Galen Medical Journal最新文献_第9页

Response to: Medical Ethics According to Avicennaâ€™s Stance: A Synopsis 回应:医学伦理根据阿维森纳<e:2>的立场:简介

Galen Medical Journal Pub Date : 2023-06-10 DOI: 10.31661/gmj.v12i.2794

Hamed Arezaei, Majid Dadmehr

引用次数: 0

Management of Chemotherapy Side Effects in Childhood Leukemia: Persian Medicine Experience. 儿童白血病化疗副作用的处理：波斯医学经验。

IF 0.5

Galen Medical Journal Pub Date : 2023-06-10 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i0.2926

Babak Daneshfard, Amir Mohammad Jaladat, Majid Nimrouzi

引用次数: 0

Emerging Biomarkers of Acute Myocardial Infarction, An Overview of the Newest MicroRNAs. 急性心肌梗死的新兴生物标志物，最新 MicroRNAs 综述。

IF 0.5

Galen Medical Journal Pub Date : 2023-05-30 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i0.2909

Venus Shahabi Raberi, Elnaz Javanshir, Mohsen Abbasnezhad, Sina Mashayekhi, Amirreza Abbasnezhad, Masumeh Ahmadzadeh, Akram Shariati

引用次数: 0

Emerging Biomarkers of Acute Myocardial Infarction, An Overview of the Newest MicroRNAs 急性心肌梗死的新兴生物标志物，最新的microrna综述

Galen Medical Journal Pub Date : 2023-05-30 DOI: 10.31661/gmj.v12i.2909

Venous Shahabi Raberi, Elnaz Javanshir, Mohsen Abbasnezhad, Sina Mashayekhi, Amirreza Abbasnezhad, Masumeh Ahmadzadeh, Akram Shariati

引用次数: 0

How Might Consideration of Cell Polarity Affect Daily Therapeutic Practices?A Literature Review:. 对细胞极性的考虑可能如何影响日常治疗实践？文献综述：。

IF 0.7

Galen Medical Journal Pub Date : 2023-05-28 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i.2970

Hamid Reza Ravanbod

{"title":"How Might Consideration of Cell Polarity Affect Daily Therapeutic Practices?A Literature Review:.","authors":"Hamid Reza Ravanbod","doi":"10.31661/gmj.v12i.2970","DOIUrl":"10.31661/gmj.v12i.2970","url":null,"abstract":"Background: In addition to biochemical gradients and transcriptional networks, cell behaviour is controlled by endogenous bioelectrical signals resulting from the action of ion channels and pumps. Cells are regulated not only by their own membrane resting potential (Vmem) but also by the Vmem of neighbouring cells, establishing networks through electrical synapses known as gap junctions. V mem is the primary factor in producing a polarity that can regulate cell assimilation of various substances. This article aimed to examine how cell polarity can change and how variations in cell polarity may lead to clinical demonstrations.Materials and methods: Using Cochrane Central, PubMed, Scopus, Web of Science (WOS), and Embase, a comprehensive qualitative literature review was conducted from February 1, 2018, to February 1, 2023, to identify studies addressing bioelectric, cell polarity, and electroceuticals in patients with foot and ankle problems.Results: Out of 1,281 publications, 27 were included. One study investigated bioelectric wound-healing. Twenty-five studies examined bioelectric nerve cell growth, whereas one study evaluated bioelectricity-induced cellular differentiation in the treatment of arteriopathies.Conclusion: The author of this systematic review support addressing the predisposing factors and healing impediments for a disease, thereby enhancing the healing process and reducing the likelihood of recurrence or parallel conditions. This method of treatment has provided a summary of evidence indicating that cell polarity could be addressed for the treatment and prevention of most if not all, foot and ankle problems. However, owing to the limitations of V mem and bioelectricity measurement and the direct or indirect involvement of genetics and chemical gradients, further studies are required to confirm these results.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"12 ","pages":"e2970"},"PeriodicalIF":0.7,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556545/pdf/GMJ-12-e2970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma:. 食管癌中自噬与微小RNA的相互作用。

IF 0.5

Galen Medical Journal Pub Date : 2023-05-23 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i.2903

Neda Gorjizadeh, Sahar Poudineh, Behnaz Barghgir, Mohammadreza Eghbali, Alireza Sarlak, Maryam Poudineh

引用次数: 0

The Immunomodulation Role of Vaginal Microenvironment On Human Papillomavirus Infection 阴道微环境对人乳头瘤病毒感染的免疫调节作用

IF 0.7

Galen Medical Journal Pub Date : 2023-05-20 DOI: 10.31661/gmj.v12i.2991

Lin Sun, Li Li, Wenxin Xu, Cen-Xin Ma

{"title":"The Immunomodulation Role of Vaginal Microenvironment On Human Papillomavirus Infection","authors":"Lin Sun, Li Li, Wenxin Xu, Cen-Xin Ma","doi":"10.31661/gmj.v12i.2991","DOIUrl":"https://doi.org/10.31661/gmj.v12i.2991","url":null,"abstract":"Background: Evidence suggests the role of the vaginal microbiome and microenvironment in the immunity state. The human papillomavirus (HPV) infection is widely dependent on the healthy vaginal microenvironment. Hence, this study aimed to investigate the role of the vaginal microenvironment in the rate of high-risk HPV (hr-HPV) infection. Materials and Methods: This cross-sectional study was performed on 512 women with hr-HPV positive (n=212) or negative (n=300) infection. The vaginal samples of women were examined regarding yeas and Gardnerella vaginalis infection. Also, Lactobacillus acidophilus, pH, and enzyme activity (such as catalase, proline aminopeptidase, and leucocyte esterase) were compared between the two groups. Also, the histopathological study was performed on the vaginal samples. Results: The higher rate of yeast and G. vaginalis infections as well as decreased L. acidophilus, were significantly observed in women with hr-HPV positive infection (P<0.001). Also, histopathological findings indicated that cervical intraepithelial neoplasia grade I-III and cervical cancer lesions were markedly higher in hr-HPV positive group compared with control women. Conclusion: The hr-HPV infection was markedly correlated to vaginal microenvironments, and it could a risk factor for the elevation of the rate of high-grade cervical lesions.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"33 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90368925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Immunomodulation Role of Vaginal Microenvironment On Human Papillomavirus Infection. 阴道微环境对人类乳头瘤病毒感染的免疫调节作用

IF 0.5

Galen Medical Journal Pub Date : 2023-05-20 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i0.2991

Lingyan Sun, Li Li, Wenxin Xu, Cen Ma

{"title":"The Immunomodulation Role of Vaginal Microenvironment On Human Papillomavirus Infection.","authors":"Lingyan Sun, Li Li, Wenxin Xu, Cen Ma","doi":"10.31661/gmj.v12i0.2991","DOIUrl":"10.31661/gmj.v12i0.2991","url":null,"abstract":"Background: Evidence suggests the role of the vaginal microbiome and microenvironment in the immunity state. The human papillomavirus (HPV) infection is widely dependent on the healthy vaginal microenvironment. Hence, this study aimed to investigate the role of the vaginal microenvironment in the rate of high-risk HPV (hr-HPV) infection.Materials and methods: This cross-sectional study was performed on 512 women with hr-HPV positive (n=212) or negative (n=300) infection. The vaginal samples of women were examined regarding yeas and Gardnerella vaginalis infection. Also, Lactobacillus acidophilus, pH, and enzyme activity (such as catalase, proline aminopeptidase, and leucocyte esterase) were compared between the two groups. Also, the histopathological study was performed on the vaginal samples.Results: The higher rate of yeast and G. vaginalis infections as well as decreased L. acidophilus, were significantly observed in women with hr-HPV positive infection (P0.001). Also, histopathological findings indicated that cervical intraepithelial neoplasia grade I-III and cervical cancer lesions were markedly higher in hr-HPV positive group compared with control women.Conclusion: The hr-HPV infection was markedly correlated to vaginal microenvironments, and it could a risk factor for the elevation of the rate of high-grade cervical lesions.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"12 ","pages":"1-7"},"PeriodicalIF":0.5,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonoelastography and Lumbopelvic Muscle Stiffness in Patients with Low Back Pain: A Systematic Review:. 下背痛患者的声弹性成像和腰叶肌僵硬：一项系统综述：。

IF 0.5

Galen Medical Journal Pub Date : 2023-05-14 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i.2465

Hossein Rafsanjani Deh Qazi, Mohammad Ali Mohseni-Bandpei, Nahid Rahmani

{"title":"Sonoelastography and Lumbopelvic Muscle Stiffness in Patients with Low Back Pain: A Systematic Review:.","authors":"Hossein Rafsanjani Deh Qazi, Mohammad Ali Mohseni-Bandpei, Nahid Rahmani","doi":"10.31661/gmj.v12i.2465","DOIUrl":"10.31661/gmj.v12i.2465","url":null,"abstract":"This study aimed to systematically review studies conducted on the application of sonoelastography (SE) to evaluate lumbopelvic muscle stiffness in patients with low back pain (LBP). All relevant articles were retrieved from the available electronic databases, including PubMed, Web of Science, Scopus, EMBASE, Cochrane library, and CINAHL, using the keywords \"Sonoelastography\", \"Elasticity Imaging Technique\", \"Muscle Stiffness\", \"Modulus Elasticity\", \"Low Back Pain\". After initial searches, studies that met the inclusion criteria (i.e., published in English and sonoelastography were used to assess lumbopelvic muscle stiffness in both patients with LBP and healthy individuals) were enrolled. Also, any animal research, abstract of the seminar and/or conference, and/or non-English-language article were excluded. The quality of the studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. In total, eight relevant studies were selected for review. Three studies were considered to have excellent quality, and five were considered fair quality using the PEDro scale. All reviewed studies have reported that SE can be considered a non-invasive method for quantifying changes in lumbopelvic muscle stiffness. Muscle stiffness was significantly higher in LBP patients compared to healthy persons, as well as across subgroups of LBP patients in various test postures (P˂0.05). Only one study was conducted on the reliability of SE in healthy individuals, while another examined the validity of SE imaging. The results of the present systematic review indicated that SE imaging is a reliable and valid tool to identify muscle changes that occur in patients with LBP and evaluate the effects of rehabilitation treatment.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"12 ","pages":"e2465"},"PeriodicalIF":0.5,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518224/pdf/GMJ-12-e2465.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Regulatory Role of miR-21 on Alzheimer's Disease by Targeting GSK-3β Signaling. miR-21 通过靶向 GSK-3β 信号对阿尔茨海默病的潜在调节作用

IF 0.5

Galen Medical Journal Pub Date : 2023-05-13 eCollection Date: 2023-01-01 DOI: 10.31661/gmj.v12i0.3027

Haojun Ding

{"title":"Potential Regulatory Role of miR-21 on Alzheimer's Disease by Targeting GSK-3β Signaling.","authors":"Haojun Ding","doi":"10.31661/gmj.v12i0.3027","DOIUrl":"10.31661/gmj.v12i0.3027","url":null,"abstract":"Background: Alzheimer's disease (AD) is the most important neurogenerative disorder with progressive dementia as its main clinical manifestation. The microRNAs (miRNAs) are identified as crucial modulators in AD progression. Nevertheless, the biological potential of miR-21 in AD is obscure. Hence, this study aimed to evaluate the possible role of miR-21 in the pathogenesis of AD via phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta (GSK-3β) signaling.Materials and methods: The miR-21 expression in the brain tissues of patients with AD, as well as normal brain tissues and Aβ1-42-stimulated SH-SY5Y cell line (AD model) was examined by in situ hybridization and quantitative real-time polymerase chain reaction. Also, the apoptosis-linked protein levels as well as programmed cell death 4 (PDCD4) were detected by western blot.Results: Our findings revealed that miR-21 was low expressed in the brain tissues of patients with AD and AD model (P0.01). Also, the miR-21 overexpression could inhibit apoptosis of the AD model (P0.01). Indeed, the miR-21 negatively regulated PDCD4 expression, which led to activated PI3K/AKT/GSK-3β signaling.Conclusion: Our study demonstrated that miR-21 cloud inhibits cell apoptosis in AD through the activation of PI3K/AKT/GSK-3β signaling pathway using inhibition of PDCD4 expression.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"12 ","pages":"1-8"},"PeriodicalIF":0.5,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0