External Validation and Extension of a Cochlear Implant Performance Prediction Model: Analysis of the Oldenburg Cohort.

IF 2.1 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY
Rieke Ollermann, Robert Böscke, John Neidhardt, Andreas Radeloff
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引用次数: 0

Abstract

Background/Objectives: Rehabilitation success with a cochlear implant (CI) varies considerably and identifying predictive factors for the reliable prediction of speech understanding with CI remains a challenge. Hoppe and colleagues have recently described a predictive model, which was specifically based on Cochlear™ recipients with a four-frequency pure tone average (4FPTA) ≤ 80 dB HL. The aim of this retrospective study is to test the applicability to an independent patient cohort with extended inclusion criteria. Methods: The Hoppe et al. model was applied to CI recipients with varying degrees of hearing loss. Model performance was analyzed for Cochlear™ recipients with 4FPTA ≤ 80 dB HL and for all recipients regardless of 4FPTA. Subgroup analyses were conducted by WRSmax and CI manufacturer. Results: The model yielded comparable results in our patient cohort when the original inclusion criteria were met (n = 24). Extending the model to patients with profound hearing loss (4FPTA > 80 dB HL; n = 238) resulted in a weaker but significant correlation (r = 0.273; p < 0.0001) between predicted and measured word recognition score at 65 dB with CI (WRS65(CI)). Also, a higher percentage of data points deviated by more than 20 pp, either better or worse. When patients provided with CIs from different manufacturers were enrolled, the prediction error was also higher than in the original cohort. In Cochlear™ recipients with a maximum word recognition score (WRSmax) > 0% (n = 83), we found a moderate correlation between measured and predicted scores (r = 0.3274; p = 0.0025). Conclusions: In conclusion, as long as the same inclusion criteria are used, the Hoppe et al. (2021) prediction model results in similar prediction success in our cohort, and thus seems applicable independently of the cohort used. Nevertheless, it has limitations when applied to a broader and more diverse patient cohort. Our data suggest that the model would benefit from adaptations for broader clinical use, as the model lacks sufficient sensitivity in identifying poor performers.

人工耳蜗植入性能预测模型的外部验证和扩展:Oldenburg队列分析。
背景/目的:人工耳蜗(CI)的康复成功率差异很大,确定可靠预测人工耳蜗语音理解的预测因素仍然是一个挑战。Hoppe及其同事最近描述了一种预测模型,该模型特别基于四频纯音平均(4FPTA)≤80 dB HL的Cochlear™受者。本回顾性研究的目的是通过扩展纳入标准来检验其对独立患者队列的适用性。方法:Hoppe等人的模型应用于不同程度听力损失的CI受者。对4FPTA≤80 dB HL的Cochlear™受者和所有不考虑4FPTA的受者的模型性能进行分析。由WRSmax和CI制造商进行亚组分析。结果:当满足原始纳入标准时,该模型在我们的患者队列中产生了可比的结果(n = 24)。将模型扩展到重度听力损失患者(4FPTA > 80 dB HL;N = 238)导致相关性较弱但显著(r = 0.273;p < 0.0001),预测和测量的单词识别分数在65 dB时具有CI (WRS65(CI))。此外,数据点偏差超过20pp的百分比更高,要么更好,要么更差。当使用不同厂家CIs的患者入组时,预测误差也高于原始队列。在最大单词识别分数(WRSmax)为bb0 %的Cochlear™受者中(n = 83),我们发现测量分数和预测分数之间存在中度相关性(r = 0.3274;P = 0.0025)。结论:总之,只要使用相同的纳入标准,Hoppe等人(2021)的预测模型在我们的队列中取得了类似的预测成功,因此似乎适用于所使用的队列。然而,当应用于更广泛和更多样化的患者群体时,它有局限性。我们的数据表明,该模型将受益于更广泛的临床应用,因为该模型在识别不良表现方面缺乏足够的灵敏度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Audiology Research
Audiology Research AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-
CiteScore
2.30
自引率
23.50%
发文量
56
审稿时长
11 weeks
期刊介绍: The mission of Audiology Research is to publish contemporary, ethical, clinically relevant scientific researches related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear that can be used by clinicians, scientists and specialists to improve understanding and treatment of patients with audiological and neurotological disorders.
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