Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies.

IF 0.5 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Galen Medical Journal Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI:10.31661/gmj.v12i.3151

Arqavan Eslamzadeh, Seyyed Mohammad Amin Kashani, Nasrin Asadi, Sina Bazmi, Shahla Rezaei, Zeinab Karimimoghadam, Peyman Nowrouzi-Sohrabi, Reza Tabrizi

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Abstract

Background: Multiple studies have investigated the serum concentrations of calcium (Ca) and magnesium (Mg) in preeclampsia, but the results have been contradictory. The objective of this systematic review and meta-analysis was to examine the association between serum calcium and magnesium levels in patients with preeclampsia and those in the healthy pregnancies.

Materials and methods: A comprehensive search was conducted in various online databases, including PubMed/Medline, Scopus, Embase, Web of Sciences, and Cochrane library to identify relevant studies on Ca and Mg levels in preeclampsia up to July 2023. Inter-study heterogeneity across the included studies was assessed using the chi-square test and I2 statistic. Pooled effect size (ES) was calculated as weighted mean differences (WMDs) with corresponding 95% confidence intervals (CI).

Results: A total of 76 articles (comprising 92 studies) were included, with a combined sample size of 10,482 participants (preeclampsia: n=3,991; controls: n=6,491). The random-effects model revealed significantly lower levels of calcium (WMD=-0.807 mg/dL, 95% CI: -0.983, -0.632, P0.01) and magnesium (WMD=-0.215, 95% CI: -0.338, -0.092, P0.01) in women with pre-eclampsia compared to the control group. However, the overall pooled WMD for calcium and magnesium levels did not significantly change when individual studies were excluded one by one.

Conclusion: This meta-analysis demonstrates that the circulating levels of calcium and magnesium in patients with preeclampsia are significantly lower than those in the control group.

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先兆子痫妇女的血清钙和镁水平：基于观察性研究的系统回顾和 Meta 分析。

背景：多项研究调查了子痫前期患者血清中钙（Ca）和镁（Mg）的浓度，但结果却相互矛盾。本系统综述和荟萃分析旨在研究子痫前期患者血清钙和镁水平与健康孕妇血清钙和镁水平之间的关联：在各种在线数据库（包括 PubMed/Medline、Scopus、Embase、Web of Sciences 和 Cochrane 图书馆）中进行了全面检索，以确定截至 2023 年 7 月有关子痫前期患者血钙和血镁水平的相关研究。采用卡方检验和 I2 统计量评估了纳入研究之间的异质性。汇总效应大小（ES）以加权平均差（WMD）和相应的95%置信区间（CI）计算：共纳入 76 篇文章（包括 92 项研究），合并样本量为 10,482 名参与者（子痫前期：n=3,991；对照组：n=6,491）。随机效应模型显示，与对照组相比，子痫前期妇女的钙水平（WMD=-0.807 mg/dL，95% CI：-0.983，-0.632，P0.01）和镁水平（WMD=-0.215，95% CI：-0.338，-0.092，P0.01）明显较低。然而，在逐一排除个别研究后，钙和镁水平的总合WMD并无明显变化：这项荟萃分析表明，子痫前期患者循环中的钙和镁水平明显低于对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Galen Medical Journal MEDICINE, RESEARCH & EXPERIMENTAL-

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期刊介绍： GMJ is open access, peer-reviewed journal in English and supported by Noncommunicable Diseases (NCD) Research Center of Fasa University of Medical Sciences that publishing by Salvia Medical Sciences Ltd. GMJ will consider all types of the following scientific papers for publication: - Editorial’s choice - Original Researches - Review articles - Case reports - Case series - Letter (to editors, to authors, etc) - Short communications - Medical Idea