described in the past. The purpose of this study is to examine vestibular testing results in children with ANSD and to better characterize vestibular dysfunction in these children. <b>Methods:</b> A retrospective review of vestibular laboratory testing results was conducted in pediatric patients diagnosed with ANSD. Vestibular evaluation included vestibular evoked myogenic potential (VEMP), rotary chair test, video head impulse test (vHIT), and videonystagmography (VNG). <b>Results:</b> A total of 30 pediatric patients with ANSD were identified, including 18 boys and 12 girls, with a mean age of 4.5 years. Bilateral ANSD was found in 24 cases, while 6 cases were unilateral. Etiologies of ANSD included a history of hyperbilirubinemia in infancy, cochlear nerve dysplasia, genetic-related conditions, etc. Vestibular dysfunction was found in 12 cases, as indicated by at least one abnormal outcome in VEMP, vHIT, or rotary chair testing. Nineteen children were cochlear implant candidates and eventually underwent unilateral or bilateral implantation. <b>Conclusions:</b> Vestibular dysfunction is significant in pediatric patients with ANSD, and vestibular outcomes appear to be related to underlying etiologies. Formal vestibular evaluation is necessary to identify such vestibular losses, and these findings will be helpful to guide clinical management and rehabilitation strategies for these children.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Outcomes After Cochlear Implantation in Older Adults: A Narrative Review of Current Evidence, Mechanisms, and Long-Term Perspectives.","authors":"Luigi Falchetta, Alfonso Scarpa, Mario Carucci, Matteo Calvanese, Luisa Savignano, Antonella Bisogno, Carla De Santis, Arianna Montanino, Caterina Criscuoli, Francesco Antonio Salzano","doi":"10.3390/audiolres16030088","DOIUrl":"10.3390/audiolres16030088","url":null,"abstract":"<p><p><b>Background:</b> Hearing loss is highly prevalent among older adults and represents a growing public health burden. Increasing attention has been given to the associations between hearing loss, cognitive decline, and dementia risk. Cochlear implantation is an established intervention for adults with severe-to-profound sensorineural hearing loss who obtain limited benefit from conventional amplification, but its potential cognitive effects remain debated. <b>Objective:</b> This narrative review summarizes current evidence on cognitive outcomes after cochlear implantation in adults and older adults, with particular attention to cognitive domains, long-term trajectories, methodological limitations, and clinical implications. <b>Main findings:</b> Available evidence suggests that cochlear implantation may be associated with improvement or stabilization of selected cognitive domains, particularly attention, executive function, working memory, and memory. However, findings are heterogeneous across studies, cognitive tools, and follow-up durations. Prospective longitudinal studies using hearing-adapted or visually presented cognitive batteries support the possibility of postoperative cognitive benefit, but the magnitude and durability of this effect vary between individuals and domains. Long-term studies suggest that cognitive improvement may be strongest during the first postoperative years and may later stabilize or attenuate, whereas auditory and quality-of-life benefits appear more consistently sustained. <b>Conclusions:</b> Cochlear implantation should be regarded as an established hearing rehabilitation strategy with robust benefits for auditory performance and quality of life, and as a potentially cognition-supportive intervention in selected older adults with severe-to-profound hearing loss. Current evidence does not yet prove that cochlear implantation prevents dementia. Future studies should use standardized hearing-adapted cognitive protocols, longer follow-up, adequate comparison groups, and clinically meaningful cognitive endpoints.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Aural Rehabilitation Needs in a Kannada-Speaking Population: A Focus Group Study with Adults with Hearing Loss, Their Significant Others and Audiologists.","authors":"Gudambe Nellithaya Spoorthi, Usha Shastri, Kaushlendra Kumar, Mohan Kumar Kalaiah","doi":"10.3390/audiolres16030087","DOIUrl":"10.3390/audiolres16030087","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The present study aimed to verify the importance of different components of aural rehabilitation and evaluate their relevance and acceptability among the Kannada-speaking population in India. This evaluation is intended to inform the development of a tailored aural rehabilitation module for this population. <b>Methods</b>: A thorough literature review was conducted to gain insights into the components of aural rehabilitation in the Western context. The insights gathered from this review served as foundational information for a focus group discussion. The focus group discussion consisted of 15 participants, including audiologists, adults with hearing loss, and their significant others. The data were transcribed and analyzed using inductive thematic analysis. <b>Results</b>: The audiologists in our study confirmed that the components of aural rehabilitation presented in the literature are essential, including sensory management, informational counseling, perceptual training, and personal adjustment counseling. Perspectives of significant others are the highlight of this study as they are less explored in the context of aural rehabilitation in India. Other themes identified from the FGDs included the involvement of family, the impact of hearing loss, awareness of various management options, and challenges/barriers related to aural rehabilitation. Furthermore, most of the adults with hearing loss and their significant others primarily viewed hearing aids as the sole solution. <b>Conclusions</b>: This study highlights the importance of a comprehensive aural rehabilitation program for adults with hearing loss and their significant others in the Kannada speaking population. It emphasizes the importance of informational counseling, communication strategies, and psychosocial support. Involving significant others might foster understanding and support, aiding in the acceptance of hearing loss and its rehabilitation, ultimately improving everyday communication and addressing functional challenges.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Mimra et al. Functional Near-Infrared Spectroscopy (fNIRS) in Objective Audiometry: A Scoping Review and Clinical Perspectives. <i>Audiol. Res.</i> 2026, <i>16</i>, 3.","authors":"Tomáš Mimra, Martin Augustynek, Marek Penhaker, Lukáš Klein","doi":"10.3390/audiolres16030085","DOIUrl":"10.3390/audiolres16030085","url":null,"abstract":"<p><p>Additional Affiliation [...].</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Speech Perception Outcomes After Hearing Aid Fitting in Conductive and Sensorineural Hearing Loss: A Prospective Longitudinal Observational Study.","authors":"Akmaral Izbassarova, Assel Imangaliyeva, Vigen Bakhshinyan, Rimma Suatbayeva, Zilola Mavlyanova, Assel Izbassarova, Murat Auyelbayev, Kanat Kumar, Aizhan Aidaralieva","doi":"10.3390/audiolres16030086","DOIUrl":"10.3390/audiolres16030086","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background/Objectives:&lt;/b&gt; Hearing loss is a leading cause of disability worldwide, with speech perception representing a key functional outcome of auditory rehabilitation. While hearing aids improve audibility, outcomes vary substantially across clinical subgroups. This study aimed to compare speech perception outcomes after hearing aid fitting in adults with conductive and sensorineural hearing loss and to identify determinants of variability in rehabilitation outcomes. &lt;b&gt;Methods:&lt;/b&gt; This prospective longitudinal observational study included 250 adults with clinically confirmed bilateral conductive or sensorineural hearing loss who underwent standardized audiological assessment, bilateral hearing-aid fitting, immediate post-fitting evaluation, and 3-month follow-up in Kazakhstan between January 2023 and December 2024. Participants were classified as having conductive (&lt;i&gt;n&lt;/i&gt; = 100) or sensorineural hearing loss (&lt;i&gt;n&lt;/i&gt; = 150) based on audiometric criteria. Speech perception was assessed using a Kazakh-language open-set speech audiometry test. Multivariable linear regression models were used to estimate differences in 3-month aided speech perception after adjustment for the corresponding immediate post-fitting aided score and prespecified demographic, clinical, and audiometric covariates. Linear mixed-effects models were used separately to assess change in aided speech perception from immediate post-fitting to 3 months and to test whether this change differed by hearing-loss type. Propensity score matching was performed as a secondary sensitivity analysis. &lt;b&gt;Results:&lt;/b&gt; Patients with conductive hearing loss demonstrated consistently higher speech perception scores than those with sensorineural hearing loss across all conditions. At 3 months, adjusted analyses showed no significant difference between groups for aided speech perception in quiet at 60 dB SPL, whereas sensorineural hearing loss remained associated with lower aided speech perception in noise at 60 dB SPL with SNR +3 dB (β = -1.73; 95% CI: -3.10 to -0.36; &lt;i&gt;p&lt;/i&gt; = 0.014). In mixed-effects models assessing repeated aided scores from immediate post-fitting to 3 months, sensorineural hearing loss was associated with lower overall aided speech perception in both quiet and noise conditions. A modest improvement over time was observed only for speech perception in noise, and the group-by-time interaction was not statistically significant. Increasing age, higher tonal thresholds, advanced hearing loss stage, and living alone were independently associated with poorer outcomes. &lt;b&gt;Conclusions:&lt;/b&gt; Aided speech perception scores were high after hearing-aid fitting in both conductive and sensorineural hearing loss; however, patients with sensorineural hearing loss showed persistently poorer outcomes, particularly in noise. These findings highlight the importance of incorporating speech-in-noise assessment and addressing clinical and social determinants to support hearing rehab","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urdu-English Perceptual Confusions in Bilingual Children with Normal Hearing and Cochlear Implants: An Analysis of Place, Manner, and Voicing Features.","authors":"Amina Asif Siddiqui, Cila Umat, Farheen Naz Anis, Ayesha Butt, Kehkashan Kanwal","doi":"10.3390/audiolres16030084","DOIUrl":"10.3390/audiolres16030084","url":null,"abstract":"<p><p><b>Background and Aims:</b> Accuracy in speech perception in bilingual children is influenced by two phonological systems. This study compares phonological development in bilingual Urdu-English (UE) children with CIs with their hearing-age-matched peers with normal hearing (NH), by investigating whether bilingualism or any spectral limitations of CI impact perception of UE phonemes. <b>Method and Procedures:</b> Children (n = 57) aged 3; 0-6; 11 years (28 CI, 29 NH) were assessed for speech perception using a custom-designed UE Speech Perception Test (UE-SPT), in quiet and noise (+5 dB SNR). Responses were analysed using confusion matrices, across phonological parameters of place, manner, and voicing to determine error patterns. <b>Outcomes and Results:</b> Significant deficits in CI children were found across all features, with voicing discrimination showing the largest errors (effect sizes d > 6), exacerbated by noise, especially for Urdu aspirated stops. CIs mastered only 8.3% Urdu-aspirated consonants at 6; 11 years compared to 91.7% mastered by NH peers, indicating critical language-specific vulnerabilities. Backing and substitutions errors were particularly seen in CI's speech, whilst manner was preserved. <b>Conclusion and Implications:</b> UE bilingual phonological complexity compounded by inadequate speech processing abilities in CIs challenges them, underscoring urgent need for targeted speech therapy interventions focusing voicing contrasts and aspirated consonants, as well as environmental accommodations that reduce noise interference and enhance listening through CI, to optimise educational outcomes. This research contributes vital clinical guidance for supporting bilingual children with cochlear implants, addressing both environmental, technological and linguistic challenges.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory Perception and Psychosocial Well-Being in Long-Term Cochlear Implant Users.","authors":"Kadriye Guney, Ozlem Topcu, Patrizia Mancini, Hilal Dincer D'Alessandro","doi":"10.3390/audiolres16030083","DOIUrl":"10.3390/audiolres16030083","url":null,"abstract":"<p><p><b>Background/Objectives</b>: This study investigated auditory perception and psychosocial well-being in long-term cochlear implant (CI) users, with a particular focus on the effects of auditory (re)habilitation on learned helplessness and speech-in-noise perception, representing everyday listening performance. <b>Methods</b>: Thirty CI users and thirty peers with typical hearing (TH) participated in the study. Speech perception was assessed using the Hearing in Noise Test (HINT) and the Matrix Test in both quiet and noisy listening conditions. Psychosocial status was evaluated using the Learned Helplessness Scale (LHS), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI). Perceived hearing quality was evaluated using the Hearing Implant Sound Quality Index (HISQUI). <b>Results</b>: CI users showed significantly poorer speech perception performance than TH participants (<i>p</i> < 0.05), whereas between-group psychosocial outcomes, including LHS, BDI, and BAI scores, did not differ significantly (<i>p</i> > 0.05). Positive correlations were observed between Matrix and HINT scores in quiet and noisy conditions. Positive associations were also observed between CI hearing thresholds and HINT/Matrix results in noisy conditions. Within the prelingually deaf CI subgroup, age at implantation was correlated with CI thresholds, as well as with speech perception performance across both tests (<i>p</i> < 0.05). <b>Conclusions</b>: Although CI users showed significantly poorer speech perception performance, their levels of learned helplessness, depression, and anxiety were comparable to those of their TH peers. These results suggest auditory benefits following long-term CI rehabilitation, while psychosocial status appears to be within a typical range despite persistent listening difficulties in daily life.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Practices in Vestibular Migraine Management Among Canadian Otolaryngologists: A National Survey.","authors":"Raisa Chowdhury, Angelina Tohme, Daniel Lelli, Darren Tse","doi":"10.3390/audiolres16030082","DOIUrl":"10.3390/audiolres16030082","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vestibular migraine is a common but often underrecognized cause of dizziness in otolaryngology practice. Although awareness has increased, variation in clinician training and management may contribute to inconsistent care. This study evaluated current diagnostic and treatment practices of Canadian otolaryngologists for vestibular migraine, including familiarity with diagnostic criteria, therapeutic approaches, perceived barriers, and educational needs.</p><p><strong>Methods: </strong>A national cross-sectional electronic survey was distributed to practicing and emeritus members of the Canadian Society of Otolaryngology-Head and Neck Surgery from February to April 2025. The 14-item survey assessed demographics, clinical exposure to dizzy patients, residency training, diagnostic familiarity, treatment patterns, referral practices, barriers to care, and preferred educational resources. Responses were anonymized and analyzed using descriptive statistics.</p><p><strong>Results: </strong>Forty-four otolaryngologists completed the survey (response rate: 7.4%). Most respondents reported being very familiar (59.1%) or moderately familiar (38.6%) with vestibular migraine diagnostic criteria, and 97.7% reported currently diagnosing and/or treating these patients. However, only 15.9% had received extensive residency training specific to migraine or vestibular migraine. Common treatments included lifestyle and dietary modification (90.9%), nutraceutical supplements (59.1%), tricyclic antidepressants (54.5%), and analgesics (52.3%). Vestibular rehabilitation therapy (29.5%) and calcitonin gene-related peptide-targeted therapies (<10%) were used less frequently. Major barriers were clinical time constraints (65.9%), lack of training or knowledge (54.5%), and diagnostic complexity (47.7%). Clinical guidelines (70.5%) and continuing medical education courses (65.9%) were identified as the most valuable supports.</p><p><strong>Conclusions: </strong>Among surveyed Canadian otolaryngologists engaged in dizziness and vestibular migraine care, substantial heterogeneity existed in training and management practices. Standardized guidance, enhanced education, and interdisciplinary collaboration may improve consistency of care and patient outcomes.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Evoked Myogenic Potentials (cVEMP and oVEMP) in Pregnancy: A Clinical Study.","authors":"Isil Cakmak Karaer, Erdinc Sarıdogan","doi":"10.3390/audiolres16030080","DOIUrl":"10.3390/audiolres16030080","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Pregnancy involves significant hormonal, cardiovascular, and physiological shifts that may potentially affect the vestibular system. The utricle and saccule, the two primary otolith organs, are responsible for detecting linear acceleration and maintaining equilibrium. This study aims to objectively evaluate the functional status of these organs throughout the three trimesters of pregnancy using Vestibular Evoked Myogenic Potentials (VEMPs). <b>Methods</b>: A prospective cross-sectional study was conducted with 64 healthy primigravida women (mean age 29.4 ± 2.3 years). Cervical VEMP (cVEMP) and ocular VEMP (oVEMP) tests were performed at three distinct time points: the first (8-9 weeks), second (20-21 weeks), and third (33-34 weeks) trimesters. Latencies (p13 and n23 for cVEMP; n10 and p15 for oVEMP) and peak-to-peak amplitudes were recorded and statistically compared across trimesters. <b>Results</b>: No statistically significant differences were found in cVEMP p13 and n23 latencies or amplitudes across the three trimesters (<i>p</i> > 0.05). Similarly, oVEMP p15 latencies and amplitudes remained stable throughout the pregnancy (<i>p</i> = 0.43 and <i>p</i> = 0.95, respectively). While a slight numerical increase in certain latencies was observed in the third trimester, and the oVEMP n10 latency was found to be consistently prolonged compared to non-pregnant norms, these values remained stable between trimesters. The inter-aural asymmetry showed no significant deviations, indicating a balanced vestibular adaptation. <b>Conclusions</b>: The functional integrity of the saccule and utricle is preserved during a healthy pregnancy. Despite the dramatic increase in gestational hormones such as estrogen and progesterone, the otolith-dependent reflex pathways (vestibulocollic and vestibulo-ocular) remain resilient. These results provide a clinical baseline for evaluating vestibular symptoms in pregnant populations, suggesting that significant VEMP abnormalities should prompt investigation into underlying vestibular pathologies rather than being attributed to normal pregnancy changes.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presbycusis Across the Lifespan: Genetic, Molecular, and Multi-Omics Contributions.","authors":"Anna Morgan, Paolo Gasparini, Giorgia Girotto","doi":"10.3390/audiolres16030081","DOIUrl":"10.3390/audiolres16030081","url":null,"abstract":"<p><p>Presbycusis, or age-related hearing loss (ARHL), is a multifactorial disorder characterized by a gradual, bilateral sensorineural decline in hearing sensitivity, predominantly affecting high-frequency sounds. It is one of the most common chronic conditions in the aging population and represents a major public health concern due to its high prevalence and progressive nature. Presbycusis significantly impairs speech perception, especially in noisy environments, leading to communication difficulties, reduced social participation, increased risk of social isolation, and a decline in quality of life. Moreover, growing evidence highlights a strong association between ARHL and cognitive impairment, dementia, depression, and increased frailty in older adults. The etiology of presbycusis is complex and involves the interplay between genetic predisposition and cumulative environmental and lifestyle-related factors. Genetic susceptibility influences cochlear aging, neural degeneration, and vulnerability to external insults. Non-genetic contributors include chronic noise exposure, cardiovascular and metabolic disorders such as diabetes and dyslipidemia, ototoxic medications, smoking, and other lifestyle factors that may accelerate cochlear damage through oxidative stress and microvascular dysfunction. This narrative review aims to provide an updated overview of the genetic and environmental determinants involved in the development and progression of presbycusis. Furthermore, it discusses the clinical implications of these factors for early identification, audiological evaluation, prevention strategies, and personalized management approaches. A better understanding of the multifactorial nature of presbycusis may support the development of targeted interventions to preserve hearing function and improve overall health outcomes in the aging population.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"16 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}