食管癌中自噬与微小RNA的相互作用。

IF 0.5 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Galen Medical Journal Pub Date : 2023-05-23 eCollection Date: 2023-01-01 DOI:10.31661/gmj.v12i.2903

Neda Gorjizadeh, Sahar Poudineh, Behnaz Barghgir, Mohammadreza Eghbali, Alireza Sarlak, Maryam Poudineh

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引用次数: 0

摘要

癌症（EC）被认为是世界上最常见和最具侵袭性的恶性肿瘤之一，多种分子改变被认为是其发病、发展、进展和侵袭的原因。然而，确切的潜在机制尚未阐明。自噬是一种高度保守的降解和回收过程，在EC的进展或治疗中具有双重作用。由于微小RNA（miRNA）被描述为能够控制致癌途径和自噬流量的上游调节因子，本研究旨在综述自噬和miRNA之间的相互作用，以及这些机制在EC预防和治疗中的潜在前景。

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The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma:.

Esophageal cancer (EC) is considered one of the most prevalent and aggressive malignancies worldwide, with a variety of molecular alterations thought to contribute to its incidence, development, progression, and invasion. However, the exact underlying mechanism has not been elucidated. Autophagy is a highly conserved degradative and recycling process that can function with a dual role in either the progression or the treatment of EC. Since microRNAs (miRNAs) are described as upstream regulators capable of controlling both oncogenic pathways and autophagic flux, the present study has aimed to review the crosstalk between autophagy and miRNAs and the potential perspective of these mechanisms in EC prevention and treatment.

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Galen Medical Journal MEDICINE, RESEARCH & EXPERIMENTAL-

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期刊介绍： GMJ is open access, peer-reviewed journal in English and supported by Noncommunicable Diseases (NCD) Research Center of Fasa University of Medical Sciences that publishing by Salvia Medical Sciences Ltd. GMJ will consider all types of the following scientific papers for publication: - Editorial’s choice - Original Researches - Review articles - Case reports - Case series - Letter (to editors, to authors, etc) - Short communications - Medical Idea