Galen Medical Journal最新文献_第4页

Hybrid Calcifying Epithelial Odontogenic Tumor and Ameloblastoma: A Report of an Extremely Rare Condition 混合性钙化上皮性牙本质瘤和釉母细胞瘤：一种极为罕见疾病的报告

IF 0.7

Galen Medical Journal Pub Date : 2023-12-17 DOI: 10.31661/gmj.v12i.3144

Mohammad Saleh Ekrampoor, Hossein Daneste, Mohammad Amin Amiri

引用次数: 0

Biological Synthesis of Silver Nanoparticles Using Lactobacillus Probiotic Bacterium and Evaluation of Their Cytotoxicity Against Oral Squamous Cell Carcinoma Cell Line 利用乳酸杆菌益生菌生物合成银纳米粒子并评估其对口腔鳞状细胞癌细胞系的细胞毒性

IF 0.7

Galen Medical Journal Pub Date : 2023-12-17 DOI: 10.31661/gmj.v12i.2905

Mohadeese Pourhaji, Farid Abbasi, Aliyeh Sehatpour, Ronak Bakhtiari

{"title":"Biological Synthesis of Silver Nanoparticles Using Lactobacillus Probiotic Bacterium and Evaluation of Their Cytotoxicity Against Oral Squamous Cell Carcinoma Cell Line","authors":"Mohadeese Pourhaji, Farid Abbasi, Aliyeh Sehatpour, Ronak Bakhtiari","doi":"10.31661/gmj.v12i.2905","DOIUrl":"https://doi.org/10.31661/gmj.v12i.2905","url":null,"abstract":"Background: The applications of nanotechnology have greatly increased in the recent years. Nanotechnology can be used for diagnosis and treatment of many conditions in medicine and dentistry. The aim of this paper is assessment the cytotoxicity of silver nanoparticles (AGNPs) synthesized employing Lactobacillus acidophilus against human oral squamous cell carcinoma (OSCC) cell line. Materials and Methods: In this in vitro, experimental study, AgNPs were biologically synthesized by using L. acidophilus, and characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), ultraviolet-visible (UV-V) spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. The methyl thiazolyl tetrazolium (MTT) test was performed to assess the cytotoxic effects of AgNPs in 3.125, 6.25, 12.5, 25, 50, and 100 μg/mL concentrations within 24 hours. Results: Synthesis of AgNPs was confirmed by visual perception of dark brown color variation (from achromatic) and maximum UV-V absorption at 428 nm. TEM and SEM indicated the spherical form of AgNPs with a median size of 397 nm. FTIR spectroscopy showed the presence of functional groups from the cells involved in the reduction process. The MTT assay indicated that the biosynthesized nanoparticles made a decrease of cell livability in a concentration dependent method. Conclusion: AgNPs produced by Lactobacillus acidophilus have the potential to inhibit OSCC cell line.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect 藻酸盐支架中的胸腺醌对兔下颌骨缺损处骨再生的影响

IF 0.7

Galen Medical Journal Pub Date : 2023-12-17 DOI: 10.31661/gmj.v12i.3141

Ehsan Aliabadi, Mohammad Mehdi Farahmand, T. Talaei-Khozani, Sheila Shahsavari-pour

{"title":"The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect","authors":"Ehsan Aliabadi, Mohammad Mehdi Farahmand, T. Talaei-Khozani, Sheila Shahsavari-pour","doi":"10.31661/gmj.v12i.3141","DOIUrl":"https://doi.org/10.31661/gmj.v12i.3141","url":null,"abstract":"Background: Thymoquinone (TQ) has some beneficial roles in bone repair. Local administration of the drugs by loading them into a scaffold leads to releasing higher concentrations of a drug in the appropriate position. This study was conducted to evaluate the effects of the local administration of TQ loaded in an alginate scaffold on bone regeneration in rabbit mandibular defect. Materials and Methods: In this experimental study, male rabbits with mandible defect were divided into 3 groups that received either alginate containing 50µM TQ, alginate or remained untreated. Then each group was subdivided into 2 groups that followed for 4 and 8 weeks (n=5). The radiological opacity, histopathology, and histomorphometrical analysis were done and data were analyzed by ANOVA and Tukey. Results: Radiological examination indicated that the presence of TQ had no significant effect on the turbidity of the images (P=0.595). TQ treatment significantly increased the bone area after 4 (P=0.011, P=0.0021, respectively) and 8 weeks (8w P=0.019, P<0.001, respectively) compared to alginate-treated and control defects. TQ also elevated the number of osteocytes (4wP<0.001, P=0.001 and 8w P<0.001, P<0.001, respectively) and osteoblasts (P<0.001, P<0.001, respectively) compared to the group receiving alginate and control. However, at 8 weeks, the number of osteoblasts was statistically similar in all the groups. In this week, although the average number of osteoblasts in the defects treated with TQ was significantly higher than the control group (P=0.01), it was similar to the group that received alginate. Conclusion: It seems that alginate containing TQ has positive effects on bone healing. TQ can be suggested as a good additive to improve bone healing and accelerate bone repair.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short Review on the Impact of Artificial Intelligence in Diagnosis Diseases: Role of Radiomics In Neuro-Oncology 人工智能对疾病诊断的影响简评：放射组学在神经肿瘤学中的作用

IF 0.7

Galen Medical Journal Pub Date : 2023-12-16 DOI: 10.31661/gmj.v12i.3158

Mohammad Rahimi, Parsa Rahimi

引用次数: 0

Schizophrenia Etiological Factors and Their Correlation with the Imbalance of the Immune System: An Update 精神分裂症的病因及其与免疫系统失衡的相关性：最新进展

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3109

Noushin Lotfi, N. Rezaei, Elham Rastgoo, Babak Khodadoustan Shahraki, Ghazaleh Zahedi, Morteza Jafarinia

{"title":"Schizophrenia Etiological Factors and Their Correlation with the Imbalance of the Immune System: An Update","authors":"Noushin Lotfi, N. Rezaei, Elham Rastgoo, Babak Khodadoustan Shahraki, Ghazaleh Zahedi, Morteza Jafarinia","doi":"10.31661/gmj.v12i.3109","DOIUrl":"https://doi.org/10.31661/gmj.v12i.3109","url":null,"abstract":"Schizophrenia (SZ) is a severe psychiatric disorder associated with a dysregulation of the immune system. Immune-related genes and environmental factors including stress, food, infections, and microbiota, alter the immune system’s homeostasis and play a role in SZ pathogenesis. The most distinctive feature in the pathophysiology of the disease is a shift in the T helper 1(Th1)/Th2 balance toward Th2 dominance in the immune system. Also, microglial and Th17 cell activation cause inﬂammatory responses in the central nervous system (CNS). Antibodies play a role in the pathophysiology of SZ and give more evidence of a link between humoral immune reactivity and the disease. Accordingly, an imbalance in cytokine activities and neuroinflammation has been considered the main contributor to the pathogenesis of the SZ. Overall, the deregulation of the immune system caused by genetic, environmental, and neurochemical effects may all play a role in the etiology of SZ. This review summarized the etiological factors for SZ and discussed the role of immune responses and their interaction with genetic and environmental factors in SZ pathogenesis.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the prognostic value of monocyte to HDL ratio (MHR) in primary PCI STEMI patients 评估初级 PCI STEMI 患者单核细胞与高密度脂蛋白比率 (MHR) 的预后价值

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3126

A. Separham, Naser Aslan-abadi, H. Sedigh, Reza Javan-ajdadi, Kazem Mehravani

{"title":"Evaluation of the prognostic value of monocyte to HDL ratio (MHR) in primary PCI STEMI patients","authors":"A. Separham, Naser Aslan-abadi, H. Sedigh, Reza Javan-ajdadi, Kazem Mehravani","doi":"10.31661/gmj.v12i.3126","DOIUrl":"https://doi.org/10.31661/gmj.v12i.3126","url":null,"abstract":"Background: The purpose of this study was to assess the prognostic value of the monocyte-to-high-density lipoprotein ratio (MHR) as a marker of inflammation in patients diagnosed with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Materials and Methods: This retrospective cross-sectional study was conducted on patients with a diagnosis of STEMI who underwent PCI between March 2021 and March 2022 at Madani Training and Research Hospital in Tabriz, Iran. Data regarding clinical and demographic properties, and laboratory parameters were obtained from medical records. Patients were categorized into two groups according to the median of admission MHR. Results: The study population consisted of 652 patients, 378 males (58%), and 275 females (42%), with a median age of 68 years (interquartile range: 57-77). Results showed that groups with higher MHR (>15.59) had higher rates of in-hospital mortality and higher major adverse cardiovascular events (MACEs) in comparison with the group featuring lower MHR (<15.59). Receiver operating characteristic (ROC) curves demonstrated that MHR could predict in-hospital mortality with a 75.7% sensitivity and 53.5% specificity, as well as predict MACE with 60.2% sensitivity and 59.7% specificity. Multivariate analyses indicated that MHR is an independent predictor of both in-hospital mortality (OR 1.05, 95% CI 1.02-1.08, P=0.002) and MACE (OR 1.05, 95% CI 1.02-1.08, P<0.001). Conclusion: This research indicated that the rise in MHR was independently associated with a higher risk of MACE and in-hospital mortality in STEMI patients undergoing primary PCI.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of MicroRNAs in Breast Cancer Metastasis to the Brain: A New Therapeutic Perspective 微RNA在乳腺癌脑转移中的作用：治疗新视角

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3193

Baback Khanegheini, Afsaneh Ghasemi, Mohammad Amin Heidari, Kamkar Aeinfar, Sina Firoozi, Mona Tamaddon, Zhila Fereidouni

引用次数: 0

The Efficacy of Self-care Behaviors, Educational Interventions, and Follow-up Strategies on Hospital Readmission and Mortality Rates in Patients with Heart Failure 自我护理行为、教育干预和随访策略对心衰患者再入院率和死亡率的影响

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3116

Zahra Khosravirad, Mohammad Rostamzadeh, Shiva Azizi, Mehran Khodashenas, Babak Khodadoustan Shahraki, Farangis Ghasemi, Maryam Ghorbanzadeh

{"title":"The Efficacy of Self-care Behaviors, Educational Interventions, and Follow-up Strategies on Hospital Readmission and Mortality Rates in Patients with Heart Failure","authors":"Zahra Khosravirad, Mohammad Rostamzadeh, Shiva Azizi, Mehran Khodashenas, Babak Khodadoustan Shahraki, Farangis Ghasemi, Maryam Ghorbanzadeh","doi":"10.31661/gmj.v12i.3116","DOIUrl":"https://doi.org/10.31661/gmj.v12i.3116","url":null,"abstract":"Heart failure (HF), a worldwide epidemic with significant morbidity and mortality risks, is frequently secondary to cardiovascular disorders and probably is the common final way to survive patients. Almost 25% of hospitalized patients with acute HF are expected to be readmitted within 30 days post-discharge, and the rates of rehospitalization increase to almost one-third at 60 days and 60 percent within one year of discharge. Although care planning for patients with heart failure is complex, multidisciplinary, and resource-dependent, optimal self-care management along with appropriate educational intervention and follow-up strategy could be able to reduce readmissions, decline the duration of hospitalization, increase life expectancy, decrease the rates of mortality, and reduce costs of healthcare services for patients with HF. However, there are contradictions in previous reports about the efficacy of self-care, mainly due to patients’ non-adherence to self-care behaviors. Therefore, the current study aimed to review the investigations on the effectiveness of self-care of HF patients in reducing hospital readmissions and increasing quality of life, and discuss novel approaches for predischarge educational interventions and postdischarge follow-up strategies.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138624920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of ChatGPT in Medical Content Development: Challenges and Hope 在医学内容开发中应用 ChatGPT：挑战与希望

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3106

Akhilesh Vikram Singh, Anudwipa Singh

引用次数: 0

Broken Heart Syndrome: A Rare Case of Recurrent Reverse Takotsubo Cardiomyopathy Associated with Acute Respiratory Failure 破碎心综合征：与急性呼吸衰竭相关的复发性反向塔克次博心肌病罕见病例

IF 0.7

Galen Medical Journal Pub Date : 2023-12-01 DOI: 10.31661/gmj.v12i.3103

Samina Jabeen, Deepak Pattanshetty

{"title":"Broken Heart Syndrome: A Rare Case of Recurrent Reverse Takotsubo Cardiomyopathy Associated with Acute Respiratory Failure","authors":"Samina Jabeen, Deepak Pattanshetty","doi":"10.31661/gmj.v12i.3103","DOIUrl":"https://doi.org/10.31661/gmj.v12i.3103","url":null,"abstract":"Background: \u0000Takotsubo cardiomyopathy accounts for 1% of acute coronary syndrome presentations and has been increasingly recognized.1 Reverse Takotsubo cardiomyopathy, a variant form of Takotsubo cardiomyopathy has been described which presents with hyperdynamic function of the apical segments and hypokinesis of the basal or mid-ventricular segments, is the rarest type of acute stress cardiomyopathy, with mid-ventricular akinesia and preservation of apical and basal contractility.2 \u0000Case Report: \u0000We report the rare case of an elderly lady admitted to our intensive care unit (ICU) with acute respiratory failure due to exacerbation of chronic obstructive lung disease and heart failure. Echocardiography revealed reverse Takotsubo cardiomyopathy. Cardiac catheterization showed nonobstructive coronary artery disease. The wall motion abnormalities resolved in 2 weeks. The case is unique in that she had an identical presentation one year earlier after she had entered the same dusty room! \u0000Conclusion: \u0000This case demonstrates that reverse Takotsubo cardiomyopathy with identical wall motion abnormalities can recur in a patient when re-exposed to similar stressful situation. Early recognition and appropriate management can prevent catastrophic outcomes.","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0