Galen Medical Journal最新文献

{"title":"The Impact of the COVID-19 Pandemic on Medical Faculty's Academic Performance and Well-Being : Short title: COVID-19 Pandemic and Medical Faculty's Academic Performance and Well-Being.","authors":"Asim Sharif","doi":"10.31661/gmj.v15i.4139","DOIUrl":"10.31661/gmj.v15i.4139","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effects of stress related to the pandemic on the medical faculty's well-being.</p><p><strong>Materials and methods: </strong>This study investigated the impact of pandemic-related stress on the well-being of medical faculty at King Abdulaziz University. Using a mixed-methods approach, 82 faculty members completed online surveys, including the GAD-7 and PHQ-9 scales to measure anxiety and depression, and participated in focus group discussions. The analysis explored the relationship between these psychological stress factors and self-reported academic performance across different demographics.</p><p><strong>Results: </strong>A high prevalence of psychological distress was found: 89.6% of faculty reported at least mild anxiety, and 84.4% reported at least mild depressive symptoms. Most participants self-rated their academic performance as good (54.5%) or excellent (36.4%), and 80.5% reported missing no crucial deadlines. Regression analyses revealed a significant positive association between depression severity and higher self-reported academic performance (β = 1.48, p = 0.025). Male gender (OR = 0.20, p = 0.022) and longer weekly working hours (OR = 0.53, p = 0.019) were associated with significantly lower odds of missing deadlines. Anxiety, depression, and other covariates were not significant predictors of overall quality of life.</p><p><strong>Conclusion: </strong>While the pandemic was associated with a high burden of anxiety and depression among faculty, this distress did not translate into widespread self-perceived declines in academic output. The counterintuitive link between higher depression scores and self-reported performance, alongside the protective effect of male gender and increased work hours against missed deadlines, suggests complex coping mechanisms and potential resilience or presenteeism.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e4139"},"PeriodicalIF":0.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of the Antibacterial Effects of Moringa Oleifera and Eucalyptus As Intracanal Irrigants on Enterococcus Faecalis: An in Vitro Study : Short title: Antimicrobial Efficacy of Herbal Products against E.faecalis.","authors":"Sahar Shakoui, Shirin Fattahi, Ladan Paya, Parya Emamverdizadeh, Negin Neshanifard, Mohammad Ali Irani, Shaghayegh Ghadimi","doi":"10.31661/gmj.v15i.4141","DOIUrl":"10.31661/gmj.v15i.4141","url":null,"abstract":"<p><strong>Background: </strong>Enterococcus faecalis has been considered as a main factor for rendodontic treatment failure. Herbal products are increasingly used as their antimicrobial efficacy. This study aimed to investigate and compare the in vitro antimicrobial effects of two plants, Moringa oleifera and eucalyptus, with sodium hypochlorite as the standard irrigation solution against Enterococcus faecalis.</p><p><strong>Materials and methods: </strong>In the present in-vitro study, thirty mandibular premolars were decoronated, and root canal instrumentation was performed. Each sample was separately autoclaved, inoculated with E. faecalis, and incubated. The samples were divided into six groups based on the type of intervention (n=5 in each group): 1) microemulsion of M. oleifera, 2) microemulsion of eucalyptus, 3) 2.5% sodium hypochlorite, 4) a solution combining both M. oleifera and eucalyptus, 5) positive control, and 6) negative control. The root canals were obturated with gutta-percha and incubated for 90 days. Microbial sampling from the root canals was performed before (S1) and after root canal irrigation (S2), and the viability of microorganisms was reported in terms of the number of colony-forming units.</p><p><strong>Results: </strong>A significant difference in CFU/mL was observed among all groups (P0.001). The negative control showed complete inhibition, whereas the positive control exhibited 105 CFU/mL. Mean bacterial counts were lowest in the Moringa+Eucalyptus group (4921±3571 CFU/mL), followed by NaOCl (5720 ± 8952 CFU/mL), Eucalyptus (7246±9257 CFU/mL), and Moringa (8053±6247 CFU/mL). Pairwise comparisons revealed no statistically significant differences between the experimental irrigants (P0.05).</p><p><strong>Conclusion: </strong>M. oleifera and eucalyptus microemulsions exhibited similar antimicrobial effects against E. faecalis, and no synergistic effect of these two extracts was observed.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e4141"},"PeriodicalIF":0.7,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Role of Carbohydrates Quantity and Quality in the Incidence of Metabolic Syndrome: A Two-Year Cohort Study : Short title: Fat and Sleep Quality.","authors":"Melika Fallah, Azadeh Aminianfar, Awat Feizi, Peyman Adibi, Hamid Reza Rouhafza, Alireza Ani, Leila Azadbakht, Ahmad Esmaillzadeh","doi":"10.31661/gmj.v15i.3984","DOIUrl":"10.31661/gmj.v15i.3984","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) defines as a cluster of risk factors and is a global public health problem. Quality and quantity of carbohydrates (CHOs) intake plays a crucial role in the development of MetS. This study aimed to investigate the role of CHOs quantity and quality in relation to MetS.</p><p><strong>Materials and methods: </strong>This prospective cohort study was conducted among healthy adults aged 18-65 years in Kerdabad, Isfahan, Iran. Participants (n=1904) were selected through a census-based sampling method. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire (FFQ). CHOs quantity and quality were evaluated using measures such as dietary glycemic index (DGI), dietary glycemic load (DGL), and fiber intake. MetS was defined by established clinical criteria ATPΙΙΙ and assessed annually over a two-year follow-up. Anthropometric measurements, blood pressure, and fasting blood samples were collected at baseline and yearly to monitor metabolic parameters. Statistical analyses included multivariate logistic regression models adjusting for potential confounders including age, sex, energy intake, physical activity, socioeconomic factors, and BMI.</p><p><strong>Results: </strong>Among 1904 participants (45% male; mean age: 39.6 ± 10.2 years; mean BMI: 27.1 ± 4.9 kg/m²), in fully adjusted models, none of the dietary CHOs quantity or quality indices were significantly associated with MetS during the two-year follow-up.</p><p><strong>Conclusion: </strong>quantity and quality of CHOs not significantly associated with MetS after adjusting for confounders. Although some trends indicated potential metabolic effects, these were not statistically significant. Further long-term research with more detailed dietary assessments is needed to clarify these relationships.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3984"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesizing Evidence on Adverse Events of Perioperative Clonidine: An Umbrella Review : Short title: Perioperative Clonidine, Bradycardia and Hypotension.","authors":"Mehrdad Sayadinia, Pourya Adibi, Tayyebeh Zarei, Mehrdad Malekshoar, Majid Vatankhah, Mohammad Sadegh Sanie Jahromi, Amir Hossein Pourdavood, Mansour Deylami, Lohrasb Taheri, Bibi Mona Razavi, Reza Sahraei, Shahram Shafa","doi":"10.31661/gmj.v15i.3537","DOIUrl":"10.31661/gmj.v15i.3537","url":null,"abstract":"<p><strong>Background: </strong>Clonidine, a potent α2-adrenoceptor agonist, is used in anesthesia for its sedative and analgesic properties, but its administration requires careful monitoring due to potential risks of hypotension and bradycardia. As there are increasing number of trials on clonidine, this study aimed to synthesize a conclusion on unwanted consequences of clonidine use in the perioperative period.</p><p><strong>Materials and methods: </strong>This umbrella review synthesizes evidence on adverse events associated with perioperative prescription of clonidine, following the PRIOR guidelines using three prominent databases of Scopus, PubMed, and Web of Science with a strategic combination of keywords. Studies included were systematic reviews, meta-analyses, and network meta-analyses published in English; studies reviewing prescribing systematic clonidine perioperative; and reporting adverse events. Primary outcomes were cardiovascular events, respiratory, neurological, and gastrointestinal complications. Data were extracted systematically by two independent reviewers and analyzed using random effects models in Stata. Pooled odds ratios and mean differences were calculated, with heterogeneity assessed using the I² statistic.</p><p><strong>Results: </strong>Our umbrella review of 8 systematic review studies including 223 studies from 1980 till now; all of which included only randomized controlled trials (RCTs). The bradycardia analysis, comprising four studies, shows a significant increased risk of bradycardia compared to control (OR: 1.653, 95% CI: 1.013 to 2.700) with some heterogeneity (P=0.0609). Hypotension meta-analysis (four studies) reveals a substantial increased risk (exp(theta): 3.281, 95% CI: 1.696 to 6.347), albeit with moderate heterogeneity (I^2=62.37%, P=0.0355). Heart rate reduction (two studies) and MAP reduction (two studies) meta-analyses indicate significant effects of clonidine, with substantial heterogeneity.</p><p><strong>Conclusion: </strong>Our comprehensive umbrella review highlights significant associations between perioperative clonidine and complications such as bradycardia and hypotension, suggesting the need for careful consideration and further investigation in clinical practice.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3537"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for Retraction of Biomedical Articles Written by Eastern Mediterranean and Turkish Authors; A Comprehensive Cross-Sectional Study During 2010-2019 : Short title: Reasons for Retraction of Biomedical Articles.","authors":"Kezhal Bijari, Mehrdad Askarian, Mehrdad Askarian","doi":"10.31661/gmj.v15i.3885","DOIUrl":"10.31661/gmj.v15i.3885","url":null,"abstract":"<p><strong>Background: </strong>Article retraction means removing a published article from the journal because of ethical issues or scientific errors in order to correct the literature. In this study, we aimed to determine the reasons for retracting biomedical articles written by authors from Iran, Saudi Arabia, Pakistan, Egypt, and Turkey.</p><p><strong>Materials and methods: </strong>This cross-sectional study included all retracted biomedical articles with first authors affiliated with Iran, Saudi Arabia, Pakistan, Egypt, or Turkey, retracted between September 1, 2010, and September 1, 2019. Data were extracted from Retraction Watch, MEDLINE, PubMed Central (PMC), Clarivate Analytics, and Scopus. Each article's information was entered into a data collection form and analyzed using SPSS version 24.</p><p><strong>Results: </strong>Of 436 retracted articles, Iran had the highest number (223), followed by Turkey (80), Egypt (72), Saudi Arabia (35), and Pakistan (26). Common causes of retraction included plagiarism, duplication, authorship issues, and fake peer review. In Iran, fake peer review (42.6%) and authorship issues (41.3%) were most prevalent. Significant inter- country differences were found in retraction frequency and causes. The most affected fields were biology, biochemistry, oncology, cardiovascular, surgery, and pathology.</p><p><strong>Conclusion: </strong>The results showed that scientific misconducts (plagiarism, duplication, authorship issues, and fake peer review) were the main reasons for retracting the articles in the five studied countries. To reduce such misconducts, regional regulatory policies, improved editorial practices, and enhanced research ethics training are urgently needed.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3885"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tamsulosin on Osteopontin Gene Expression in Preventing Ethylene Glycol-Induced Kidney Stone in Male Wistar Rats : Short title: Effect of Tamsulosin on Osteopontin Gene Expression.","authors":"Ramin Parvizrad, Elahe Ghorbani Marghamlki, Somayeh Nikfar, Sara Khalili Dermani","doi":"10.31661/gmj.v15i.4050","DOIUrl":"10.31661/gmj.v15i.4050","url":null,"abstract":"<p><strong>Background: </strong>Tamsulosin, an α1-adrenergic receptor antagonist, has been proposed as a potential therapeutic agent against urolithiasis-induced renal damage. However, limited in vivo evidence exists regarding its renoprotective mechanisms.</p><p><strong>Materials and methods: </strong>Forty male Wistar rats were randomly allocated into four groups (n=10/group): positive control, negative control (ethylene glycol-induced urolithiasis), prevention (tamsulosin administered simultaneously with ethylene glycol), and treatment (tamsulosin administered after model induction). Biochemical parameters including serum creatinine, urea, uric acid, calcium, and phosphorus were measured using rat-validated commercial kits (Pars Azmun, Iran). Normal ranges were defined based on published reference values. Gene expression was analyzed by qPCR using the 2^-ΔΔCt method. Study design and reporting followed the ARRIVE checklist.</p><p><strong>Results: </strong>At day 30, the prevention group exhibited significantly lower serum creatinine (0.60 ± 0.08 mg/dL) compared to the negative control (0.98 ± 0.12 mg/dL, P0.01). Although urea levels were slightly higher in the prevention group (4.0 ± 0.7 mg/dL) versus the negative control (3.22 ± 0.6 mg/dL), the calculated BUN/creatinine ratio was significantly improved (46.7 vs. 33.0, P0.05). No significant changes were observed in serum calcium or phosphorus. Gene expression analysis showed upregulation of protective markers in the prevention group.</p><p><strong>Conclusion: </strong>In vivo findings on the beneficial effects of tamsulosin on the renal profile in ethylene glycol-induced urolithiasis illustrate its protective effects on the renal system through improvement of creatinine clearance and BUN/creatinine balance. This underscores its probable use as a protective therapeutic agent against renal injury of crystallization origin.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e4050"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Traditional Chinese Medicine External Treatment in Older Patients with Nocturia: A Meta-analysis : Short title: Traditional Chinese Medicine External Therapy for Elderly Nocturia.","authors":"Huiying Zhang, Jinhua Geng, Chunyan Ruan, Qiaoli Lin, Liqin Chen, Yanxiang Luo, Shaoqing Liu, Shaoxia Wu","doi":"10.31661/gmj.v15i.3986","DOIUrl":"10.31661/gmj.v15i.3986","url":null,"abstract":"<p><strong>Background: </strong>To assess the efficacy and clinical value of traditional Chinese medicine external treatment (TCMET) for older patients with nocturia.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Biological Medicine Database (CBM), VIP Chinese Science and Technology Journal Full-text Database (VP-CSJFD), and Wanfang database from their inception to September 30, 2024. Studies focusing on applying TCMET for older patients with nocturia were included. Primary outcome measures comprised the times of nocturia, Pittsburgh sleep quality index (PSQI) scores, and overall response rate. The extracted data was analyzed using Stata software (Version 17.0).</p><p><strong>Results: </strong>15 articles were included in this study (Figure-1), including 580 patients in the TCMET group and 318 patients in the conventional western medicine treatment (CWMT) group. The overall response rate after TCMET treatment in patients with nocturia was 94% [ES=0.94, 95%CI (0.91, 0.94)]. The number of nocturia episodes after treatment decreased by 2.39 times compared to before treatment [SMD=2.39, 95% CI (1.30, 3.48)]. TCMET treatment resulted in a 4.77-point decrease in patients' PSQI scores from baseline [SMD=4.77, 95% CI: 1.67, 7.86]. Compared with CWMT, TCMET did not show significant superiority in improving overall response rate or PSQI scores (P0.05); however, it significantly reduced nocturnal voiding frequency (P0.05).</p><p><strong>Conclusion: </strong>According to the existing literature evidence, TCMET can reduce the times of nocturia and improve sleep quality in older patients with nocturia. It is an effective treatment for older patients with nocturia.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3986"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Jaundice and Weight Loss after Birth in Neonates Referring to the KOSAR Hospital, Qazvin-Iran : Short title: Jaundice and Weight Loss.","authors":"MohammadReza Maleki, Fatemeh Samiee Rad, Masoomeh Hadi, Asghar Ghorbani","doi":"10.31661/gmj.v15i.3896","DOIUrl":"10.31661/gmj.v15i.3896","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the association between the incidence of neonatal jaundice and the weight loss of newborns in postnatal days.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 200 infants with jaundice were examined. The required information was obtained from the medical records. In this study, newborns were divided into two groups based on hyperbilirubinemia. Bilirubin level was compared in two groups on the fourth day of referral. Effect of weight loss was determined on hyperbilirubinemia by logistic regression.</p><p><strong>Results: </strong>The study compared 137 healthy neonates with 53 hyperbilirubinemic neonates, finding significantly greater weight loss (0.25±0.18 kg vs. 0.09±0.11 kg, P0.001) and higher bilirubin levels (17.13±1.05 vs. 12.60±1.89 mg/dL, P0.001) in the latter group. Hyperbilirubinemic neonates had younger mothers (27.23±3.26 vs. 28.63±3.21 years, P=0.007), lower nulliparity (60.4% vs. 75.9%, P=0.033), and higher breastfeeding rates (96.2% vs. 18.6%, P0.001). Logistic regression confirmed weight loss as a strong predictor (aOR=2.14×106, P0.001), with ROC analysis showing high diagnostic accuracy (AUC=0.86-0.88). Optimal cutoffs were 0.175 kg (89% sensitivity) and 4.95% weight loss (91% sensitivity). Maternal and neonatal blood groups also influenced risk.</p><p><strong>Conclusion: </strong>Neonates at risk need to be more closely monitored for jaundice and weighting, thus, early detection and timely treatment can be done.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3896"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Bibliometric Analysis of Herbal Medicine Research in Chinese and Iranian Complementary and Alternative Medicine (CAM) Clinical Trials : Short title: Iranian and Chinese CAM Trials.","authors":"Shahram Shafa, Tayyebeh Zarei, Majid Vatankhah, Fatemeh Rahmanian, Ehsan Rahmanian, Sara Rahmanian, Mansour Deylami, Mojtaba Ghaedi, Amir Hossein Pourdavood, Lohrasb Taheri, Somayeh Mehrpour, Mehrdad Malekshoar, Bibi Mona Razavi, Fatemeh Eftekharian","doi":"10.31661/gmj.v15i.3573","DOIUrl":"10.31661/gmj.v15i.3573","url":null,"abstract":"<p><strong>Background: </strong>Traditional medicine, rooted in ancient history, resurged due to concerns over synthetic pharmaceuticals' adverse effects. Persian medicine, emphasizing medicinal plants, aligns with global healthcare recommendations. Both Iranian and Chinese medicine have influenced medical knowledge historically. Patients worldwide value Traditional Chinese Medicine (TCM) for chronic and severe illnesses. This study goal was to conduct a bibliometric analysis of herbal medicine research in Iranian and Chinese CAM clinical trials to identify trends, patterns, and differences in research productivity and impact.</p><p><strong>Materials and methods: </strong>This bibliometric study compared Chinese and Iranian CAM clinical trials using Web of Science data. It focused on RCTs, applying search terms for CAM and Chinese or Iranian CAM, with exclusion criteria to filter out irrelevant publications. No limitation was posed on publication time. The dataset included author information, article details, keywords, and citation history. It calculated the Annual Growth Rate (AGR) and used visual tools like the Three-Field Plot to illustrate associations. Additionally, Lotka's Law was applied to author productivity, and a co-citation collaboration network was analyzed using Bibliometrix r package.</p><p><strong>Results: </strong>Key findings for Iranian CAM include 71 documents by 342 authors with an average document age of 3.11 years. Chinese CAM featured 255 documents by 1857 authors with an average document age of 5.75 years. Iranian CAM showed a negative annual growth rate of -18.05%, while Chinese CAM had a positive rate of 5.65%. The included studies for Chinese CAM span from 2004 to 2024, while those for Iranian CAM range from 2015 to 2024. The most cited Iranian CAM document had 66 citations, and in Chinese CAM, \"TONG XL, 2012\" and \"LIU XL, 2019\" had the highest total citations. Decentralized research practices were observed in China, while Tehran and Shiraz universities led clinical trials in Iran.</p><p><strong>Conclusion: </strong>Our study indicates differing research trends in Iranian and Chinese herbal medicine. Iranian CAM research showed a declining trend, with Tehran and Shiraz universities leading clinical trials, while Chinese CAM research displayed a growing landscape with a more decentralized approach and greater historical prominence among authors.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"15 ","pages":"e3573"},"PeriodicalIF":0.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success of Dental Implants Placed Without Primary Stability: A Retrospective Study in a Private Practice :.","authors":"Alireza Etezadinia, Hossein Salehivaziri, Seyed Mohammad Mirmoezzi, Emad Taghizadeh, Seyed Mohammad Mahdi Mirmohammadi","doi":"10.31661/gmj.v14iSP1.4114","DOIUrl":"10.31661/gmj.v14iSP1.4114","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study evaluated the success rates of dental implants placed without primary stability in a private practice setting, utilizing three contemporary implant systems (Neodent GM Helix, Biotem AR, MegaGen AnyOne) and stability-oriented protocols.</p><p><strong>Materials and methods: </strong>Records from 63 patients receiving 97 implants (Neodent GM Helix, n=35; Biotem AR, n=39; MegaGen AnyOne, n=23; 76 in maxilla, 21 in mandible) placed between January 2021 and September 2024 in Qazvin, Iran, were reviewed. Absence of primary stability was defined as insertion torque 10 N·cm and/or intraoperative spinning. Immediate placements (n=23) received grafting; all implants were submerged, uncovered at approximately 3 months, and loaded at approximately 4 months. Success was assessed using modified Albrektsson/Buser criteria. Statistical analysis included Wilson 95% confidence intervals and Fisher's exact or χ² tests.</p><p><strong>Results: </strong>Overall success rate was 95.9% (93/97; 95% CI 89.9-98.4%). Success rate by system was 97.1 % (34/35) for Neodent, 94.9% (37/39) for Biotem, 95.7% (22/23) for MegaGen with no significant difference among the systems (P=0.91). Immediate placements achieved a 100% success rate (23 out of 23 implants), compared to 94.6% for delayed placements (70 out of 74 implants), with no significant difference (P=0.58). Success rates were 96.1% in the maxilla (73 out of 76 implants) and 95.2% in the mandible (20 out of 21 implants), with no significant difference (P=1.00). Four early failures occurred (≤4 weeks), all in delayed placements; no late failures were observed. Systemic conditions (diabetes, hypertension, hypothyroidism) did not increase failure rates (P=0.61). All implant failures occurred in posterior regions and delayed timing of placement, while anterior and immediately placed implants achieved 100% success.</p><p><strong>Conclusion: </strong>In carefully selected cases employing atraumatic techniques, socket grafting and sealing for immediate sites, and conservative loading protocols, implants placed without primary stability demonstrated clinically acceptable success rates comparable to private practice benchmarks. Nonetheless, the absence of mechanical primary stability remains a risk factor, particularly in the posterior maxilla or type IV bone; these findings do not advocate replacing primary stability. Prospective, multicenter studies with standardized Implant Stability Quotient (ISQ) monitoring are recommended.</p>","PeriodicalId":44017,"journal":{"name":"Galen Medical Journal","volume":"14 S Pt 1","pages":"e4114"},"PeriodicalIF":0.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}