Adjuvant Therapies in Colon Cancer

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2020-09-22 DOI:10.5772/INTECHOPEN.93874

T. Prasanna, D. Yip

引用次数: 0

Abstract

Most of the patients with localized colon cancer undergo curative resection. However, significant number of patients will recur with metastatic disease, especially those with node positive cancer. Adjuvant chemotherapy has shown to improve cure rate and survival by eradicating micrometastases. The benefit of adjuvant therapy is well established in node-positive cancers, while their role in stage II cancer is not well defined. A number of molecular markers have been identified that are prognostic and/or predictive in colon cancer. Such molecular markers, and other clinicopathological features play an important role in selection of appropriate therapy and duration of treatment. Emerging evidence for the utility of genomic profiling or detection of circulating tumor DNA (ctDNA) are promising which may further facilitate decision making in the future. This chapter reviews the evolution of adjuvant therapy for resected colon cancer, the current evidence and the factors influence the choice of therapy.

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结肠癌的辅助治疗

大多数局部结肠癌患者接受根治性切除术。然而，相当数量的患者会复发转移性疾病，特别是那些淋巴结阳性的癌症。辅助化疗已被证明通过根除微转移提高治愈率和生存率。辅助治疗在淋巴结阳性癌症中的益处已得到证实，但在II期癌症中的作用尚未明确。许多分子标记已被确定为结肠癌的预后和/或预测。这些分子标记物和其他临床病理特征在选择合适的治疗方法和治疗时间方面起着重要作用。利用基因组谱分析或循环肿瘤DNA (ctDNA)检测的新证据是有希望的，这可能进一步促进未来的决策。本章综述了结肠癌切除术辅助治疗的发展，目前的证据和影响治疗选择的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

自引率

0.00%

发文量

期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.