The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma:.

Abstract

Esophageal cancer (EC) is considered one of the most prevalent and aggressive malignancies worldwide, with a variety of molecular alterations thought to contribute to its incidence, development, progression, and invasion. However, the exact underlying mechanism has not been elucidated. Autophagy is a highly conserved degradative and recycling process that can function with a dual role in either the progression or the treatment of EC. Since microRNAs (miRNAs) are described as upstream regulators capable of controlling both oncogenic pathways and autophagic flux, the present study has aimed to review the crosstalk between autophagy and miRNAs and the potential perspective of these mechanisms in EC prevention and treatment.