Galen Medical Journal最新文献

{"title":"Impact of Ligamentous Adhesion to the Posterior Cruciate Ligament on Radiological, Arthroscopic, and Clinical Outcomes One Year After ACL Reconstruction: A Cohort Study :.","authors":"Ali Yeganeh, Shayan Amiri, Mehdi Moghtadaei, Pedram Doulabi, Javad KhajeMozafari, Ahmad Hemmatyar, Amir Mehrvar, Khatere Mokhtari, Mohammad Eslami Vaghar","doi":"10.31661/gmj.v14i.3589","DOIUrl":"https://doi.org/10.31661/gmj.v14i.3589","url":null,"abstract":"<p><strong>Background: </strong>The anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) play a crucial role in maintaining knee stability by controlling anterior and posterior tibial translation. After ACL reconstruction, residual ACL tissue may adhere to the PCL, potentially altering knee biomechanics and affecting postoperative recovery. The clinical significance of this adhesion remains uncertain. This study aimed to evaluate the relationship between ACL-PCL adhesion and radiological, arthroscopic, and clinical outcomes one year after ACL reconstruction.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included patients with ACL tears who underwent reconstructive surgery at hospitals in Tehran between 2022 and 2023. Patients were divided into two groups based on arthroscopic findings: those with ACL remnant adhesion to the PCL and those without adhesion. Demographic data, postoperative MRI findings (chondral lesions, articular cartilage damage, meniscal injuries, varus deformity, and concomitant ligament injuries), and clinical outcomes assessed by Lachman and pivot shift tests were compared between groups. Statistical analysis was performed using SPSS software using chi-square and McNemar's tests.</p><p><strong>Results: </strong>A total of 87 patients were evaluated (mean age 30.42 ± 5.79 years), including 78 males and 9 females. ACL remnant adhesion to the PCL was observed in 74 patients (85.1%). Articular cartilage damage was more frequent in the non-adhesion group (23.1%). Medial meniscal injuries were present in 56.3% of patients and were more common in the non-adhesion group (76.9%). Lateral and root meniscal injuries, as well as concomitant MCL and PCL injuries, were more frequently observed in the adhesion group. Varus deformity showed no significant association with adhesion status. No significant differences were found in Lachman or pivot shift test results, and adhesion was not associated with age or gender.</p><p><strong>Conclusion: </strong>ACL remnant adhesion to the PCL is a common finding after ACL reconstruction but was not associated with adverse radiological findings or short-term clinical outcomes. Further studies are needed to assess its long-term clinical relevance.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3589"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Difficult Airway with Dental Malocclusions during Laryngoscopy with Video Laryngoscopy in Patients Undergoing Elective Surgery :.","authors":"Mehrdad Malekshoar, Tayyebeh Zarei, Maryam Pourbahri, Mohammad Shirgir, Majid Vatankhah","doi":"10.31661/gmj.v14i.3586","DOIUrl":"https://doi.org/10.31661/gmj.v14i.3586","url":null,"abstract":"<p><strong>Background: </strong>Managing difficult airways in surgical patients remains a significant challenge for primary care physicians and anesthesiologists, often leading to high-stress situations. Dental malocclusion is a critical factor that can complicate airway management during laryngoscopy.To investigate the relationship between dental malocclusion classes and difficult airway indicators, such as video laryngoscopy grade and Malampathi criteria, in patients undergoing elective surgery.</p><p><strong>Materials and methods: </strong>This descriptive-analytical study randomly sampled patients scheduled for elective surgery at Shahid Mohammadi Hospital in 2022. Data were collected using a checklist that included variables such as age, sex, height, weight, dental malocclusion class, Malampathi scale, and video laryngoscopy grade. The Chi-square test and multiple logistic regression were applied to compare proportions between groups. A p-value of 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The study found no significant relationship between dental malocclusion class and height, weight, or age. However, the prevalence of malocclusion across all three classes was higher in male patients. A significant association was observed between dental malocclusion class and both Malampathi criteria and video laryngoscopy grade (P0.005). Specifically, as the malocclusion class increased, both the laryngoscopy grade and Malampathi grade also increased.</p><p><strong>Conclusion: </strong>This study highlights a significant relationship between dental malocclusion class and difficult airway indicators, such as video laryngoscopy grade and Malampathi criteria. Higher grades of laryngoscopy grade and Malampathi criteria were associated with Class 2 and Class 3 dental malocclusions. These findings underscore the importance of dental occlusion assessment in predicting and managing difficult airways in surgical patients.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3586"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Ma-ol-asal Syrup for Chemotherapy-induced Fatigue in Gastrointestinal Cancer Patients: A Randomized Double-blinded Placebo-controlled Clinical Trial :.","authors":"Ata Amani, Bayazid Ghaderi, Mehdi Pasalar, Khaled Rahmani, Kiarash Zare, Thomas Rampp, Ghazaleh Heydarirad","doi":"10.31661/gmj.v14i.3913","DOIUrl":"https://doi.org/10.31661/gmj.v14i.3913","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy-induced fatigue (CIF) is a common and debilitating side effect in cancer patients, particularly those with gastrointestinal cancers. This study explores the potential of Ma-ol-asal, a traditional Persian herbal syrup, as a holistic, supportive approach to alleviate CIF's physical and psychological burdens.</p><p><strong>Materials and methods: </strong>This randomized, double-blind, placebo-controlled trial involved 120 gastrointestinal cancer patients with fatigue, randomly assigned to receive 10 mL of Ma-ol-asal (compound honey syrup) or placebo thrice daily for four weeks. Fatigue was assessed with validated scales at baseline and post-intervention once, with data analyzed to evaluate efficacy.</p><p><strong>Results: </strong>After withdrawals, 42 patients per group remained. No significant demographic or lab differences were observed. Both groups had comparable scores post-treatment across all measures, with no significant differences. Adverse events, mainly nausea, vomiting, and abdominal pain, were similar. Perception of benefit varied between groups.</p><p><strong>Conclusion: </strong>Our study shows Ma-ol-asal syrup isn't superior to placebo for chemotherapy-induced fatigue, highlighting significant placebo effects. This emphasizes the need to understand harnessing placebo responses to improve symptom management safely.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3913"},"PeriodicalIF":0.6,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Diabetes with Drug Use, Family History and Alcohol; Insights from the PERSIAN Cohort Study for Health Service Management :.","authors":"Mohammad Khammarnia, Alireza Ansari-Moghaddam, Zahra Takamoli Poshtehee, Fariba Shahraki-Sanavi, Mahdi Mohammadi","doi":"10.31661/gmj.v14i.3853","DOIUrl":"https://doi.org/10.31661/gmj.v14i.3853","url":null,"abstract":"<p><strong>Background: </strong>In recent decades, the prevalence of diabetes, alcohol and tobacco consumption has increased in Iran and the world. This study aimed to investigate the relationship between diabetes with family history, alcohol and tobacco consumption in Iran.</p><p><strong>Materials and methods: </strong>A cross-sectional study was carried out in the southeast of Iran in 2023_2024. The target population consisted of 10,016 individuals aged between 35 and 70 years. The data required for this study was obtained from the data collected by ZACS (Zahedan Adult Cohort Study) in the southeast of Iran (The Persian Cohort and ZACS data are the same. In fact, ZACS is part of the Persian Cohort). The data on general information, diabetes, family history of diabetes and alcohol consumption were collected through a standard questionnaire and were analyzed using descriptive statistics and independent t-tests, chi-square and logistic regression in SPSS 22 software.</p><p><strong>Results: </strong>The prevalence of diabetes was 19.0% and it was more prevalent in women (20.1%), unemployed people (21.9%) and age groups of 60 years and older (P0.05). The prevalence of diabetes was 37.8% in first relatives and 19.4% in second relatives. Although only 2.4% of people consumed alcohol, diabetes was less common in people who consumed alcohol than in others (P0.001). In univariate results, drug use reduced the chance of developing diabetes (OR=0.86, P=0.026). However, there was not significant relationship between drug use and diabetes after adjusting for history of diabetes in relatives (OR=0.99, P=0.229). Family history had a positive effect on developing diabetes (P0.001).</p><p><strong>Conclusion: </strong>The findings showed the family history had a positive effect on developing diabetes. These results show the necessity of examining the family history of people, identifying people at risk, and also providing the necessary education for the prevention of diabetes. It is recommended that people with a family history of diabetes take diabetes preventive measures and modify their lifestyle.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3853"},"PeriodicalIF":0.6,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Laparoscopic Surgery of Deep Infiltrating Endometriosis: A Prospective Cohort Study in Yas Infertility Center, Tehran :.","authors":"Fatemeh Davari Tanha, Mahbod Ebrahimi, Fatemeh Salehi, Nooshin Faraji, Shaghayegh Norozi Larki","doi":"10.31661/gmj.v14i.3899","DOIUrl":"https://doi.org/10.31661/gmj.v14i.3899","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is a prevalent medical condition that significantly affect the quality of life in a substantial proportion of women, affecting their fertility and manifesting with many symptoms like gastrointestinal symptoms. The present study aimed to evaluate the impact of laparoscopic surgery for endometriosis on general and sexual quality of life, and gastrointestinal symptoms in patients diagnosed with deep infiltrating endometriosis (DIE).</p><p><strong>Materials and methods: </strong>This prospective cohort study was conducted on 129 women diagnosed with DIE-associated infertility and referred to Yas Infertility Center in Tehran , from 2022 to 2023. Demographic data and the presence and severity of gastrointestinal symptoms were recorded. These symptoms were reassessed one month following endometriosis surgery. Participants were also asked to complete the SF-36 Quality of Life Questionnaire and Female Sexual Function Index (FSFI) questionnaires before the surgical procedure and one month later. Data were analyzed using SPSS version 24.</p><p><strong>Results: </strong>This study of 129 patients (mean age 34.82±5.83 years, BMI 25.64±3.77 kg/m²) revealed near-universal ovarian involvement (99.2%) and adhesions (99.2%), primarily affecting rectosigmoid (24.1%) and cervix (29.5%). Pre-intervention, 98.4% reported abdominal pain (47.3% severe), 37.9% bloating, and 24.8% constipation. Post-intervention showed dramatic improvements: pain-free cases rose to 90.7%, bloating reduced to 9.3%, and constipation to 6.2% (all P0.0001). The FSFI score increased (57.6±28.8 to 65.2±27.4, P0.0001), and SF-36 pain scores halved (6.8±1.2 to 2.7±0.9, P0.0001), though vitality and emotional well-being remained unchanged. Surgical complications included hemoglobin drop (17.8%) and intestinal injury (6.2%).</p><p><strong>Conclusion: </strong>The findings of this study indicate that laparoscopic treatment of DIE not only alleviates gastrointestinal symptoms but also significantly enhances the quality of life and sexual function in affected women.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 ","pages":"e3899"},"PeriodicalIF":0.6,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Accuracy of CBCT and MDCT Imaging Modalities in Determining the Distance between the Incus and the Facial Nerve and the Round Window and the Oval Window: A Cadaveric Cross-sectional Study :.","authors":"Sanaz Sharifishoshtari, Nader Saki, Zohreh Roozbahani, Yasamin Mehrab, Ali Hesari","doi":"10.31661/gmj.vi.3919","DOIUrl":"https://doi.org/10.31661/gmj.vi.3919","url":null,"abstract":"<p><strong>Background: </strong>Hearing loss is the most common birth defect, and cochlear implants are an effective treatment for severe sensorineural loss. This study compared CBCT and MDCT accuracy in measuring key ear structures to aid cochlear implant planning.</p><p><strong>Materials and methods: </strong>In this cadaveric cross-sectional laboratory study, 12 temporal bones along with their covering soft tissue in the archive of the ENT department of Imam Khomeini Hospital in Ahvaz were studied. Imaging was performed using high-resolution CBCT, low-resolution CBCT, and MDCT modalities. Measurements were performed by an oral and maxillofacial radiologist and a general radiologist. The obtained data were analyzed descriptively and analytically in SPSS21 software.</p><p><strong>Results: </strong>The results revealed a high agreement between the data related to the distance of the incus from the facial nerve and the distance of the oval window from the round window in High-resolution CBCT, Low-resolution CBCT, and MDCT images. However, there was a significant difference in the measurement of MDCT and low-resolution CBCT compared to high-resolution CBCT. There was no significant difference in the measurement between MDCT and low-resolution CBCT.</p><p><strong>Conclusion: </strong>Based on our study and some previous studies on quantitative measurements of CBCT and MDCT imaging, low-resolution CBCT can be more reliably replaced by MDCT and achieve acceptable results compared to MDCT using a lower radiation dose. More studies are needed regarding the significant difference between high-resolution CBCT and MDCT, but the higher resolution of the borders in high-resolution CBCT images may be the reason for this result.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e3919"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Morphologic Dimensions of Humulus Appendix of Pterygoid Plate Using Cone Beam Computed Tomography (CBCT) in Ahvazian Patients, Iran :.","authors":"Zahra Saadi, Sanaz Sharifi Shushtari, Alireza Hashemi Ashtiani, Ali Tayebi","doi":"10.31661/gmj.vi.3901","DOIUrl":"https://doi.org/10.31661/gmj.vi.3901","url":null,"abstract":"<p><strong>Background: </strong>Today, CBCT has found a special place in dentistry due to the high quality and accuracy of images and providing information, and its use is increasing. With its help, we can examine many parts of the anatomy that are difficult to evaluate. The purpose of this study is to investigate the morphological dimensions of the humulus of the pterygoid appendage using cone beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>In this retrospective study, the statistical population was the imaging reccords of patients who referred to the radiology department of Ahvaz Dental School for CBCT of the upper jaw, whose values were stored in the NNT software. The size of the humulus (length and width) and its slope in the coronal and axial sections of the images were evaluated by two oral and maxillofacial radiologists. The results were analyzed using SPSS software version 22.</p><p><strong>Results: </strong>Eighty pterygoid hamuli from 38 males and 42 females (age 26-64 years, mean 43.18 ± 11.57) were analyzed. No significant gender differences were observed in length (P=0.096), width (P=0.300), axial angle (P=0.067), or coronal angle (P=0.102). Age-related comparisons revealed significant variation: hamular length and width increased in the 31-40 and 51 year groups versus 30 years (P=0.022-0.031), axial angle was higher in 31-40 and 51 year groups (P=0.003-0.006), and coronal angle increased in 31-40 and 51 year groups (P=0.047-0.049).</p><p><strong>Conclusion: </strong>These findings indicate gradual morphometric changes with age, independent of gender. The length of PH increases with age and then decreases. While the width increases with age. There was no significant difference between length and width measurements in men and women. These findings help to diagnose vague pains in the oropharynx region related to the altered morphology of PH.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e3901"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Investigation of the Effect of Three Decontamination Methods on Surface Alterations of Dental Implants :.","authors":"Shohreh Khalilzadeh, Soroush Etesami","doi":"10.31661/gmj.vi.3864","DOIUrl":"https://doi.org/10.31661/gmj.vi.3864","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to evaluate the effectiveness of three decontamination methods on the surface alterations of dental implants and the removal of bacterial plaque from their surfaces.</p><p><strong>Materials and methods: </strong>In this experimental in vitro study, 24 titanium cylinders with sandblasted, large-grit, acid-etched (SLA) surfaces were contaminated with Staphylococcus aureus to simulate biofilm formation. Samples were randomly assigned to four groups (n=6): titanium curette, diode laser, titanium brush, and saline flush control. Surface roughness (Ra and Rz) was measured using scanning electron microscopy (SEM) before and after cleaning. Colony-forming units (CFUs) were quantified post-treatment to assess bacterial removal. Statistical analyses included Kruskal-Wallis tests, Mann-Whitney pairwise comparisons, and one-way ANOVA with post hoc LSD tests (α=0.05).</p><p><strong>Results: </strong>Surface roughness differed significantly among groups after cleaning (Ra, P=.002; Rz, P=.002). Titanium curette and titanium brush produced smoother surfaces than diode laser and control, with the curette achieving the greatest reduction in roughness. CFU analysis revealed significant differences among groups (F=3.26, P=.043). Contrary to expectations, the saline flush control showed the lowest CFU counts, whereas titanium curette and titanium brush exhibited higher bacterial counts than control (P.05), and diode laser did not differ significantly from control (P=.151).</p><p><strong>Conclusion: </strong>The titanium curette and titanium brush caused the samples' most significant surface roughness changes. However, the effectiveness of these methods for bacterial plaque removal was lower than that of the control group and the Diode laser group.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e3864"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Accuracy of CBCT and MDCT Images in Measuring the Thickness of the Posterior Footplate of the Middle Ear in Iranian :.","authors":"Sanaz Sharifi Shooshtari, Nader Saki, Zohreh Roozbahani, Kowsar Farahmandfar, Nila Bagheri","doi":"10.31661/gmj.vi.3900","DOIUrl":"https://doi.org/10.31661/gmj.vi.3900","url":null,"abstract":"<p><strong>Background: </strong>Advancements in radiological imaging have transitioned from two-dimensional radiography to three-dimensional cone beam computed tomography (CBCT), offering high spatial resolution with reduced radiation doses compared to multidetector computed tomography (MDCT). While MDCT remains the standard for detailed visualization of bony structures like the ossicular chain, its higher radiation exposure is a concern. This study compares the accuracy of high-resolution (HR) and low-resolution (LR) CBCT with MDCT in measuring the thickness of the posterior footplate of the middle ear to identify a reliable, low-radiation alternative.</p><p><strong>Materials and methods: </strong>Twelve adult human temporal bones from Imam Khomeini Hospital's ENT Department were imaged using HR-CBCT, LR-CBCT (Jundishapur Dental School), and MDCT (Siemens Sensation 64-slice). Standardized imaging protocols ensured reproducibility, with measurements of posterior footplate thickness conducted in axial, coronal, and sagittal planes by two blinded radiologists. Data were analyzed using SPSS v23, with inter-modality agreement assessed via Kappa coefficient and differences evaluated with the McNemar test.</p><p><strong>Results: </strong>Mean posterior footplate thickness was 2.38 mm (HR-CBCT), 2.37 mm (LR-CBCT), and 2.23 mm (MDCT), with no significant differences (P0.05). HR-CBCT and LR-CBCT showed comparable accuracy to MDCT.</p><p><strong>Conclusion: </strong>CBCT, particularly HR-CBCT, offers a reliable, lower-radiation alternative to MDCT for otologic imaging, maintaining high resolution for middle ear assessments.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e3900"},"PeriodicalIF":0.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Micronucleus Count in Oral Squamous Cell Carcinoma (OSCC) Newly Diagnosed Patients Compared to Previously Treated Ones: A Cytologic Study :.","authors":"Marjan Mohammadi, Noushin Jalayer Naderi, Ata Garajei, Seyed Masoud Sajedi","doi":"10.31661/gmj.vi.3968","DOIUrl":"https://doi.org/10.31661/gmj.vi.3968","url":null,"abstract":"<p><strong>Background: </strong>Early detection and monitoring of genomic damages are vital for improving therapeutic outcomes. Quantification of micronuclei in exfoliated buccal mucosa cells has emerged as a reliable biomarker for assessing genomic alterations and cytogenetic damage in precancerous and cancerous conditions.</p><p><strong>Materials and methods: </strong>This study evaluated exfoliated buccal cells from two groups of OSCC patients: seventeen newly diagnosed individuals who hadn't yet undergone OSCC treatments and seventeen patients assessed at least six months after treatments. Micronuclei were identified and quantified in the cytology samples, and statistical analyses including the T-test, Mann-Whitney U, Kruskal-Wallis, and Spearman's correlation tests were applied at a significance threshold of P0.05 to compare modalities between groups.</p><p><strong>Results: </strong>The newly diagnosed group exhibited a mean micronucleus frequency of 0.028±0.013 per 10³ cell, whereas the treated group demonstrated a significantly lower mean frequency of 0.016±0.020 per 10³ cell (P=0.03). Further stratification of treated patients by intervention type (surgery alone, surgery combined with radiotherapy, and surgery followed by radiotherapy and chemotherapy) yielded mean counts of 0.006±0.003 per 10³ cell, 0.014±0.010 per 10³ cell, and 0.026±0.025 per 10³ cell, respectively. These variations did not reach statistical significance (P=0.29).</p><p><strong>Conclusion: </strong>The findings show that treatment reduces cytogenetic damage, as reflected by diminished micronucleus formation. Consequently, micronucleus assessment in buccal mucosa cells may serve as a noninvasive, cost-effective tool for monitoring therapeutic efficacy and predicting the recovery process in OSCC patients.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e3968"},"PeriodicalIF":0.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}