Galen Medical Journal最新文献

{"title":"Determining the Factors Predicting the Success of Medical Management in Patients with Ectopic Pregnancy : Medical management in patients with ectopic pregnancy.","authors":"Ayda Roostaee, Zeinab Safarpour Lima, Sima Sharif Kazemi, Ghazaleh Dezyani, Seyed Taleb Pourseyedian","doi":"10.31661/gmj.vi.3761","DOIUrl":"https://doi.org/10.31661/gmj.vi.3761","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy is considered the most common cause of pregnancy-related deaths in the first trimester. Methotrexate is recognized as an effective drug for the treatment of ectopic pregnancy. The aim of this study was to determine the associated and predictive factors for success in medical treatment among patients with ectopic pregnancy (EP).</p><p><strong>Materials and methods: </strong>After collection of Demographic information, serum β-hCG levels and ultrasound findings were evaluated and compared between two groups: those with successful medical treatment and those without.</p><p><strong>Results: </strong>The mean β-hCG level have not significant difference between the two groups (P=0.806). The frequency of previous IUD use in the successful treatment group was 8%, while there were no cases in the failure group; however, this difference was not statistically significant (P=0.547). The frequency of prior EP, the observed frequency of hematoma and the frequency of tubal ring observation, which also showed no significant difference (respectively P=0.9, P=0.9 and P=0.111). Logistic regression analysis revealed that none of the investigated variables were significant predictors of treatment success. However, the presence of a tubal ring (OR: 6.500, 95% CI: 0.799-52.897, p = 0.080) and increased endometrial thickness (OR: 1.317, 95% CI: 0.971-1.786, p = 0.077) showed borderline significance. Commonly considered factors, such as gestational age, β-hCG levels, patient age, parity, and gravidity, did not significantly influence treatment success. The study highlights a high success rate for single-dose methotrexate therapy and the potential utility of tubal ring and endometrial thickness as clinical indicators, warranting further investigation.</p><p><strong>Conclusion: </strong>The results of this study indicate that single-dose methotrexate treatment for tubal ectopic pregnancy leads to a high success rate. Given the sample size of this study, none of the variables had a significant impact on treatment success or predictive power.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3761"},"PeriodicalIF":0.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of a Low-Glucose Diet on Amniotic Fluid Index in Pregnant Women with Idiopathic Polyhydramnios: A Clinical Trial : Low-Glucose Diet and Amniotic Fluid Index in Pregnant Women.","authors":"Zahra Fardiazar, Rana Modabber, Hosein Azizi, Fatemeh Pourteymour Fard Tabrizi, Fatemeh Abbasalizadeh, Shamsi Abbasalizadeh","doi":"10.31661/gmj.vi.3857","DOIUrl":"https://doi.org/10.31661/gmj.vi.3857","url":null,"abstract":"<p><strong>Background: </strong>Polyhydramnios, defined as excessive amniotic fluid accumulation, increases the risk of maternal and fetal complications. In idiopathic cases, management options are limited. This prospective interventional study aimed to evaluate the effect of a low-glucose diet on the amniotic fluid index (AFI) in normoglycemic pregnant women with idiopathic polyhydramnios.</p><p><strong>Materials and methods: </strong>A prospective interventional study was conducted involving 51 pregnant women between 24 to 35 weeks of gestation with idiopathic polyhydramnios at Al-Zahra Women's Tertiary Referral University Hospital from 2024 to 2025. A low glucose dietary pattern was implemented by a nutrition specialist. AFI was measured at baseline, and two- and four-week's post-intervention. To assess differences and changes in AFI across three visits paired T-tests and Repeated measures ANOVA were used.</p><p><strong>Results: </strong>The mean AFI levels at the initial visit, and at two and four weeks later, were 27.19, 22.41, and 19.5 cm, respectively. We noted a significant reduction in AFI at both the two- and four-week marks compared to the baseline (P= 0.001). The rate of decrease in AFI after two weeks (mean= 22.4, P= 0.001) was greater than that observed four weeks later (mean= 19.5; P= 0.004).</p><p><strong>Conclusion: </strong>The study demonstrated that reducing excessive oral sugar intake and modifying dietary habits resulted in a reduction of the amniotic fluid index (AFI) in pregnant women with idiopathic polyhydramnios.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3857"},"PeriodicalIF":0.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Antimicrobial Resistance and Risk Factors in Patients with Pyogenic Liver Abscess: A Four-Year Cross-Sectional Study : Resistance Trends in Pyogenic Liver Abscess.","authors":"Jie Liu, Fengmei Wang","doi":"10.31661/gmj.vi.3873","DOIUrl":"https://doi.org/10.31661/gmj.vi.3873","url":null,"abstract":"<p><strong>Background: </strong>Pyogenic liver abscess (PLA) is a serious liver infection, particularly common in patients with immune deficiencies or chronic liver diseases. Given the rising antimicrobial resistance in PLA-associated pathogens, this study aimed to investigate the temporal trends in antimicrobial resistance and associated risk factors in PLA patients over a four-year period.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted at Tianjin First Center Hospital, China, by reviewing the medical records of PLA patients from January 2019 to December 2023. Patients were categorized into two groups: Klebsiella pneumoniae (KPLA) and non-Klebsiella pneumoniae (NKPLA). Data on clinical characteristics, laboratory results, imaging findings, microbiological culture results, and antimicrobial susceptibility patterns were collected. Temporal changes in antimicrobial resistance and associated risk factors were analyzed.</p><p><strong>Results: </strong>A total of 328 patients were included, of whom 297 (90.5%) were infected with Klebsiella pneumoniae (KPLA) and 31 (9.5%) with non-Klebsiella pathogens (NKPLA). Over the four-year period, the number of PLA cases gradually increased, with K. pneumoniae remaining the predominant pathogen. Resistance to ceftriaxone (20% in 2019 and 20% in 2023) and ciprofloxacin (25% in 2019 and 23% in 2023) showed slight variations, while carbapenem resistance decreased (imipenem: 7% in 2019 and 4% in 2023, meropenem: 6% in 2019 and 4% in 2023). In comparing the KPLA and NKPLA groups, KPLA patients were more likely to have diabetes (61.6% vs. 38.7%, P=0.01) and cryptogenic origin (65.7% vs. 41.9%, P0.05). NKPLA cases had higher prevalence of hepatobiliary disease (32.3% vs. 18.2%, P=0.04) and malignancy (19.4% vs. 8.8%, P=0.03).</p><p><strong>Conclusion: </strong>This study highlights the increasing antimicrobial resistance in K. pneumoniae and E. coli associated with PLA, underscoring the need for updated local antibiograms and revised empirical therapy protocols. Furthermore, the clinical and microbiological differences between KPLA and NKPLA suggest that pathogen-specific and resistance-based stratification should replace traditional classifications.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3873"},"PeriodicalIF":0.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Timing of Endoscopy on Mortality in Non-variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort Study :.","authors":"Mahdi Foroughian, Ali Ravaghi, Seyed Reza Habibzadeh, Ladan Goshayeshi, Zahra Abbasi Shaye, Maryam Ziyaei, Morteza Talebi Doluee","doi":"10.31661/gmj.vi.3550","DOIUrl":"https://doi.org/10.31661/gmj.vi.3550","url":null,"abstract":"<p><strong>Background: </strong>Non-variceal upper gastrointestinal bleeding is a common problem worldwide, which is associated with a significant mortality rate. The purpose of this study was to investigate the relationship between the mortality rate of patients referred to the emergency room with non-variceal upper gastrointestinal bleeding and the time of therapeutic-diagnostic endoscopy.</p><p><strong>Materials and methods: </strong>This study was a retrospective cohort observational study at Imam Reza Hospital in Mashhad, which was conducted in patients presenting with obvious symptoms of non-variceal acute gastrointestinal bleeding between April 2017 and March 2018. Underlying variables, endoscopic history, hemoglobin level, Glasgow - Blatchford score, blood pressure and the endoscopic result were extracted from patients' records. The time of death was followed up by telephone within 30 days after hospitalization. Data were compared based on the time of endoscopy since arrival. Patients with gastrointestinal bleeding were initially evaluated in the emergency room, unstable patients were transferred to the emergency room for stabilization and initial measures, and other patients were transferred to the emergency room, and the unstable patients were excluded from the plan.</p><p><strong>Results: </strong>In this study, 189 patients (with an average age of 60.11 ± 17.59 years) were examined. 23 cases (12.16%) of death were recorded within 30 days. 26 people (13.75%) underwent emergency endoscopy within 0 to 6 hours of referral. Forty-four people (23.28%) underwent endoscopy within 6 to 12 hours and the rest (119 people, 62.96%) within 12 to 24 hours. There was no significant difference between deceased and recovered subjects in terms of various study variables, including Blatchford score, number of days hospitalized in the ward and intensive care unit, and the number of units of compressed red blood cells injected (P0.05). Diabetes was significantly more prevalent in patients undergoing endoscopy 12 h compared to the 12 h (3.36% vs. 32.86%; P=0.001). adjusting for diabetes, the timing of endoscopy (within 12 hours vs. after 12 hours) was not significantly associated with mortality, with both crude (OR 1.25, 95% CI 0.63-2.49, P=0.523) and adjusted (OR 1.30, 95% CI 0.65-2.60, P=0.456) odds ratios.</p><p><strong>Conclusion: </strong>Our study showed no association between endoscopy time and mortality in patients with upper gastrointestinal bleeding; however, this finding should be confirmed in future studies in more controlled populations as a clinical trial.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3550"},"PeriodicalIF":0.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Accuracy of Mechanism, Glasgow Coma Scale, Age, And Pressure (MGAP) in Polytraumatic Patients: A Cross-sectional Study :.","authors":"Marzieh Meraji, Hamed Tabesh, Mahboobe Tashakkori, Mahdi Foroughian, Elham Pishbin, Morteza Talebi Doluee","doi":"10.31661/gmj.vi.3552","DOIUrl":"https://doi.org/10.31661/gmj.vi.3552","url":null,"abstract":"<p><strong>Background: </strong>Trauma, an external assault's corporeal aftermath, manifests as wounds or injuries, breaching or not breaching the skin, wrought by environmental forces upon the human, and is considered One of the world's foremost public health challenges intertwines complex societal, environmental, and medical issues. In order to evaluate the severity of trauma, it seems necessary to have a quantitative scale that can be measured. Therefore, the aim of this study is to look into the predictive power of two scoring indices, The Injury Severity Score (ISS) and MGAP, in patients with multiple traumas.</p><p><strong>Materials and methods: </strong>This research is a cross-sectional type and was conducted on trauma patients, aged 18 and over, with at least two traumas, hospitalized for over 24 hours in Taleghani Hospital in Mashhad in the period of one year from October 2020 to October 2021. For ISS, the Abbreviated Injury Scale (AIS) scores for affected organs in six body areas were determined, and the three highest AIS scores were calculated. For the MGAP score, data on injury mechanism, age, Glasgow Coma Scale (GCS), and systolic blood pressure were extracted. A chi-square test was conducted to ascertain the correlations between categorical variables and the status of survival. Additionally, Positive Triage Accuracy was measured and compared for ISS and MGAP.</p><p><strong>Results: </strong>In this research, 699 cases were investigated. Among the patients, 567 (81%) were male and 132 (19%) were female. Also (92%) 641 patients were discharged alive and (8%) 58 patients died. Among the 114 patients admitted to the ICU, 45 (39%) died. Cases mislabeled as medium or low risk that experienced death happened in 7 cases (of 598 available records; 1.17%) based on the ISS risk stratification system with 98.18% Positive Triage Accuracy and 44 cases (of 698 available records; 6.30%), based on the MGAP risk stratification system with 32.75% positive triage accuracy.</p><p><strong>Conclusion: </strong>The findings show the robust predictive power of ISS, with a low mislabeling rate and high triage accuracy. Conversely, the MGAP system demonstrated a higher mislabeling rate, suggesting that its application may yield incorrect results in certain situations and settings. This shows the need for cautious consideration when applying the MGAP risk stratification system, as its performance may not be universally applicable across all scenarios.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3552"},"PeriodicalIF":0.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of A20 in Acute Leukemia: A20 in Acute Leukemia.","authors":"Hongxia Wu, Jun Bai, Qiong Fa, Ke Yang, YanHong Li","doi":"10.31661/gmj.vi.3869","DOIUrl":"https://doi.org/10.31661/gmj.vi.3869","url":null,"abstract":"<p><p>Acute leukemia (AL) is a malignant tumor originating from hematopoietic stem cells. Its outstanding feature is the abnormal proliferation and aggregation of clonal leukemia cells in bone marrow and other hematopoietic tissues. Although chemotherapy, targeted immunotherapy and hematopoietic stem cell transplantation have been widely used in clinic, there are still relapse and refractory cases in AL patients. Finding new therapeutic targets and screening prognostic molecules are of great significance for the treatment and prognosis of AL. A20 protein, also known as tumor necrosis factor α-induced protein 3 (TNFAIP3), is a key protein that negatively inhibits the activation of nuclear transcription factor kB (NF-κB) and plays an important role in anti-tumor immune and inflammatory response. In leukemia and lymphoma, A20 is often inactivated, mutated or deleted. Lack of A20 can significantly inhibit the surveillance function of immune cells and mediate tumor immune escape. Therefore, exploring the mechanism of A20 in AL may have important research value and clinical significance for the treatment of AL. The purpose of this paper is to review the research progress of A20 in acute leukemia, and provide new theoretical basis and reference value for the pathogenesis research and targeted therapy of leukemia.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3869"},"PeriodicalIF":0.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Magnesium Sulfate for Post-Cesarean Pain Control: A Double-blind Clinical Trial : Magnesium Sulfate for Post-cesarean Pain.","authors":"Satinik Darzi, Amirhosein Shahabi, Morteza Partovian, Sahereh Arabian, Fatemeh Paknazar, Fatemeh Khari","doi":"10.31661/gmj.vi.3741","DOIUrl":"https://doi.org/10.31661/gmj.vi.3741","url":null,"abstract":"<p><strong>Background: </strong>The use of magnesium sulfate as a part of analgesia has been used in recent years. The purpose of this research is to investigate the effectiveness of magnesium sulfate in controlling pain after elective repeat cesarean section under spinal anesthesia.</p><p><strong>Materials and methods: </strong>In this double-blind study, 78 women who were candidates for cesarean section were randomly selected and divided into two groups of control and intervention of 39 people. Before spinal anesthesia, in the intervention group was injected 50 mg/kg of magnesium sulfate intravenously, and in the control group was injected with the same volume of normal saline. Pain intensity was assessed using the Visual Analogue Scale at 6, 12, 18 and 24 hours after the surgery operation and was recorded in a checklist along with vital signs and possible complications. The results were statistically analyzed using version 25 SPSS statistical software.</p><p><strong>Results: </strong>There was no significant difference between the intervention and control groups in the presence of complications during recovery time and up to 24 hours after surgery (P0.05). The pain score during the first 6 hours after surgery was equal to 8.56±1.51 in the intervention group and 8.21±1.15 in the control group. At 24 hours after surgery, this amount decreased to 4.23±1.08 in the intervention group and 4.49±0.79 in the control group. Although there was a difference in pain scores between the intervention and control groups up to 24 hours after surgery, this difference was not statistically significant (P0.05).</p><p><strong>Conclusion: </strong>This study showed that the administration or non-administration of magnesium sulfate has no effect on increasing the time of postpartum analgesia and reducing the need for pethidine.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3741"},"PeriodicalIF":0.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring CYP17 Gene Polymorphism as a Predictive Marker in Iraqi Women with Polycystic Ovary Syndrome and Its Association with Hormonal Dysregulation : CYP17A1 Polymorphism in Iraqi women with PCOS.","authors":"Saleh Ali Alqadoori, Nour Saeed Hassan, Farah Ali Dawood","doi":"10.31661/gmj.vi.3746","DOIUrl":"https://doi.org/10.31661/gmj.vi.3746","url":null,"abstract":"<p><strong>Background: </strong>Although most women of reproductive age diagnosed with polycystic ovary syndrome (PCOS) represent a common disorder with significant long-term health implications. Investigations on the CYP17A1 gene, which plays a pivotal role in androgen biogenesis, explored its potential role as a predictive marker for the risk of PCOS. This research was conducted to evaluate the association of CYP17A1 polymorphism (rs743572 variant) with susceptibility to polycystic ovarian syndrome (PCOS) among the Iraqi population.</p><p><strong>Materials and methods: </strong>We executed a case-control study consisting of 66 PCOS patients and 74 controls. Restriction Fragment Length Polymorphism (RFLP) was used to detect the genotypes.</p><p><strong>Results: </strong>The TT genotype of CYP17A1 was significantly associated with an increased risk of PCOS, with an approximately fourfold higher odds of developing PCOS versus the CC genotype. No significant increase in risk was seen for the CT genotype. The TT polymorphism of CYP17A1 (rs743572) was significantly associated with PCOS (adjusted OR=3.97, P=0.03), while the CT variant showed a non-significant trend, after adjusting for age and BMI.</p><p><strong>Conclusion: </strong>The current study, by providing further evidence for the association between CYP17A1 genetic polymorphisms and PCOS in multi-ethnic populations, has important implications for the management of this complex disorder, indicating the potential use of genotyping in assessing the genetic risk of the disorder in different ethnic groups.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3746"},"PeriodicalIF":0.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Management and Epidemiology of Scorpion Stings in Khuzestan Province, Iran: A Five-year Study : Five-year Study of Scorpion Stings in Khuzestan Province.","authors":"Soheila Aminzadeh, Ali Sahnalizadeh, Mohammad Hossein Gharibreza, Elham Farhadi, Ali Hasan Rahmani, Maryam Salehcheh","doi":"10.31661/gmj.vi.3810","DOIUrl":"https://doi.org/10.31661/gmj.vi.3810","url":null,"abstract":"<p><strong>Background: </strong>Scorpion stings are a significant public health concern in many countries, particularly in Iran's Khuzestan province. This study investigates the clinical and laboratory correlations in patients hospitalized for scorpion stings at Razi Hospital, Ahvaz, Iran, from 2018 to 2022, aiming to enhance patient care and preventive strategies.</p><p><strong>Materials and methods: </strong>This descriptive, cross-sectional, retrospective study employed census sampling. Age, gender, sting season, sting site, delay to visiting hospital, hospitalization duration, antiscorpion treatment vials prescription, clinical symptom and laboratory findings were collected from medical records of patients hospitalized for scorpion stings during the study period, using a standardized checklist for clinical and laboratory parameters.</p><p><strong>Results: </strong>Our analysis of 799 scorpion sting cases revealed a male predominance (55.9%) and the highest incidence among individuals aged 21-40 years, with most stings occurring in summer. The extremities, particularly hands and feet, were the most common sting sites. Pain, erythema, and swelling were the leading symptoms, with most patients seeking medical care within three hours. Hospitalization was common, typically lasting at least one day. Disturbances in urinalysis (U/A) were the most frequent laboratory abnormality. Younger women in intensive care exhibited severe symptoms, including seizures, jaundice, and hematuria, which correlated with abnormalities in CBC, biochemical markers, PT, and U/A. These findings highlight the importance of timely clinical and laboratory assessments to improve outcomes.</p><p><strong>Conclusion: </strong>Scorpion stings continue to represent a public health challenge with a range of clinical manifestations and laboratory correlations. By enhancing awareness and preparedness, we can mitigate the impact of this health concern and improve patient outcomes for those affected by scorpion envenomations.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3810"},"PeriodicalIF":0.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application Effect of Poly-L-Lactic Acid Filler in Surgical Repair of Scar Contraction After Nasal Implant Surgery : Poly-L-Lactic Acid Filler in Surgical Repair of Scar Contraction.","authors":"Xiang Wang","doi":"10.31661/gmj.vi.3699","DOIUrl":"https://doi.org/10.31661/gmj.vi.3699","url":null,"abstract":"<p><strong>Background: </strong>Nose implant procedure is one of the most common aesthetic surgeries that can be performed, but patients frequently experience complications like scar contracture that's quite bothersome. Numerous treatment approaches have been attempted, most notably with the Poly-L-lactic Acid Filler (PLLA) which seems to offer some promise. In this paper, we will attempt to assess the use of PLLA filler in surgically correcting scar contractures associated with nose implant surgery, this study aims to explore the application effect of Poly-L-lactic Acid Filler in surgical repair of scar contraction after nasal implant surgery and provide some reference value for relevant research.</p><p><strong>Case presentation: </strong>nose implant procedure is one of the most common aesthetic surgeries that can be performed, but patients frequently experience complications like scar contracture that's quite bothersome. Numerous treatment approaches have been attempted, most notably with the Poly-L-lactic Acid Filler (PLLA) which seems to offer some promise. In this paper, we will attempt to assess the use of PLLA filler in surgically correcting scar contractures associated with nose implant surgery.</p><p><strong>Conclusion: </strong>It is highly suggested that PLLA Filler is a valid treatment option for scar contracture repair enhancement after nasal implant procedures. However, it's best practice to verify long-term results on larger sample sizes.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3699"},"PeriodicalIF":0.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}