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Financial hardship in metastatic colorectal cancer patients 转移性结直肠癌癌症患者的经济困难
IF 4.2
Colorectal Cancer Pub Date : 2020-12-01 DOI: 10.2217/crc-2020-0023
V. Shankaran
{"title":"Financial hardship in metastatic colorectal cancer patients","authors":"V. Shankaran","doi":"10.2217/crc-2020-0023","DOIUrl":"https://doi.org/10.2217/crc-2020-0023","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48510306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune checkpoint inhibitor response in mismatch repair-deficient colorectal cancer and other solid tumors: is it truly disease-agnostic? 免疫检查点抑制剂应答错配修复缺陷结直肠癌和其他实体肿瘤:它真的是疾病不可知论吗?
IF 4.2
Colorectal Cancer Pub Date : 2020-12-01 DOI: 10.2217/crc-2020-0020
I. Sahin
{"title":"Immune checkpoint inhibitor response in mismatch repair-deficient colorectal cancer and other solid tumors: is it truly disease-agnostic?","authors":"I. Sahin","doi":"10.2217/crc-2020-0020","DOIUrl":"https://doi.org/10.2217/crc-2020-0020","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47839532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Landscape of Current Targeted Therapies for Advanced Colorectal Cancer 癌症晚期结直肠靶向治疗现状
IF 4.2
Colorectal Cancer Pub Date : 2020-11-16 DOI: 10.5772/INTECHOPEN.93978
A. Pissarra, C. Abreu, A. Mansinho, Ana Lúcia Costa, S. Dâmaso, S. Lobo-Martins, Marta Martins, L. Costa
{"title":"Landscape of Current Targeted Therapies for Advanced Colorectal Cancer","authors":"A. Pissarra, C. Abreu, A. Mansinho, Ana Lúcia Costa, S. Dâmaso, S. Lobo-Martins, Marta Martins, L. Costa","doi":"10.5772/INTECHOPEN.93978","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.93978","url":null,"abstract":"Colorectal cancer (CRC) is one of the most frequent and lethal cancer types worldwide. While surgery with chemotherapy and radiotherapy remains the only curative approach for localized CRC, for metastatic disease the therapeutic landscape has significantly evolved over the last years. Development and approval of novel targeted therapies, such as monoclonal antibodies against EGFR and VEGF, have significantly increased the median survival of patients with metastatic disease, with some trials reporting a benefit over 40 months. Increasing accessibility of high throughput sequencing has unraveled several new therapeutic targets. Actionable alterations, such as HER2 overexpression, BRAF mutations, and NTRK fusions, are currently available in metastatic disease, providing significant therapeutic opportunities for these patients, while new emerging agents, as immune checkpoint inhibitors, promise better treatment options in the near future. In this chapter, an overview of established and future CRC targeted therapies in the clinical setting is provided, as well as their mechanism of action, limitations, and future applicability.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42370281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Public Health: Prevention 公共卫生：预防
IF 4.2
Colorectal Cancer Pub Date : 2020-11-05 DOI: 10.5772/INTECHOPEN.94396
A. Nawi
{"title":"Public Health: Prevention","authors":"A. Nawi","doi":"10.5772/INTECHOPEN.94396","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.94396","url":null,"abstract":"Nowadays, colorectal cancer prevention strategies play an essential role in reducing the incidence and mortality of the cases. A well-designed and establishment of the clinical pathway of screening programme needed in all country. Types of screening tools used may vary between the country with the use of FOBT and colonoscopy. The standard guideline related to screening programme such as for high-risk group should be emphasized more as compared to the low-risk group. The uptake of screening for CRC should be highlighted more as the program have showed a significantly reduction of the cases and mortality. The barrier of CRC screening uptake mainly due to poor awareness, discomfort, low physician recommendation, low socioeconomic and improper screening programme. Therefore others prevention strategies beside screening program such as health education and interactive intervention strategies need to be empower.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46808809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indocyanine Green Fluorescence in Colorectal Cancer 癌症大肠癌组织中的吲哚青绿荧光
IF 4.2
Colorectal Cancer Pub Date : 2020-11-03 DOI: 10.5772/intechopen.94375
E. Vargas, C. Ginestà
{"title":"Indocyanine Green Fluorescence in Colorectal Cancer","authors":"E. Vargas, C. Ginestà","doi":"10.5772/intechopen.94375","DOIUrl":"https://doi.org/10.5772/intechopen.94375","url":null,"abstract":"Fluorescence vision using indocyanine green is a surgical tool with increasing applications in colorectal cancer surgery. This tool has received acceptance in several disciplines as a potential method to improve visualization of the surgical field, improve lymph node resection and decrease the incidence of anastomotic leaks (ALs). In colorectal surgery specifically, some studies have shown that intraoperative fluorescence imaging is a safe and feasible method to evaluate anastomotic perfusion, and its use could affect the incidence of anastomotic leaks. Currently, controlled trials are carried out to validate these conclusions, as well as new indications for indocyanine green such as detection and guidance in the management of hepatic colorectal metastases, visualization of ureters and even as tumor marking and improvement the lymph node harvest of early tumors. These advances could offer great value to surgeons and patients, by improving the accuracy and results of cancer resections.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49610257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging and Diagnosis for Planning the Surgical Procedure 计划手术的影像学和诊断
IF 4.2
Colorectal Cancer Pub Date : 2020-10-20 DOI: 10.5772/intechopen.93873
F. Bauer
{"title":"Imaging and Diagnosis for Planning the Surgical Procedure","authors":"F. Bauer","doi":"10.5772/intechopen.93873","DOIUrl":"https://doi.org/10.5772/intechopen.93873","url":null,"abstract":"The preoperative imaging diagnosis of rectal cancer lies at the heart of oncological staging and has a crucial influence on patient management and therapy planning. Rectal cancer is common, and accurate preoperative staging of tumors using high-resolution magnetic resonance imaging (MRI) is a crucial part of modern multidisciplinary team management (MDT). Indeed, rectal MRI has the ability to accurately evaluate a number of important findings that maBay impact patient management, including distance of the tumor to the mesorectal fascia, presence of lymph nodes, presence of extramural vascular invasion (EMVI), and involvement of the anterior peritoneal reflection/peritoneum and the sphincter complex. Many of these findings are difficult to assess in non-expert hands. In this chapter, we present currently used staging modalities with focus on MRI, including optimization of imaging techniques, tumor staging, interpretation help as well as essentials for reporting.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46577049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Colorectal Cancer in Vietnam 越南癌症结直肠癌
IF 4.2
Colorectal Cancer Pub Date : 2020-10-19 DOI: 10.5772/intechopen.93730
L. Ngoan, Le Hoai Chuong
{"title":"Colorectal Cancer in Vietnam","authors":"L. Ngoan, Le Hoai Chuong","doi":"10.5772/intechopen.93730","DOIUrl":"https://doi.org/10.5772/intechopen.93730","url":null,"abstract":"In this chapter, we focus on the up-to-date status of colorectal cancer occurrence in an Asian country with nearly 100 million in population. Protective and risk factors, time trend of colorectal cancer from 2005 to 2018 will be presented. Perspective of colorectal cancer prevention and research will be highlighted. Data will be derived and based out of current running research projects of prospective cohort study, case-control study, and population-based mortality registration in Vietnam from 2005 to 2020. The association colorectal cancer with lifestyle, diet, cooking methods, demographic factors is taken into analysis. Time trend, colorectal cancer survival, mortality will be presented.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43027108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Laparoscopic Right Colectomy. Intracorporeal Anastomosis Is Associated with Better Outcome 腹腔镜右结肠切除术。体内吻合与更好的结果相关
IF 4.2
Colorectal Cancer Pub Date : 2020-10-14 DOI: 10.5772/intechopen.93996
G. Santoro, Simone Novello, U. Grossi, M. Zucchella, A. Nava, G. Zanus
{"title":"Laparoscopic Right Colectomy. Intracorporeal Anastomosis Is Associated with Better Outcome","authors":"G. Santoro, Simone Novello, U. Grossi, M. Zucchella, A. Nava, G. Zanus","doi":"10.5772/intechopen.93996","DOIUrl":"https://doi.org/10.5772/intechopen.93996","url":null,"abstract":"Colon cancer is the third most common cancer in man and woman in the developed world. Laparoscopic right colectomy is the standard of care for right colon cancer. Since the first report on laparoscopic approach in 1991, the surgical technique has been improved and currently all procedure is performed intracorporeally. The ileo-colic anastomosis can be performed either intracorporeal and extracorporeal: the differences in clinical outcome, complications rate, hospital stay and quality of life between that two techniques are not still clear and a large number of studies has been published about that. According to most recent meta-analysis, intracorporeal anastomosis have showed better outcome in anastomotic leakage rate, surgical site infection rate, development of incisional hernia, postoperative pain and recovery of gastrointestinal function.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43808447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinoids in Treatment of Colorectal Cancer 类维生素a治疗结直肠癌
IF 4.2
Colorectal Cancer Pub Date : 2020-09-24 DOI: 10.5772/INTECHOPEN.93699
C. Facey, B. Boman
{"title":"Retinoids in Treatment of Colorectal Cancer","authors":"C. Facey, B. Boman","doi":"10.5772/INTECHOPEN.93699","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.93699","url":null,"abstract":"Retinoids are vitamin A metabolites best known for their role in embryonic development. Indeed, retinoid acid (RA) signaling plays a key role in regulating the development of the embryo body-plan by controlling embryonic stem cells (SCs). Retinoids function through their ability to induce cellular differentiation. Mutations in RA signaling pathway genes occur in most human cancers. The classic example is the chromosomal translocation involving RA receptor alpha in acute promyelocytic leukemia (APL). Because all-trans retinoic acid (ATRA) is a highly effective and often curative treatment for APL patients, determining if retinoids are efficacious for other cancer types is imperative. We review the current research on retinoids in colorectal cancer (CRC) and provide bioinformatics analyses of RA signaling. Our results show that most RA pathway genes are overexpressed and often mutated in CRC. Moreover, aberrant expression of many RA signaling proteins predicts decreased CRC patient survival. We also review aldehyde dehydrogenase (ALDH) expression in CRC because ALDH is a key enzyme in RA signaling, which regulates colonic SCs. Further investigation of RA signaling mechanisms that regulate colon SCs and how dysregulation contributes to the SC overpopulation that drives CRC growth should provide insight into strategies for designing new SC-targeted therapies for CRC.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49147864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Palliative Care in Colorectal Cancer 结直肠癌的姑息治疗
IF 4.2
Colorectal Cancer Pub Date : 2020-09-24 DOI: 10.5772/INTECHOPEN.93513
R. Caponero
{"title":"Palliative Care in Colorectal Cancer","authors":"R. Caponero","doi":"10.5772/INTECHOPEN.93513","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.93513","url":null,"abstract":"Approximately 25% of patients present with liver metastases at the time of the first diagnosis and up to 50% will further develop recurrence in the liver during their disease course. Traditionally approached surgically, by resection of the primitive tumor or stoma, the management to incurable stage IV colorectal cancer patients has significantly changed over the last three decades and is nowadays multidisciplinary, with a pivotal role played by chemotherapy. Most patients with stage IV colorectal cancer have a poor prognosis, but numerous palliative modalities are available today. When a cure is no longer possible, treatment is directed toward providing symptomatic relief. Good symptom management in oncology is associated with improved patient and family quality of life, greater treatment compliance, and may even offer survival advantages.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48097206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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